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The map label for this gene is pyrH

Identifier: 82701792

GI number: 82701792

Start: 754677

End: 755393

Strand: Direct

Name: pyrH

Synonym: Nmul_A0659

Alternate gene names: 82701792

Gene position: 754677-755393 (Clockwise)

Preceding gene: 82701791

Following gene: 82701793

Centisome position: 23.7

GC content: 56.07

Gene sequence:

>717_bases
ATGACCATACCCGCTTATAAACGCATCCTGCTGAAGCTCTCGGGCGAAGCTCTCATGGGTGACGATAGTTATGGCATCAA
CCGGGATGTAATCGAACGAATCGTGGCCGAGATAGCCGAAGTGAATCAGCTGGGTGTCGAGGTTGCGGTAGTGATAGGAG
GGGGCAACATTTTCCGGGGAATGACCTCCTCCGCGGAAGGCATGGACCGGGCCACCGCGGACTATATGGGGATGCTGGCC
ACCGTCATGAATGCGCTGGCGTTACAGGATGCGATGCGGCGTGCCGGTCTGGTGAGCAGGGTGCAATCCGCCCTCCGCAT
CGATCAGGTGGTGGAACCGTATATTCGGGGCAAGGCCATACGCTATCTGGAGGAGGGCAAAATAGTCATTTTTGCCGCCG
GCACGGGTAATCCATTTTTTACGACCGATACAGCGGCGGCTCTGCGGGGAATGGAGATGAACGTGGATATCGTGCTCAAG
GCCACCAAGGTCGATGGGGTATATACCACCGATCCCAAAATAAATCCGGATGCAGAACGCTACCAGAGACTGTCGTTTGA
TACTGCCATTGCCGAGAATCTCAAGGTGATGGATGCCACCGCGCTGACTTTGTGCCGCGACCAGAAGCTTCCGCTCAAAG
TCTTCAGTATCTTCAAGGCGGAGGCGTTGAGACGGGTAGTCATGGGCGAGGAAGAGGGCACGTTGGTGGAGGTCTGA

Upstream 100 bases:

>100_bases
GGGAAGGGATAGAAAAGAAATCTGGCGACTTTGCTGCCGAAGTCATGGCGCAGGTGGGTCAGGCCAAACAGGAAAAAGCG
TCTTAGCCGCCGGATTGCTC

Downstream 100 bases:

>100_bases
GGGCTTTCTGGCTACCTTGGCCATATGGCCGCATTATAGTAGGGGCCATAGCTTGGAATTGCCGTCATCGTGCCGCGGCA
TGGACGCCAAACAGTGACGT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MTIPAYKRILLKLSGEALMGDDSYGINRDVIERIVAEIAEVNQLGVEVAVVIGGGNIFRGMTSSAEGMDRATADYMGMLA
TVMNALALQDAMRRAGLVSRVQSALRIDQVVEPYIRGKAIRYLEEGKIVIFAAGTGNPFFTTDTAAALRGMEMNVDIVLK
ATKVDGVYTTDPKINPDAERYQRLSFDTAIAENLKVMDATALTLCRDQKLPLKVFSIFKAEALRRVVMGEEEGTLVEV

Sequences:

>Translated_238_residues
MTIPAYKRILLKLSGEALMGDDSYGINRDVIERIVAEIAEVNQLGVEVAVVIGGGNIFRGMTSSAEGMDRATADYMGMLA
TVMNALALQDAMRRAGLVSRVQSALRIDQVVEPYIRGKAIRYLEEGKIVIFAAGTGNPFFTTDTAAALRGMEMNVDIVLK
ATKVDGVYTTDPKINPDAERYQRLSFDTAIAENLKVMDATALTLCRDQKLPLKVFSIFKAEALRRVVMGEEEGTLVEV
>Mature_237_residues
TIPAYKRILLKLSGEALMGDDSYGINRDVIERIVAEIAEVNQLGVEVAVVIGGGNIFRGMTSSAEGMDRATADYMGMLAT
VMNALALQDAMRRAGLVSRVQSALRIDQVVEPYIRGKAIRYLEEGKIVIFAAGTGNPFFTTDTAAALRGMEMNVDIVLKA
TKVDGVYTTDPKINPDAERYQRLSFDTAIAENLKVMDATALTLCRDQKLPLKVFSIFKAEALRRVVMGEEEGTLVEV

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=233, Percent_Identity=54.5064377682403, Blast_Score=267, Evalue=5e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_NITMU (Q2YBA5)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411358.1
- HSSP:   P65938
- ProteinModelPortal:   Q2YBA5
- SMR:   Q2YBA5
- STRING:   Q2YBA5
- GeneID:   3785144
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0659
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q2YBA5
- ProtClustDB:   PRK00358
- BioCyc:   NMUL323848:NMUL_A0659-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25987; Mature: 25855

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 74-74 BINDING 162-162 BINDING 168-168 BINDING 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPAYKRILLKLSGEALMGDDSYGINRDVIERIVAEIAEVNQLGVEVAVVIGGGNIFRG
CCCHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHCC
MTSSAEGMDRATADYMGMLATVMNALALQDAMRRAGLVSRVQSALRIDQVVEPYIRGKAI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
RYLEEGKIVIFAAGTGNPFFTTDTAAALRGMEMNVDIVLKATKVDGVYTTDPKINPDAER
EEEECCCEEEEEECCCCCCEECCHHHHHCCCCCCEEEEEEEEEECCEEECCCCCCCCHHH
YQRLSFDTAIAENLKVMDATALTLCRDQKLPLKVFSIFKAEALRRVVMGEEEGTLVEV
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEC
>Mature Secondary Structure 
TIPAYKRILLKLSGEALMGDDSYGINRDVIERIVAEIAEVNQLGVEVAVVIGGGNIFRG
CCHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHCC
MTSSAEGMDRATADYMGMLATVMNALALQDAMRRAGLVSRVQSALRIDQVVEPYIRGKAI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
RYLEEGKIVIFAAGTGNPFFTTDTAAALRGMEMNVDIVLKATKVDGVYTTDPKINPDAER
EEEECCCEEEEEECCCCCCEECCHHHHHCCCCCCEEEEEEEEEECCEEECCCCCCCCHHH
YQRLSFDTAIAENLKVMDATALTLCRDQKLPLKVFSIFKAEALRRVVMGEEEGTLVEV
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA