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The map label for this gene is hflC [H]

Identifier: 82701578

GI number: 82701578

Start: 493339

End: 494217

Strand: Reverse

Name: hflC [H]

Synonym: Nmul_A0444

Alternate gene names: 82701578

Gene position: 494217-493339 (Counterclockwise)

Preceding gene: 82701579

Following gene: 82701577

Centisome position: 15.52

GC content: 52.79

Gene sequence:

>879_bases
GTGAAAAACTATACTCCAATGTTATTGACTGTCCTTATCATCCTGTTTCTTGTGGCAAGCTCGTCACTGTATATAGTCGA
CCAGCGGCAGCAGGCGATTCTGTTCCAGTTGGGTGAAGTGGTGGATGTAAAGACATCTCCGGGTCTTTATTTCAAAATCC
CGCTGGCGCAGAACGTGCGCTACTTTGACTCGCGCATTCTGACGCTGGATACGGCCGAGCCGGAACGCTTCATAACGTCC
GAAAAAAAGAACGTTCTGGTGGATCTGTTCGTGAAGTGGCGTATCGTGGACGTCAAGCAATACTATGTCAGCGTGCGCGG
GGACGAGATGCTCGCCCAGACGCGTCTGTCGCAAACGGTCAATTCCAGCTTGCGTGATGAATTCGGTAACCGGACGGTAC
ATGACGTCGTATCCGGCGAACGCGACAAAATCATGGAAATCATGCGGCAAAAGGCCGATGCGGATGCGCGTAAAATCGGA
GTGGAAGTCGTAGACGTTCGTTTGAAGAGAGTGGACCTGCCGCAGGAAGTAAGTGAATCCGTCTACCGCAGAATGGAGGC
TGAGCGGAAACGTGTGGCGAATGAACTGCGCTCGACCGGCGCCGCCGAATCCGAGAAGATTCGGGCGGATGCGGATCGCC
AGCGCGAGGTCGTTCTTGCCGAAGCCTACCGGAAAGCCCAGGAAATAAAGGGTGAAGGCGATGCGAAAGCGGCGAGTATT
TATGCCAGCGCCTACGAGTCGAATCCGGAATTCTATTCCTTTTATCGCAGCCTCGACGCCTACACGGAAATCTTCAAAAA
CAAGAACGATATCATGGTACTGGAACCGACCTCCGAGTTTTTCAAGTATATGAGGAATTCGGGGCGCGGAGGGAAATAG

Upstream 100 bases:

>100_bases
AGTGCCGGAGACACAGCTTGCGTCGCCGCCGGAACCTACGGCCGATGCCGCTACCCGCACCCGGGAAGCATTTCGTGGCC
GCGAACGGGAGACAAGATAA

Downstream 100 bases:

>100_bases
ATGTGCCGGTAGATAGCTCATTCGGATGAAGCAGCCTTCCGGGAATACGGCGGGCTGCTTCGGGGGTACCGACAGCAATT
CCAGGGGCCGATATCGCTCC

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MKNYTPMLLTVLIILFLVASSSLYIVDQRQQAILFQLGEVVDVKTSPGLYFKIPLAQNVRYFDSRILTLDTAEPERFITS
EKKNVLVDLFVKWRIVDVKQYYVSVRGDEMLAQTRLSQTVNSSLRDEFGNRTVHDVVSGERDKIMEIMRQKADADARKIG
VEVVDVRLKRVDLPQEVSESVYRRMEAERKRVANELRSTGAAESEKIRADADRQREVVLAEAYRKAQEIKGEGDAKAASI
YASAYESNPEFYSFYRSLDAYTEIFKNKNDIMVLEPTSEFFKYMRNSGRGGK

Sequences:

>Translated_292_residues
MKNYTPMLLTVLIILFLVASSSLYIVDQRQQAILFQLGEVVDVKTSPGLYFKIPLAQNVRYFDSRILTLDTAEPERFITS
EKKNVLVDLFVKWRIVDVKQYYVSVRGDEMLAQTRLSQTVNSSLRDEFGNRTVHDVVSGERDKIMEIMRQKADADARKIG
VEVVDVRLKRVDLPQEVSESVYRRMEAERKRVANELRSTGAAESEKIRADADRQREVVLAEAYRKAQEIKGEGDAKAASI
YASAYESNPEFYSFYRSLDAYTEIFKNKNDIMVLEPTSEFFKYMRNSGRGGK
>Mature_292_residues
MKNYTPMLLTVLIILFLVASSSLYIVDQRQQAILFQLGEVVDVKTSPGLYFKIPLAQNVRYFDSRILTLDTAEPERFITS
EKKNVLVDLFVKWRIVDVKQYYVSVRGDEMLAQTRLSQTVNSSLRDEFGNRTVHDVVSGERDKIMEIMRQKADADARKIG
VEVVDVRLKRVDLPQEVSESVYRRMEAERKRVANELRSTGAAESEKIRADADRQREVVLAEAYRKAQEIKGEGDAKAASI
YASAYESNPEFYSFYRSLDAYTEIFKNKNDIMVLEPTSEFFKYMRNSGRGGK

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=311, Percent_Identity=36.3344051446945, Blast_Score=200, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17569499, Length=171, Percent_Identity=29.8245614035088, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71987612, Length=175, Percent_Identity=27.4285714285714, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI25153583, Length=175, Percent_Identity=27.4285714285714, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 33576; Mature: 33576

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNYTPMLLTVLIILFLVASSSLYIVDQRQQAILFQLGEVVDVKTSPGLYFKIPLAQNVR
CCCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCEEEECCCCEEEEECHHHCHH
YFDSRILTLDTAEPERFITSEKKNVLVDLFVKWRIVDVKQYYVSVRGDEMLAQTRLSQTV
HHCCEEEEEECCCCHHHHHCCCHHHHEEEEEHHEEEEEHHHHEECCCHHHHHHHHHHHHH
NSSLRDEFGNRTVHDVVSGERDKIMEIMRQKADADARKIGVEVVDVRLKRVDLPQEVSES
HHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHEEHHHHHCCCHHHHHHH
VYRRMEAERKRVANELRSTGAAESEKIRADADRQREVVLAEAYRKAQEIKGEGDAKAASI
HHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
YASAYESNPEFYSFYRSLDAYTEIFKNKNDIMVLEPTSEFFKYMRNSGRGGK
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKNYTPMLLTVLIILFLVASSSLYIVDQRQQAILFQLGEVVDVKTSPGLYFKIPLAQNVR
CCCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCEEEECCCCEEEEECHHHCHH
YFDSRILTLDTAEPERFITSEKKNVLVDLFVKWRIVDVKQYYVSVRGDEMLAQTRLSQTV
HHCCEEEEEECCCCHHHHHCCCHHHHEEEEEHHEEEEEHHHHEECCCHHHHHHHHHHHHH
NSSLRDEFGNRTVHDVVSGERDKIMEIMRQKADADARKIGVEVVDVRLKRVDLPQEVSES
HHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHEEHHHHHCCCHHHHHHH
VYRRMEAERKRVANELRSTGAAESEKIRADADRQREVVLAEAYRKAQEIKGEGDAKAASI
HHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
YASAYESNPEFYSFYRSLDAYTEIFKNKNDIMVLEPTSEFFKYMRNSGRGGK
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]