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The map label for this gene is pncB2 [H]

Identifier: 82702036

GI number: 82702036

Start: 1031130

End: 1032503

Strand: Direct

Name: pncB2 [H]

Synonym: Nmul_A0907

Alternate gene names: 82702036

Gene position: 1031130-1032503 (Clockwise)

Preceding gene: 82702035

Following gene: 82702043

Centisome position: 32.38

GC content: 58.22

Gene sequence:

>1374_bases
GTGAACCCACTCTCCAGCCCGCTACTGACCGACCATTACCAGTTGACCATGCTGGAGAGCTACCTTCAGCAGGGAATGCA
GGAAACTGCGGTTTTCGAGCTGTTTTTCCGCAAGCTTCCCCCGACCCGGAATTTTCTGGTGGCGGCGGGTCTGGAACAGG
CGCTGGAATTCCTTGAGAACCTGCATTTTTCAGCGGGGGAGTTGACATGGCTCAAGGCCCGGTTTGGACCTGCTCTTGTA
AATTACCTTGAACAATTCCGGTTTACCGGCGATGTGGATGCAATGCCGGAAGGGACGCTTTTTTTTCCGGATGAGCCCAT
CCTTCGGATCACGGCGCCGCTGCCGCAAGCCCAGTTCGTTGAATCGCGTATCATCAACCTGCTGCATTTCGAAACCCTGA
TCGCCTCAAAGGCAGCACGCTCAGTGCTGGTTGCGCCCGGCAAACTCCTGGTGGATTTCGGCATGCGCCGGGCACATGGA
GCGGAAGCCGCGTTGCTTGCCGCCCGGGCAAGTTATCTTGCCGGTTTTTCCGGCACATCAACAGTACTTGCGGCGGCAAT
ATATGGCATGCCTTCGTTCGGCACCGTTGCTCATTCCTACATTCAGGCCCATACAGACGAGACTGCCGCTTTCGAACATC
TTGTGCGTTGCCATCCGAAAAACTCGACGCTGCTGATCGATACCTACGACACCGAGGCGGCTGCCATCAAGGTCGTCGCC
CTGGCCCGCAAACTTGCACCGGAGGGCATCGAGGTAAGTGGCGTCCGGCTGGACAGCGGCGACTTGGGAATGCATGCCCG
GCGCGTGCGCCGGATACTCGACGAGGGGAGACTCGAAAAAACCCGCATCTTTGCCAGCGGTAATCTGAACGAAAATCGGG
TGCATGAACTGATTTCATCCGGCGCTCCCATTGACGGCTTTGGCGTGGGTACTGCATTAGACGTGTCGAGCGACGCTCCG
GCGCTGGATTGCGCCTATAAGCTGCAGGAGTACGCCGGCAAGGCCCGCCGCAAACGCTCCGAGGGAAAAGCGACATGGCC
GGGTCGGAAGCAGGTGTATCGCAAATATGACCCGAATGGCCAAGCGATGCGCGATGTTATTGCACTGGAAAAGGATGATT
CGCATGAGGGCGAGCCTTTAATTGTCCCTGTGATGCGGAATGGGCGGCGCATTGAAGGGATCGACGGGAATGGGAAGCTG
GAGGCCATCCGCCGGCGAACAGTGGCGAACTATGCCCGCCTGCCGGAACCCCTCCGATCGCTTGAAACGGCATCCGCTTA
CCCGGTCGAAATCTCCCCCTCGCTGCAGGCTCTGGCAAAACAGGTGGATGACGAGTGCGGCCTCATTACCTCTACCCGGA
ACCTTTGCGTCTGA

Upstream 100 bases:

>100_bases
ATGCAGTACGGGGGCTGGATGCCGACGCAACCAGCGCCGCCCTAGAGGAAATGGCCCATCTGGGCGCAAAACTCATCGAT
TTCGAAACCATTGTCCCTGC

Downstream 100 bases:

>100_bases
GCGGGTGTTGACCTGACCTTCGTATCCTGCCGCGCTCGAGGATACCTTCGGAGGAGTAGGGACGGCTCATGCAACTGCCT
CGTTGAGGGTGCCCGCCAGC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB2 [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MNPLSSPLLTDHYQLTMLESYLQQGMQETAVFELFFRKLPPTRNFLVAAGLEQALEFLENLHFSAGELTWLKARFGPALV
NYLEQFRFTGDVDAMPEGTLFFPDEPILRITAPLPQAQFVESRIINLLHFETLIASKAARSVLVAPGKLLVDFGMRRAHG
AEAALLAARASYLAGFSGTSTVLAAAIYGMPSFGTVAHSYIQAHTDETAAFEHLVRCHPKNSTLLIDTYDTEAAAIKVVA
LARKLAPEGIEVSGVRLDSGDLGMHARRVRRILDEGRLEKTRIFASGNLNENRVHELISSGAPIDGFGVGTALDVSSDAP
ALDCAYKLQEYAGKARRKRSEGKATWPGRKQVYRKYDPNGQAMRDVIALEKDDSHEGEPLIVPVMRNGRRIEGIDGNGKL
EAIRRRTVANYARLPEPLRSLETASAYPVEISPSLQALAKQVDDECGLITSTRNLCV

Sequences:

>Translated_457_residues
MNPLSSPLLTDHYQLTMLESYLQQGMQETAVFELFFRKLPPTRNFLVAAGLEQALEFLENLHFSAGELTWLKARFGPALV
NYLEQFRFTGDVDAMPEGTLFFPDEPILRITAPLPQAQFVESRIINLLHFETLIASKAARSVLVAPGKLLVDFGMRRAHG
AEAALLAARASYLAGFSGTSTVLAAAIYGMPSFGTVAHSYIQAHTDETAAFEHLVRCHPKNSTLLIDTYDTEAAAIKVVA
LARKLAPEGIEVSGVRLDSGDLGMHARRVRRILDEGRLEKTRIFASGNLNENRVHELISSGAPIDGFGVGTALDVSSDAP
ALDCAYKLQEYAGKARRKRSEGKATWPGRKQVYRKYDPNGQAMRDVIALEKDDSHEGEPLIVPVMRNGRRIEGIDGNGKL
EAIRRRTVANYARLPEPLRSLETASAYPVEISPSLQALAKQVDDECGLITSTRNLCV
>Mature_457_residues
MNPLSSPLLTDHYQLTMLESYLQQGMQETAVFELFFRKLPPTRNFLVAAGLEQALEFLENLHFSAGELTWLKARFGPALV
NYLEQFRFTGDVDAMPEGTLFFPDEPILRITAPLPQAQFVESRIINLLHFETLIASKAARSVLVAPGKLLVDFGMRRAHG
AEAALLAARASYLAGFSGTSTVLAAAIYGMPSFGTVAHSYIQAHTDETAAFEHLVRCHPKNSTLLIDTYDTEAAAIKVVA
LARKLAPEGIEVSGVRLDSGDLGMHARRVRRILDEGRLEKTRIFASGNLNENRVHELISSGAPIDGFGVGTALDVSSDAP
ALDCAYKLQEYAGKARRKRSEGKATWPGRKQVYRKYDPNGQAMRDVIALEKDDSHEGEPLIVPVMRNGRRIEGIDGNGKL
EAIRRRTVANYARLPEPLRSLETASAYPVEISPSLQALAKQVDDECGLITSTRNLCV

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=521, Percent_Identity=28.5988483685221, Blast_Score=189, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI71997947, Length=443, Percent_Identity=33.1828442437923, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI71997952, Length=443, Percent_Identity=33.1828442437923, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI71997955, Length=221, Percent_Identity=39.8190045248869, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24581587, Length=430, Percent_Identity=33.2558139534884, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI161076680, Length=211, Percent_Identity=38.8625592417062, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24581595, Length=211, Percent_Identity=38.8625592417062, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI28574709, Length=211, Percent_Identity=38.8625592417062, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24581593, Length=211, Percent_Identity=38.8625592417062, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24581591, Length=211, Percent_Identity=38.8625592417062, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 50233; Mature: 50233

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPLSSPLLTDHYQLTMLESYLQQGMQETAVFELFFRKLPPTRNFLVAAGLEQALEFLEN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHH
LHFSAGELTWLKARFGPALVNYLEQFRFTGDVDAMPEGTLFFPDEPILRITAPLPQAQFV
CCCCCCCEEEEHHHHCHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCEEEECCCCHHHHH
ESRIINLLHFETLIASKAARSVLVAPGKLLVDFGMRRAHGAEAALLAARASYLAGFSGTS
HHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHCHHHCCCCHHHHHHHHHHHHHCCCCHH
TVLAAAIYGMPSFGTVAHSYIQAHTDETAAFEHLVRCHPKNSTLLIDTYDTEAAAIKVVA
HHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHH
LARKLAPEGIEVSGVRLDSGDLGMHARRVRRILDEGRLEKTRIFASGNLNENRVHELISS
HHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHC
GAPIDGFGVGTALDVSSDAPALDCAYKLQEYAGKARRKRSEGKATWPGRKQVYRKYDPNG
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCH
QAMRDVIALEKDDSHEGEPLIVPVMRNGRRIEGIDGNGKLEAIRRRTVANYARLPEPLRS
HHHHHHHHHCCCCCCCCCEEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHCCHHHHH
LETASAYPVEISPSLQALAKQVDDECGLITSTRNLCV
HHCCCCCCEEECHHHHHHHHHHCCCCCEEECCCCCCC
>Mature Secondary Structure
MNPLSSPLLTDHYQLTMLESYLQQGMQETAVFELFFRKLPPTRNFLVAAGLEQALEFLEN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHH
LHFSAGELTWLKARFGPALVNYLEQFRFTGDVDAMPEGTLFFPDEPILRITAPLPQAQFV
CCCCCCCEEEEHHHHCHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCEEEECCCCHHHHH
ESRIINLLHFETLIASKAARSVLVAPGKLLVDFGMRRAHGAEAALLAARASYLAGFSGTS
HHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHCHHHCCCCHHHHHHHHHHHHHCCCCHH
TVLAAAIYGMPSFGTVAHSYIQAHTDETAAFEHLVRCHPKNSTLLIDTYDTEAAAIKVVA
HHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHH
LARKLAPEGIEVSGVRLDSGDLGMHARRVRRILDEGRLEKTRIFASGNLNENRVHELISS
HHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHC
GAPIDGFGVGTALDVSSDAPALDCAYKLQEYAGKARRKRSEGKATWPGRKQVYRKYDPNG
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCH
QAMRDVIALEKDDSHEGEPLIVPVMRNGRRIEGIDGNGKLEAIRRRTVANYARLPEPLRS
HHHHHHHHHCCCCCCCCCEEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHCCHHHHH
LETASAYPVEISPSLQALAKQVDDECGLITSTRNLCV
HHCCCCCCEEECHHHHHHHHHHCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]