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The map label for this gene is hemF [H]

Identifier: 82701270

GI number: 82701270

Start: 141112

End: 142011

Strand: Direct

Name: hemF [H]

Synonym: Nmul_A0135

Alternate gene names: 82701270

Gene position: 141112-142011 (Clockwise)

Preceding gene: 82701269

Following gene: 82701271

Centisome position: 4.43

GC content: 58.56

Gene sequence:

>900_bases
ATGAGCACTGCACAACAAGCCCGGGAGTTCTTTACGGGACTGCAGCAACGCATTGTGGAGGGACTGGAAAAAGTCGATGG
CACGCACTTCCGCCGTGATGAATGGGAGCGACCGGAAGGAGGCGGGGGCCTGAGTTGCGTACTGGAAGAGGGTAACGTGC
TGGAGCGCGGCGGAGTGAACTACTCGCACGTGTTCGGGGGAGGCTTGCCCGCCTCCGCTACCGCTGCGAGACCTGAACTG
GCGGGAAGGGGTTTCGAGGCCATGGGAGTGTCGCTCGTGCTGCATCCTCGCAATCCCTATGCCCCTACCGTGCATCTCAA
TGTGCGCTATCTGGAAGCGCGCAAGGAAGGCGCCGAACCCGTATGGTGGTTCGGCGGGGGCATGGATCTGACGCCCTATT
ACGGCTTTGAAGAAGATGCAGTGCATTTTCACCAGACCTGCAAGGACGCGCTGCAACCATTCGGCAACGATTTCCATCCG
CGCTTCAAGAAATGGTGCGACGAATATTTTTACCTCAAGCATCGCAGGGAGCCGCGAGGTATTGGCGGCATTTTCTATGA
TGATCTAAGTAAACCCGACTTTGACAGCTGCTTCAGCCTGACGAAGAGTGTGGGCACTCACTTCCTGGATGCCTACCTGC
CGATTCTGGAGCGGCGGAAGAGTGTACCCTACGGCGAGCGCGAACGCGACTTTCAGGCCTACCGGCGCGGCCGCTATGTG
GAATTCAACCTCGTGTGGGACCGGGGAACCCTGTTTGGGCTGCAGTCGGGGGGGCGTACTGAATCCATCCTCATGTCCCT
GCCCCCGGTCGTGAAATGGCGTTACGACTGGAAGCCGGAGCCGGGCAGCGCGGAAGACAGGCTTTATACCAATTTTTTGA
TCGGGAAGGATTGGGTGTAA

Upstream 100 bases:

>100_bases
ATGCGACGTGATATCGGGTATCGGGCTATTAACCACCGTAAATAGCGGTGGACGGGGTGGAAGAAAAAACTCAGCAGCAA
ACAGGTGTATGGGAGATCGG

Downstream 100 bases:

>100_bases
GCCGTTATGGATAGCTGGTCGTTTCGCGACGGCATACTATGGCGCAACGGTTTGTTATAAAATATGCAATCAGTGGGGAC
GTAGCTCAGCTGGGAGAGCG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MSTAQQAREFFTGLQQRIVEGLEKVDGTHFRRDEWERPEGGGGLSCVLEEGNVLERGGVNYSHVFGGGLPASATAARPEL
AGRGFEAMGVSLVLHPRNPYAPTVHLNVRYLEARKEGAEPVWWFGGGMDLTPYYGFEEDAVHFHQTCKDALQPFGNDFHP
RFKKWCDEYFYLKHRREPRGIGGIFYDDLSKPDFDSCFSLTKSVGTHFLDAYLPILERRKSVPYGERERDFQAYRRGRYV
EFNLVWDRGTLFGLQSGGRTESILMSLPPVVKWRYDWKPEPGSAEDRLYTNFLIGKDWV

Sequences:

>Translated_299_residues
MSTAQQAREFFTGLQQRIVEGLEKVDGTHFRRDEWERPEGGGGLSCVLEEGNVLERGGVNYSHVFGGGLPASATAARPEL
AGRGFEAMGVSLVLHPRNPYAPTVHLNVRYLEARKEGAEPVWWFGGGMDLTPYYGFEEDAVHFHQTCKDALQPFGNDFHP
RFKKWCDEYFYLKHRREPRGIGGIFYDDLSKPDFDSCFSLTKSVGTHFLDAYLPILERRKSVPYGERERDFQAYRRGRYV
EFNLVWDRGTLFGLQSGGRTESILMSLPPVVKWRYDWKPEPGSAEDRLYTNFLIGKDWV
>Mature_298_residues
STAQQAREFFTGLQQRIVEGLEKVDGTHFRRDEWERPEGGGGLSCVLEEGNVLERGGVNYSHVFGGGLPASATAARPELA
GRGFEAMGVSLVLHPRNPYAPTVHLNVRYLEARKEGAEPVWWFGGGMDLTPYYGFEEDAVHFHQTCKDALQPFGNDFHPR
FKKWCDEYFYLKHRREPRGIGGIFYDDLSKPDFDSCFSLTKSVGTHFLDAYLPILERRKSVPYGERERDFQAYRRGRYVE
FNLVWDRGTLFGLQSGGRTESILMSLPPVVKWRYDWKPEPGSAEDRLYTNFLIGKDWV

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=298, Percent_Identity=46.3087248322148, Blast_Score=266, Evalue=2e-71,
Organism=Escherichia coli, GI1788777, Length=296, Percent_Identity=65.2027027027027, Blast_Score=412, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6320249, Length=314, Percent_Identity=46.8152866242038, Blast_Score=280, Evalue=3e-76,
Organism=Drosophila melanogaster, GI17864388, Length=295, Percent_Identity=48.8135593220339, Blast_Score=286, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34277; Mature: 34146

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAQQAREFFTGLQQRIVEGLEKVDGTHFRRDEWERPEGGGGLSCVLEEGNVLERGGVN
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCEEECCCCC
YSHVFGGGLPASATAARPELAGRGFEAMGVSLVLHPRNPYAPTVHLNVRYLEARKEGAEP
EEEEECCCCCCCCCCCCCHHHCCCCCCCCEEEEEECCCCCCCEEEEEEEEEECHHCCCCE
VWWFGGGMDLTPYYGFEEDAVHFHQTCKDALQPFGNDFHPRFKKWCDEYFYLKHRREPRG
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
IGGIFYDDLSKPDFDSCFSLTKSVGTHFLDAYLPILERRKSVPYGERERDFQAYRRGRYV
CCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEE
EFNLVWDRGTLFGLQSGGRTESILMSLPPVVKWRYDWKPEPGSAEDRLYTNFLIGKDWV
EEEEEECCCEEEEECCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCC
>Mature Secondary Structure 
STAQQAREFFTGLQQRIVEGLEKVDGTHFRRDEWERPEGGGGLSCVLEEGNVLERGGVN
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCEEECCCCC
YSHVFGGGLPASATAARPELAGRGFEAMGVSLVLHPRNPYAPTVHLNVRYLEARKEGAEP
EEEEECCCCCCCCCCCCCHHHCCCCCCCCEEEEEECCCCCCCEEEEEEEEEECHHCCCCE
VWWFGGGMDLTPYYGFEEDAVHFHQTCKDALQPFGNDFHPRFKKWCDEYFYLKHRREPRG
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
IGGIFYDDLSKPDFDSCFSLTKSVGTHFLDAYLPILERRKSVPYGERERDFQAYRRGRYV
CCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEE
EFNLVWDRGTLFGLQSGGRTESILMSLPPVVKWRYDWKPEPGSAEDRLYTNFLIGKDWV
EEEEEECCCEEEEECCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA