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The map label for this gene is hisG

Identifier: 82701953

GI number: 82701953

Start: 934988

End: 935671

Strand: Reverse

Name: hisG

Synonym: Nmul_A0820

Alternate gene names: 82701953

Gene position: 935671-934988 (Counterclockwise)

Preceding gene: 82701957

Following gene: 82701952

Centisome position: 29.38

GC content: 55.26

Gene sequence:

>684_bases
ATGACGAGCATCACCATCGCCCTTTCCAAGGGGCGGATTTTTGACGATACCGCACCCCTGCTTAAAGCCGCGGGAATTAT
TCCGCTGGATGACCCCGAAACATCACGCAAGCTGATCCTTGCCACCAATCGCGACGACGTGCGGCTCATCATCGTACGGG
CTTCGGATGTACCGACCTATGTGCAATATGGCGCGGCAGACATGGGCATCGCGGGAAAGGATGTGCTGCTGGAGCATGGC
GGCGCAGGGCTCTATCAGCCTCTCGATTTGAATATCGCCCGCTGTCGCATGATGGTGGCTGTACGCAGCGATTTTGACTA
TGAATCTGCGGTCCGGCGGGGCGCGCGAGTGCGAGTCGCTACCAAGTATCTACAGACGGCGCGTGAACACTTTGCGGAAA
AAGGAATGCATGTCGATCTCATCAAGCTCTATGGATCCATGGAGCTTGCTCCCCTGGTAGGATTGGCGGACGCAATCGTG
GATCTGGTTTCAAGCGGCAATACGCTGAAAGCGAACAATCTCAAGGCCGTCGAAGAAATAATGCCGATCTCATCCCGACT
GATCATCAATCAGGCAGCGTTGAAATTGAAACGCCGCGCAATACAACCGATGCTGGAAGCCTTCTCGGCTGCGATTACTC
CCCTTACACCTCTATCTCCTTACCCCCTTGGAGCAACCCCCTGA

Upstream 100 bases:

>100_bases
GAGCCCGTTGCTGGAATTCCGGGATTGTCATTCGTCCTTGAATTGTCGGCAAACCGGCTCGACGACTTTTGCGGTAAAAT
ACAGCCTTTGCGCATTCTTC

Downstream 100 bases:

>100_bases
GCGGGCTCGGAACTGCAACTGCCCCGCTCGTTTATCCCTTATCCCTTTCCTTACCCCTCATGATTTCGATAAAGAGATTG
TCTTCTGCCGATACCGAGTT

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MTSITIALSKGRIFDDTAPLLKAAGIIPLDDPETSRKLILATNRDDVRLIIVRASDVPTYVQYGAADMGIAGKDVLLEHG
GAGLYQPLDLNIARCRMMVAVRSDFDYESAVRRGARVRVATKYLQTAREHFAEKGMHVDLIKLYGSMELAPLVGLADAIV
DLVSSGNTLKANNLKAVEEIMPISSRLIINQAALKLKRRAIQPMLEAFSAAITPLTPLSPYPLGATP

Sequences:

>Translated_227_residues
MTSITIALSKGRIFDDTAPLLKAAGIIPLDDPETSRKLILATNRDDVRLIIVRASDVPTYVQYGAADMGIAGKDVLLEHG
GAGLYQPLDLNIARCRMMVAVRSDFDYESAVRRGARVRVATKYLQTAREHFAEKGMHVDLIKLYGSMELAPLVGLADAIV
DLVSSGNTLKANNLKAVEEIMPISSRLIINQAALKLKRRAIQPMLEAFSAAITPLTPLSPYPLGATP
>Mature_226_residues
TSITIALSKGRIFDDTAPLLKAAGIIPLDDPETSRKLILATNRDDVRLIIVRASDVPTYVQYGAADMGIAGKDVLLEHGG
AGLYQPLDLNIARCRMMVAVRSDFDYESAVRRGARVRVATKYLQTAREHFAEKGMHVDLIKLYGSMELAPLVGLADAIVD
LVSSGNTLKANNLKAVEEIMPISSRLIINQAALKLKRRAIQPMLEAFSAAITPLTPLSPYPLGATP

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=189, Percent_Identity=37.037037037037, Blast_Score=89, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=186, Percent_Identity=29.0322580645161, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_NITMU (Q2YAU4)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411519.1
- ProteinModelPortal:   Q2YAU4
- SMR:   Q2YAU4
- STRING:   Q2YAU4
- GeneID:   3786689
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0820
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- PhylomeDB:   Q2YAU4
- ProtClustDB:   PRK01686
- BioCyc:   NMUL323848:NMUL_A0820-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 24596; Mature: 24465

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSITIALSKGRIFDDTAPLLKAAGIIPLDDPETSRKLILATNRDDVRLIIVRASDVPTY
CCEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCHH
VQYGAADMGIAGKDVLLEHGGAGLYQPLDLNIARCRMMVAVRSDFDYESAVRRGARVRVA
HHCCCCCCCCCCCHHEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCHHHH
TKYLQTAREHFAEKGMHVDLIKLYGSMELAPLVGLADAIVDLVSSGNTLKANNLKAVEEI
HHHHHHHHHHHHHCCCCEEEHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHH
MPISSRLIINQAALKLKRRAIQPMLEAFSAAITPLTPLSPYPLGATP
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSITIALSKGRIFDDTAPLLKAAGIIPLDDPETSRKLILATNRDDVRLIIVRASDVPTY
CEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCHH
VQYGAADMGIAGKDVLLEHGGAGLYQPLDLNIARCRMMVAVRSDFDYESAVRRGARVRVA
HHCCCCCCCCCCCHHEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCHHHH
TKYLQTAREHFAEKGMHVDLIKLYGSMELAPLVGLADAIVDLVSSGNTLKANNLKAVEEI
HHHHHHHHHHHHHCCCCEEEHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHH
MPISSRLIINQAALKLKRRAIQPMLEAFSAAITPLTPLSPYPLGATP
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA