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The map label for this gene is ubiB [C]

Identifier: 78779477

GI number: 78779477

Start: 1005283

End: 1006941

Strand: Reverse

Name: ubiB [C]

Synonym: PMT9312_1094

Alternate gene names: 78779477

Gene position: 1006941-1005283 (Counterclockwise)

Preceding gene: 78779480

Following gene: 78779476

Centisome position: 58.91

GC content: 30.38

Gene sequence:

>1659_bases
ATGACAAGATCTTATTCGAAATATTCAGCAAAAGGTGACTTAGTTTGGTTGATGTTGAGACCATGGATTTTAATCCCAAG
AGTTTTATATATCGTTTTAACTTTTATTTTTCTTTTTATAAGAATACTTTTTCAAGGTAACAGTAAAAATAAAAATGTAC
AAAAAAATCTTTCAAAATATCTTTTTGATGTAATAACTGATTTAGGACCTTGTTTTATAAAATTAGGACAAGCACTTTCA
ACTAGACCGGATCTTGTTAGACAAGATTGGCTTACAGAACTAGCAAACTTACAGGATAATCTCCCAGCATTTGATCACAA
AATTGCTTTAAAAATTATTGAAGAAGAACTTGGAGCTCCTGCTAATGAATTATTTGATGAGTTCCCAGATAGTCCTATTG
CTTCAGCAAGCTTAGGTCAAGTTTACAAAGCAAAAATAAAAAATAATATTTATCTTGCTGTGAAAGTACAGAGGCCAAAC
TTGTACTTTCTTATAAGAAGAGATGTTGTAATTTTAAGGTTTCTAGCAACCTTCTTTTCACCATTTTTACCATTAAATAT
TGGTGTTGGAATTGGAGAAATAATAGATGAATTTGGCAGGTCACTTTTTGATGAAATTGACTACGAAAAAGAAGGCGAAA
ATGCTTTAAAGTTTGCAGATTTATTCAAAGAAAACCCTAATGTTTTTATCCCTAAATTTGAAAAACAGTTTTCATCAAAA
AGGGTTATCACAACCTCTTGGATTGATGGAGTTAAGTTAAGAGATCGGTATTTATTGGAGGAAAATAACTTAATACCCTC
CTCTTTTATAAAAACTTGTGTAATCAGTGGTCTACAGCAATTATTTGAATATGGATATTTTCATGCCGACCCACATCCTG
GCAATATGTTTGCTCTAAAAGGAGGTAATGCAGATTGTGGTCATTTAGCTTATGTGGATTTCGGAATGATGGATGAAATT
ACAAACTCAGATAGACTTACTCTCATTAAGGCAATTGTTCACATAATAAATGAAGAATATTATCTTCTTGCAAAAGATTT
CCAGAAATTAGGTTTTTTAACCAAAGATCAAGATCTTCAAAAACTTGTTTCACCATTAAGAGAAGTTCTAGGAGGATCTC
TAGGTGCTGAGGTTGGGAATTTTAATCTTAAAAACGTAACAGATAAATTCTCAAAGCTAATGTATTCTTATCCATTTAGG
GTCCCTAGTAGATTTGCATTAATAATAAGGGCAGTTGTTAGTCAAGAAGGATTAGCGCTAAGACTAGATCCTGAATTTAA
AATCTTAAAAATTGCATATCCTTATATTGCCAAAAAACTACTTACCGATAATTCTGAGGAGATTTTAGAAATTCTTCTAG
AAGTTGTTTTTGATAAAAAAGGTAGAATTCAAATTGAAAAAGTTGAAAGTTTATTGAATATTTTATTTAAAGATTCTGAA
AATATTAATTCAGATCTTATACCAGTTGCTAATGCTGGGTTGAAATTATTTGTCGGTAAACAAGGATCGGAAGTTCGTAA
GAATCTTCTTTTAAGTCTTATAAAAGATGACAAATTAGAATTTACTGATGCGAAAAAACTCTTAAGTTTAATTAGAGATA
CTTTTAGCCCTTTGAATATTGCAAAAAGTGCAGTTCAAAAAATTATTTCTCCAGTTTAG

Upstream 100 bases:

>100_bases
GAAAAACTTTTTAGTTAGAAAAGATGAAATGCTCATAAAGTATTATTGACATATATAGAATGAACTAAATGGAATTCTTC
TTTGATATCTTTTGATTTTA

Downstream 100 bases:

>100_bases
TTTTTATATTAATATCTAATAAATTTACTTATTATTTTTAATTGATTAAGATTAAATTAATTTAATTATTTTTCTCATAA
GATTAAGTAGTTAAAGAATT

Product: kinase-like

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MTRSYSKYSAKGDLVWLMLRPWILIPRVLYIVLTFIFLFIRILFQGNSKNKNVQKNLSKYLFDVITDLGPCFIKLGQALS
TRPDLVRQDWLTELANLQDNLPAFDHKIALKIIEEELGAPANELFDEFPDSPIASASLGQVYKAKIKNNIYLAVKVQRPN
LYFLIRRDVVILRFLATFFSPFLPLNIGVGIGEIIDEFGRSLFDEIDYEKEGENALKFADLFKENPNVFIPKFEKQFSSK
RVITTSWIDGVKLRDRYLLEENNLIPSSFIKTCVISGLQQLFEYGYFHADPHPGNMFALKGGNADCGHLAYVDFGMMDEI
TNSDRLTLIKAIVHIINEEYYLLAKDFQKLGFLTKDQDLQKLVSPLREVLGGSLGAEVGNFNLKNVTDKFSKLMYSYPFR
VPSRFALIIRAVVSQEGLALRLDPEFKILKIAYPYIAKKLLTDNSEEILEILLEVVFDKKGRIQIEKVESLLNILFKDSE
NINSDLIPVANAGLKLFVGKQGSEVRKNLLLSLIKDDKLEFTDAKKLLSLIRDTFSPLNIAKSAVQKIISPV

Sequences:

>Translated_552_residues
MTRSYSKYSAKGDLVWLMLRPWILIPRVLYIVLTFIFLFIRILFQGNSKNKNVQKNLSKYLFDVITDLGPCFIKLGQALS
TRPDLVRQDWLTELANLQDNLPAFDHKIALKIIEEELGAPANELFDEFPDSPIASASLGQVYKAKIKNNIYLAVKVQRPN
LYFLIRRDVVILRFLATFFSPFLPLNIGVGIGEIIDEFGRSLFDEIDYEKEGENALKFADLFKENPNVFIPKFEKQFSSK
RVITTSWIDGVKLRDRYLLEENNLIPSSFIKTCVISGLQQLFEYGYFHADPHPGNMFALKGGNADCGHLAYVDFGMMDEI
TNSDRLTLIKAIVHIINEEYYLLAKDFQKLGFLTKDQDLQKLVSPLREVLGGSLGAEVGNFNLKNVTDKFSKLMYSYPFR
VPSRFALIIRAVVSQEGLALRLDPEFKILKIAYPYIAKKLLTDNSEEILEILLEVVFDKKGRIQIEKVESLLNILFKDSE
NINSDLIPVANAGLKLFVGKQGSEVRKNLLLSLIKDDKLEFTDAKKLLSLIRDTFSPLNIAKSAVQKIISPV
>Mature_551_residues
TRSYSKYSAKGDLVWLMLRPWILIPRVLYIVLTFIFLFIRILFQGNSKNKNVQKNLSKYLFDVITDLGPCFIKLGQALST
RPDLVRQDWLTELANLQDNLPAFDHKIALKIIEEELGAPANELFDEFPDSPIASASLGQVYKAKIKNNIYLAVKVQRPNL
YFLIRRDVVILRFLATFFSPFLPLNIGVGIGEIIDEFGRSLFDEIDYEKEGENALKFADLFKENPNVFIPKFEKQFSSKR
VITTSWIDGVKLRDRYLLEENNLIPSSFIKTCVISGLQQLFEYGYFHADPHPGNMFALKGGNADCGHLAYVDFGMMDEIT
NSDRLTLIKAIVHIINEEYYLLAKDFQKLGFLTKDQDLQKLVSPLREVLGGSLGAEVGNFNLKNVTDKFSKLMYSYPFRV
PSRFALIIRAVVSQEGLALRLDPEFKILKIAYPYIAKKLLTDNSEEILEILLEVVFDKKGRIQIEKVESLLNILFKDSEN
INSDLIPVANAGLKLFVGKQGSEVRKNLLLSLIKDDKLEFTDAKKLLSLIRDTFSPLNIAKSAVQKIISPV

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=280, Percent_Identity=26.4285714285714, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI41393593, Length=268, Percent_Identity=29.8507462686567, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI217035081, Length=279, Percent_Identity=24.3727598566308, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI34147522, Length=252, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI27363457, Length=248, Percent_Identity=26.2096774193548, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI217416386, Length=248, Percent_Identity=26.2096774193548, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI2367309, Length=429, Percent_Identity=25.8741258741259, Blast_Score=159, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17559152, Length=276, Percent_Identity=29.7101449275362, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI32565180, Length=282, Percent_Identity=27.6595744680851, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323282, Length=268, Percent_Identity=30.2238805970149, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325148, Length=248, Percent_Identity=27.4193548387097, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6321319, Length=246, Percent_Identity=26.8292682926829, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24662575, Length=381, Percent_Identity=25.1968503937008, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI22024280, Length=306, Percent_Identity=25.4901960784314, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI18859849, Length=264, Percent_Identity=25.7575757575758, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 62877; Mature: 62746

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSYSKYSAKGDLVWLMLRPWILIPRVLYIVLTFIFLFIRILFQGNSKNKNVQKNLSKY
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LFDVITDLGPCFIKLGQALSTRPDLVRQDWLTELANLQDNLPAFDHKIALKIIEEELGAP
HHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
ANELFDEFPDSPIASASLGQVYKAKIKNNIYLAVKVQRPNLYFLIRRDVVILRFLATFFS
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCEEEEEHHHHHHHHHHHHHHC
PFLPLNIGVGIGEIIDEFGRSLFDEIDYEKEGENALKFADLFKENPNVFIPKFEKQFSSK
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEECCCHHHHHCCC
RVITTSWIDGVKLRDRYLLEENNLIPSSFIKTCVISGLQQLFEYGYFHADPHPGNMFALK
CEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEC
GGNADCGHLAYVDFGMMDEITNSDRLTLIKAIVHIINEEYYLLAKDFQKLGFLTKDQDLQ
CCCCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHHCCCCEEHHHHHHHCCCCCCCHHHH
KLVSPLREVLGGSLGAEVGNFNLKNVTDKFSKLMYSYPFRVPSRFALIIRAVVSQEGLAL
HHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEE
RLDPEFKILKIAYPYIAKKLLTDNSEEILEILLEVVFDKKGRIQIEKVESLLNILFKDSE
EECCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCC
NINSDLIPVANAGLKLFVGKQGSEVRKNLLLSLIKDDKLEFTDAKKLLSLIRDTFSPLNI
CCCCCCCEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHH
AKSAVQKIISPV
HHHHHHHHHCCC
>Mature Secondary Structure 
TRSYSKYSAKGDLVWLMLRPWILIPRVLYIVLTFIFLFIRILFQGNSKNKNVQKNLSKY
CCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LFDVITDLGPCFIKLGQALSTRPDLVRQDWLTELANLQDNLPAFDHKIALKIIEEELGAP
HHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
ANELFDEFPDSPIASASLGQVYKAKIKNNIYLAVKVQRPNLYFLIRRDVVILRFLATFFS
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCEEEEEHHHHHHHHHHHHHHC
PFLPLNIGVGIGEIIDEFGRSLFDEIDYEKEGENALKFADLFKENPNVFIPKFEKQFSSK
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEECCCHHHHHCCC
RVITTSWIDGVKLRDRYLLEENNLIPSSFIKTCVISGLQQLFEYGYFHADPHPGNMFALK
CEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEC
GGNADCGHLAYVDFGMMDEITNSDRLTLIKAIVHIINEEYYLLAKDFQKLGFLTKDQDLQ
CCCCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHHCCCCEEHHHHHHHCCCCCCCHHHH
KLVSPLREVLGGSLGAEVGNFNLKNVTDKFSKLMYSYPFRVPSRFALIIRAVVSQEGLAL
HHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEE
RLDPEFKILKIAYPYIAKKLLTDNSEEILEILLEVVFDKKGRIQIEKVESLLNILFKDSE
EECCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCC
NINSDLIPVANAGLKLFVGKQGSEVRKNLLLSLIKDDKLEFTDAKKLLSLIRDTFSPLNI
CCCCCCCEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHH
AKSAVQKIISPV
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]