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The map label for this gene is pepA [H]

Identifier: 78779814

GI number: 78779814

Start: 1342233

End: 1343705

Strand: Direct

Name: pepA [H]

Synonym: PMT9312_1430

Alternate gene names: 78779814

Gene position: 1342233-1343705 (Clockwise)

Preceding gene: 78779813

Following gene: 78779822

Centisome position: 78.53

GC content: 34.96

Gene sequence:

>1473_bases
ATGCAATTTTCCACATTCCAAAAAAATCTAGATAACTGGCAAGGTGCTTCATTAATTTTTGGGGTTTTAGAGGAAGAAAT
TGCAAGCCAACTTGAAAACATAAAATTTATTGTTGACCCAAAATTATTACTAAAAAAAGTGACCCAAAAAAAATTCAAGG
GAGAAAAAGGGGAAACTTTAAGCTTTGAATTTTTAGATCAAAAATTAGAAACTTTAATCATAGTTGGTCTTGGCAAATCG
AAATACCTCAATAAAAGTGATATAGAAAACTCCATAGGAAATCTAATTAGAAAAACTGTTGATAAAAATGAAAAAATCAG
TATCTTGCTACCTTGGGAATTAATAAATTCACAACTAGAAATAAATCAATTAGCAGAGTCAGCAAGACTATCTGCTTATA
AGGACAATAGATTCAATAAGAAAAAAGATGAAAAAAAAGTTCTTAAAGAAATAGAGTTTTTGAATTTTAAAAGCTTTGAG
AATATTTGTTTTGAAGAGGCAGAAAAAATATGTGAAGGTGTAGAACTAGCCAGAAGACTTGTAGCCGCCCCTCCAAATAG
TCTTACACCCCAAGAAATGTCTATGCAAGCTTCTCAAATAGCTAAAGATCATGGTTTGGAAGTAAAAATTTTAGAGGCAA
AAGAATGTGAAGATTTAGGAATGGGCGCATATTTAGCTGTAGCAAAAGGTTCTGATCTAGATCCTAAATTTATACACCTT
ACTTTGAAGTCAGAGGGGCCTATAAAAGAAAAGATTGCGATTGTTGGGAAGGGTTTAACCTTTGATTCTGGAGGATACAA
CCTGAAAGTAGGAGCCTCTCAAATTGAAATGATGAAATATGATATGGGCGGAAGCGCTGCAGTGTTAGGAGCGGCAAAAG
CACTTGGAGCAATAAAACCAAAGGGACTAGAAATACATTTTATTGTGGCAGCTTGCGAAAACATGATAAATGGATCTGCA
GTACATCCTGGAGATGTAGTTAAGGCATCTAATGGTAAGACAATTGAAATAAATAACACTGATGCAGAGGGTAGACTCAC
ATTAGCTGATGCTTTAACTTACGCATCCGATTTAAAACCGGATTCAATAATAGATCTCGCCACCTTAACAGGAGCTATTG
TTGTTGCATTAGGGAATGATGTAGCTGGATTTTGGAGCAATAATGATGATCTAGCAAATGATCTAAAAGCTGCATCAGCC
CAGGCTGGAGAAGAATTATGGCGAATGCCCTTACAAAAAGCGTATAAAGAAGGCTTAAAGTCTCATATAGCTGATATGAA
AAATACAGGTCCCAGGGCAGGTGGGTCAATAACTGCTGCTTTGTTTTTAGAGGAATTCTTTGATACAGAGATTAAATGGG
CTCATATTGATATTGCTGGGACTTGTTGGACTGATAAAAATAAGGGAATTAATCCATCAGGTGCAACCGGTTTTGGAGTT
AAAACTCTTGTTCAATGGATTAAAAATAAATAA

Upstream 100 bases:

>100_bases
ACTGATATATTTATGGTTACCACCTTTTAACAAAGAAACTCGAGATAGGTGGACAACTACTTTCACAAACAACTAAAAGT
TAATTAAATCCATTTTACAA

Downstream 100 bases:

>100_bases
CTATTTTAAAATCATTCAATCCAAAGATTTGTTGATCTAGCGTTATTCCCCCATAATTTATCCAACCTCTGATCTCTCCC
ACATGAGAATCTATAGAACT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MQFSTFQKNLDNWQGASLIFGVLEEEIASQLENIKFIVDPKLLLKKVTQKKFKGEKGETLSFEFLDQKLETLIIVGLGKS
KYLNKSDIENSIGNLIRKTVDKNEKISILLPWELINSQLEINQLAESARLSAYKDNRFNKKKDEKKVLKEIEFLNFKSFE
NICFEEAEKICEGVELARRLVAAPPNSLTPQEMSMQASQIAKDHGLEVKILEAKECEDLGMGAYLAVAKGSDLDPKFIHL
TLKSEGPIKEKIAIVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKPKGLEIHFIVAACENMINGSA
VHPGDVVKASNGKTIEINNTDAEGRLTLADALTYASDLKPDSIIDLATLTGAIVVALGNDVAGFWSNNDDLANDLKAASA
QAGEELWRMPLQKAYKEGLKSHIADMKNTGPRAGGSITAALFLEEFFDTEIKWAHIDIAGTCWTDKNKGINPSGATGFGV
KTLVQWIKNK

Sequences:

>Translated_490_residues
MQFSTFQKNLDNWQGASLIFGVLEEEIASQLENIKFIVDPKLLLKKVTQKKFKGEKGETLSFEFLDQKLETLIIVGLGKS
KYLNKSDIENSIGNLIRKTVDKNEKISILLPWELINSQLEINQLAESARLSAYKDNRFNKKKDEKKVLKEIEFLNFKSFE
NICFEEAEKICEGVELARRLVAAPPNSLTPQEMSMQASQIAKDHGLEVKILEAKECEDLGMGAYLAVAKGSDLDPKFIHL
TLKSEGPIKEKIAIVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKPKGLEIHFIVAACENMINGSA
VHPGDVVKASNGKTIEINNTDAEGRLTLADALTYASDLKPDSIIDLATLTGAIVVALGNDVAGFWSNNDDLANDLKAASA
QAGEELWRMPLQKAYKEGLKSHIADMKNTGPRAGGSITAALFLEEFFDTEIKWAHIDIAGTCWTDKNKGINPSGATGFGV
KTLVQWIKNK
>Mature_490_residues
MQFSTFQKNLDNWQGASLIFGVLEEEIASQLENIKFIVDPKLLLKKVTQKKFKGEKGETLSFEFLDQKLETLIIVGLGKS
KYLNKSDIENSIGNLIRKTVDKNEKISILLPWELINSQLEINQLAESARLSAYKDNRFNKKKDEKKVLKEIEFLNFKSFE
NICFEEAEKICEGVELARRLVAAPPNSLTPQEMSMQASQIAKDHGLEVKILEAKECEDLGMGAYLAVAKGSDLDPKFIHL
TLKSEGPIKEKIAIVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKPKGLEIHFIVAACENMINGSA
VHPGDVVKASNGKTIEINNTDAEGRLTLADALTYASDLKPDSIIDLATLTGAIVVALGNDVAGFWSNNDDLANDLKAASA
QAGEELWRMPLQKAYKEGLKSHIADMKNTGPRAGGSITAALFLEEFFDTEIKWAHIDIAGTCWTDKNKGINPSGATGFGV
KTLVQWIKNK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=447, Percent_Identity=35.3467561521253, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI47155554, Length=418, Percent_Identity=31.8181818181818, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1790710, Length=511, Percent_Identity=34.6379647749511, Blast_Score=261, Evalue=1e-70,
Organism=Escherichia coli, GI87082123, Length=329, Percent_Identity=37.3860182370821, Blast_Score=187, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=317, Percent_Identity=34.384858044164, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=255, Percent_Identity=30.5882352941176, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24661038, Length=454, Percent_Identity=29.5154185022026, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI21355725, Length=318, Percent_Identity=33.3333333333333, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI161077148, Length=456, Percent_Identity=27.6315789473684, Blast_Score=168, Evalue=8e-42,
Organism=Drosophila melanogaster, GI20130057, Length=456, Percent_Identity=27.6315789473684, Blast_Score=168, Evalue=8e-42,
Organism=Drosophila melanogaster, GI20129969, Length=461, Percent_Identity=26.8980477223427, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24662227, Length=454, Percent_Identity=26.6519823788546, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21355645, Length=450, Percent_Identity=26.6666666666667, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24662223, Length=450, Percent_Identity=26.6666666666667, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI19922386, Length=371, Percent_Identity=29.3800539083558, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI20129963, Length=451, Percent_Identity=28.3813747228381, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI21357381, Length=332, Percent_Identity=31.6265060240964, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI221379063, Length=332, Percent_Identity=31.6265060240964, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI221379062, Length=332, Percent_Identity=31.6265060240964, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24646701, Length=280, Percent_Identity=28.2142857142857, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24646703, Length=280, Percent_Identity=28.2142857142857, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21358201, Length=280, Percent_Identity=28.2142857142857, Blast_Score=86, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53573; Mature: 53573

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFSTFQKNLDNWQGASLIFGVLEEEIASQLENIKFIVDPKLLLKKVTQKKFKGEKGETL
CCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHCCCCCCEE
SFEFLDQKLETLIIVGLGKSKYLNKSDIENSIGNLIRKTVDKNEKISILLPWELINSQLE
EHHHHHHHHCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHCCHHH
INQLAESARLSAYKDNRFNKKKDEKKVLKEIEFLNFKSFENICFEEAEKICEGVELARRL
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
VAAPPNSLTPQEMSMQASQIAKDHGLEVKILEAKECEDLGMGAYLAVAKGSDLDPKFIHL
HCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCEEEEE
TLKSEGPIKEKIAIVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKP
EECCCCCHHHHHEEEECCEEECCCCCEEEECHHHEEHEEECCCCCHHHHHHHHHHCCCCC
KGLEIHFIVAACENMINGSAVHPGDVVKASNGKTIEINNTDAEGRLTLADALTYASDLKP
CCEEEEEHHHHHHHHCCCCCCCCCCEEECCCCCEEEEECCCCCCEEEHHHHHHHHHCCCC
DSIIDLATLTGAIVVALGNDVAGFWSNNDDLANDLKAASAQAGEELWRMPLQKAYKEGLK
CHHHHHHHHHCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHIADMKNTGPRAGGSITAALFLEEFFDTEIKWAHIDIAGTCWTDKNKGINPSGATGFGV
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCH
KTLVQWIKNK
HHHHHHHHCC
>Mature Secondary Structure
MQFSTFQKNLDNWQGASLIFGVLEEEIASQLENIKFIVDPKLLLKKVTQKKFKGEKGETL
CCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHCCCCCCEE
SFEFLDQKLETLIIVGLGKSKYLNKSDIENSIGNLIRKTVDKNEKISILLPWELINSQLE
EHHHHHHHHCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHCCHHH
INQLAESARLSAYKDNRFNKKKDEKKVLKEIEFLNFKSFENICFEEAEKICEGVELARRL
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
VAAPPNSLTPQEMSMQASQIAKDHGLEVKILEAKECEDLGMGAYLAVAKGSDLDPKFIHL
HCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCEEEEE
TLKSEGPIKEKIAIVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKP
EECCCCCHHHHHEEEECCEEECCCCCEEEECHHHEEHEEECCCCCHHHHHHHHHHCCCCC
KGLEIHFIVAACENMINGSAVHPGDVVKASNGKTIEINNTDAEGRLTLADALTYASDLKP
CCEEEEEHHHHHHHHCCCCCCCCCCEEECCCCCEEEEECCCCCCEEEHHHHHHHHHCCCC
DSIIDLATLTGAIVVALGNDVAGFWSNNDDLANDLKAASAQAGEELWRMPLQKAYKEGLK
CHHHHHHHHHCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHIADMKNTGPRAGGSITAALFLEEFFDTEIKWAHIDIAGTCWTDKNKGINPSGATGFGV
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCH
KTLVQWIKNK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA