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The map label for this gene is prlC [H]

Identifier: 82545862

GI number: 82545862

Start: 3488100

End: 3490142

Strand: Reverse

Name: prlC [H]

Synonym: SBO_3496

Alternate gene names: 82545862

Gene position: 3490142-3488100 (Counterclockwise)

Preceding gene: 82545868

Following gene: 82545861

Centisome position: 77.22

GC content: 55.46

Gene sequence:

>2043_bases
ATGACGAATCCGTTACTGACTCCCTTTGAATTGCCTCCGTTTTCTAAAATTCTCCCGGAACATGTCGTTCCAGCCGTGAC
TCAGGCGCTGAACGATTGCCGCGAAAATGTGGAGCGCGTAGTAGCGCAAGGGGCACCGTACACCTGGGAAAATCTCTGCC
AGCCGTTGGCGGAAGTGGACGATGTGTTGGGGCGTATCTTCTCCCCGGTCAGCCACCTGAACTCGGTGAAAAATAGCCCG
GAACTGCGTGAAGCCTACGAGCAAACCCTGCCGCTGCTGTCGGAATACAGCACCTGGGTAGGGCAACATGAAGGGCTGTA
TAAAGCGTACCGCGACCTGCGCGATGGCGATCATTACGCCACGCTGAACACGGCGCAGAAGAAAGCGGTTGATAACGCCC
TGCGTGATTTTGAACTCTCTGGCATAGGTCTGCCGAAAGAGAAACAGCAGCGTTACGGCGAAATTGCGACCCGTCTTTCT
GAACTGGGCAACCAGTACAGCAACAACGTCCTCGATGCGACAATGGGCTGGACCAAACTCGTTACCGACGAAGCGGAGCT
GGCGGGGATGCCTGAAAGCGCGCTGGCTGCGGCAAAAGCCCAGGCCGAAGCGAAAGAGCTGGAAGGCTACCTGCTGACGC
TGGATATCCCAAGCTACCTGCCGGTAATGACCTACTGCGACAACCAGGCCTTGCGTGAAGAGATGTATCGCGCTTACAGC
ACCCGCGCCTCCGATCAAGGCCCGAACGCCGGTAAATGGGATAACAGCAAGGTGATGGAAGAGATCCTCGCTCTGCGTCA
CGAACTGGCGCAACTGCTGGGCTTTGAAAACTACGCCTTTAAATCCCTTGCCACTAAAATGGCAGAAAACCCGCAGCAGG
TGCTGGATTTCTTAACCGATCTGGCAAAACGCGCGCGTCCGCAAGGCGAAAAAGAGCTGGCACAACTGCGCGCCTTCGCC
AAAGCGGAATTTGGCGTCGATGAGTTGCAGCCGTGGGATATCGCGTACTACAGCGAAAAACAAAAACAGCACCTCTACAG
CATCAGTGACGAACAGCTGCGTCCGTACTTCCCGGAAAACAAAGCGGTTAACGGCCTGTTTGAAGTGGTGAAACGTATTT
ACGGCATCACCGCTAAAGAGCGTAAAGATGTTGATGTCTGGCATCCGGATGTACGTTTCTTCGAACTGTATGACGAGAAC
AACGAACTGCGCGGCAGCTTCTACCTCGATCTGTATGCCCGTGAAAACAAGCGCGGCGGGGCGTGGATGGATGACTGCGT
AGGCCAGATGCGTAAAGCTGACGGTTCTCTGCAAAAACCGGTCGCGTATTTGACTTGTAACTTCAACCGCCCGGTAAATG
GTAAACCGGCGCTGTTCACTCACGACGAAGTGATCACCCTGTTCCACGAGTTCGGTCACGGCCTGCACCATATGCTGACC
CGCATCGAAACCGCTGGTGTTTCCGGTATCAGCGGTGTGCCGTGGGATGCGGTCGAACTGCCGAGTCAGTTTATGGAAAA
CTGGTGCTGGGAGCCGGAGGCGCTGGCGTTTATCTCTGGTTACTATGAAACCGGCGAACCGCTGCCGAAAGAGTTGCTGG
ATAAAATGCTGGCGGCGAAGAACTACCAGGCGGCGCTGTTTATTCTGCGCCAGCTGGAGTTCGGCCTGTTCGATTTCCGC
CTCCATGCCGAGTTCCGCCCGGATCAGGGTGCGAAAATCCTCGAAACTCTGGCAGAAATCAAGAAACTGGTTGCCGTAGT
ACCGTCTCCATCCTGGGGCCGTTTCCCGCACGCTTTCAGCCATATTTTCGCCGGTGGTTATGCCGCAGGTTACTACAGCT
ACCTGTGGGCTGACGTACTGGCGGCAGATGCCTTCTCGCGCTTTGAGGAAGAGGGCATTTTCAACCGTGAAACCGGGCAG
TCGTTCCTCGACAACATTCTGAGCCGTGGCGGTTCAGAAGAGCCGATGGATCTGTTCAAACGCTTCCGTGGTCGTGAACC
GCAGCTGGATGCGATGCTGGAGCATTACGGCATTAAGGGCTGA

Upstream 100 bases:

>100_bases
CGTTTCTCATTGAAATTCACTACACTTAACCCCATGCTACACACATTATGTAAAGCGCCTGTTGAGCGCTTCCTTAACCT
CTTTAACCAGGACTGCGCGA

Downstream 100 bases:

>100_bases
TCATTCAGTGAAAATCTGCTTAATTGATGAAACAGGCGCCGGAGACGGCGCCTTATCTGTTCTGGCGGCCCGCTGGGGGC
TGGAGCACGATGAAGACAAC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MTNPLLTPFELPPFSKILPEHVVPAVTQALNDCRENVERVVAQGAPYTWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSP
ELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLS
ELGNQYSNNVLDATMGWTKLVTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
TRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFA
KAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDEN
NELRGSFYLDLYARENKRGGAWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGYYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFR
LHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQ
SFLDNILSRGGSEEPMDLFKRFRGREPQLDAMLEHYGIKG

Sequences:

>Translated_680_residues
MTNPLLTPFELPPFSKILPEHVVPAVTQALNDCRENVERVVAQGAPYTWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSP
ELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLS
ELGNQYSNNVLDATMGWTKLVTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
TRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFA
KAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDEN
NELRGSFYLDLYARENKRGGAWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGYYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFR
LHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQ
SFLDNILSRGGSEEPMDLFKRFRGREPQLDAMLEHYGIKG
>Mature_679_residues
TNPLLTPFELPPFSKILPEHVVPAVTQALNDCRENVERVVAQGAPYTWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSPE
LREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSE
LGNQYSNNVLDATMGWTKLVTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYST
RASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFAK
AEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDENN
ELRGSFYLDLYARENKRGGAWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLTR
IETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGYYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFRL
HAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQS
FLDNILSRGGSEEPMDLFKRFRGREPQLDAMLEHYGIKG

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=640, Percent_Identity=31.40625, Blast_Score=315, Evalue=7e-86,
Organism=Homo sapiens, GI14149738, Length=642, Percent_Identity=31.3084112149533, Blast_Score=290, Evalue=4e-78,
Organism=Homo sapiens, GI156105687, Length=618, Percent_Identity=26.8608414239482, Blast_Score=203, Evalue=3e-52,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=99.7058823529412, Blast_Score=1407, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=687, Percent_Identity=32.3144104803493, Blast_Score=325, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI71999758, Length=574, Percent_Identity=25.609756097561, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI32565901, Length=637, Percent_Identity=23.861852433281, Blast_Score=137, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319793, Length=691, Percent_Identity=28.6541244573082, Blast_Score=297, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6322715, Length=701, Percent_Identity=22.8245363766049, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21356111, Length=692, Percent_Identity=27.8901734104046, Blast_Score=254, Evalue=2e-67,
Organism=Drosophila melanogaster, GI20129717, Length=682, Percent_Identity=25.5131964809384, Blast_Score=190, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 77194; Mature: 77063

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLTPFELPPFSKILPEHVVPAVTQALNDCRENVERVVAQGAPYTWENLCQPLAEVD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DVLGRIFSPVSHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEE
TLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSELGNQYSNNVLDATMGWTKL
EHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHH
VTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
HCCCHHHCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTD
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQGEKELAQLRAFAKAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPEN
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCC
KAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDENNELRGSFYLDLYARENKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCC
AWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCHHCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGYYETGEPLPKELLDKMLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
NYQAALFILRQLEFGLFDFRLHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFS
CHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQSFLDNILSRGGSEEPMDLFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLEHYGIKG
HHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TNPLLTPFELPPFSKILPEHVVPAVTQALNDCRENVERVVAQGAPYTWENLCQPLAEVD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DVLGRIFSPVSHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEE
TLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSELGNQYSNNVLDATMGWTKL
EHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHH
VTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
HCCCHHHCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTD
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQGEKELAQLRAFAKAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPEN
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCC
KAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDENNELRGSFYLDLYARENKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCC
AWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCHHCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGYYETGEPLPKELLDKMLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
NYQAALFILRQLEFGLFDFRLHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFS
CHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQSFLDNILSRGGSEEPMDLFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLEHYGIKG
HHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]