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The map label for this gene is holA [H]

Identifier: 82701647

GI number: 82701647

Start: 581138

End: 582154

Strand: Direct

Name: holA [H]

Synonym: Nmul_A0513

Alternate gene names: 82701647

Gene position: 581138-582154 (Clockwise)

Preceding gene: 82701646

Following gene: 82701648

Centisome position: 18.25

GC content: 56.93

Gene sequence:

>1017_bases
ATGCGTATTGCGCCCGAACAGCTTGCGCGGCATCTCGATAAACAGCTTGCACCGCTTTATACGGTATCCGGCGACGAATT
ACTTCTGGCAATCGAAGCTGCCGACCTGATCCGTGTAAAAGCGCGCCAAGGCGGGTATATCGAACGGGAAATTTTCAACG
TCGATAGCTATTTCAACTGGACAGAGCTGGAACGGTGCAGCAACAGCCTGTCGTTGTTCGGCGAAAGACGTATAATCGAT
CTGCGCATCCCCTCGGGCAAGCCGGGCAATCAGGGCAGCGCCGTTTTGGAGAAATACTGCCGCGCCCTGCCGCCAGATAC
CGTCACACTTGTCACCCTGCCCCGGATCGACCAGCAAGGTGCGGCAACCAGATGGTTCAAGGCGCTTGATGCAGCAGGAG
CAGTCATTACGGTTTATCCGGTAGAACGCGGGCGGCTGCCCGACTGGATAGGCCAGCGGCTCACCATGCAAGGGCAGAAT
GCCGACATCGACACGCTGCAATTTCTTGCCGACAAGGTAGAGGGCAATCTGCTCGCAGCCTATCAGGAACTCAAGAAACT
TGCGTTGCTTTATCCACCCGGAATGCTGTCGTTCGAGCAGGTGAAGGATGCCGTGCTCGATGTCGCCCGTTATGATGCAT
TCAAACTATCCGATGCAATGGTTGCCGGGGATACCGCGCGCTATACGCGCATCCTGGAGGTTTTGCAGGGTGAAGGCATG
GCATTGCCGCTGATCGTCAATACGCTGGCGGGGCAGATCCGCCTTCTTGTCGCGATTCGTACCGGACTCGACGCAGGGAA
ACCGCCGGGACAATTGACCAGCCAGTCTCGAGTATGGCGGGACCGGCAGAAAATAATGGAGAACGCCGCTCGCCGCCTGA
ACCTTGAACAGTTGGCATCGGCGTTGTCACATGCCGCTAAAATAGACAGAGTCAGCAAGGGCGTTGCAAGCGGCGATCCC
TGGGATGAGTTGCTCCAACTGGGTTTGCGTTTTGCGAAGATCGGGCAGCGGCAGTAG

Upstream 100 bases:

>100_bases
GCGGCGCCTTGGAGCAGTCAAGGTGGCGGAACTGAATAAGTCTCCACAGGTGAACCCCTGACCGTTGACGCCTGTGTTGC
GGTAACCTGAAGGCGAAGGC

Downstream 100 bases:

>100_bases
TTAAAGCATGGCAAAACGATGACGCAAACGGAGGATAGCCGGCATAGGCCGGGCTTCACCCGATCTGCCGTTACTGAACT
CTTATCCGCGAACGCCGGAG

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MRIAPEQLARHLDKQLAPLYTVSGDELLLAIEAADLIRVKARQGGYIEREIFNVDSYFNWTELERCSNSLSLFGERRIID
LRIPSGKPGNQGSAVLEKYCRALPPDTVTLVTLPRIDQQGAATRWFKALDAAGAVITVYPVERGRLPDWIGQRLTMQGQN
ADIDTLQFLADKVEGNLLAAYQELKKLALLYPPGMLSFEQVKDAVLDVARYDAFKLSDAMVAGDTARYTRILEVLQGEGM
ALPLIVNTLAGQIRLLVAIRTGLDAGKPPGQLTSQSRVWRDRQKIMENAARRLNLEQLASALSHAAKIDRVSKGVASGDP
WDELLQLGLRFAKIGQRQ

Sequences:

>Translated_338_residues
MRIAPEQLARHLDKQLAPLYTVSGDELLLAIEAADLIRVKARQGGYIEREIFNVDSYFNWTELERCSNSLSLFGERRIID
LRIPSGKPGNQGSAVLEKYCRALPPDTVTLVTLPRIDQQGAATRWFKALDAAGAVITVYPVERGRLPDWIGQRLTMQGQN
ADIDTLQFLADKVEGNLLAAYQELKKLALLYPPGMLSFEQVKDAVLDVARYDAFKLSDAMVAGDTARYTRILEVLQGEGM
ALPLIVNTLAGQIRLLVAIRTGLDAGKPPGQLTSQSRVWRDRQKIMENAARRLNLEQLASALSHAAKIDRVSKGVASGDP
WDELLQLGLRFAKIGQRQ
>Mature_338_residues
MRIAPEQLARHLDKQLAPLYTVSGDELLLAIEAADLIRVKARQGGYIEREIFNVDSYFNWTELERCSNSLSLFGERRIID
LRIPSGKPGNQGSAVLEKYCRALPPDTVTLVTLPRIDQQGAATRWFKALDAAGAVITVYPVERGRLPDWIGQRLTMQGQN
ADIDTLQFLADKVEGNLLAAYQELKKLALLYPPGMLSFEQVKDAVLDVARYDAFKLSDAMVAGDTARYTRILEVLQGEGM
ALPLIVNTLAGQIRLLVAIRTGLDAGKPPGQLTSQSRVWRDRQKIMENAARRLNLEQLASALSHAAKIDRVSKGVASGDP
WDELLQLGLRFAKIGQRQ

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=329, Percent_Identity=29.7872340425532, Blast_Score=130, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 37490; Mature: 37490

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAPEQLARHLDKQLAPLYTVSGDELLLAIEAADLIRVKARQGGYIEREIFNVDSYFNW
CCCCHHHHHHHHHHHHCCEEEECCCCEEEEEEHHHHHHHHHCCCCCCHHHHCCCCCCCCH
TELERCSNSLSLFGERRIIDLRIPSGKPGNQGSAVLEKYCRALPPDTVTLVTLPRIDQQG
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCC
AATRWFKALDAAGAVITVYPVERGRLPDWIGQRLTMQGQNADIDTLQFLADKVEGNLLAA
HHHHHHHHHHHCCCEEEEEECCCCCCCHHHCCCEEECCCCCCHHHHHHHHHHHCCHHHHH
YQELKKLALLYPPGMLSFEQVKDAVLDVARYDAFKLSDAMVAGDTARYTRILEVLQGEGM
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHCCHHHCCCHHHHHHHHHHHHCCCC
ALPLIVNTLAGQIRLLVAIRTGLDAGKPPGQLTSQSRVWRDRQKIMENAARRLNLEQLAS
CHHHHHHHHHHHHHEEHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
ALSHAAKIDRVSKGVASGDPWDELLQLGLRFAKIGQRQ
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRIAPEQLARHLDKQLAPLYTVSGDELLLAIEAADLIRVKARQGGYIEREIFNVDSYFNW
CCCCHHHHHHHHHHHHCCEEEECCCCEEEEEEHHHHHHHHHCCCCCCHHHHCCCCCCCCH
TELERCSNSLSLFGERRIIDLRIPSGKPGNQGSAVLEKYCRALPPDTVTLVTLPRIDQQG
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCC
AATRWFKALDAAGAVITVYPVERGRLPDWIGQRLTMQGQNADIDTLQFLADKVEGNLLAA
HHHHHHHHHHHCCCEEEEEECCCCCCCHHHCCCEEECCCCCCHHHHHHHHHHHCCHHHHH
YQELKKLALLYPPGMLSFEQVKDAVLDVARYDAFKLSDAMVAGDTARYTRILEVLQGEGM
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHCCHHHCCCHHHHHHHHHHHHCCCC
ALPLIVNTLAGQIRLLVAIRTGLDAGKPPGQLTSQSRVWRDRQKIMENAARRLNLEQLAS
CHHHHHHHHHHHHHEEHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
ALSHAAKIDRVSKGVASGDPWDELLQLGLRFAKIGQRQ
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]