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The map label for this gene is proA

Identifier: 82701648

GI number: 82701648

Start: 582550

End: 583815

Strand: Direct

Name: proA

Synonym: Nmul_A0514

Alternate gene names: 82701648

Gene position: 582550-583815 (Clockwise)

Preceding gene: 82701647

Following gene: 82701649

Centisome position: 18.29

GC content: 57.66

Gene sequence:

>1266_bases
ATGGACATCATCGACATCAAGACCTATATGCACTCCATCGGGCGTGAAGCCCGAGCCGCCTCGCGCTTGATTGCCAAAGC
GGAAACGGCGGCCAAGAACCGGGCACTTACACAGATGGCGGTGGCTATAAAACGGGATGAGCAGCAGCTGTTGGCAGCGA
ATGCCCGGGACGTGGAAAATGCGAAAGAACGGGGATTGGAAGCGGCAATGATAGACCGGTTGACGCTCACGCCCAAAAGC
GTGGCGAGCATGGCCGAAGGTTTGCTGCAAATAGCAGCGCTAGCCGATCCGGTCGGTGAAATAAGCGATTTGAACTACCG
TCCCTCCGGCATACAGGTGGGAAAAATGCGCGTACCGCTGGGCGTGATCGGCATCATTTATGAAGCGCGCCCCAACGTCA
CGGCCGATGCCGCGGGGTTGTGCCTCAAGGCGGGTAACGCAGCGATATTGCGCGGGGGATCGGAAGCCATTTACAGCAAT
CAGGCGATCGCGGCGTGCGTCAGGGAGGGGCTTAAGACCGCCGGTTTGCCCGAGACGGCGATACAGGTTATCGAAACAAC
CGACCGGGCTGCCGTGGGTGAACTCGTCACCATGAAAGAATTCGTCGATGTCATCGTGCCCCGCGGCGGCAAGGGGTTGA
TCGAGCGCATCTCGAATGAAGCGCGCATCCCCGTCATCAAGCACCTGGATGGCGTATGCCATATTTATATCGACGAAGAA
GCGGACCAGGAAAAGGCCATTCGTGTTGCGGACAACGCCAAGACCCAGCGCTACGGCACCTGCAACACACTCGAAACATT
GCTGGTGCATGAGAATATTGCCGGGGAAGTGCTGCCGCCGCTGTGCAGAATCTACCTGGACAAGGGCGTGGAACTGCGCG
GCGATCCGGCCTCGCAGGCGATCATTCCGGAAATGAAGGAAGCCAGGGAGGAAGACTGGTATACGGAATATCTTGCGCCT
GTCTTGAGCGTGCGGGTGGTAAGCAGTCTCGATCAGGCTATCGAGCACATTACGATTTACGGCTCCCAACACACGGATTC
CATCATTACCGAGAATTACAGCAACGCGCGCCGTTTCTTGCGCGAAGTGGATTCCAGTTCTGTCATGGTGAATGCCTCCA
CCCGCTTCGCGGATGGATTCGAGTACGGCCTCGGCGCGGAAATTGGTATCTCCACCGATAAGCTTCATGCTCGCGGCCCG
GTGGGACTGGAAGGATTGACCAGCCAGAAATTCATCGTCCTGGGTGACGGGCATATCCGGCAGTAG

Upstream 100 bases:

>100_bases
AATTTTATTCCTGACAATAGTCGGGCTTGACCCGGAATCCAGTTCCGGAATCCCAGTTACTCCTGCAATTTTAATTTACT
GTCTGAATGGAACCATTGAC

Downstream 100 bases:

>100_bases
GTTTCCAGGAATAAGGTTCAATTTTATTTCCTTAAACTAATAAGGTTTTCATGGCTCAGCTTACCGAAATCAAAGTACCG
GATATTGGCGACTTCAAGGA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MDIIDIKTYMHSIGREARAASRLIAKAETAAKNRALTQMAVAIKRDEQQLLAANARDVENAKERGLEAAMIDRLTLTPKS
VASMAEGLLQIAALADPVGEISDLNYRPSGIQVGKMRVPLGVIGIIYEARPNVTADAAGLCLKAGNAAILRGGSEAIYSN
QAIAACVREGLKTAGLPETAIQVIETTDRAAVGELVTMKEFVDVIVPRGGKGLIERISNEARIPVIKHLDGVCHIYIDEE
ADQEKAIRVADNAKTQRYGTCNTLETLLVHENIAGEVLPPLCRIYLDKGVELRGDPASQAIIPEMKEAREEDWYTEYLAP
VLSVRVVSSLDQAIEHITIYGSQHTDSIITENYSNARRFLREVDSSSVMVNASTRFADGFEYGLGAEIGISTDKLHARGP
VGLEGLTSQKFIVLGDGHIRQ

Sequences:

>Translated_421_residues
MDIIDIKTYMHSIGREARAASRLIAKAETAAKNRALTQMAVAIKRDEQQLLAANARDVENAKERGLEAAMIDRLTLTPKS
VASMAEGLLQIAALADPVGEISDLNYRPSGIQVGKMRVPLGVIGIIYEARPNVTADAAGLCLKAGNAAILRGGSEAIYSN
QAIAACVREGLKTAGLPETAIQVIETTDRAAVGELVTMKEFVDVIVPRGGKGLIERISNEARIPVIKHLDGVCHIYIDEE
ADQEKAIRVADNAKTQRYGTCNTLETLLVHENIAGEVLPPLCRIYLDKGVELRGDPASQAIIPEMKEAREEDWYTEYLAP
VLSVRVVSSLDQAIEHITIYGSQHTDSIITENYSNARRFLREVDSSSVMVNASTRFADGFEYGLGAEIGISTDKLHARGP
VGLEGLTSQKFIVLGDGHIRQ
>Mature_421_residues
MDIIDIKTYMHSIGREARAASRLIAKAETAAKNRALTQMAVAIKRDEQQLLAANARDVENAKERGLEAAMIDRLTLTPKS
VASMAEGLLQIAALADPVGEISDLNYRPSGIQVGKMRVPLGVIGIIYEARPNVTADAAGLCLKAGNAAILRGGSEAIYSN
QAIAACVREGLKTAGLPETAIQVIETTDRAAVGELVTMKEFVDVIVPRGGKGLIERISNEARIPVIKHLDGVCHIYIDEE
ADQEKAIRVADNAKTQRYGTCNTLETLLVHENIAGEVLPPLCRIYLDKGVELRGDPASQAIIPEMKEAREEDWYTEYLAP
VLSVRVVSSLDQAIEHITIYGSQHTDSIITENYSNARRFLREVDSSSVMVNASTRFADGFEYGLGAEIGISTDKLHARGP
VGLEGLTSQKFIVLGDGHIRQ

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=416, Percent_Identity=37.0192307692308, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI21361368, Length=416, Percent_Identity=37.0192307692308, Blast_Score=267, Evalue=1e-71,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=47.710843373494, Blast_Score=380, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17569967, Length=410, Percent_Identity=36.5853658536585, Blast_Score=281, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17569969, Length=410, Percent_Identity=36.5853658536585, Blast_Score=281, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6324899, Length=431, Percent_Identity=38.2830626450116, Blast_Score=293, Evalue=3e-80,
Organism=Drosophila melanogaster, GI21357643, Length=413, Percent_Identity=39.225181598063, Blast_Score=292, Evalue=3e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_NITMU (Q2YBP9)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411214.1
- ProteinModelPortal:   Q2YBP9
- SMR:   Q2YBP9
- STRING:   Q2YBP9
- GeneID:   3785643
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0514
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   GICGAME
- PhylomeDB:   Q2YBP9
- ProtClustDB:   PRK00197
- BioCyc:   NMUL323848:NMUL_A0514-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45626; Mature: 45626

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIIDIKTYMHSIGREARAASRLIAKAETAAKNRALTQMAVAIKRDEQQLLAANARDVEN
CCEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHH
AKERGLEAAMIDRLTLTPKSVASMAEGLLQIAALADPVGEISDLNYRPSGIQVGKMRVPL
HHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEEECCC
GVIGIIYEARPNVTADAAGLCLKAGNAAILRGGSEAIYSNQAIAACVREGLKTAGLPETA
EEEEEEEECCCCCCCCCCCCEEECCCEEEEECCCHHHHCCHHHHHHHHHHHHCCCCCHHH
IQVIETTDRAAVGELVTMKEFVDVIVPRGGKGLIERISNEARIPVIKHLDGVCHIYIDEE
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHCCCEEEEEECCC
ADQEKAIRVADNAKTQRYGTCNTLETLLVHENIAGEVLPPLCRIYLDKGVELRGDPASQA
CCHHHHEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEECCCCCCCH
IIPEMKEAREEDWYTEYLAPVLSVRVVSSLDQAIEHITIYGSQHTDSIITENYSNARRFL
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHCCHHHHHHHH
REVDSSSVMVNASTRFADGFEYGLGAEIGISTDKLHARGPVGLEGLTSQKFIVLGDGHIR
HHCCCCCEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCC
Q
C
>Mature Secondary Structure
MDIIDIKTYMHSIGREARAASRLIAKAETAAKNRALTQMAVAIKRDEQQLLAANARDVEN
CCEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHH
AKERGLEAAMIDRLTLTPKSVASMAEGLLQIAALADPVGEISDLNYRPSGIQVGKMRVPL
HHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEEECCC
GVIGIIYEARPNVTADAAGLCLKAGNAAILRGGSEAIYSNQAIAACVREGLKTAGLPETA
EEEEEEEECCCCCCCCCCCCEEECCCEEEEECCCHHHHCCHHHHHHHHHHHHCCCCCHHH
IQVIETTDRAAVGELVTMKEFVDVIVPRGGKGLIERISNEARIPVIKHLDGVCHIYIDEE
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHCCCEEEEEECCC
ADQEKAIRVADNAKTQRYGTCNTLETLLVHENIAGEVLPPLCRIYLDKGVELRGDPASQA
CCHHHHEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEECCCCCCCH
IIPEMKEAREEDWYTEYLAPVLSVRVVSSLDQAIEHITIYGSQHTDSIITENYSNARRFL
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHCCHHHHHHHH
REVDSSSVMVNASTRFADGFEYGLGAEIGISTDKLHARGPVGLEGLTSQKFIVLGDGHIR
HHCCCCCEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCC
Q
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA