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The map label for this gene is dxr

Identifier: 82701796

GI number: 82701796

Start: 757859

End: 759046

Strand: Direct

Name: dxr

Synonym: Nmul_A0663

Alternate gene names: 82701796

Gene position: 757859-759046 (Clockwise)

Preceding gene: 82701795

Following gene: 82701797

Centisome position: 23.8

GC content: 58.25

Gene sequence:

>1188_bases
ATGATCGCTGTTCGTCATCTCACTATTCTGGGTTCCACAGGAAGCATCGGCGTAAGCACGCTCGATGTAGTGGCGCGTCA
CCCCGACCGCTTTCGCGTGGTAGCCCTTACCGCGAACAAGAGCGTGCAGAAAATTCTGGAACAATGCCGGCGTTTTGAGC
CGCGCTATGCGGTGCTGCTGGATGAGGCCAGCGCCGAACTACTGCAGGTGGAAATTCGCCGGGCTGGCCTTGCCACTGAA
GTGCTGTGGGGGGTGGATTCGCTGGAAAAGGTCGCTTCGCTGCCGGACGTGGATACAGTGATGGCAGCGATCGTGGGGGC
GGCGGGGATACGTCCGACATTTGCAGCGGCTGCGACCGGCAAGCGGGTATTGCTTGCCAACAAGGAAACAATGGTGATGG
CGGGACGCATATTCACGGACGTGGTCAAGGAAAATCATGCCACGCTGCTCCCGATCGATAGTGAACACAATGCCATTTTC
CAATCCCTGCCGCAGCACTTCAGTGGGGATCTGCGCGCGGTGGGCGTGCGTCGCATTCTGCTGACCGCATCAGGCGGGCC
CTTTCGGCAGATGCCCTTGGCCGCACTGGAAAATGTAACCCCCGGGCAGGCATGTGCTCATCCCAACTGGGTAATGGGGC
AGAAAATTTCGGTGGATTCCGCTACCATGATGAACAAGGGACTCGAAGTCATCGAAGCGCACTGGTTGTTCGAAGCCTCG
CCCGAGCAAATAGAGGTCGTCGTTCACCCGCAGAGCATCATTCATTCCATGGTCGAGTATGTGGATGGCTCGGTATTGGC
ACAACTGGGTAATCCTGATATGCGTACTCCCATTGCCCATGCACTCGGCTTCCCTGAACGGATCGAGACCGGAGTCAACC
CCCTGGATATGTTCAAGGTTGCCCGGCTCGATTTCGAGGCCCCCGATTTTGAACGCTTTCCCTGTCTACGGCTGGCATAT
CAGGCGCTGGCAAGCGGCGGGAGTGCCCCCGCTGTGCTGAATGCCGCCAATGAAGTGGCGGTGGATTCCTTTCTCAAATG
TCTAATGCCCTTCACGTCCATTCCCGCCATGATCGAGGATGTCATGCAGACAATTGGCCGCCGGGACATCGCGACTCTGG
ATGATGTGCTGGCAGCGGACGGCATGGCGCGCGAAGCGGCCCAAGAATGGCTGACGTGTCTGGCGTAA

Upstream 100 bases:

>100_bases
CTATTTTGCCGGGCCACGGTGGTATACTTGACAGGATCGATGCGCTGACTTCAACCCTGCCCATTGCGGCTCTGGCACTT
CTCCTGCTACATACCTGATC

Downstream 100 bases:

>100_bases
AGTGTCGCAATCATTGGCCTTTCCGGCAGGTCGGACAACGGTTTATCCACCCCTTCTGAAGAAAGCTTCTCATTCATCCC
GGGGAGCTGGCCAGTCGGCT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MIAVRHLTILGSTGSIGVSTLDVVARHPDRFRVVALTANKSVQKILEQCRRFEPRYAVLLDEASAELLQVEIRRAGLATE
VLWGVDSLEKVASLPDVDTVMAAIVGAAGIRPTFAAAATGKRVLLANKETMVMAGRIFTDVVKENHATLLPIDSEHNAIF
QSLPQHFSGDLRAVGVRRILLTASGGPFRQMPLAALENVTPGQACAHPNWVMGQKISVDSATMMNKGLEVIEAHWLFEAS
PEQIEVVVHPQSIIHSMVEYVDGSVLAQLGNPDMRTPIAHALGFPERIETGVNPLDMFKVARLDFEAPDFERFPCLRLAY
QALASGGSAPAVLNAANEVAVDSFLKCLMPFTSIPAMIEDVMQTIGRRDIATLDDVLAADGMAREAAQEWLTCLA

Sequences:

>Translated_395_residues
MIAVRHLTILGSTGSIGVSTLDVVARHPDRFRVVALTANKSVQKILEQCRRFEPRYAVLLDEASAELLQVEIRRAGLATE
VLWGVDSLEKVASLPDVDTVMAAIVGAAGIRPTFAAAATGKRVLLANKETMVMAGRIFTDVVKENHATLLPIDSEHNAIF
QSLPQHFSGDLRAVGVRRILLTASGGPFRQMPLAALENVTPGQACAHPNWVMGQKISVDSATMMNKGLEVIEAHWLFEAS
PEQIEVVVHPQSIIHSMVEYVDGSVLAQLGNPDMRTPIAHALGFPERIETGVNPLDMFKVARLDFEAPDFERFPCLRLAY
QALASGGSAPAVLNAANEVAVDSFLKCLMPFTSIPAMIEDVMQTIGRRDIATLDDVLAADGMAREAAQEWLTCLA
>Mature_395_residues
MIAVRHLTILGSTGSIGVSTLDVVARHPDRFRVVALTANKSVQKILEQCRRFEPRYAVLLDEASAELLQVEIRRAGLATE
VLWGVDSLEKVASLPDVDTVMAAIVGAAGIRPTFAAAATGKRVLLANKETMVMAGRIFTDVVKENHATLLPIDSEHNAIF
QSLPQHFSGDLRAVGVRRILLTASGGPFRQMPLAALENVTPGQACAHPNWVMGQKISVDSATMMNKGLEVIEAHWLFEAS
PEQIEVVVHPQSIIHSMVEYVDGSVLAQLGNPDMRTPIAHALGFPERIETGVNPLDMFKVARLDFEAPDFERFPCLRLAY
QALASGGSAPAVLNAANEVAVDSFLKCLMPFTSIPAMIEDVMQTIGRRDIATLDDVLAADGMAREAAQEWLTCLA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=397, Percent_Identity=58.4382871536524, Blast_Score=446, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_NITMU (Q2YBA1)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411362.1
- ProteinModelPortal:   Q2YBA1
- SMR:   Q2YBA1
- STRING:   Q2YBA1
- GeneID:   3785148
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0663
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q2YBA1
- ProtClustDB:   PRK05447
- BioCyc:   NMUL323848:NMUL_A0663-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42778; Mature: 42778

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: BINDING 128-128 BINDING 155-155 BINDING 184-184 BINDING 207-207 BINDING 229-229

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAVRHLTILGSTGSIGVSTLDVVARHPDRFRVVALTANKSVQKILEQCRRFEPRYAVLL
CEEEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHCCCCCEEEEE
DEASAELLQVEIRRAGLATEVLWGVDSLEKVASLPDVDTVMAAIVGAAGIRPTFAAAATG
EHHHHHHHHHHHHHHCHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHCCC
KRVLLANKETMVMAGRIFTDVVKENHATLLPIDSEHNAIFQSLPQHFSGDLRAVGVRRIL
CEEEEECCCCEEEHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCHHHEEEEEEE
LTASGGPFRQMPLAALENVTPGQACAHPNWVMGQKISVDSATMMNKGLEVIEAHWLFEAS
EEECCCCCHHCCHHHHCCCCCCCCCCCCCCCCCCEECCCHHHHHHHCHHHHHHHHHCCCC
PEQIEVVVHPQSIIHSMVEYVDGSVLAQLGNPDMRTPIAHALGFPERIETGVNPLDMFKV
CCEEEEEECCHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHCCCHHHHHHCCCHHHHHHH
ARLDFEAPDFERFPCLRLAYQALASGGSAPAVLNAANEVAVDSFLKCLMPFTSIPAMIED
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VMQTIGRRDIATLDDVLAADGMAREAAQEWLTCLA
HHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MIAVRHLTILGSTGSIGVSTLDVVARHPDRFRVVALTANKSVQKILEQCRRFEPRYAVLL
CEEEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHCCCCCEEEEE
DEASAELLQVEIRRAGLATEVLWGVDSLEKVASLPDVDTVMAAIVGAAGIRPTFAAAATG
EHHHHHHHHHHHHHHCHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHCCC
KRVLLANKETMVMAGRIFTDVVKENHATLLPIDSEHNAIFQSLPQHFSGDLRAVGVRRIL
CEEEEECCCCEEEHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCHHHEEEEEEE
LTASGGPFRQMPLAALENVTPGQACAHPNWVMGQKISVDSATMMNKGLEVIEAHWLFEAS
EEECCCCCHHCCHHHHCCCCCCCCCCCCCCCCCCEECCCHHHHHHHCHHHHHHHHHCCCC
PEQIEVVVHPQSIIHSMVEYVDGSVLAQLGNPDMRTPIAHALGFPERIETGVNPLDMFKV
CCEEEEEECCHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHCCCHHHHHHCCCHHHHHHH
ARLDFEAPDFERFPCLRLAYQALASGGSAPAVLNAANEVAVDSFLKCLMPFTSIPAMIED
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VMQTIGRRDIATLDDVLAADGMAREAAQEWLTCLA
HHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA