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The map label for this gene is tkt [H]

Identifier: 78780088

GI number: 78780088

Start: 1591545

End: 1593551

Strand: Direct

Name: tkt [H]

Synonym: PMT9312_1703

Alternate gene names: 78780088

Gene position: 1591545-1593551 (Clockwise)

Preceding gene: 78780087

Following gene: 78780094

Centisome position: 93.12

GC content: 36.47

Gene sequence:

>2007_bases
ATGGTTGCTGCATCTGTTTCAATAGAATCACTCTGTGTAAATAGTATAAGAATGCTTGCTGTAGATGCAGTAAATAAATC
TAATAGTGGGCATCCTGGTTTACCAATGGGATGTGCTCCTATGGGTTATGCACTATGGCAAAACATACTAAATCACAACC
CCAATAATCCAAAATGGTTTAATAGAGATCGTTTTGTATTATCAGCTGGTCATGGCTGTATGTTGTTATATTCCTTGCTT
CATCTAACAGGATACAAATCAGTTTCCATAGAAGATATTAAAGAATTTAGACAATGGGGATCAAAAACTCCTGGTCATCC
AGAAACATTCGAAACTGAGGGAGTTGAAGTTACAGCTGGACCTCTCGGAGCTGGTATTTCTAATGCAGTTGGTTTAGCAA
TAGCTGAAACTCACTTAGCAGCCAAATTCAATAAGCCTGATTGCAATATCGTTGATCATTATACTTACGTCATAATGGGT
GACGGCTGTAATCAAGAAGGTATCGCATCAGAGGCTTGCTCATTAGCTGGTCACCTTAAGCTTGGAAAATTAATTGCGCT
CTATGACGATAATCAAATTACAATTGATGGACGTACAGATGTCTCTTTCACTGAAGATGTTTTAAAAAGATACGAAGCTT
ATGGATGGCATGTACAACATGTTGAAGATGGTAATCATGATGTTAAAGGAATAACTGAAGCTATCGAAAAAGCAAAATCA
ATTACAAACAAACCTTCTATTATAAAAATCTCTACAACAATAGGTTATGGTTCTCCTAATAAATCAGATACTGCAGGAAT
TCATGGTGCAGCTGTTGGAGAAGAAGAAGCTTCATTAACCAGAGAGTTTTTAAATTGGGAATATCCTCCATTTGAAATTC
CAGATGAAGTATATAAACATTTCAGAAAATCAATAGACAAGGGCGAAAACTTAGAGAAAGAATGGGATTCTAGATTTGAA
GAATATCAGAAAAAATATCCCTCTGAAGGAGCCGAATTAAAAAGAATGTTAAAAGGCCAATTACCTGAGAATTGGGATTC
AGATCTCCCATCTTATACACCTAATGATAAAGGTTTAGCTACCAGAAAGCATTCACAAATATGTTTAGGTGCTCTAGGTC
CTAACCTACCAGAATTAATTGGTGGATCAGCAGATTTAACTCACTCTAACTATACAGATATCAAAGGAGAAACAGGATCA
TTCCAGCCTCATAGTCCTGAAAAAAGATATTTACATTTTGGAGTAAGAGAGCATGCAATGGCAGCAGTACTTAATGGTAT
TGCATATCACAATAGCGGTCTTATACCCTATGGTGGAACCTTCCTTGTTTTCGCGGATTATATGAGAGGTTCAATGAGAC
TTTCAGCACTTAGCGAATTAGGAGTTATCTATGTATTAACCCATGATTCAATTGGTGTAGGCGAAGATGGTCCAACACAT
CAACCTATTGAAACTATCCCTTCTCTTCGAGCCATGCCTAACATGCTAGTTTTCAGACCAGGAGATGGAAATGAGACGAG
TGGAGCTTATAAGCTTGCTATTAAAAATCGCAAAAGACCTTCTGCCCTTTGTTTAAGTAGACAAGGTATGCCTAATCAAG
AAAACACTTCAATTGAAAAAGTTGCACTAGGAGGATATATAGTTGCTGATTGCGAAGGAACACCAGATTTAATATTTATT
GGAACTGGAAGTGAACTAAATCTTTGTATTGAAGCAAGTAAGGAGATTTCAAACTTAGGTAAAAAAACTAGAGTTGTCTC
TATGCCATGCATAGAACTTTTCGAAGAACAAGAAGAATCTTACAAAGAAAGTGTTTTACCTAATAGTGTGACTAAGAGAG
TTGTAGTAGAAGCTGCCCATTCATTTGGTTGGCATAAATATACAGGTTTTGATGGGATTTGTATTACTATGGATAGGTTT
GGTGCATCAGCACCTGGTGGCGAGTGTATGAAAAATTTTGGATTTACAGTTGAAAACGTTGTAAATAAAACAAAGGAAAT
TCTATAA

Upstream 100 bases:

>100_bases
AATTCTTTCGGCTTTGGTGGTCACAATGTTTGCCTTGCTTTTAGCAAAATGAATTGAAGACAACCAATTCTGTATTTCCA
AATTATCTTATTTTAAAAAA

Downstream 100 bases:

>100_bases
GCATTATTGATAATTACACTGAAGAATTACATTCTTCAAGTTTATCTTTTAGTTGATCAAGAGATTCATCAGAAATTTTC
GAATTCATTGGACAATGTTT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MVAASVSIESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWFNRDRFVLSAGHGCMLLYSLL
HLTGYKSVSIEDIKEFRQWGSKTPGHPETFETEGVEVTAGPLGAGISNAVGLAIAETHLAAKFNKPDCNIVDHYTYVIMG
DGCNQEGIASEACSLAGHLKLGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVKGITEAIEKAKS
ITNKPSIIKISTTIGYGSPNKSDTAGIHGAAVGEEEASLTREFLNWEYPPFEIPDEVYKHFRKSIDKGENLEKEWDSRFE
EYQKKYPSEGAELKRMLKGQLPENWDSDLPSYTPNDKGLATRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGS
FQPHSPEKRYLHFGVREHAMAAVLNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPIETIPSLRAMPNMLVFRPGDGNETSGAYKLAIKNRKRPSALCLSRQGMPNQENTSIEKVALGGYIVADCEGTPDLIFI
GTGSELNLCIEASKEISNLGKKTRVVSMPCIELFEEQEESYKESVLPNSVTKRVVVEAAHSFGWHKYTGFDGICITMDRF
GASAPGGECMKNFGFTVENVVNKTKEIL

Sequences:

>Translated_668_residues
MVAASVSIESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWFNRDRFVLSAGHGCMLLYSLL
HLTGYKSVSIEDIKEFRQWGSKTPGHPETFETEGVEVTAGPLGAGISNAVGLAIAETHLAAKFNKPDCNIVDHYTYVIMG
DGCNQEGIASEACSLAGHLKLGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVKGITEAIEKAKS
ITNKPSIIKISTTIGYGSPNKSDTAGIHGAAVGEEEASLTREFLNWEYPPFEIPDEVYKHFRKSIDKGENLEKEWDSRFE
EYQKKYPSEGAELKRMLKGQLPENWDSDLPSYTPNDKGLATRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGS
FQPHSPEKRYLHFGVREHAMAAVLNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPIETIPSLRAMPNMLVFRPGDGNETSGAYKLAIKNRKRPSALCLSRQGMPNQENTSIEKVALGGYIVADCEGTPDLIFI
GTGSELNLCIEASKEISNLGKKTRVVSMPCIELFEEQEESYKESVLPNSVTKRVVVEAAHSFGWHKYTGFDGICITMDRF
GASAPGGECMKNFGFTVENVVNKTKEIL
>Mature_668_residues
MVAASVSIESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWFNRDRFVLSAGHGCMLLYSLL
HLTGYKSVSIEDIKEFRQWGSKTPGHPETFETEGVEVTAGPLGAGISNAVGLAIAETHLAAKFNKPDCNIVDHYTYVIMG
DGCNQEGIASEACSLAGHLKLGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVKGITEAIEKAKS
ITNKPSIIKISTTIGYGSPNKSDTAGIHGAAVGEEEASLTREFLNWEYPPFEIPDEVYKHFRKSIDKGENLEKEWDSRFE
EYQKKYPSEGAELKRMLKGQLPENWDSDLPSYTPNDKGLATRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGS
FQPHSPEKRYLHFGVREHAMAAVLNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPIETIPSLRAMPNMLVFRPGDGNETSGAYKLAIKNRKRPSALCLSRQGMPNQENTSIEKVALGGYIVADCEGTPDLIFI
GTGSELNLCIEASKEISNLGKKTRVVSMPCIELFEEQEESYKESVLPNSVTKRVVVEAAHSFGWHKYTGFDGICITMDRF
GASAPGGECMKNFGFTVENVVNKTKEIL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=581, Percent_Identity=26.6781411359725, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI205277463, Length=679, Percent_Identity=24.300441826215, Blast_Score=159, Evalue=1e-38,
Organism=Homo sapiens, GI4507521, Length=679, Percent_Identity=24.300441826215, Blast_Score=159, Evalue=1e-38,
Organism=Homo sapiens, GI225637459, Length=592, Percent_Identity=22.6351351351351, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI225637463, Length=491, Percent_Identity=24.0325865580448, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI225637461, Length=491, Percent_Identity=24.0325865580448, Blast_Score=114, Evalue=4e-25,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=50.9803921568627, Blast_Score=688, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=50.2262443438914, Blast_Score=672, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=581, Percent_Identity=24.9569707401033, Blast_Score=140, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6325331, Length=668, Percent_Identity=53.1437125748503, Blast_Score=684, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319593, Length=672, Percent_Identity=50.4464285714286, Blast_Score=660, Evalue=0.0,
Organism=Drosophila melanogaster, GI45551847, Length=675, Percent_Identity=25.9259259259259, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI45550715, Length=675, Percent_Identity=25.9259259259259, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24645119, Length=646, Percent_Identity=25.8513931888545, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24666278, Length=584, Percent_Identity=24.8287671232877, Blast_Score=140, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73219; Mature: 73219

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAASVSIESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWF
CEECCCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
NRDRFVLSAGHGCMLLYSLLHLTGYKSVSIEDIKEFRQWGSKTPGHPETFETEGVEVTAG
CCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECC
PLGAGISNAVGLAIAETHLAAKFNKPDCNIVDHYTYVIMGDGCNQEGIASEACSLAGHLK
CCCCCHHHHHHHHHHHHHHHEECCCCCCCEEECEEEEEECCCCCCCCHHHHHHHHHCCCC
LGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVKGITEAIEKAKS
CCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHH
ITNKPSIIKISTTIGYGSPNKSDTAGIHGAAVGEEEASLTREFLNWEYPPFEIPDEVYKH
HCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
FRKSIDKGENLEKEWDSRFEEYQKKYPSEGAELKRMLKGQLPENWDSDLPSYTPNDKGLA
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCE
TRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGSFQPHSPEKRYLHFGVREHAM
ECCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCHHHHHH
AAVLNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
HHHHHHHHCCCCCCCCCCCHHEEEEHHHCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
QPIETIPSLRAMPNMLVFRPGDGNETSGAYKLAIKNRKRPSALCLSRQGMPNQENTSIEK
CCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHCCCCCCCCCCCCEE
VALGGYIVADCEGTPDLIFIGTGSELNLCIEASKEISNLGKKTRVVSMPCIELFEEQEES
EEECCEEEEECCCCCCEEEEECCCCEEEEEECHHHHHHCCCCCEEEECHHHHHHHHHHHH
YKESVLPNSVTKRVVVEAAHSFGWHKYTGFDGICITMDRFGASAPGGECMKNFGFTVENV
HHHHCCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCCCCHHHHHHCCCCHHHH
VNKTKEIL
HHHHHHCC
>Mature Secondary Structure
MVAASVSIESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWF
CEECCCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
NRDRFVLSAGHGCMLLYSLLHLTGYKSVSIEDIKEFRQWGSKTPGHPETFETEGVEVTAG
CCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECC
PLGAGISNAVGLAIAETHLAAKFNKPDCNIVDHYTYVIMGDGCNQEGIASEACSLAGHLK
CCCCCHHHHHHHHHHHHHHHEECCCCCCCEEECEEEEEECCCCCCCCHHHHHHHHHCCCC
LGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVKGITEAIEKAKS
CCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHH
ITNKPSIIKISTTIGYGSPNKSDTAGIHGAAVGEEEASLTREFLNWEYPPFEIPDEVYKH
HCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
FRKSIDKGENLEKEWDSRFEEYQKKYPSEGAELKRMLKGQLPENWDSDLPSYTPNDKGLA
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCE
TRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGSFQPHSPEKRYLHFGVREHAM
ECCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCHHHHHH
AAVLNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
HHHHHHHHCCCCCCCCCCCHHEEEEHHHCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
QPIETIPSLRAMPNMLVFRPGDGNETSGAYKLAIKNRKRPSALCLSRQGMPNQENTSIEK
CCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHCCCCCCCCCCCCEE
VALGGYIVADCEGTPDLIFIGTGSELNLCIEASKEISNLGKKTRVVSMPCIELFEEQEES
EEECCEEEEECCCCCCEEEEECCCCEEEEEECHHHHHHCCCCCEEEECHHHHHHHHHHHH
YKESVLPNSVTKRVVVEAAHSFGWHKYTGFDGICITMDRFGASAPGGECMKNFGFTVENV
HHHHCCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCCCCHHHHHHCCCCHHHH
VNKTKEIL
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]