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The map label for this gene is hisD

Identifier: 82701952

GI number: 82701952

Start: 933606

End: 934928

Strand: Reverse

Name: hisD

Synonym: Nmul_A0819

Alternate gene names: 82701952

Gene position: 934928-933606 (Counterclockwise)

Preceding gene: 82701953

Following gene: 82701951

Centisome position: 29.36

GC content: 55.03

Gene sequence:

>1323_bases
ATGATTTCGATAAAGAGATTGTCTTCTGCCGATACCGAGTTCGATAAGGCGCTGTCGGAACTGCTGGCGTTTGAAAACAC
CCAGGATGCAAAGCTGGAGGCTGCTGTCGCAGATATTCTCGCGAAGATCAGGACGGAGGGAGATAAAGCCTTGCTGGAAT
ACACGCTCCGTTTCGATCGCGTGGATGCAAAATCGGCGGCGGATCTGGAATTGCCCCGAAATCGCCTGCAACAAGCTCTT
CATAACCTGCCTGGCGAGCAACGTAACGCCCTGGAGCAGGCTGCGGAACGGGTCCGCGTCTATCATGAGAAACAGTTGAC
GCAATCCTGGAGCTACGTGGAGCCTGACGGAACACACCTTGGGCAGAAAATCACCCCTCTCGATCGTGCCGGTCTGTATG
TTCCCGGCGGCAAGGCAGCCTACCCTTCATCAGTCCTGATGAACGCAATTCCCGCCAAGGTGGCAGGAGTGGGCGAACTT
GTCATGGTGACACCCACTCCACAGGGCGAAGTAAATGACCTGGTGCTCGCTGCTGCGGCCATTTGCGAGGTTGACCGGGT
TTTCACCATAGGGGGCGCTCAAGCCGTGGGCGCACTGGCATATGGCACCCCTACCGTGCCGCGAGTGGACAAGATCGTCG
GCCCGGGAAACGCTTATGTGGCAACAGCCAAGCGGCATGTTTTCGGTGTGGTAGGGATCGATATGCTCGCGGGACCTTCC
GAAATTCTGATCATCTGCGATGGCAAAACCAATCCGGACTGGATTGCGATGGACATGTTTTCCCAGGCGGAGCACGACGA
GTTGGCGCAGGCAATCCTGCTGTCACCCGATCTTCATTTTATCGAAACAGTCGCAGCGAGTATCGTCCGGCAGCTGGAAA
CGATGCCACGCAAGGAGATAATCCGGACTTCGCTCGAAAACAGGAGCGCCTTGATTCAGGTGCATGATCTGGAAGAAGCC
TGTGAGATCGCCAACAGCATCGCGCCCGAACATCTGGAGTTATCAGTAGAACAGCCGGAAAAGTGGGTGGAAAAAATAAG
ACACGCGGGTGCGATTTTTCTGGGTCGCCATACATCGGAAGCGCTGGGAGATTATTGCGCGGGTCCCAACCACGTCCTCC
CCACTTCCCGTACTGCACGCTTTTCGTCGCCACTCGGAGTATACGATTTTCAGAAACGCAGCAGCATTATTCAGGTATCG
GGGCAGGGATCAGCGAAATTGGGCGCCATTGCCTCTATCCTGGCCCAAGGTGAAGGGCTGCAGGCACACGCAATGTCAGC
GGAATATCGTTACACAAAAAAAATAGCCCTTGGAAAAAATTGA

Upstream 100 bases:

>100_bases
TTACACCTCTATCTCCTTACCCCCTTGGAGCAACCCCCTGAGCGGGCTCGGAACTGCAACTGCCCCGCTCGTTTATCCCT
TATCCCTTTCCTTACCCCTC

Downstream 100 bases:

>100_bases
GGACCTCTCCCGGATTTCCTTCTCCCCCGCCGGGAAAGCCGGAAGCCGGGCGAGAGCGTACAATCCATTCTTATGATAAA
TCCTGGGAATTTTGCGCATG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MISIKRLSSADTEFDKALSELLAFENTQDAKLEAAVADILAKIRTEGDKALLEYTLRFDRVDAKSAADLELPRNRLQQAL
HNLPGEQRNALEQAAERVRVYHEKQLTQSWSYVEPDGTHLGQKITPLDRAGLYVPGGKAAYPSSVLMNAIPAKVAGVGEL
VMVTPTPQGEVNDLVLAAAAICEVDRVFTIGGAQAVGALAYGTPTVPRVDKIVGPGNAYVATAKRHVFGVVGIDMLAGPS
EILIICDGKTNPDWIAMDMFSQAEHDELAQAILLSPDLHFIETVAASIVRQLETMPRKEIIRTSLENRSALIQVHDLEEA
CEIANSIAPEHLELSVEQPEKWVEKIRHAGAIFLGRHTSEALGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRSSIIQVS
GQGSAKLGAIASILAQGEGLQAHAMSAEYRYTKKIALGKN

Sequences:

>Translated_440_residues
MISIKRLSSADTEFDKALSELLAFENTQDAKLEAAVADILAKIRTEGDKALLEYTLRFDRVDAKSAADLELPRNRLQQAL
HNLPGEQRNALEQAAERVRVYHEKQLTQSWSYVEPDGTHLGQKITPLDRAGLYVPGGKAAYPSSVLMNAIPAKVAGVGEL
VMVTPTPQGEVNDLVLAAAAICEVDRVFTIGGAQAVGALAYGTPTVPRVDKIVGPGNAYVATAKRHVFGVVGIDMLAGPS
EILIICDGKTNPDWIAMDMFSQAEHDELAQAILLSPDLHFIETVAASIVRQLETMPRKEIIRTSLENRSALIQVHDLEEA
CEIANSIAPEHLELSVEQPEKWVEKIRHAGAIFLGRHTSEALGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRSSIIQVS
GQGSAKLGAIASILAQGEGLQAHAMSAEYRYTKKIALGKN
>Mature_440_residues
MISIKRLSSADTEFDKALSELLAFENTQDAKLEAAVADILAKIRTEGDKALLEYTLRFDRVDAKSAADLELPRNRLQQAL
HNLPGEQRNALEQAAERVRVYHEKQLTQSWSYVEPDGTHLGQKITPLDRAGLYVPGGKAAYPSSVLMNAIPAKVAGVGEL
VMVTPTPQGEVNDLVLAAAAICEVDRVFTIGGAQAVGALAYGTPTVPRVDKIVGPGNAYVATAKRHVFGVVGIDMLAGPS
EILIICDGKTNPDWIAMDMFSQAEHDELAQAILLSPDLHFIETVAASIVRQLETMPRKEIIRTSLENRSALIQVHDLEEA
CEIANSIAPEHLELSVEQPEKWVEKIRHAGAIFLGRHTSEALGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRSSIIQVS
GQGSAKLGAIASILAQGEGLQAHAMSAEYRYTKKIALGKN

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=398, Percent_Identity=40.2010050251256, Blast_Score=285, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6319819, Length=408, Percent_Identity=35.7843137254902, Blast_Score=243, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_NITMU (Q2YAU5)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411518.1
- ProteinModelPortal:   Q2YAU5
- SMR:   Q2YAU5
- STRING:   Q2YAU5
- GeneID:   3786688
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0819
- eggNOG:   COG0141
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- PhylomeDB:   Q2YAU5
- ProtClustDB:   PRK00877
- BioCyc:   NMUL323848:NMUL_A0819-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 47628; Mature: 47628

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 330-330 ACT_SITE 331-331 BINDING 133-133 BINDING 194-194 BINDING 217-217 BINDING 240-240 BINDING 262-262 BINDING 265-265 BINDING 331-331 BINDING 364-364 BINDING 418-418 BINDING 423-423

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISIKRLSSADTEFDKALSELLAFENTQDAKLEAAVADILAKIRTEGDKALLEYTLRFDR
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
VDAKSAADLELPRNRLQQALHNLPGEQRNALEQAAERVRVYHEKQLTQSWSYVEPDGTHL
CCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GQKITPLDRAGLYVPGGKAAYPSSVLMNAIPAKVAGVGELVMVTPTPQGEVNDLVLAAAA
CCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHH
ICEVDRVFTIGGAQAVGALAYGTPTVPRVDKIVGPGNAYVATAKRHVFGVVGIDMLAGPS
HHHHHHEEEECCHHHHHHHHCCCCCCCCHHHHCCCCCCEEEEHHHHEEEEEHHHHHCCCC
EILIICDGKTNPDWIAMDMFSQAEHDELAQAILLSPDLHFIETVAASIVRQLETMPRKEI
EEEEEECCCCCCCEEEHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHH
IRTSLENRSALIQVHDLEEACEIANSIAPEHLELSVEQPEKWVEKIRHAGAIFLGRHTSE
HHHHHCCCCEEEEEECHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCEEEEECCCHH
ALGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRSSIIQVSGQGSAKLGAIASILAQGEGL
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCEEEECCCCCCHHHHHHHHHHCCCCC
QAHAMSAEYRYTKKIALGKN
EEHHCCCCHHHHEEEECCCC
>Mature Secondary Structure
MISIKRLSSADTEFDKALSELLAFENTQDAKLEAAVADILAKIRTEGDKALLEYTLRFDR
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
VDAKSAADLELPRNRLQQALHNLPGEQRNALEQAAERVRVYHEKQLTQSWSYVEPDGTHL
CCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GQKITPLDRAGLYVPGGKAAYPSSVLMNAIPAKVAGVGELVMVTPTPQGEVNDLVLAAAA
CCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHH
ICEVDRVFTIGGAQAVGALAYGTPTVPRVDKIVGPGNAYVATAKRHVFGVVGIDMLAGPS
HHHHHHEEEECCHHHHHHHHCCCCCCCCHHHHCCCCCCEEEEHHHHEEEEEHHHHHCCCC
EILIICDGKTNPDWIAMDMFSQAEHDELAQAILLSPDLHFIETVAASIVRQLETMPRKEI
EEEEEECCCCCCCEEEHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHH
IRTSLENRSALIQVHDLEEACEIANSIAPEHLELSVEQPEKWVEKIRHAGAIFLGRHTSE
HHHHHCCCCEEEEEECHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCEEEEECCCHH
ALGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRSSIIQVSGQGSAKLGAIASILAQGEGL
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCEEEECCCCCCHHHHHHHHHHCCCCC
QAHAMSAEYRYTKKIALGKN
EEHHCCCCHHHHEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA