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The map label for this gene is ubiH [H]

Identifier: 82701265

GI number: 82701265

Start: 134929

End: 136236

Strand: Direct

Name: ubiH [H]

Synonym: Nmul_A0130

Alternate gene names: 82701265

Gene position: 134929-136236 (Clockwise)

Preceding gene: 82701264

Following gene: 82701266

Centisome position: 4.24

GC content: 57.87

Gene sequence:

>1308_bases
ATGATCGACGCTCAATATCAATATGACTACGACCTGATCATCATCGGCGGCGGTCCGGTGGGCATGGCGTTGGCTCTCGC
CCTACGGAACAGCGGGTTGTCGGTGCTGTTGCTGGAGGCGCGCGGGTTGCCGGAAAAAGCGGAAGACCCGCGTCCTCTGG
CATTATCCCAAGGCAGCCGGCTTGTCCTGCAGCGGCTGGGTGTCTGGAAGGCGCTATCCGACGTTACTCCTATCTTCACC
ATTCATGTCTCCAACCAGGGAGGGCTCGGCCGAACCGTGATGATGGCCCGTGAAATAGGCGTGCCCGCGCTGGGATACGT
AGTGAATTACGATGAAGTGTTCCGTGCAATGCACAAGGCCCTTCAAAAGTGCAAAATGGATTACCTGACAGGAGCGCAGG
TAACCCATATGGAAGCAAGCGACGGATTTGGACGGGTGGAATTTGAACATGAGGGGATAACAAAAAAGGCAACAGCCAGG
CTGCTGGCCGTGGCCGACGGGGGCCGTCTCACCGCACAGATCGAAGGCATCACGCAACAGGTGCATGACTACGAGCAATG
GGCGATTGTTGCGCGTGTAAAGACCGAGCATTTTGAGGAGCATTTGGCGGAGCAGGTTTCCAGAACAGAATTATCAGATG
CAAAACAGTCGCTTGCGCGAGTTCGAACGAGACCGGGAATGCGGTCCTTGCAGGCCAAGGCTGCGGAGGATGCTCCTAGA
AGCCATCAACCCGGTGTGGCTTATGAACGCTTCACTCCGGAGGGTCCCGTTGCACTACTGCCCGCGGGCGACGGCTTTGC
ACTGGTATGGACCATCTCTCCCGACAGGGTGCAGGAAATTCTCGGGCTGGATGATGCCGCCTTTCTTGAGCGGTTACACG
GCCATTTCGGCGATCGTCTCGGCAGATTTGTTGAAGCCGGCAAGCGCTCCGGTTTTCCCCTTGCACTCAAGTACGCGACT
CCTGTCACGGCCTCTCGCACCGTGTTGATTGGCAATGCCGCCCAGACGCTGCACCCGGTTGCCGGACAGGGCTTCAACCT
GGGGCTGCGCGATGCGTGGGAGCTGGCTGAGGAAATTATGGCATTTCCTGCGGAAACCGGTACACCTGCCATGCTTGCCC
GCTACAGCAGCAAGCGCCGGTTGGACAGCAACATGGGACGTACCTTCACGCACTCGCTGGTTAAACTCTTTTCCAACGGC
AATCCCTTTTTGAGCACGGTGCGCGGCGCGGGGTTAAGTGCGCTCGATTGCCTGCCACAGCTCAAAAAGTTCGTTGCGCG
GCGCATGATATTCGGTGCAAGAGGTTGA

Upstream 100 bases:

>100_bases
CAAGACAAAAGGCCGCCAGGGGCAGTAGTGCTCAGCAGCAGTGGCAGCCAGGAGTAACCAGGGGCAATAACAGAAATCCG
CTTCACAAGCCAGCTTTTCC

Downstream 100 bases:

>100_bases
TCCCGGGGATGAAGTTGAGATCGCCCGAGCATGCACGCCCCCGTCCGTTCGTGAAGCGCAAAACGGATAAGGGTCAGAGC
GGTTTGGCGCAAGATAACGC

Product: UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MIDAQYQYDYDLIIIGGGPVGMALALALRNSGLSVLLLEARGLPEKAEDPRPLALSQGSRLVLQRLGVWKALSDVTPIFT
IHVSNQGGLGRTVMMAREIGVPALGYVVNYDEVFRAMHKALQKCKMDYLTGAQVTHMEASDGFGRVEFEHEGITKKATAR
LLAVADGGRLTAQIEGITQQVHDYEQWAIVARVKTEHFEEHLAEQVSRTELSDAKQSLARVRTRPGMRSLQAKAAEDAPR
SHQPGVAYERFTPEGPVALLPAGDGFALVWTISPDRVQEILGLDDAAFLERLHGHFGDRLGRFVEAGKRSGFPLALKYAT
PVTASRTVLIGNAAQTLHPVAGQGFNLGLRDAWELAEEIMAFPAETGTPAMLARYSSKRRLDSNMGRTFTHSLVKLFSNG
NPFLSTVRGAGLSALDCLPQLKKFVARRMIFGARG

Sequences:

>Translated_435_residues
MIDAQYQYDYDLIIIGGGPVGMALALALRNSGLSVLLLEARGLPEKAEDPRPLALSQGSRLVLQRLGVWKALSDVTPIFT
IHVSNQGGLGRTVMMAREIGVPALGYVVNYDEVFRAMHKALQKCKMDYLTGAQVTHMEASDGFGRVEFEHEGITKKATAR
LLAVADGGRLTAQIEGITQQVHDYEQWAIVARVKTEHFEEHLAEQVSRTELSDAKQSLARVRTRPGMRSLQAKAAEDAPR
SHQPGVAYERFTPEGPVALLPAGDGFALVWTISPDRVQEILGLDDAAFLERLHGHFGDRLGRFVEAGKRSGFPLALKYAT
PVTASRTVLIGNAAQTLHPVAGQGFNLGLRDAWELAEEIMAFPAETGTPAMLARYSSKRRLDSNMGRTFTHSLVKLFSNG
NPFLSTVRGAGLSALDCLPQLKKFVARRMIFGARG
>Mature_435_residues
MIDAQYQYDYDLIIIGGGPVGMALALALRNSGLSVLLLEARGLPEKAEDPRPLALSQGSRLVLQRLGVWKALSDVTPIFT
IHVSNQGGLGRTVMMAREIGVPALGYVVNYDEVFRAMHKALQKCKMDYLTGAQVTHMEASDGFGRVEFEHEGITKKATAR
LLAVADGGRLTAQIEGITQQVHDYEQWAIVARVKTEHFEEHLAEQVSRTELSDAKQSLARVRTRPGMRSLQAKAAEDAPR
SHQPGVAYERFTPEGPVALLPAGDGFALVWTISPDRVQEILGLDDAAFLERLHGHFGDRLGRFVEAGKRSGFPLALKYAT
PVTASRTVLIGNAAQTLHPVAGQGFNLGLRDAWELAEEIMAFPAETGTPAMLARYSSKRRLDSNMGRTFTHSLVKLFSNG
NPFLSTVRGAGLSALDCLPQLKKFVARRMIFGARG

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=450, Percent_Identity=24.2222222222222, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI32967307, Length=229, Percent_Identity=29.2576419213974, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1789274, Length=434, Percent_Identity=34.5622119815668, Blast_Score=195, Evalue=6e-51,
Organism=Escherichia coli, GI1789273, Length=431, Percent_Identity=28.0742459396752, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1786883, Length=425, Percent_Identity=27.0588235294118, Blast_Score=116, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 47485; Mature: 47485

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDAQYQYDYDLIIIGGGPVGMALALALRNSGLSVLLLEARGLPEKAEDPRPLALSQGSR
CCCCCEECCEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEECCCCCH
LVLQRLGVWKALSDVTPIFTIHVSNQGGLGRTVMMAREIGVPALGYVVNYDEVFRAMHKA
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCHHHHEECHHHHHHHHHHH
LQKCKMDYLTGAQVTHMEASDGFGRVEFEHEGITKKATARLLAVADGGRLTAQIEGITQQ
HHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCHHHHEEEEEEECCCEEEEEEHHHHHH
VHDYEQWAIVARVKTEHFEEHLAEQVSRTELSDAKQSLARVRTRPGMRSLQAKAAEDAPR
HHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
SHQPGVAYERFTPEGPVALLPAGDGFALVWTISPDRVQEILGLDDAAFLERLHGHFGDRL
CCCCCCCEECCCCCCCEEEEECCCCEEEEEEECHHHHHHHHCCCHHHHHHHHHHHHHHHH
GRFVEAGKRSGFPLALKYATPVTASRTVLIGNAAQTLHPVAGQGFNLGLRDAWELAEEIM
HHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCHHHHCCCCCCCCCCCHHHHHHHHHHHH
AFPAETGTPAMLARYSSKRRLDSNMGRTFTHSLVKLFSNGNPFLSTVRGAGLSALDCLPQ
HCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHH
LKKFVARRMIFGARG
HHHHHHHHHHHCCCC
>Mature Secondary Structure
MIDAQYQYDYDLIIIGGGPVGMALALALRNSGLSVLLLEARGLPEKAEDPRPLALSQGSR
CCCCCEECCEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEECCCCCH
LVLQRLGVWKALSDVTPIFTIHVSNQGGLGRTVMMAREIGVPALGYVVNYDEVFRAMHKA
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCHHHHEECHHHHHHHHHHH
LQKCKMDYLTGAQVTHMEASDGFGRVEFEHEGITKKATARLLAVADGGRLTAQIEGITQQ
HHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCHHHHEEEEEEECCCEEEEEEHHHHHH
VHDYEQWAIVARVKTEHFEEHLAEQVSRTELSDAKQSLARVRTRPGMRSLQAKAAEDAPR
HHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
SHQPGVAYERFTPEGPVALLPAGDGFALVWTISPDRVQEILGLDDAAFLERLHGHFGDRL
CCCCCCCEECCCCCCCEEEEECCCCEEEEEEECHHHHHHHHCCCHHHHHHHHHHHHHHHH
GRFVEAGKRSGFPLALKYATPVTASRTVLIGNAAQTLHPVAGQGFNLGLRDAWELAEEIM
HHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCHHHHCCCCCCCCCCCHHHHHHHHHHHH
AFPAETGTPAMLARYSSKRRLDSNMGRTFTHSLVKLFSNGNPFLSTVRGAGLSALDCLPQ
HCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHH
LKKFVARRMIFGARG
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]