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The map label for this gene is macA [H]

Identifier: 82702079

GI number: 82702079

Start: 1102426

End: 1103580

Strand: Direct

Name: macA [H]

Synonym: Nmul_A0950

Alternate gene names: 82702079

Gene position: 1102426-1103580 (Clockwise)

Preceding gene: 82702078

Following gene: 82702080

Centisome position: 34.62

GC content: 59.65

Gene sequence:

>1155_bases
ATGCAAACAAAAAAAACACTGGTCCGTTTCGCCATTATCATTGTTATTCTCATGGTGGCGGGTTATGCAATATGGTTTGC
AATGCGTCCGGCGCCCATAGAGGTTGAGCTTGCGACCATCGGGCGGAGTACAGTGGAAGCCACCGTGGTGAATACACGTG
CCGGAACAGTGACCGCATGCCGGCGTGCCAAGCTTGCGCCAGCGGCGGGAGGGCAGATTGTCAAGTTGCAGGTCAAGGAG
GGTGACAGGGTCAAGAAAGGACAGGTATTGCTGGAACTGTGGAATACGGATCTGACCGCCCAGCGCGATCTTGCCCGGCG
CCAGCTCATCACCGCGGAAGAGCGGCGCCGCGAAGCCTGCATCCTTGCGGCCCATGCCGGCCGCGAGGCCGAGCGTGCGC
GTCAGCTCGCCGAGAGAGGCTTCGTCAGCGCCCAGAACCGGGAGAATGCCGATGCCGATGCGCGCGCCCGGCAAGCGAGC
TGCGATGCGACTATTGCCGATGTGAAGCGGGCGCGAGCTCAGGTAGAAGTAACAGAGGCGGGGCTGGAGCGCACGGTTCT
GACTGCTCCATTTGACGGCATTGTGGCGCTTGTCACCGGGGAGCTGGGTGAATATACCACTCCGTCCCCCCCGGGGATTC
CCACCCCGCCGGCTATTGATCTGATCGATGATAGTTGTCTGTATGTTACCGCTCCAATGGATGAAGTCGATGCGCCCAAG
CTGAAGATCGGCCAACTCGCCCGCATTACGATTGATGCCTTGCCCGGCCAGATCTTCCCCGGCAAGGTGCGGCGGGTGGC
GCCCTATGTCACGGAGGTAGAGAAGCAGGCGCGCACGGTGGATATCGAAGTGGATTTCGAAGAAATACCGGAACGGCCGT
TGCTGGTGGGGTATAGCGCAGATGTCGAAGTGGTGATCGAACGGCATGAGAATGTGCTGCGCGTGCCCACCCAGGCGATC
CGTCAGGGTGGCAAGGTGTTGTTGGTGAACGAGGAGAACCGATTGGTTGAACGCAGGCTGGAAACAGGACTGGCCAACTG
GGCATTTACCGAAGTCACCGGTGGCCTGGAGGAAGGCGATCGCGTGTTGCTGTCATCAGAGGCAAAGGAAATCAAAGCCG
GTATACAAGTCCGGGAGAAGGTTGCCGAGCAGTGA

Upstream 100 bases:

>100_bases
ATGGGCGATAATCCTTCCTTTTTTCTTCATTGAGCAGCATGGGCAGTGTCCTTGGCTGCTTGAAGCGGCTACTTGCTTTC
ACCCGATTTATCCATTCTCC

Downstream 100 bases:

>100_bases
ATCAATGGAGTGATCCGTTGATTCACTTCGCCAGAATGGAATGATTCGCCTTACTGACATTTCGCGTGTTTTCCATATGG
GAGACCAGGGGGTACGAGCG

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MQTKKTLVRFAIIIVILMVAGYAIWFAMRPAPIEVELATIGRSTVEATVVNTRAGTVTACRRAKLAPAAGGQIVKLQVKE
GDRVKKGQVLLELWNTDLTAQRDLARRQLITAEERRREACILAAHAGREAERARQLAERGFVSAQNRENADADARARQAS
CDATIADVKRARAQVEVTEAGLERTVLTAPFDGIVALVTGELGEYTTPSPPGIPTPPAIDLIDDSCLYVTAPMDEVDAPK
LKIGQLARITIDALPGQIFPGKVRRVAPYVTEVEKQARTVDIEVDFEEIPERPLLVGYSADVEVVIERHENVLRVPTQAI
RQGGKVLLVNEENRLVERRLETGLANWAFTEVTGGLEEGDRVLLSSEAKEIKAGIQVREKVAEQ

Sequences:

>Translated_384_residues
MQTKKTLVRFAIIIVILMVAGYAIWFAMRPAPIEVELATIGRSTVEATVVNTRAGTVTACRRAKLAPAAGGQIVKLQVKE
GDRVKKGQVLLELWNTDLTAQRDLARRQLITAEERRREACILAAHAGREAERARQLAERGFVSAQNRENADADARARQAS
CDATIADVKRARAQVEVTEAGLERTVLTAPFDGIVALVTGELGEYTTPSPPGIPTPPAIDLIDDSCLYVTAPMDEVDAPK
LKIGQLARITIDALPGQIFPGKVRRVAPYVTEVEKQARTVDIEVDFEEIPERPLLVGYSADVEVVIERHENVLRVPTQAI
RQGGKVLLVNEENRLVERRLETGLANWAFTEVTGGLEEGDRVLLSSEAKEIKAGIQVREKVAEQ
>Mature_384_residues
MQTKKTLVRFAIIIVILMVAGYAIWFAMRPAPIEVELATIGRSTVEATVVNTRAGTVTACRRAKLAPAAGGQIVKLQVKE
GDRVKKGQVLLELWNTDLTAQRDLARRQLITAEERRREACILAAHAGREAERARQLAERGFVSAQNRENADADARARQAS
CDATIADVKRARAQVEVTEAGLERTVLTAPFDGIVALVTGELGEYTTPSPPGIPTPPAIDLIDDSCLYVTAPMDEVDAPK
LKIGQLARITIDALPGQIFPGKVRRVAPYVTEVEKQARTVDIEVDFEEIPERPLLVGYSADVEVVIERHENVLRVPTQAI
RQGGKVLLVNEENRLVERRLETGLANWAFTEVTGGLEEGDRVLLSSEAKEIKAGIQVREKVAEQ

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=379, Percent_Identity=27.4406332453826, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87081951, Length=254, Percent_Identity=27.9527559055118, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42061; Mature: 42061

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTKKTLVRFAIIIVILMVAGYAIWFAMRPAPIEVELATIGRSTVEATVVNTRAGTVTAC
CCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEEECCCCEEEEEEEECCCCHHHHH
RRAKLAPAAGGQIVKLQVKEGDRVKKGQVLLELWNTDLTAQRDLARRQLITAEERRREAC
HHCCCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCHHHHCCCEE
ILAAHAGREAERARQLAERGFVSAQNRENADADARARQASCDATIADVKRARAQVEVTEA
EEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHEEEEHHH
GLERTVLTAPFDGIVALVTGELGEYTTPSPPGIPTPPAIDLIDDSCLYVTAPMDEVDAPK
CCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCCCC
LKIGQLARITIDALPGQIFPGKVRRVAPYVTEVEKQARTVDIEVDFEEIPERPLLVGYSA
EECCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEECHHHCCCCCEEEEECC
DVEVVIERHENVLRVPTQAIRQGGKVLLVNEENRLVERRLETGLANWAFTEVTGGLEEGD
CHHHEEECCCCEEECCHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCHHHHCCCCCCCC
RVLLSSEAKEIKAGIQVREKVAEQ
EEEECCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQTKKTLVRFAIIIVILMVAGYAIWFAMRPAPIEVELATIGRSTVEATVVNTRAGTVTAC
CCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEEECCCCEEEEEEEECCCCHHHHH
RRAKLAPAAGGQIVKLQVKEGDRVKKGQVLLELWNTDLTAQRDLARRQLITAEERRREAC
HHCCCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCHHHHCCCEE
ILAAHAGREAERARQLAERGFVSAQNRENADADARARQASCDATIADVKRARAQVEVTEA
EEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHEEEEHHH
GLERTVLTAPFDGIVALVTGELGEYTTPSPPGIPTPPAIDLIDDSCLYVTAPMDEVDAPK
CCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCCCC
LKIGQLARITIDALPGQIFPGKVRRVAPYVTEVEKQARTVDIEVDFEEIPERPLLVGYSA
EECCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEECHHHCCCCCEEEEECC
DVEVVIERHENVLRVPTQAIRQGGKVLLVNEENRLVERRLETGLANWAFTEVTGGLEEGD
CHHHEEECCCCEEECCHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCHHHHCCCCCCCC
RVLLSSEAKEIKAGIQVREKVAEQ
EEEECCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]