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The map label for this gene is purM [H]

Identifier: 78780066

GI number: 78780066

Start: 1569981

End: 1571024

Strand: Reverse

Name: purM [H]

Synonym: PMT9312_1681

Alternate gene names: 78780066

Gene position: 1571024-1569981 (Counterclockwise)

Preceding gene: 78780068

Following gene: 78780065

Centisome position: 91.92

GC content: 30.84

Gene sequence:

>1044_bases
ATGGATTACAAAACATCAGGTGTTGATATAGAGGCTGGGCGAGAATTTGTTTCCGAAATTAAACAGGCAGTTGAAGGAAC
GCATACATCTAATGTGATTGACGGTATTGGTGGGTTCGGAGGTTTATTTAGAATCCCTGTCGATAGTTTTAAAAAACCAG
TTCTAGTTTCAGGAACTGATGGTGTTGGAACAAAATTAGAATTAGCCCAAAGTAAAAACTTTCACTTTGAGGTTGGTATT
GATTTGGTTGCTATGTGCATGAATGATATTATTACTTGCGGCGCAAAACCTTTATTTTTTCTTGATTATATCGCTACTGG
CAAGCTTGATAAAAAACAATTATTGCAGGTTGTTCAAGGAATTTCACATGGCTGTGGAGAAAATAACTGTTCATTACTCG
GTGGGGAAACTGCTGAAATGCCAGGATTTTATTCAAATAACAAGTATGATTTGGCAGGATTTTGTGTAGGAATAGTTGAC
GAGGATAAGCTTATTAATGGTAAAAAAATATCAGAAAATGACTTAATAATTGCTTTAAAAAGTAATGGAGTTCATAGTAA
CGGTTTTAGTTTAGTAAGAAAAATAATTCAAAACAATAATCAATTAGATAAAGAATTTGAAAAAGTTTCTCACTTAAATT
TTTATGATGAGTTATTGAAACCTACAAAGATCTACAATAATGTTGTTAATCAAATATTATCCGAAAATATAGAAATTAAA
GCAATGTCTCATATTACTGGTGGAGGTATTCCAGAGAATCTTCCAAGATGCATACCTTCTGATTTTATTCCTTATATCAA
CACCAATTCTTGGGAAATACCAATTTTATTTAAATTCCTAAAAGAAAAAGGGACGATTCCTGAAAAAGATTTTTGGAATA
CTTTTAACCTTGGGGTAGGATTTTGCTTAATTATTGATAAACAATTTAAAGATTCAATATTAAATATCTGTAAAGATCAT
GATATCGATAGTTGGGAGATTGGAAAGATAGTTCGAAAAAATGATTCAACAATTAGTAAATTTTTGCCTGAAATTTTAAC
TTAA

Upstream 100 bases:

>100_bases
ACTTTGTTTTTAAAAAATAAATCTATTTGATAAATAATTACTGGACAAAAGCAATCTTCGGAGGAATATCTATATAGGGA
AAGTCTATCATTTTTATTTC

Downstream 100 bases:

>100_bases
GTTTTTTTTAAAATAATTTAAATGAGTTTTAAAAAATTTTTTATACACAAATGAAAAAGTTAGATGTAATATAATAAGAT
TAGCGCCGAATTATATCGGA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MDYKTSGVDIEAGREFVSEIKQAVEGTHTSNVIDGIGGFGGLFRIPVDSFKKPVLVSGTDGVGTKLELAQSKNFHFEVGI
DLVAMCMNDIITCGAKPLFFLDYIATGKLDKKQLLQVVQGISHGCGENNCSLLGGETAEMPGFYSNNKYDLAGFCVGIVD
EDKLINGKKISENDLIIALKSNGVHSNGFSLVRKIIQNNNQLDKEFEKVSHLNFYDELLKPTKIYNNVVNQILSENIEIK
AMSHITGGGIPENLPRCIPSDFIPYINTNSWEIPILFKFLKEKGTIPEKDFWNTFNLGVGFCLIIDKQFKDSILNICKDH
DIDSWEIGKIVRKNDSTISKFLPEILT

Sequences:

>Translated_347_residues
MDYKTSGVDIEAGREFVSEIKQAVEGTHTSNVIDGIGGFGGLFRIPVDSFKKPVLVSGTDGVGTKLELAQSKNFHFEVGI
DLVAMCMNDIITCGAKPLFFLDYIATGKLDKKQLLQVVQGISHGCGENNCSLLGGETAEMPGFYSNNKYDLAGFCVGIVD
EDKLINGKKISENDLIIALKSNGVHSNGFSLVRKIIQNNNQLDKEFEKVSHLNFYDELLKPTKIYNNVVNQILSENIEIK
AMSHITGGGIPENLPRCIPSDFIPYINTNSWEIPILFKFLKEKGTIPEKDFWNTFNLGVGFCLIIDKQFKDSILNICKDH
DIDSWEIGKIVRKNDSTISKFLPEILT
>Mature_347_residues
MDYKTSGVDIEAGREFVSEIKQAVEGTHTSNVIDGIGGFGGLFRIPVDSFKKPVLVSGTDGVGTKLELAQSKNFHFEVGI
DLVAMCMNDIITCGAKPLFFLDYIATGKLDKKQLLQVVQGISHGCGENNCSLLGGETAEMPGFYSNNKYDLAGFCVGIVD
EDKLINGKKISENDLIIALKSNGVHSNGFSLVRKIIQNNNQLDKEFEKVSHLNFYDELLKPTKIYNNVVNQILSENIEIK
AMSHITGGGIPENLPRCIPSDFIPYINTNSWEIPILFKFLKEKGTIPEKDFWNTFNLGVGFCLIIDKQFKDSILNICKDH
DIDSWEIGKIVRKNDSTISKFLPEILT

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=340, Percent_Identity=43.5294117647059, Blast_Score=292, Evalue=3e-79,
Organism=Homo sapiens, GI209869995, Length=340, Percent_Identity=43.5294117647059, Blast_Score=292, Evalue=3e-79,
Organism=Homo sapiens, GI209869993, Length=340, Percent_Identity=43.5294117647059, Blast_Score=292, Evalue=3e-79,
Organism=Escherichia coli, GI1788845, Length=336, Percent_Identity=45.2380952380952, Blast_Score=306, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17567511, Length=350, Percent_Identity=38.2857142857143, Blast_Score=216, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6321203, Length=338, Percent_Identity=40.5325443786982, Blast_Score=254, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24582400, Length=266, Percent_Identity=39.4736842105263, Blast_Score=196, Evalue=3e-50,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38524; Mature: 38524

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKTSGVDIEAGREFVSEIKQAVEGTHTSNVIDGIGGFGGLFRIPVDSFKKPVLVSGTD
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEECCHHHCCCCEEEECCC
GVGTKLELAQSKNFHFEVGIDLVAMCMNDIITCGAKPLFFLDYIATGKLDKKQLLQVVQG
CCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHH
ISHGCGENNCSLLGGETAEMPGFYSNNKYDLAGFCVGIVDEDKLINGKKISENDLIIALK
HHCCCCCCCCEEECCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCEECCCCEEEEEE
SNGVHSNGFSLVRKIIQNNNQLDKEFEKVSHLNFYDELLKPTKIYNNVVNQILSENIEIK
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHCCCEEE
AMSHITGGGIPENLPRCIPSDFIPYINTNSWEIPILFKFLKEKGTIPEKDFWNTFNLGVG
EEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHCCCHHCCCCE
FCLIIDKQFKDSILNICKDHDIDSWEIGKIVRKNDSTISKFLPEILT
EEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MDYKTSGVDIEAGREFVSEIKQAVEGTHTSNVIDGIGGFGGLFRIPVDSFKKPVLVSGTD
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEECCHHHCCCCEEEECCC
GVGTKLELAQSKNFHFEVGIDLVAMCMNDIITCGAKPLFFLDYIATGKLDKKQLLQVVQG
CCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHH
ISHGCGENNCSLLGGETAEMPGFYSNNKYDLAGFCVGIVDEDKLINGKKISENDLIIALK
HHCCCCCCCCEEECCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCEECCCCEEEEEE
SNGVHSNGFSLVRKIIQNNNQLDKEFEKVSHLNFYDELLKPTKIYNNVVNQILSENIEIK
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHCCCEEE
AMSHITGGGIPENLPRCIPSDFIPYINTNSWEIPILFKFLKEKGTIPEKDFWNTFNLGVG
EEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHCCCHHCCCCE
FCLIIDKQFKDSILNICKDHDIDSWEIGKIVRKNDSTISKFLPEILT
EEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA