Click here to switch to the map view.

The map label for this gene is purH

Identifier: 78484784

GI number: 78484784

Start: 492005

End: 493567

Strand: Reverse

Name: purH

Synonym: Tcr_0439

Alternate gene names: 78484784

Gene position: 493567-492005 (Counterclockwise)

Preceding gene: 78484785

Following gene: 78484783

Centisome position: 20.33

GC content: 45.81

Gene sequence:

>1563_bases
ATGAAACCTGTTCGCCGCGCCCTGATTAGCGTCTCAGATAAAAATGGCATTTTAGAGTTTGCCAAGTCTTTAACCGCTAT
GGATGTTGTCATCTTATCAACAGGAGGAACCTATAAAGTTCTTTCTGAAGCCGGCTTACCTGTTACAGAGGTTTCGGAAT
ATACAGGTTTTCCTGAAATGATGGATGGTCGAGTCAAAACACTTCATCCAAAAATTCACGGTGGTTTGTTGGGACGTCGA
GGCACAGATGATGCTGTTATGGCAGAACATGGCATTGATCCTATCGATATGGTGGTTGTTAACCTTTATCCTTTCGAAGC
CACGGTTGCCAAACCGGACTGTTCACTAGAAGATGCCATTGAAAACATTGATATTGGAGGGCCGACGATGCTTCGTTCCG
CGGCCAAAAACCATAAGGATGTTGCTGTTGTCACAGACCCGCACGATTATGCCCGCATTTTAGAAGAAATGGAATCGAAT
GATGGTCAACTATCTCATGCAACCCGTTTTGATCTAGCCATCAAAACATTTGAACAAACAGCACGCTATGACGGAGCGAT
CTCAAACTACTTCGGCACCATGTTCAGCGACGATAAAGACGATACTTTCCCGCGCACATACAACACCCAGTTTGTGAAAA
AACAATCGATGCGTTATGGCGAAAACCCACATCAGTCGGCGGCTTTTTATACAGAACGCAACCCAACCGAAGCCTCTATT
TCAACCGCTAAACAACTTCAAGGCAAGGCATTGTCTTTCAATAACATTGCCGATACAGATGCGGCATTAGAGCTGGTCAA
AACCTTTGAAGAAACCGCTTGTGTTATTGTCAAACATGCCAATCCGTGTGGTGTTTCCATTGGTGAAAACGTTTTTGAAT
CTTATGACCGAGCTTATAAAACCGATCCAACCTCTGCCTTCGGAGGCATTATTGCATTCAATCGCGCGTTAGATCAAGAA
ACCGCTCAAGCCATAATTGATCGTCAGTTTGTTGAAGTCATCATCGCACCGAATGTGTCTGAAGATGCTAAGAATGTCAT
TGCGGCTAAACAAAATGTTCGTTTATTGGTGTGTGGTGATTTAGGCATCCAAGAGCCTGCTTATGACTACAAACGCGTAA
CAGGTGGTTTATTGGTTCAAGACCGTGATTTAGGTTCGGTAACGGAAGACGAGCTGAAAGTCGTCACCAAACGAGCGCCC
AGCGAAAAAGAAATGGCGGACTTGCAATTTGCTTGGAAAGTGGCGAAGTACGTTAAATCAAATGCCATCGTTTATGTCAA
AGACGGCATGACCATTGGAGTAGGGGCAGGCCAAATGAGCCGTGTTTATTCTGCCAAAATTGCTGGTATTAAAGCGGCGG
ATGAAGGCCTTGAAGTGCCAGGTTCCGTGATGGCTTCAGATGCCTTCTTCCCTTTCAGAGATGGCATTGATGCGGCCGCT
GAAGCCGGTATCACAGCCGTGATTCACCCAGGTGGGTCAATGCGAGACCAAGAAGTGATTGATGCAGCGGATGAGCACGG
CATCGCGATGGTCTTCACTGGCATGCGTCACTTTAAACACTAA

Upstream 100 bases:

>100_bases
AGAAAGAAAATGCAGCTTTATAAAATAACACCTGCATAACGAATTCGCCTCTAGCAGGCACCCTTTTTACTGACTAACCA
ATTTTGGAGATAATTCCCTT

Downstream 100 bases:

>100_bases
AGACACTGATTGAAATACGATAGATTTATAAGAGAGAAAAACACATGAACGTACTCATTATTGGAAGCGGTGGTCGTGAA
CATGCCTTGGCATGGAAAAC

Product: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MKPVRRALISVSDKNGILEFAKSLTAMDVVILSTGGTYKVLSEAGLPVTEVSEYTGFPEMMDGRVKTLHPKIHGGLLGRR
GTDDAVMAEHGIDPIDMVVVNLYPFEATVAKPDCSLEDAIENIDIGGPTMLRSAAKNHKDVAVVTDPHDYARILEEMESN
DGQLSHATRFDLAIKTFEQTARYDGAISNYFGTMFSDDKDDTFPRTYNTQFVKKQSMRYGENPHQSAAFYTERNPTEASI
STAKQLQGKALSFNNIADTDAALELVKTFEETACVIVKHANPCGVSIGENVFESYDRAYKTDPTSAFGGIIAFNRALDQE
TAQAIIDRQFVEVIIAPNVSEDAKNVIAAKQNVRLLVCGDLGIQEPAYDYKRVTGGLLVQDRDLGSVTEDELKVVTKRAP
SEKEMADLQFAWKVAKYVKSNAIVYVKDGMTIGVGAGQMSRVYSAKIAGIKAADEGLEVPGSVMASDAFFPFRDGIDAAA
EAGITAVIHPGGSMRDQEVIDAADEHGIAMVFTGMRHFKH

Sequences:

>Translated_520_residues
MKPVRRALISVSDKNGILEFAKSLTAMDVVILSTGGTYKVLSEAGLPVTEVSEYTGFPEMMDGRVKTLHPKIHGGLLGRR
GTDDAVMAEHGIDPIDMVVVNLYPFEATVAKPDCSLEDAIENIDIGGPTMLRSAAKNHKDVAVVTDPHDYARILEEMESN
DGQLSHATRFDLAIKTFEQTARYDGAISNYFGTMFSDDKDDTFPRTYNTQFVKKQSMRYGENPHQSAAFYTERNPTEASI
STAKQLQGKALSFNNIADTDAALELVKTFEETACVIVKHANPCGVSIGENVFESYDRAYKTDPTSAFGGIIAFNRALDQE
TAQAIIDRQFVEVIIAPNVSEDAKNVIAAKQNVRLLVCGDLGIQEPAYDYKRVTGGLLVQDRDLGSVTEDELKVVTKRAP
SEKEMADLQFAWKVAKYVKSNAIVYVKDGMTIGVGAGQMSRVYSAKIAGIKAADEGLEVPGSVMASDAFFPFRDGIDAAA
EAGITAVIHPGGSMRDQEVIDAADEHGIAMVFTGMRHFKH
>Mature_520_residues
MKPVRRALISVSDKNGILEFAKSLTAMDVVILSTGGTYKVLSEAGLPVTEVSEYTGFPEMMDGRVKTLHPKIHGGLLGRR
GTDDAVMAEHGIDPIDMVVVNLYPFEATVAKPDCSLEDAIENIDIGGPTMLRSAAKNHKDVAVVTDPHDYARILEEMESN
DGQLSHATRFDLAIKTFEQTARYDGAISNYFGTMFSDDKDDTFPRTYNTQFVKKQSMRYGENPHQSAAFYTERNPTEASI
STAKQLQGKALSFNNIADTDAALELVKTFEETACVIVKHANPCGVSIGENVFESYDRAYKTDPTSAFGGIIAFNRALDQE
TAQAIIDRQFVEVIIAPNVSEDAKNVIAAKQNVRLLVCGDLGIQEPAYDYKRVTGGLLVQDRDLGSVTEDELKVVTKRAP
SEKEMADLQFAWKVAKYVKSNAIVYVKDGMTIGVGAGQMSRVYSAKIAGIKAADEGLEVPGSVMASDAFFPFRDGIDAAA
EAGITAVIHPGGSMRDQEVIDAADEHGIAMVFTGMRHFKH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=482, Percent_Identity=39.6265560165975, Blast_Score=291, Evalue=1e-78,
Organism=Escherichia coli, GI1790439, Length=525, Percent_Identity=72.5714285714286, Blast_Score=785, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985564, Length=609, Percent_Identity=32.8407224958949, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI71985574, Length=348, Percent_Identity=27.0114942528736, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71985556, Length=120, Percent_Identity=37.5, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323056, Length=491, Percent_Identity=36.2525458248472, Blast_Score=279, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6323768, Length=479, Percent_Identity=35.4906054279749, Blast_Score=274, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24649832, Length=611, Percent_Identity=35.0245499181669, Blast_Score=317, Evalue=2e-86,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_THICR (Q31II8)

Other databases:

- EMBL:   CP000109
- RefSeq:   YP_390709.1
- HSSP:   P31335
- ProteinModelPortal:   Q31II8
- SMR:   Q31II8
- STRING:   Q31II8
- GeneID:   3761258
- GenomeReviews:   CP000109_GR
- KEGG:   tcx:Tcr_0439
- NMPDR:   fig|317025.3.peg.617
- eggNOG:   COG0138
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- PhylomeDB:   Q31II8
- BioCyc:   TCRU317025:TCR_0439-MONOMER
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 56606; Mature: 56606

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVRRALISVSDKNGILEFAKSLTAMDVVILSTGGTYKVLSEAGLPVTEVSEYTGFPEM
CCHHHHHHHCCCCCCHHHHHHHHHHHEEEEEEECCCCEEEHHHCCCCHHHHHHHCCCHHH
MDGRVKTLHPKIHGGLLGRRGTDDAVMAEHGIDPIDMVVVNLYPFEATVAKPDCSLEDAI
HCCCCEEECCHHHCCCCCCCCCCCHHHHHCCCCHHHEEEEEEECCEEEECCCCCCHHHHH
ENIDIGGPTMLRSAAKNHKDVAVVTDPHDYARILEEMESNDGQLSHATRFDLAIKTFEQT
HHCCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
ARYDGAISNYFGTMFSDDKDDTFPRTYNTQFVKKQSMRYGENPHQSAAFYTERNPTEASI
HHHCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHH
STAKQLQGKALSFNNIADTDAALELVKTFEETACVIVKHANPCGVSIGENVFESYDRAYK
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEEECCCCCCCCHHHHHHHHHHHHHC
TDPTSAFGGIIAFNRALDQETAQAIIDRQFVEVIIAPNVSEDAKNVIAAKQNVRLLVCGD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCEEEEECC
LGIQEPAYDYKRVTGGLLVQDRDLGSVTEDELKVVTKRAPSEKEMADLQFAWKVAKYVKS
CCCCCCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
NAIVYVKDGMTIGVGAGQMSRVYSAKIAGIKAADEGLEVPGSVMASDAFFPFRDGIDAAA
CCEEEEECCCEEEECCCHHHHHHHHHHCCCEECCCCCCCCCHHHHCCCCCCCCCCCCHHH
EAGITAVIHPGGSMRDQEVIDAADEHGIAMVFTGMRHFKH
HCCCEEEECCCCCCCHHHHHHHHCCCCEEEEEECHHHHCC
>Mature Secondary Structure
MKPVRRALISVSDKNGILEFAKSLTAMDVVILSTGGTYKVLSEAGLPVTEVSEYTGFPEM
CCHHHHHHHCCCCCCHHHHHHHHHHHEEEEEEECCCCEEEHHHCCCCHHHHHHHCCCHHH
MDGRVKTLHPKIHGGLLGRRGTDDAVMAEHGIDPIDMVVVNLYPFEATVAKPDCSLEDAI
HCCCCEEECCHHHCCCCCCCCCCCHHHHHCCCCHHHEEEEEEECCEEEECCCCCCHHHHH
ENIDIGGPTMLRSAAKNHKDVAVVTDPHDYARILEEMESNDGQLSHATRFDLAIKTFEQT
HHCCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
ARYDGAISNYFGTMFSDDKDDTFPRTYNTQFVKKQSMRYGENPHQSAAFYTERNPTEASI
HHHCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHH
STAKQLQGKALSFNNIADTDAALELVKTFEETACVIVKHANPCGVSIGENVFESYDRAYK
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEEECCCCCCCCHHHHHHHHHHHHHC
TDPTSAFGGIIAFNRALDQETAQAIIDRQFVEVIIAPNVSEDAKNVIAAKQNVRLLVCGD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCEEEEECC
LGIQEPAYDYKRVTGGLLVQDRDLGSVTEDELKVVTKRAPSEKEMADLQFAWKVAKYVKS
CCCCCCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
NAIVYVKDGMTIGVGAGQMSRVYSAKIAGIKAADEGLEVPGSVMASDAFFPFRDGIDAAA
CCEEEEECCCEEEECCCHHHHHHHHHHCCCEECCCCCCCCCHHHHCCCCCCCCCCCCHHH
EAGITAVIHPGGSMRDQEVIDAADEHGIAMVFTGMRHFKH
HCCCEEEECCCCCCCHHHHHHHHCCCCEEEEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA