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The map label for this gene is serS

Identifier: 82701314

GI number: 82701314

Start: 190904

End: 192274

Strand: Direct

Name: serS

Synonym: Nmul_A0180

Alternate gene names: 82701314

Gene position: 190904-192274 (Clockwise)

Preceding gene: 82701313

Following gene: 82701315

Centisome position: 6.0

GC content: 55.36

Gene sequence:

>1371_bases
ATGTTAGATATTCATCTGTTACGTACGCAACTGGATCACGTTGCCAGGCTTCTTGCCGAGCGTAACTACGTTTTTCCTCT
TGCTGAATTCAGTGCCCTGGAAGCGGAACGAAAAAATCTTCAAACCTCCACCCAGGAATTGCAAGCGCGCCGCAATGGCG
CGTCGAAGCAGATCGGCAATGCCAAGAGCAGGGGCGAAGATGCCAGCGCGATTCTCGCAGAGGTCGCTCATCTGGGTGAT
GAGCTGAAGCAGGCGGAATCCCGGCTGGATCAGGTACAGGCTGCGCTGCAGCACATCCTGCTGCAAATACCCAACCTGCC
GCACAGCAGCGTGCCGGAGGGCAGAAGCGAATCGGATAACAGGGAAGTGCGACGTTGGGGAACTCCACCCACATTTGATT
TCAGCCCGGCCGATCATGTGAGCATAGGCGAGCGACTGGGATTACTGGATTTTCCCACTGCTGCCAAGATCAGCGGCGCC
CGCTTCAGCCTGCTGACAGGCTCGCTTGCGCACCTGCATCGCGCACTGGCTCAATTCATGCTCGATGTTCATGTCCGCGA
ACATGGGTATACAGAGACCTACGTGCCCTATCTGGTCAATGCGGAAAGTTTGCGGGGTACCGGCCAGCTGCCGAAGTTCA
AGGAAGATTTGTTCGAGGTTCCACGAAGAAAAACAGCCGAACCTTTCCTGGAAAACCAGCCGGTTGCTGCAACGCTGCCA
TCGAATAGCAATAGTCCGCAAGGAGGACAGGACGATGATGACTTATACTTGATTCCCACTTCCGAGGTTCCGCTGAGCAA
CATCGTGCGTGACCGCATCGTCGATCCTGAATTGCTGCCTATCAAGCTTACTGCGCATACCCCCTGCTTTCGCTCCGAAG
CGGGGAGCTACGGCAGGGATACTCGCGGAATGATCCGGCAGCATCAGTTCGAGAAGGTGGAACTGGTGCAAATTGTCCAT
CCTGCACACTCCTATAAAGCGCTGGAAGAGCTGACAGGCCATGCCGAAGCAATTCTTCAGAAGCTGAAACTGCCTTACCG
GGTGATGGCGTTATGCACGGCCGACATGGGGTTTGCCGCCGCCAAGACGTACGACATCGAAGTATGGTTACCGCAGCAAG
GCACCTATCGGGAAATTTCCTCATGCAGTAACTGTGAAGCATTCCAGGCACGGCGCATGCAGGCACGTTTTCGCAATGAG
AAAGGCAAGCCGGAACTGTTGCACACACTCAACGGGTCGGGTCTGGCGGTGGGACGGACGCTGGTGGCGATACTGGAAAA
TTTCCAGAATGCAGACGGCAGCGTATCGATTCCCAAGGTTTTGCAAGGCTATATGGGCGGAACCGAGCGGCTTGTGCCCC
ATAACGCATAA

Upstream 100 bases:

>100_bases
TCGAAAGTAAAATATCCGAAAGACTGGCGTATCTGCGCGAGCTGGACAAACAGGCAAAAAAAGAATCATAAGATAGAACC
TGCGTCGATTTGGAGTCGAG

Downstream 100 bases:

>100_bases
GGCAATCAGACGTATCTTTTTACCATTGTTACCATTGGAGAGGCTCGCTAACCATGCAAAATGTACCTGGCAGTGAAAAT
GTTCATGCGGCAATCGAGGA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MLDIHLLRTQLDHVARLLAERNYVFPLAEFSALEAERKNLQTSTQELQARRNGASKQIGNAKSRGEDASAILAEVAHLGD
ELKQAESRLDQVQAALQHILLQIPNLPHSSVPEGRSESDNREVRRWGTPPTFDFSPADHVSIGERLGLLDFPTAAKISGA
RFSLLTGSLAHLHRALAQFMLDVHVREHGYTETYVPYLVNAESLRGTGQLPKFKEDLFEVPRRKTAEPFLENQPVAATLP
SNSNSPQGGQDDDDLYLIPTSEVPLSNIVRDRIVDPELLPIKLTAHTPCFRSEAGSYGRDTRGMIRQHQFEKVELVQIVH
PAHSYKALEELTGHAEAILQKLKLPYRVMALCTADMGFAAAKTYDIEVWLPQQGTYREISSCSNCEAFQARRMQARFRNE
KGKPELLHTLNGSGLAVGRTLVAILENFQNADGSVSIPKVLQGYMGGTERLVPHNA

Sequences:

>Translated_456_residues
MLDIHLLRTQLDHVARLLAERNYVFPLAEFSALEAERKNLQTSTQELQARRNGASKQIGNAKSRGEDASAILAEVAHLGD
ELKQAESRLDQVQAALQHILLQIPNLPHSSVPEGRSESDNREVRRWGTPPTFDFSPADHVSIGERLGLLDFPTAAKISGA
RFSLLTGSLAHLHRALAQFMLDVHVREHGYTETYVPYLVNAESLRGTGQLPKFKEDLFEVPRRKTAEPFLENQPVAATLP
SNSNSPQGGQDDDDLYLIPTSEVPLSNIVRDRIVDPELLPIKLTAHTPCFRSEAGSYGRDTRGMIRQHQFEKVELVQIVH
PAHSYKALEELTGHAEAILQKLKLPYRVMALCTADMGFAAAKTYDIEVWLPQQGTYREISSCSNCEAFQARRMQARFRNE
KGKPELLHTLNGSGLAVGRTLVAILENFQNADGSVSIPKVLQGYMGGTERLVPHNA
>Mature_456_residues
MLDIHLLRTQLDHVARLLAERNYVFPLAEFSALEAERKNLQTSTQELQARRNGASKQIGNAKSRGEDASAILAEVAHLGD
ELKQAESRLDQVQAALQHILLQIPNLPHSSVPEGRSESDNREVRRWGTPPTFDFSPADHVSIGERLGLLDFPTAAKISGA
RFSLLTGSLAHLHRALAQFMLDVHVREHGYTETYVPYLVNAESLRGTGQLPKFKEDLFEVPRRKTAEPFLENQPVAATLP
SNSNSPQGGQDDDDLYLIPTSEVPLSNIVRDRIVDPELLPIKLTAHTPCFRSEAGSYGRDTRGMIRQHQFEKVELVQIVH
PAHSYKALEELTGHAEAILQKLKLPYRVMALCTADMGFAAAKTYDIEVWLPQQGTYREISSCSNCEAFQARRMQARFRNE
KGKPELLHTLNGSGLAVGRTLVAILENFQNADGSVSIPKVLQGYMGGTERLVPHNA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=363, Percent_Identity=35.8126721763085, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI8923421, Length=434, Percent_Identity=31.1059907834101, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI225579074, Length=358, Percent_Identity=33.2402234636872, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI1787120, Length=452, Percent_Identity=56.4159292035398, Blast_Score=510, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17539260, Length=482, Percent_Identity=30.4979253112033, Blast_Score=215, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17542084, Length=346, Percent_Identity=28.3236994219653, Blast_Score=140, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=423, Percent_Identity=32.1513002364066, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6321799, Length=416, Percent_Identity=29.0865384615385, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24581334, Length=373, Percent_Identity=32.4396782841823, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17737985, Length=369, Percent_Identity=29.5392953929539, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_NITMU (Q2YCN3)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_410880.1
- HSSP:   Q9N0F3
- ProteinModelPortal:   Q2YCN3
- SMR:   Q2YCN3
- STRING:   Q2YCN3
- GeneID:   3785088
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0180
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- PhylomeDB:   Q2YCN3
- ProtClustDB:   PRK05431
- BioCyc:   NMUL323848:NMUL_A0180-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 50698; Mature: 50698

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 314-314 BINDING 413-413

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIHLLRTQLDHVARLLAERNYVFPLAEFSALEAERKNLQTSTQELQARRNGASKQIGN
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
AKSRGEDASAILAEVAHLGDELKQAESRLDQVQAALQHILLQIPNLPHSSVPEGRSESDN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
REVRRWGTPPTFDFSPADHVSIGERLGLLDFPTAAKISGARFSLLTGSLAHLHRALAQFM
HHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHH
LDVHVREHGYTETYVPYLVNAESLRGTGQLPKFKEDLFEVPRRKTAEPFLENQPVAATLP
HHHHHHHCCCCCCCCCCEECHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHCCCCEEEECC
SNSNSPQGGQDDDDLYLIPTSEVPLSNIVRDRIVDPELLPIKLTAHTPCFRSEAGSYGRD
CCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHCCCCCCCC
TRGMIRQHQFEKVELVQIVHPAHSYKALEELTGHAEAILQKLKLPYRVMALCTADMGFAA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCE
AKTYDIEVWLPQQGTYREISSCSNCEAFQARRMQARFRNEKGKPELLHTLNGSGLAVGRT
EEEEEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHH
LVAILENFQNADGSVSIPKVLQGYMGGTERLVPHNA
HHHHHHHHCCCCCCEEHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MLDIHLLRTQLDHVARLLAERNYVFPLAEFSALEAERKNLQTSTQELQARRNGASKQIGN
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
AKSRGEDASAILAEVAHLGDELKQAESRLDQVQAALQHILLQIPNLPHSSVPEGRSESDN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
REVRRWGTPPTFDFSPADHVSIGERLGLLDFPTAAKISGARFSLLTGSLAHLHRALAQFM
HHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHH
LDVHVREHGYTETYVPYLVNAESLRGTGQLPKFKEDLFEVPRRKTAEPFLENQPVAATLP
HHHHHHHCCCCCCCCCCEECHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHCCCCEEEECC
SNSNSPQGGQDDDDLYLIPTSEVPLSNIVRDRIVDPELLPIKLTAHTPCFRSEAGSYGRD
CCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHCCCCCCCC
TRGMIRQHQFEKVELVQIVHPAHSYKALEELTGHAEAILQKLKLPYRVMALCTADMGFAA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCE
AKTYDIEVWLPQQGTYREISSCSNCEAFQARRMQARFRNEKGKPELLHTLNGSGLAVGRT
EEEEEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHH
LVAILENFQNADGSVSIPKVLQGYMGGTERLVPHNA
HHHHHHHHCCCCCCEEHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA