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The map label for this gene is clcA [H]

Identifier: 78780179

GI number: 78780179

Start: 1689375

End: 1690733

Strand: Direct

Name: clcA [H]

Synonym: PMT9312_1794

Alternate gene names: 78780179

Gene position: 1689375-1690733 (Clockwise)

Preceding gene: 78780178

Following gene: 78780181

Centisome position: 98.84

GC content: 34.36

Gene sequence:

>1359_bases
ATGCCAAACTTTATAAAAGATAATATTCAAAAAACAAGTAATAATTCTTCTCGTAGCATTAAAAAATTATTAAGACAAAG
ATCTCTAGTCGTTGTATTTTCACTCTTATTAACAGGTTTAGGGGCCTCAATTACAAGCATATCTTTTAAAACTGGAATCT
ATTTTATTAATAATTGGAGATTAGCATTATTAGACCAATTCCCATCTATTGCGGTCTTACCTATTTTTGGAGCTCTAGGA
GGAGCTATTGCAGGATATTTGATCAAAAATATTGCACCTGCTGCAAAAGGTTCAGGTGTGAGTCAAATCATGGGTTTCTT
AAGACATAAAAAAGTTCCAATGAATTTAAAAGTAGGATTAGTAAAGCTCATATCAGGAATTATTGCTATTGGCAGTGGAT
TCCCTTTAGGCCCAGAAGGTCCATCAGTTCAAATGGGAGGATCAGTAGCTTGGCAAATGGCCAAGTGGCTCAAAGCTCCT
ACAGCTTTCAGAAGAGTAATCGTAGCAGCAGGTGGTGGTGCTGGAATAGCTGCAGTATTTAGCGCTCCATTAGGAGGGTT
TGTCTATGCAATAGAAGAGTTATTAAACTCTGCTAGACCAGTAATTTTGCTATTAGTAGTAATTACAACTTTTATTGCAG
ATTCATCTGCTGATATTATTCAAGCCTTGGGTTTAGATCCTAAAGCAGGAGGCTTTGATTTTAACCTCGGATTTTTGATT
CAAAAAGAATATGACCCATCAGTTTTTTTCTTACCTGTAGATTTTATTTACTTAGTTTTACTGGGAATAATTATTGGGAT
ATTTGCAGAATTGTACAGCAGATATGTTTTGTTAATGCAAAATCTTGGAAAAAAGTGGTATAAAAATAAATTTGTTTTAA
AAATGAGTATCTGTGGACTTATTTTAGGAAGTATCTACTCTTGTTTACCCAGTACATTTCATAATTTAGATGAATTACAG
AAAATAATAGCTGAACAAAATATAAGTATTGGAATTGCTTTATTAGCAGTTTTAGTACTATTTATCACGACTGGTTTGGC
TGCAGCATCTGGAGCTCCTGGAGGATTATTCTATCCAATGCTTACTTTAGGAGGAGCAATCGGACTAATAATGGGAAGCT
GGGTAGAAATTGCGACAGGACATGCTCCAAGTACGTACATTTTTGCGGGAATGGGAGCTTTCGTAGCTGGCTGTTCACGA
ACACCAATAACAGCAATGTTTTTAGCTTTTGCTTTAACAAAAAATTTATTAATAATGAAACCTGTCTTAATCAGCTGCAT
TGCCAGTTTCTTGATAGCAAGAGCTTTTAATGAAGAATCAATTTATGAAAGACAAATACAAATAGAATTAGAAGACTAA

Upstream 100 bases:

>100_bases
TATTACTAAAAATAAAATTAATCCATATTCAGATGAACTTTATCGCTATCTTCAATTTGATGAAATACACGATTTCAGCT
TGACAAAGTAATCATGGACT

Downstream 100 bases:

>100_bases
GAAACTATCTTCAATCAAAAACAGCAGTTTTGCTGTTATAAACAAATACTTGATGATTTAGATGTAATCTAACCGCTCTT
GCTAAAGCTATTCTTTCAAT

Product: putative chloride channel

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MPNFIKDNIQKTSNNSSRSIKKLLRQRSLVVVFSLLLTGLGASITSISFKTGIYFINNWRLALLDQFPSIAVLPIFGALG
GAIAGYLIKNIAPAAKGSGVSQIMGFLRHKKVPMNLKVGLVKLISGIIAIGSGFPLGPEGPSVQMGGSVAWQMAKWLKAP
TAFRRVIVAAGGGAGIAAVFSAPLGGFVYAIEELLNSARPVILLLVVITTFIADSSADIIQALGLDPKAGGFDFNLGFLI
QKEYDPSVFFLPVDFIYLVLLGIIIGIFAELYSRYVLLMQNLGKKWYKNKFVLKMSICGLILGSIYSCLPSTFHNLDELQ
KIIAEQNISIGIALLAVLVLFITTGLAAASGAPGGLFYPMLTLGGAIGLIMGSWVEIATGHAPSTYIFAGMGAFVAGCSR
TPITAMFLAFALTKNLLIMKPVLISCIASFLIARAFNEESIYERQIQIELED

Sequences:

>Translated_452_residues
MPNFIKDNIQKTSNNSSRSIKKLLRQRSLVVVFSLLLTGLGASITSISFKTGIYFINNWRLALLDQFPSIAVLPIFGALG
GAIAGYLIKNIAPAAKGSGVSQIMGFLRHKKVPMNLKVGLVKLISGIIAIGSGFPLGPEGPSVQMGGSVAWQMAKWLKAP
TAFRRVIVAAGGGAGIAAVFSAPLGGFVYAIEELLNSARPVILLLVVITTFIADSSADIIQALGLDPKAGGFDFNLGFLI
QKEYDPSVFFLPVDFIYLVLLGIIIGIFAELYSRYVLLMQNLGKKWYKNKFVLKMSICGLILGSIYSCLPSTFHNLDELQ
KIIAEQNISIGIALLAVLVLFITTGLAAASGAPGGLFYPMLTLGGAIGLIMGSWVEIATGHAPSTYIFAGMGAFVAGCSR
TPITAMFLAFALTKNLLIMKPVLISCIASFLIARAFNEESIYERQIQIELED
>Mature_451_residues
PNFIKDNIQKTSNNSSRSIKKLLRQRSLVVVFSLLLTGLGASITSISFKTGIYFINNWRLALLDQFPSIAVLPIFGALGG
AIAGYLIKNIAPAAKGSGVSQIMGFLRHKKVPMNLKVGLVKLISGIIAIGSGFPLGPEGPSVQMGGSVAWQMAKWLKAPT
AFRRVIVAAGGGAGIAAVFSAPLGGFVYAIEELLNSARPVILLLVVITTFIADSSADIIQALGLDPKAGGFDFNLGFLIQ
KEYDPSVFFLPVDFIYLVLLGIIIGIFAELYSRYVLLMQNLGKKWYKNKFVLKMSICGLILGSIYSCLPSTFHNLDELQK
IIAEQNISIGIALLAVLVLFITTGLAAASGAPGGLFYPMLTLGGAIGLIMGSWVEIATGHAPSTYIFAGMGAFVAGCSRT
PITAMFLAFALTKNLLIMKPVLISCIASFLIARAFNEESIYERQIQIELED

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=433, Percent_Identity=29.7921478060046, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71985148, Length=303, Percent_Identity=27.3927392739274, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71985141, Length=304, Percent_Identity=27.6315789473684, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322500, Length=390, Percent_Identity=24.8717948717949, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI281361606, Length=400, Percent_Identity=22.5, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161078208, Length=400, Percent_Identity=22.5, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28573073, Length=400, Percent_Identity=22.5, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24665008, Length=431, Percent_Identity=23.8979118329466, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573071, Length=400, Percent_Identity=23, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281361608, Length=400, Percent_Identity=23, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573075, Length=400, Percent_Identity=23, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 48369; Mature: 48238

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNFIKDNIQKTSNNSSRSIKKLLRQRSLVVVFSLLLTGLGASITSISFKTGIYFINNWR
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCEEEEECCE
LALLDQFPSIAVLPIFGALGGAIAGYLIKNIAPAAKGSGVSQIMGFLRHKKVPMNLKVGL
EHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHH
VKLISGIIAIGSGFPLGPEGPSVQMGGSVAWQMAKWLKAPTAFRRVIVAAGGGAGIAAVF
HHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHCHHHHHHHHEECCCCCHHHHHH
SAPLGGFVYAIEELLNSARPVILLLVVITTFIADSSADIIQALGLDPKAGGFDFNLGFLI
HCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEEEE
QKEYDPSVFFLPVDFIYLVLLGIIIGIFAELYSRYVLLMQNLGKKWYKNKFVLKMSICGL
EECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHH
ILGSIYSCLPSTFHNLDELQKIIAEQNISIGIALLAVLVLFITTGLAAASGAPGGLFYPM
HHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LTLGGAIGLIMGSWVEIATGHAPSTYIFAGMGAFVAGCSRTPITAMFLAFALTKNLLIMK
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHH
PVLISCIASFLIARAFNEESIYERQIQIELED
HHHHHHHHHHHHHHHCCHHHHEEEEEEEEECC
>Mature Secondary Structure 
PNFIKDNIQKTSNNSSRSIKKLLRQRSLVVVFSLLLTGLGASITSISFKTGIYFINNWR
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCEEEEECCE
LALLDQFPSIAVLPIFGALGGAIAGYLIKNIAPAAKGSGVSQIMGFLRHKKVPMNLKVGL
EHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHH
VKLISGIIAIGSGFPLGPEGPSVQMGGSVAWQMAKWLKAPTAFRRVIVAAGGGAGIAAVF
HHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHCHHHHHHHHEECCCCCHHHHHH
SAPLGGFVYAIEELLNSARPVILLLVVITTFIADSSADIIQALGLDPKAGGFDFNLGFLI
HCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEEEE
QKEYDPSVFFLPVDFIYLVLLGIIIGIFAELYSRYVLLMQNLGKKWYKNKFVLKMSICGL
EECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHH
ILGSIYSCLPSTFHNLDELQKIIAEQNISIGIALLAVLVLFITTGLAAASGAPGGLFYPM
HHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LTLGGAIGLIMGSWVEIATGHAPSTYIFAGMGAFVAGCSRTPITAMFLAFALTKNLLIMK
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHH
PVLISCIASFLIARAFNEESIYERQIQIELED
HHHHHHHHHHHHHHHCCHHHHEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA