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The map label for this gene is dbh [H]

Identifier: 82702078

GI number: 82702078

Start: 1101121

End: 1102278

Strand: Direct

Name: dbh [H]

Synonym: Nmul_A0949

Alternate gene names: 82702078

Gene position: 1101121-1102278 (Clockwise)

Preceding gene: 82702077

Following gene: 82702079

Centisome position: 34.58

GC content: 57.6

Gene sequence:

>1158_bases
ATGGCCCGCTGCGTTGCCCATCTCGATATGGATGCTTTTTACGCTTCGGTCGAGTTGAAACGATACCCGCAATTGCGCGG
ATTACCGGTGATAATCGGCGGAAGCGCGGAGCAGCAGCCAGAACTTTTCAATGGTGAGCCGCGTTTTGCAAAACTGAAAG
GTTATGCGGGACGGGGTGTGGTAACCACCGCTACTTACGAGGCTCGCGCTTTCGGCGTTTCCTCCGGCATGGGCTTGATG
AAAGCGGCGCAGTTGGCCCCGGAGGCTATCCTGCTGCCCGCCGACTTCAGCGCATACCGCCGTTATTCGAATCTGTTCAA
AACGGCCGTTGCTTTGGTCGCGCCTCGTATAGAGGATCGCGGTATCGATGAGATTTACATCGATCTCAGTGACTCGGCCG
AAGATATCGTGACTCTTGCCCGGCGCATCAAGCAGGCTGTGCGGGAAAGCACCGGGTTGTCCTGTTCTATCGGCGTGGCG
CCAAACAAGCTTCTGGCAAAAATCTGCTCAGACCTTGAAAAGCCGGATGGTCTCACTCTCCTGAGCATGGCCGATGTTCC
AGCCAGAATCTGGCCTCTTCCCGTCCGTAAAATTAATGGCATCGGTCCGAAGGCAAACCAGAAACTGGCAGCGTCAGGTA
TTTTCACCATCGGTGATCTGGCACAAGTAGACATCGCTTTCCTGCAGGCGCGGTTCGGGCGCAGCAACGGCTGCTGGCTG
TATGAGGCTTCCCGGGGCATTGACGAGCGTTCCGTCGTGACTCATGCGGAGCCCAGGTCGATCAGCCGCGAGACGACTTT
CGAGCGGGATCTGCATGCGCGTCGCGATCGTCCCATTCTTTCTGAAATTTTCACCGGCCTATGCGCGGGAGTCGCCGAAG
ATCTTCAGCGCAAGGGCTATGCTGCCCGTACCATCGGCATCAAATTGCGGTATGAAGATTTTCGCACCGTAACCCGCGAC
ATCACGCTCCCAGTTCCCACAGCGAATGCCGCCGTCATTCGCAAGGCAGCCCAGGAATGCCTGCGGCGCGTCTCTCTTGA
GCAGAAAATACGGTTGCTTGGCGTTCGCGCGAGCGGGTTGTGTTCCGAGACGCTGGCGCAGAGCGCGGACATGAGTCAGC
AAAGGGAACTTCCCCTGGCTGTGCCGGACATCCGATGA

Upstream 100 bases:

>100_bases
TGCTCGGTACGCGCGCCGCGCTCTCAACCCCCCCGCTCATGACCCTGCGCAGGATCTGAATGTTCCCGTCTTGCCGCTTT
GCCTCGAACGGATAGGAGGA

Downstream 100 bases:

>100_bases
AGAAGTGTGCATACAGATTGCTCGTTGCCCAAGTGGGCCAGTGAAATATGGGCGATAATCCTTCCTTTTTTCTTCATTGA
GCAGCATGGGCAGTGTCCTT

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: Pol IV [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MARCVAHLDMDAFYASVELKRYPQLRGLPVIIGGSAEQQPELFNGEPRFAKLKGYAGRGVVTTATYEARAFGVSSGMGLM
KAAQLAPEAILLPADFSAYRRYSNLFKTAVALVAPRIEDRGIDEIYIDLSDSAEDIVTLARRIKQAVRESTGLSCSIGVA
PNKLLAKICSDLEKPDGLTLLSMADVPARIWPLPVRKINGIGPKANQKLAASGIFTIGDLAQVDIAFLQARFGRSNGCWL
YEASRGIDERSVVTHAEPRSISRETTFERDLHARRDRPILSEIFTGLCAGVAEDLQRKGYAARTIGIKLRYEDFRTVTRD
ITLPVPTANAAVIRKAAQECLRRVSLEQKIRLLGVRASGLCSETLAQSADMSQQRELPLAVPDIR

Sequences:

>Translated_385_residues
MARCVAHLDMDAFYASVELKRYPQLRGLPVIIGGSAEQQPELFNGEPRFAKLKGYAGRGVVTTATYEARAFGVSSGMGLM
KAAQLAPEAILLPADFSAYRRYSNLFKTAVALVAPRIEDRGIDEIYIDLSDSAEDIVTLARRIKQAVRESTGLSCSIGVA
PNKLLAKICSDLEKPDGLTLLSMADVPARIWPLPVRKINGIGPKANQKLAASGIFTIGDLAQVDIAFLQARFGRSNGCWL
YEASRGIDERSVVTHAEPRSISRETTFERDLHARRDRPILSEIFTGLCAGVAEDLQRKGYAARTIGIKLRYEDFRTVTRD
ITLPVPTANAAVIRKAAQECLRRVSLEQKIRLLGVRASGLCSETLAQSADMSQQRELPLAVPDIR
>Mature_384_residues
ARCVAHLDMDAFYASVELKRYPQLRGLPVIIGGSAEQQPELFNGEPRFAKLKGYAGRGVVTTATYEARAFGVSSGMGLMK
AAQLAPEAILLPADFSAYRRYSNLFKTAVALVAPRIEDRGIDEIYIDLSDSAEDIVTLARRIKQAVRESTGLSCSIGVAP
NKLLAKICSDLEKPDGLTLLSMADVPARIWPLPVRKINGIGPKANQKLAASGIFTIGDLAQVDIAFLQARFGRSNGCWLY
EASRGIDERSVVTHAEPRSISRETTFERDLHARRDRPILSEIFTGLCAGVAEDLQRKGYAARTIGIKLRYEDFRTVTRDI
TLPVPTANAAVIRKAAQECLRRVSLEQKIRLLGVRASGLCSETLAQSADMSQQRELPLAVPDIR

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Homo sapiens, GI84043967, Length=422, Percent_Identity=27.2511848341232, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI7706681, Length=423, Percent_Identity=27.6595744680851, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI7705344, Length=433, Percent_Identity=25.4041570438799, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI154350220, Length=343, Percent_Identity=25.9475218658892, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI5729982, Length=157, Percent_Identity=34.3949044585987, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786425, Length=329, Percent_Identity=37.0820668693009, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1787432, Length=238, Percent_Identity=29.8319327731092, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI193205700, Length=425, Percent_Identity=27.5294117647059, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI193205702, Length=255, Percent_Identity=32.156862745098, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17537959, Length=214, Percent_Identity=27.1028037383178, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19923006, Length=300, Percent_Identity=30, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24668444, Length=125, Percent_Identity=35.2, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 42174; Mature: 42043

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARCVAHLDMDAFYASVELKRYPQLRGLPVIIGGSAEQQPELFNGEPRFAKLKGYAGRGV
CCCEEHHCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCEEEECCCCCCCE
VTTATYEARAFGVSSGMGLMKAAQLAPEAILLPADFSAYRRYSNLFKTAVALVAPRIEDR
EEEEEEHHHHCCCCCCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCC
GIDEIYIDLSDSAEDIVTLARRIKQAVRESTGLSCSIGVAPNKLLAKICSDLEKPDGLTL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCEEE
LSMADVPARIWPLPVRKINGIGPKANQKLAASGIFTIGDLAQVDIAFLQARFGRSNGCWL
EEECCCCCHHCCCCHHHHCCCCCCCCCHHHHCCCEEECHHHHHHHHHHHHHCCCCCCEEE
YEASRGIDERSVVTHAEPRSISRETTFERDLHARRDRPILSEIFTGLCAGVAEDLQRKGY
EECCCCCCHHHEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
AARTIGIKLRYEDFRTVTRDITLPVPTANAAVIRKAAQECLRRVSLEQKIRLLGVRASGL
EEEEEEEEEEEHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHCHHHHHHHEECCCCCH
CSETLAQSADMSQQRELPLAVPDIR
HHHHHHHHCCCHHHCCCCCCCCCCC
>Mature Secondary Structure 
ARCVAHLDMDAFYASVELKRYPQLRGLPVIIGGSAEQQPELFNGEPRFAKLKGYAGRGV
CCEEHHCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCEEEECCCCCCCE
VTTATYEARAFGVSSGMGLMKAAQLAPEAILLPADFSAYRRYSNLFKTAVALVAPRIEDR
EEEEEEHHHHCCCCCCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCC
GIDEIYIDLSDSAEDIVTLARRIKQAVRESTGLSCSIGVAPNKLLAKICSDLEKPDGLTL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCEEE
LSMADVPARIWPLPVRKINGIGPKANQKLAASGIFTIGDLAQVDIAFLQARFGRSNGCWL
EEECCCCCHHCCCCHHHHCCCCCCCCCHHHHCCCEEECHHHHHHHHHHHHHCCCCCCEEE
YEASRGIDERSVVTHAEPRSISRETTFERDLHARRDRPILSEIFTGLCAGVAEDLQRKGY
EECCCCCCHHHEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
AARTIGIKLRYEDFRTVTRDITLPVPTANAAVIRKAAQECLRRVSLEQKIRLLGVRASGL
EEEEEEEEEEEHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHCHHHHHHHEECCCCCH
CSETLAQSADMSQQRELPLAVPDIR
HHHHHHHHCCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA