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The map label for this gene is zwf [H]

Identifier: 78779468

GI number: 78779468

Start: 996007

End: 997530

Strand: Reverse

Name: zwf [H]

Synonym: PMT9312_1085

Alternate gene names: 78779468

Gene position: 997530-996007 (Counterclockwise)

Preceding gene: 78779469

Following gene: 78779467

Centisome position: 58.36

GC content: 34.78

Gene sequence:

>1524_bases
ATGCCTTCAACTTTAAGTAATCCTCTAAGATTAGGTTTACGGCAGGAAAGAGTTATATCTCCACAATGCTTAGTAATATT
TGGTGCTAGTGGAGACCTTACTCATAGAAAATTAATACCAGCCTTATTTGAACTCTATTTGCAAAGAAGAATTCCTAGTG
AATTTGGAATAGTTGGTTGTGCGAGAAGACCTTGGACTGATAATGAATTTAGAGAAAAGATGAAAGTAAAGCTATCCACT
CAAATTTCTGGTAAGGAAAAGGAGTGGGAACAATTTTCCAATTATCTTTTTTATGAACCAGTTGACTTACAACAAAGCGA
TCATGTCGTAAGGCTTTCTAAAAGATTAAATAAAATTGATAAAAGACAAGCTACTCATGGAAATAGAACATTTTATTTAT
CAGTATCTCCAAATTTCTATGCAAGTGGATGTAAAGCTCTTAAAATAGCTGGCCTTTTAGATGACCCTAAGAAAAGTCGT
TTAGTGATTGAAAAACCTTTTGGAAGAGATTATTCAAGTGCAAAAAAATTGAACAAGATCGTTCAAAGTTGTGCTGAAGA
AAGTCAGATTTATAGGATTGATCATTATTTAGGTAAAGAGACAGTTCAAAACATTCTTGTTATGAGGTTTGCTAATACTA
TTTTTGAACCAATCTGGAACAGAAATTATATATCAAGTGTTCAAATTACTTCATCTGAAACAGTAGGTGTTGAAGATAGA
GCAGGTTATTACGAAAGCTCTGGTGCTTTAAGAGATATGCTTCAAAATCATATGACTCAAATGCTCGCTGTTACTGCTAT
GGAACCTCCTGGGAAATTTGAACCAGAAGCTATAAGAAATGAAAAAGCTAAGGTTCTTCAAGCTTCAAAACTTGCTGACG
AAAATGAACCGTGGAATTGTTGTATAAGAGGTCAATATGGGGAGGGAGGAAATATCTCAAATCTTCTCAAAGGATATAGG
CAGGAAGATGGTGTTAATTGTAATAGCACAACAGAAACTTATATTGCGACAAAAGTTTTCGTTGATAACTGGCGTTGGCA
AGGGGTACCTTTTTATTTAAGAACTGGGAAAAGACTACCTAAAAGACTTGGAGAAATAGTCTTGACTTTTAAAGACGTTC
CTGTTCATTTATTTGAATCAACAATAATAAATCCTGCTCCAAATCAACTTATCCTAAGAATTCAGCCAAATGAAGGTGCT
ACTTTTAACTTTGAGGTAAAATCCCCTGGTTCTGGGATGAAATCCAGACCTGTTGAGATGGAATTTTCTTATGATGAATC
ATTTGGAGAACCCTCAGATGAAGGCTATGTAAGATTACTAGCTGATGCAATGCTTTCTGATCCAACCTTATTTACACGAA
GTGATGAAGTAGAGGCAGCTTGGAAACTTTATACGCCATTAATAGAATTGATGGATAATTCTCCTTGGAAGTTACCTATT
TATAATTATGAATCTATGACGTGGGGACCTCCTGAGTCTGATCAATTACTTTCAAAAGATAATATTTTCTGGCGCAGACC
TTAA

Upstream 100 bases:

>100_bases
TTTAGATATAAGTTTCTCCTACTAAATACTTTTTGGTTTAGACACAATATGTAGCTAATCTTAGAAAAAAAGAGGATTTT
AAAAAAAGAATATTAAAAAT

Downstream 100 bases:

>100_bases
AAATGAAACCTCAACTAACACTCCAAACCCCATTAGAGCTTCCTTATCAGGAGGTTTCTAATTACCTTAATAAGTTATGG
ATTTCGGAAGATAAAGATAA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MPSTLSNPLRLGLRQERVISPQCLVIFGASGDLTHRKLIPALFELYLQRRIPSEFGIVGCARRPWTDNEFREKMKVKLST
QISGKEKEWEQFSNYLFYEPVDLQQSDHVVRLSKRLNKIDKRQATHGNRTFYLSVSPNFYASGCKALKIAGLLDDPKKSR
LVIEKPFGRDYSSAKKLNKIVQSCAEESQIYRIDHYLGKETVQNILVMRFANTIFEPIWNRNYISSVQITSSETVGVEDR
AGYYESSGALRDMLQNHMTQMLAVTAMEPPGKFEPEAIRNEKAKVLQASKLADENEPWNCCIRGQYGEGGNISNLLKGYR
QEDGVNCNSTTETYIATKVFVDNWRWQGVPFYLRTGKRLPKRLGEIVLTFKDVPVHLFESTIINPAPNQLILRIQPNEGA
TFNFEVKSPGSGMKSRPVEMEFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWKLYTPLIELMDNSPWKLPI
YNYESMTWGPPESDQLLSKDNIFWRRP

Sequences:

>Translated_507_residues
MPSTLSNPLRLGLRQERVISPQCLVIFGASGDLTHRKLIPALFELYLQRRIPSEFGIVGCARRPWTDNEFREKMKVKLST
QISGKEKEWEQFSNYLFYEPVDLQQSDHVVRLSKRLNKIDKRQATHGNRTFYLSVSPNFYASGCKALKIAGLLDDPKKSR
LVIEKPFGRDYSSAKKLNKIVQSCAEESQIYRIDHYLGKETVQNILVMRFANTIFEPIWNRNYISSVQITSSETVGVEDR
AGYYESSGALRDMLQNHMTQMLAVTAMEPPGKFEPEAIRNEKAKVLQASKLADENEPWNCCIRGQYGEGGNISNLLKGYR
QEDGVNCNSTTETYIATKVFVDNWRWQGVPFYLRTGKRLPKRLGEIVLTFKDVPVHLFESTIINPAPNQLILRIQPNEGA
TFNFEVKSPGSGMKSRPVEMEFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWKLYTPLIELMDNSPWKLPI
YNYESMTWGPPESDQLLSKDNIFWRRP
>Mature_506_residues
PSTLSNPLRLGLRQERVISPQCLVIFGASGDLTHRKLIPALFELYLQRRIPSEFGIVGCARRPWTDNEFREKMKVKLSTQ
ISGKEKEWEQFSNYLFYEPVDLQQSDHVVRLSKRLNKIDKRQATHGNRTFYLSVSPNFYASGCKALKIAGLLDDPKKSRL
VIEKPFGRDYSSAKKLNKIVQSCAEESQIYRIDHYLGKETVQNILVMRFANTIFEPIWNRNYISSVQITSSETVGVEDRA
GYYESSGALRDMLQNHMTQMLAVTAMEPPGKFEPEAIRNEKAKVLQASKLADENEPWNCCIRGQYGEGGNISNLLKGYRQ
EDGVNCNSTTETYIATKVFVDNWRWQGVPFYLRTGKRLPKRLGEIVLTFKDVPVHLFESTIINPAPNQLILRIQPNEGAT
FNFEVKSPGSGMKSRPVEMEFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWKLYTPLIELMDNSPWKLPIY
NYESMTWGPPESDQLLSKDNIFWRRP

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=485, Percent_Identity=35.6701030927835, Blast_Score=282, Evalue=4e-76,
Organism=Homo sapiens, GI109389365, Length=485, Percent_Identity=35.6701030927835, Blast_Score=282, Evalue=6e-76,
Organism=Homo sapiens, GI52145310, Length=495, Percent_Identity=27.6767676767677, Blast_Score=165, Evalue=1e-40,
Organism=Escherichia coli, GI1788158, Length=488, Percent_Identity=37.5, Blast_Score=331, Evalue=8e-92,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=34.639175257732, Blast_Score=295, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6324088, Length=473, Percent_Identity=33.8266384778013, Blast_Score=263, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24643350, Length=485, Percent_Identity=33.8144329896907, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24643352, Length=485, Percent_Identity=33.8144329896907, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI221513548, Length=454, Percent_Identity=27.9735682819383, Blast_Score=191, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 58125; Mature: 57994

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSTLSNPLRLGLRQERVISPQCLVIFGASGDLTHRKLIPALFELYLQRRIPSEFGIVGC
CCCCCCCHHHHCCCHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHCEEEC
ARRPWTDNEFREKMKVKLSTQISGKEKEWEQFSNYLFYEPVDLQQSDHVVRLSKRLNKID
CCCCCCCHHHHHHHHEEEEECCCCCHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHHHHH
KRQATHGNRTFYLSVSPNFYASGCKALKIAGLLDDPKKSRLVIEKPFGRDYSSAKKLNKI
HHHCCCCCEEEEEEECCCHHCCCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHH
VQSCAEESQIYRIDHYLGKETVQNILVMRFANTIFEPIWNRNYISSVQITSSETVGVEDR
HHHHHHHCCEEEHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCC
AGYYESSGALRDMLQNHMTQMLAVTAMEPPGKFEPEAIRNEKAKVLQASKLADENEPWNC
CCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
CIRGQYGEGGNISNLLKGYRQEDGVNCNSTTETYIATKVFVDNWRWQGVPFYLRTGKRLP
EEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCEECCCCCEECCCHHHH
KRLGEIVLTFKDVPVHLFESTIINPAPNQLILRIQPNEGATFNFEVKSPGSGMKSRPVEM
HHHHHEEEEECCCCHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCEEE
EFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWKLYTPLIELMDNSPWKLPI
EECCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEE
YNYESMTWGPPESDQLLSKDNIFWRRP
ECCCCCCCCCCCCCCHHCCCCEEEECC
>Mature Secondary Structure 
PSTLSNPLRLGLRQERVISPQCLVIFGASGDLTHRKLIPALFELYLQRRIPSEFGIVGC
CCCCCCHHHHCCCHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHCEEEC
ARRPWTDNEFREKMKVKLSTQISGKEKEWEQFSNYLFYEPVDLQQSDHVVRLSKRLNKID
CCCCCCCHHHHHHHHEEEEECCCCCHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHHHHH
KRQATHGNRTFYLSVSPNFYASGCKALKIAGLLDDPKKSRLVIEKPFGRDYSSAKKLNKI
HHHCCCCCEEEEEEECCCHHCCCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHH
VQSCAEESQIYRIDHYLGKETVQNILVMRFANTIFEPIWNRNYISSVQITSSETVGVEDR
HHHHHHHCCEEEHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCC
AGYYESSGALRDMLQNHMTQMLAVTAMEPPGKFEPEAIRNEKAKVLQASKLADENEPWNC
CCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
CIRGQYGEGGNISNLLKGYRQEDGVNCNSTTETYIATKVFVDNWRWQGVPFYLRTGKRLP
EEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCEECCCCCEECCCHHHH
KRLGEIVLTFKDVPVHLFESTIINPAPNQLILRIQPNEGATFNFEVKSPGSGMKSRPVEM
HHHHHEEEEECCCCHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCEEE
EFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWKLYTPLIELMDNSPWKLPI
EECCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEE
YNYESMTWGPPESDQLLSKDNIFWRRP
ECCCCCCCCCCCCCCHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1643289 [H]