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The map label for this gene is capL [H]

Identifier: 82701404

GI number: 82701404

Start: 291260

End: 292534

Strand: Direct

Name: capL [H]

Synonym: Nmul_A0270

Alternate gene names: 82701404

Gene position: 291260-292534 (Clockwise)

Preceding gene: 82701402

Following gene: 82701405

Centisome position: 9.15

GC content: 51.06

Gene sequence:

>1275_bases
GTGGTGGCAGTGGTTGGGCTAGGCTATGTGGGATTACCTTTGGCGGTGGAGTTCGGAAAAAAAAGGAAAACCATCGGCTA
CGATCTTTCGAGCAGCAAGATAGCAAGTTACAAGCAATTTATCGATCCGACCGGCGAGGTTTCCTCCGATGACCTGAAAG
CCGCGAAGCAGCTTCATGTCACTACTGACCCGGCTGAGTTGTCACAGGCGGATTATATTGTCGTGGCCGTTCCAACACCC
GTGGACGCAGCCCATCAGCCCGATTTTCGTCCTCTCATAGGTGCGAGCGAAACCGTGGGAAAACATATGAAGCGGGGAGC
AATCGTTATTTACGAATCCACCGTTTACCCGGGAGCAACCGAGGAAGTCTGTATTCCTGTCCTTGAGAAACATTCCGGCA
TGAAATGGAAAGACGATTTTCATGTCGGCTTCTCGCCCGAACGGATTAACCCCGGCGACAAGCAGCATACGCTCACAAAG
ATTCTGAAGGTTGTCTCTGGAGACGATGAGGATACGCTGGAAAAAATTGCAGCACTTTATGAGAGCATAATTACCGCCGG
CGTGCACCGTGCGTCCAGCATCAAGGTAGCGGAAGCAGCCAAAGTAATCGAAAATACTCAGCGAGACCTGAATATCGCGT
TGATGAATGAACTGGCGATTATTTTCGACAAACTGGACATTGACACGCTGGAAGTGCTGCAGGCGGCTGGCACCAAATGG
AATTTTTTACCCTTTCGCCCGGGCCTGGTCGGAGGCCATTGTATCGGCGTCGATCCCTACTATCTTACTCACAAGGCGGA
AATGGTCGGTTATATTCCCCAGGTTATCCTCGCGGGACGCCGTATCAATGACAGTATGGCCAAATTCGTGGCGGAACAAA
CGATCAAACATATCATCAAGGCCGATATCAACGTTCGGAGTGCGCGTGTAAATGTTCTCGGCCTGGCCTTCAAGGAAAAC
TGTCCTGATCTCAGGAATTCCAAGGTTGCCGATCTGATCAGTGAACTTAAAAGCTATGGGATAGAGATTCACGTCCACGA
TCCTGTAGCCAGTATTGAAGAAGCCCGCCACGAATACGGTGTGGAACTTGAATCATGGGAGGACCTTCCACGCGCGGATG
CAATGATTGTTGCCGTTGCCCACCGCCAGTTCACTGAAATGCCCTTGACCCAGTTTCAGACCAAAATCACGGACAAAGGG
TGTTTCATCGATGTGAAATCCCAGTTCGATCCTGCCGCGCTGCGAGAGGCTGGCTTAAACGTGTGGAGACTGTGA

Upstream 100 bases:

>100_bases
GGTATTCGAGGTGGTATGGCTGGATGATATTGGATGGAAACGATCTGGTTTTGTGCCGTTATAACGTCTATAAGTATAAA
GCGGGAGGTGACTGATGAGT

Downstream 100 bases:

>100_bases
AGGATAGTACGCCTGGTATGGCTGCTTACCCAAAATGGCTGCGGCATTTGCAGGACCATTCCTACTGCTGGCTGGTCACG
GGGGTTGCGGGCTTCATCGG

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MVAVVGLGYVGLPLAVEFGKKRKTIGYDLSSSKIASYKQFIDPTGEVSSDDLKAAKQLHVTTDPAELSQADYIVVAVPTP
VDAAHQPDFRPLIGASETVGKHMKRGAIVIYESTVYPGATEEVCIPVLEKHSGMKWKDDFHVGFSPERINPGDKQHTLTK
ILKVVSGDDEDTLEKIAALYESIITAGVHRASSIKVAEAAKVIENTQRDLNIALMNELAIIFDKLDIDTLEVLQAAGTKW
NFLPFRPGLVGGHCIGVDPYYLTHKAEMVGYIPQVILAGRRINDSMAKFVAEQTIKHIIKADINVRSARVNVLGLAFKEN
CPDLRNSKVADLISELKSYGIEIHVHDPVASIEEARHEYGVELESWEDLPRADAMIVAVAHRQFTEMPLTQFQTKITDKG
CFIDVKSQFDPAALREAGLNVWRL

Sequences:

>Translated_424_residues
MVAVVGLGYVGLPLAVEFGKKRKTIGYDLSSSKIASYKQFIDPTGEVSSDDLKAAKQLHVTTDPAELSQADYIVVAVPTP
VDAAHQPDFRPLIGASETVGKHMKRGAIVIYESTVYPGATEEVCIPVLEKHSGMKWKDDFHVGFSPERINPGDKQHTLTK
ILKVVSGDDEDTLEKIAALYESIITAGVHRASSIKVAEAAKVIENTQRDLNIALMNELAIIFDKLDIDTLEVLQAAGTKW
NFLPFRPGLVGGHCIGVDPYYLTHKAEMVGYIPQVILAGRRINDSMAKFVAEQTIKHIIKADINVRSARVNVLGLAFKEN
CPDLRNSKVADLISELKSYGIEIHVHDPVASIEEARHEYGVELESWEDLPRADAMIVAVAHRQFTEMPLTQFQTKITDKG
CFIDVKSQFDPAALREAGLNVWRL
>Mature_424_residues
MVAVVGLGYVGLPLAVEFGKKRKTIGYDLSSSKIASYKQFIDPTGEVSSDDLKAAKQLHVTTDPAELSQADYIVVAVPTP
VDAAHQPDFRPLIGASETVGKHMKRGAIVIYESTVYPGATEEVCIPVLEKHSGMKWKDDFHVGFSPERINPGDKQHTLTK
ILKVVSGDDEDTLEKIAALYESIITAGVHRASSIKVAEAAKVIENTQRDLNIALMNELAIIFDKLDIDTLEVLQAAGTKW
NFLPFRPGLVGGHCIGVDPYYLTHKAEMVGYIPQVILAGRRINDSMAKFVAEQTIKHIIKADINVRSARVNVLGLAFKEN
CPDLRNSKVADLISELKSYGIEIHVHDPVASIEEARHEYGVELESWEDLPRADAMIVAVAHRQFTEMPLTQFQTKITDKG
CFIDVKSQFDPAALREAGLNVWRL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=406, Percent_Identity=29.5566502463054, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1788340, Length=365, Percent_Identity=23.013698630137, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560350, Length=461, Percent_Identity=23.8611713665944, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46751; Mature: 46751

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAVVGLGYVGLPLAVEFGKKRKTIGYDLSSSKIASYKQFIDPTGEVSSDDLKAAKQLHV
CEEEEECCCCCCHHHEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHEEE
TTDPAELSQADYIVVAVPTPVDAAHQPDFRPLIGASETVGKHMKRGAIVIYESTVYPGAT
ECCHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCC
EEVCIPVLEKHSGMKWKDDFHVGFSPERINPGDKQHTLTKILKVVSGDDEDTLEKIAALY
HHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
ESIITAGVHRASSIKVAEAAKVIENTQRDLNIALMNELAIIFDKLDIDTLEVLQAAGTKW
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCC
NFLPFRPGLVGGHCIGVDPYYLTHKAEMVGYIPQVILAGRRINDSMAKFVAEQTIKHIIK
CEECCCCCCCCCEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
ADINVRSARVNVLGLAFKENCPDLRNSKVADLISELKSYGIEIHVHDPVASIEEARHEYG
HCCCEEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHC
VELESWEDLPRADAMIVAVAHRQFTEMPLTQFQTKITDKGCFIDVKSQFDPAALREAGLN
CCCHHHCCCCCCCEEEEEEHHHHHHCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHCCCC
VWRL
CCCC
>Mature Secondary Structure
MVAVVGLGYVGLPLAVEFGKKRKTIGYDLSSSKIASYKQFIDPTGEVSSDDLKAAKQLHV
CEEEEECCCCCCHHHEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHEEE
TTDPAELSQADYIVVAVPTPVDAAHQPDFRPLIGASETVGKHMKRGAIVIYESTVYPGAT
ECCHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCC
EEVCIPVLEKHSGMKWKDDFHVGFSPERINPGDKQHTLTKILKVVSGDDEDTLEKIAALY
HHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
ESIITAGVHRASSIKVAEAAKVIENTQRDLNIALMNELAIIFDKLDIDTLEVLQAAGTKW
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCC
NFLPFRPGLVGGHCIGVDPYYLTHKAEMVGYIPQVILAGRRINDSMAKFVAEQTIKHIIK
CEECCCCCCCCCEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
ADINVRSARVNVLGLAFKENCPDLRNSKVADLISELKSYGIEIHVHDPVASIEEARHEYG
HCCCEEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHC
VELESWEDLPRADAMIVAVAHRQFTEMPLTQFQTKITDKGCFIDVKSQFDPAALREAGLN
CCCHHHCCCCCCCEEEEEEHHHHHHCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHCCCC
VWRL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]