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The map label for this gene is rfbD [H]

Identifier: 82543418

GI number: 82543418

Start: 881684

End: 882583

Strand: Reverse

Name: rfbD [H]

Synonym: SBO_0867

Alternate gene names: 82543418

Gene position: 882583-881684 (Counterclockwise)

Preceding gene: 82543419

Following gene: 82543417

Centisome position: 19.53

GC content: 47.22

Gene sequence:

>900_bases
ATGAATATCCTCCTTTTTGGCAAAACAGGGCAGGTAGGTTGGGAACTACAGCGTGCTCTGGCACCTCTGGGTAATTTGAT
TGCTCTTGATGTTCACTCCACTGATTATTGTGGTGATTTTAGTAATTCTGAAGGTGTAGCTGAAACTGTCAAAAAAATTC
GCCCTGATGTTATTGTTAATGCGGCTGCTCATACCGCGGTAGATAAGGCTGAGTCAGAACCCGAATTTGCACAATTACTC
AATGCGACAAGTGTTGAAGCGATTGCAAAAGCAGCCAATGAGGTCGGTGCATGGGTTATTCACTACTCTACTGACTACGT
ATTTCCGGGAACCGGTGAAATACCATGGCAGGAGGCGGATGCAACCGCACCGCTGAACGTTTATGGTGAAACCAAGTTAG
CCGGGGAAAAAGCATTACAAGAGCATTGTGCGAAGCATCTTATTTTCCGGACCAGCTGGGTCTATGCAGGTAAAGGAAAT
AACTTCGCCAAAACGATGTTGCGTCTGGCAAAAGAGCGTGAAGAATTAGCTGTTATTAACGATCAGTTTGGTGCGCCAAC
TGGCGCAGAGTTACTGGCTGATTGTACGGCACATGCCATTCGTGTGGCACTGAATAAACCGGAAGTCGCAGGCTTGTACC
ATCTGGTAGCTAGTGGTACCACAACGTGGCACGATTATGCTGCGCTGGTTTTTGAAGAGGCGCGCAAAGCAGGCATTCCC
CTTGCACTCAACAAGCTCAACGCAGTACCAACAACAGCCTATCCTACACCAGCTCGTCGTCCGCATAACTCTCGCCTTGA
TACAGAAAAATTTCAGCAGAACTTTGCGCTTGTCTTGCCTGACTGGCAGATTGGCGTGAAACGCATGCTCAACGAATTAT
TTACGACTACAGCTATTTAA

Upstream 100 bases:

>100_bases
AGACAGTGGAATGGTACCTGTCCAATACAAAATGGGTTGATAATGTGAAAAGTGGTGCCTATCAATCGTGGATTGAAGAG
AACTATGAGGGCCGCCAGTA

Downstream 100 bases:

>100_bases
TAGTTTTTGCATCTTGTTCGTGATGGTGGAGCAAGATGAATTAAAAGGAATGATGAAATGAAAACGCGTAAAGGTATTAT
TTTAGCGGGCGGTTCTGGTA

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MNILLFGKTGQVGWELQRALAPLGNLIALDVHSTDYCGDFSNSEGVAETVKKIRPDVIVNAAAHTAVDKAESEPEFAQLL
NATSVEAIAKAANEVGAWVIHYSTDYVFPGTGEIPWQEADATAPLNVYGETKLAGEKALQEHCAKHLIFRTSWVYAGKGN
NFAKTMLRLAKEREELAVINDQFGAPTGAELLADCTAHAIRVALNKPEVAGLYHLVASGTTTWHDYAALVFEEARKAGIP
LALNKLNAVPTTAYPTPARRPHNSRLDTEKFQQNFALVLPDWQIGVKRMLNELFTTTAI

Sequences:

>Translated_299_residues
MNILLFGKTGQVGWELQRALAPLGNLIALDVHSTDYCGDFSNSEGVAETVKKIRPDVIVNAAAHTAVDKAESEPEFAQLL
NATSVEAIAKAANEVGAWVIHYSTDYVFPGTGEIPWQEADATAPLNVYGETKLAGEKALQEHCAKHLIFRTSWVYAGKGN
NFAKTMLRLAKEREELAVINDQFGAPTGAELLADCTAHAIRVALNKPEVAGLYHLVASGTTTWHDYAALVFEEARKAGIP
LALNKLNAVPTTAYPTPARRPHNSRLDTEKFQQNFALVLPDWQIGVKRMLNELFTTTAI
>Mature_299_residues
MNILLFGKTGQVGWELQRALAPLGNLIALDVHSTDYCGDFSNSEGVAETVKKIRPDVIVNAAAHTAVDKAESEPEFAQLL
NATSVEAIAKAANEVGAWVIHYSTDYVFPGTGEIPWQEADATAPLNVYGETKLAGEKALQEHCAKHLIFRTSWVYAGKGN
NFAKTMLRLAKEREELAVINDQFGAPTGAELLADCTAHAIRVALNKPEVAGLYHLVASGTTTWHDYAALVFEEARKAGIP
LALNKLNAVPTTAYPTPARRPHNSRLDTEKFQQNFALVLPDWQIGVKRMLNELFTTTAI

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=255, Percent_Identity=28.2352941176471, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI33519455, Length=255, Percent_Identity=28.2352941176471, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1788352, Length=299, Percent_Identity=94.6488294314381, Blast_Score=591, Evalue=1e-170,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 32594; Mature: 32594

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILLFGKTGQVGWELQRALAPLGNLIALDVHSTDYCGDFSNSEGVAETVKKIRPDVIVN
CEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCEEE
AAAHTAVDKAESEPEFAQLLNATSVEAIAKAANEVGAWVIHYSTDYVFPGTGEIPWQEAD
HHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHHHHHCEEEEEEECCEEECCCCCCCCCCCC
ATAPLNVYGETKLAGEKALQEHCAKHLIFRTSWVYAGKGNNFAKTMLRLAKEREELAVIN
CCCCEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHEEEC
DQFGAPTGAELLADCTAHAIRVALNKPEVAGLYHLVASGTTTWHDYAALVFEEARKAGIP
CCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
LALNKLNAVPTTAYPTPARRPHNSRLDTEKFQQNFALVLPDWQIGVKRMLNELFTTTAI
EEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNILLFGKTGQVGWELQRALAPLGNLIALDVHSTDYCGDFSNSEGVAETVKKIRPDVIVN
CEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCEEE
AAAHTAVDKAESEPEFAQLLNATSVEAIAKAANEVGAWVIHYSTDYVFPGTGEIPWQEAD
HHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHHHHHCEEEEEEECCEEECCCCCCCCCCCC
ATAPLNVYGETKLAGEKALQEHCAKHLIFRTSWVYAGKGNNFAKTMLRLAKEREELAVIN
CCCCEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHEEEC
DQFGAPTGAELLADCTAHAIRVALNKPEVAGLYHLVASGTTTWHDYAALVFEEARKAGIP
CCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
LALNKLNAVPTTAYPTPARRPHNSRLDTEKFQQNFALVLPDWQIGVKRMLNELFTTTAI
EEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7559340 [H]