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The map label for this gene is glxR [H]

Identifier: 82701306

GI number: 82701306

Start: 179913

End: 180842

Strand: Direct

Name: glxR [H]

Synonym: Nmul_A0172

Alternate gene names: 82701306

Gene position: 179913-180842 (Clockwise)

Preceding gene: 82701304

Following gene: 82701307

Centisome position: 5.65

GC content: 58.82

Gene sequence:

>930_bases
ATGACGGGCAGAACGAAAATTGGTTTCATCGGTCTTGGCATCATGGGTAAGCCAATGGCGAGCCATCTGCTCAGGGGCGG
TCATACCTTATTTCTGCATTCCCGCAGCGGCGTGCCGGGAGAATTGCTCACGCAGGGGGGACAAGCGTGTTCTTCGCCGG
CTGAAGTCGCGCAGAACGCTGACCTTATCATTACCATGCTTCCGGACACGGGGGATGTGGAGCGGGTGCTGTTCGGTGAC
AAGGGGGTGGCGGAGGGATTGAGCGCGGGGCGAAGTAAAGGCGGGATCGTGATGGACATGAGTACCATCTCGCCAGTTGA
GACGCGGAAATTCGCCGCTGAAATCAATGAGCTTGGGTGCGAGTACGTGGATGCCCCCGTTTCAGGCGGAGATATCGGCG
CCCGGAACGGCACTCTCACCATCATGGTCGGCGCCACTTCTTCGGCCTTCGTGCAGGTGAAGCCGGTTCTCGAGTTTATG
GGTAAAACGATAACCCTGATCGGTCCCACTGGCACGGGCCAGGTCTGCAAGCTTGCCAATCAGATCATCGCCGCGCTTAC
TATCGAAGCGGTGGGTGAAGGTTTGCTATTCGCCTCGAAAGCGGGGGCCGATGTGCGGAAAGTGCGCCAGGCATTAATGG
GCGGTTTCGCTTATTCCCGCGTGCTGGAAGTACACGGCGAGCGCATGATCGAGCGCGCGTTTGAGCCGGGATTTCGCGTC
GAGCTGCACCGGAAGGATCTGGGCCTTGCTTTGTCCCATGCCCGTACACTGGGCGTGAGCCTGCCCGGTACGGCGACTGT
TCAGGAATTGCTGAATGCGTGCATCGCGCATGGCGGGGCCGGATGGGATAGTTCGGCCCTGGTACGGATGCTGGAAAAAC
TGGCGAATCATGAGATCGAGACCATCGAAGGCTCGCATGATGAATCATGA

Upstream 100 bases:

>100_bases
AAGTTTACACCAGACCGGCTCAGACTCATGCGAAAATCGGGGCAGAAAACGAGGAGCGAAGGTGAATAATCACTGACGCG
GTCACCGCATAGGCACGGGT

Downstream 100 bases:

>100_bases
GTTGAATTGGCGGCAATGAACCGTATGAATGACGCTCTCGAACTTGTAAAAAAGCTTCGGACCTTTCTGCCCGCGGAATC
GGTGCTGCATGAGACCGAAG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTGRTKIGFIGLGIMGKPMASHLLRGGHTLFLHSRSGVPGELLTQGGQACSSPAEVAQNADLIITMLPDTGDVERVLFGD
KGVAEGLSAGRSKGGIVMDMSTISPVETRKFAAEINELGCEYVDAPVSGGDIGARNGTLTIMVGATSSAFVQVKPVLEFM
GKTITLIGPTGTGQVCKLANQIIAALTIEAVGEGLLFASKAGADVRKVRQALMGGFAYSRVLEVHGERMIERAFEPGFRV
ELHRKDLGLALSHARTLGVSLPGTATVQELLNACIAHGGAGWDSSALVRMLEKLANHEIETIEGSHDES

Sequences:

>Translated_309_residues
MTGRTKIGFIGLGIMGKPMASHLLRGGHTLFLHSRSGVPGELLTQGGQACSSPAEVAQNADLIITMLPDTGDVERVLFGD
KGVAEGLSAGRSKGGIVMDMSTISPVETRKFAAEINELGCEYVDAPVSGGDIGARNGTLTIMVGATSSAFVQVKPVLEFM
GKTITLIGPTGTGQVCKLANQIIAALTIEAVGEGLLFASKAGADVRKVRQALMGGFAYSRVLEVHGERMIERAFEPGFRV
ELHRKDLGLALSHARTLGVSLPGTATVQELLNACIAHGGAGWDSSALVRMLEKLANHEIETIEGSHDES
>Mature_308_residues
TGRTKIGFIGLGIMGKPMASHLLRGGHTLFLHSRSGVPGELLTQGGQACSSPAEVAQNADLIITMLPDTGDVERVLFGDK
GVAEGLSAGRSKGGIVMDMSTISPVETRKFAAEINELGCEYVDAPVSGGDIGARNGTLTIMVGATSSAFVQVKPVLEFMG
KTITLIGPTGTGQVCKLANQIIAALTIEAVGEGLLFASKAGADVRKVRQALMGGFAYSRVLEVHGERMIERAFEPGFRVE
LHRKDLGLALSHARTLGVSLPGTATVQELLNACIAHGGAGWDSSALVRMLEKLANHEIETIEGSHDES

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=298, Percent_Identity=31.2080536912752, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI40556376, Length=285, Percent_Identity=27.0175438596491, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1786719, Length=294, Percent_Identity=57.4829931972789, Blast_Score=343, Evalue=1e-95,
Organism=Escherichia coli, GI145693186, Length=295, Percent_Identity=40.3389830508475, Blast_Score=218, Evalue=4e-58,
Organism=Escherichia coli, GI1790315, Length=289, Percent_Identity=34.9480968858132, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1789092, Length=290, Percent_Identity=28.2758620689655, Blast_Score=101, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17557316, Length=256, Percent_Identity=33.984375, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24655230, Length=300, Percent_Identity=34, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI19922568, Length=300, Percent_Identity=34, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28574115, Length=282, Percent_Identity=24.468085106383, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 32332; Mature: 32201

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRTKIGFIGLGIMGKPMASHLLRGGHTLFLHSRSGVPGELLTQGGQACSSPAEVAQNA
CCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEECCCCCCHHHHHCCCCCCCCHHHHHCCC
DLIITMLPDTGDVERVLFGDKGVAEGLSAGRSKGGIVMDMSTISPVETRKFAAEINELGC
CEEEEECCCCCCCCEEEECCCCHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCC
EYVDAPVSGGDIGARNGTLTIMVGATSSAFVQVKPVLEFMGKTITLIGPTGTGQVCKLAN
CEECCCCCCCCCCCCCCEEEEEEECCCCCEEEEHHHHHHCCCEEEEECCCCCCHHHHHHH
QIIAALTIEAVGEGLLFASKAGADVRKVRQALMGGFAYSRVLEVHGERMIERAFEPGFRV
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
ELHRKDLGLALSHARTLGVSLPGTATVQELLNACIAHGGAGWDSSALVRMLEKLANHEIE
EEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEE
TIEGSHDES
EECCCCCCC
>Mature Secondary Structure 
TGRTKIGFIGLGIMGKPMASHLLRGGHTLFLHSRSGVPGELLTQGGQACSSPAEVAQNA
CCCCEEEEEECCCCCCHHHHHHHCCCCEEEEECCCCCCHHHHHCCCCCCCCHHHHHCCC
DLIITMLPDTGDVERVLFGDKGVAEGLSAGRSKGGIVMDMSTISPVETRKFAAEINELGC
CEEEEECCCCCCCCEEEECCCCHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCC
EYVDAPVSGGDIGARNGTLTIMVGATSSAFVQVKPVLEFMGKTITLIGPTGTGQVCKLAN
CEECCCCCCCCCCCCCCEEEEEEECCCCCEEEEHHHHHHCCCEEEEECCCCCCHHHHHHH
QIIAALTIEAVGEGLLFASKAGADVRKVRQALMGGFAYSRVLEVHGERMIERAFEPGFRV
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
ELHRKDLGLALSHARTLGVSLPGTATVQELLNACIAHGGAGWDSSALVRMLEKLANHEIE
EEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEE
TIEGSHDES
EECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]