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The map label for this gene is ubiB [H]

Identifier: 78484745

GI number: 78484745

Start: 451311

End: 452951

Strand: Reverse

Name: ubiB [H]

Synonym: Tcr_0400

Alternate gene names: 78484745

Gene position: 452951-451311 (Counterclockwise)

Preceding gene: 78484746

Following gene: 78484744

Centisome position: 18.66

GC content: 47.29

Gene sequence:

>1641_bases
ATGAATATCATTAGTAAATCTTTTCGACAACTGACTCGCATCATTAAAATCAACCGCGTCCTGACCCATTATCAAATCGA
CAAACTGGTCTTAAGTGACACCAAATATGCGTGGTTGATTGTCGCCAACCTGCTGTTGCCATGGAACTGGCGCTTTCAAT
CCAAAGGCAACCGTGGTGAACGCATTCGGCTGGCTTTGGAAGAACTTGGCCCAATCTTCATCAAACTGGGACAGGCGCTT
TCCACCCGAAAAGATTTGCTGCCGGAAGACATCTCGGTTGAATTACGAAAACTGCAAGACGATTGTCCACCGTTTGACGA
GCAACATTCCATCAGCATCATTGAAAAAGGTTTGAAACGCCCTATTGAAGAAGCCTATGCCAGCTTTGACCCGACGCCGA
TGGCTTCGGCGTCCATTGCACAAGTGCATGCCGCCACCTTATACGACGGCTCTGAAGTGGTTGTCAAAGTGGTTCGACCC
GACATCAAACCAGTGATTGAACAAGACGTTTCCATCATGAAATCTCTAGCGCAGTTATTGGAAGCGGCGGTGAAAGAATC
GAAACGCCTGCACCCGACCGAAGTGGTGGAAGAGTTTGAAAAAACCATTCTAGATGAGCTGGATATGATGCGAGAAGCGT
CCAATGCCTCGCAATTGCGTCGTAACTTTGAACATTCCGATTTGCTGTATGTACCCGACATTTACTGGTCCCACACCAAT
GATAATGTGATGACGATGGAACGTATTTACGGCATCCGTATTTCTGAAATCGATAAATTAAAAGCCGCTAACATTGATTT
AACGGATCTTTCGGCAAAAGGCGTGACCATCTTTTTCACCCAGGTGTTCAAACACAATTTCTTCCATGCCGACATGCACC
CGGGCAACATTTTTGTGTTGCCGGATGGACGTTATGCCGCCATTGATTTCGGCATTATGGGCACCCTCAACCCAGAAGAC
CAGCGTTATTTGGCAGAAAACTTCCTGGCCTTTTTCAATCGTGATTATTTACGTGTGTCCGAACTCCACATTGAATCCGG
CTGGGTGCCGGCCGATACCCGAGTCAACGAATTGGAATCGGCCATTCGCTCCGTCTGCGAACCGATTTGGGATCGTCCGT
TAAAAGAAATTTCATTCGGTTTGTTCCTGATGCGCCTATTCCAAACCGCACGTCGTTTCGGCATGGAAGTACAACCGCAG
TTGGTGTTGCTGCAAAAAACGCTACTCAACATTGAAGGGCTTGGACGCCAACTGGATGACGAACTTGATTTATGGGATAC
CGCCAAACCCTTTTTGGAAGATTGGATGCAAGAGCGTGTGGGGCTAAAAAGCCTGGTTAAAAACACCAAAGCCAATCTGC
CCTTCTGGATTGAGCAGGCACCAAGCTTACCGGGCTTATTGCACAGCAGCTTGCAAAAGCTGTCGCATGCCAATTTCGAT
CAGCAATCTGAACAAATTGCCCGTCTGGAACAACAGCTCGCCAAACAACAAAAAGCGGATCGCAATCGCGCCATCGCGGT
GTTGTTGTTTGTTGTGGCCGCCATTCCAGAGCTCACGCATGTGCCTTATTTGATGCAACAGATATGGTTACAAGGGCTTA
TTGCACTGTTAGGGCTTTATTTCCTTTTTAAAAAACCATAA

Upstream 100 bases:

>100_bases
TTTGCGCACAATGTACAGCAAACCACCCAAGCGGTGGACCAACTGGCTGAACGCATTCAACGTCTGCAAAACACTTCTTC
CACTTAATTGACGACAGAAC

Downstream 100 bases:

>100_bases
TCTCTCGGACGAGAAAGGCACGCGATGTTTCATTTAAAACAGCATGGCACCACCGTCAAAACCGAGTTTGTTGCCGGGTT
GACGACCTTCTTAACCATGC

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MNIISKSFRQLTRIIKINRVLTHYQIDKLVLSDTKYAWLIVANLLLPWNWRFQSKGNRGERIRLALEELGPIFIKLGQAL
STRKDLLPEDISVELRKLQDDCPPFDEQHSISIIEKGLKRPIEEAYASFDPTPMASASIAQVHAATLYDGSEVVVKVVRP
DIKPVIEQDVSIMKSLAQLLEAAVKESKRLHPTEVVEEFEKTILDELDMMREASNASQLRRNFEHSDLLYVPDIYWSHTN
DNVMTMERIYGIRISEIDKLKAANIDLTDLSAKGVTIFFTQVFKHNFFHADMHPGNIFVLPDGRYAAIDFGIMGTLNPED
QRYLAENFLAFFNRDYLRVSELHIESGWVPADTRVNELESAIRSVCEPIWDRPLKEISFGLFLMRLFQTARRFGMEVQPQ
LVLLQKTLLNIEGLGRQLDDELDLWDTAKPFLEDWMQERVGLKSLVKNTKANLPFWIEQAPSLPGLLHSSLQKLSHANFD
QQSEQIARLEQQLAKQQKADRNRAIAVLLFVVAAIPELTHVPYLMQQIWLQGLIALLGLYFLFKKP

Sequences:

>Translated_546_residues
MNIISKSFRQLTRIIKINRVLTHYQIDKLVLSDTKYAWLIVANLLLPWNWRFQSKGNRGERIRLALEELGPIFIKLGQAL
STRKDLLPEDISVELRKLQDDCPPFDEQHSISIIEKGLKRPIEEAYASFDPTPMASASIAQVHAATLYDGSEVVVKVVRP
DIKPVIEQDVSIMKSLAQLLEAAVKESKRLHPTEVVEEFEKTILDELDMMREASNASQLRRNFEHSDLLYVPDIYWSHTN
DNVMTMERIYGIRISEIDKLKAANIDLTDLSAKGVTIFFTQVFKHNFFHADMHPGNIFVLPDGRYAAIDFGIMGTLNPED
QRYLAENFLAFFNRDYLRVSELHIESGWVPADTRVNELESAIRSVCEPIWDRPLKEISFGLFLMRLFQTARRFGMEVQPQ
LVLLQKTLLNIEGLGRQLDDELDLWDTAKPFLEDWMQERVGLKSLVKNTKANLPFWIEQAPSLPGLLHSSLQKLSHANFD
QQSEQIARLEQQLAKQQKADRNRAIAVLLFVVAAIPELTHVPYLMQQIWLQGLIALLGLYFLFKKP
>Mature_546_residues
MNIISKSFRQLTRIIKINRVLTHYQIDKLVLSDTKYAWLIVANLLLPWNWRFQSKGNRGERIRLALEELGPIFIKLGQAL
STRKDLLPEDISVELRKLQDDCPPFDEQHSISIIEKGLKRPIEEAYASFDPTPMASASIAQVHAATLYDGSEVVVKVVRP
DIKPVIEQDVSIMKSLAQLLEAAVKESKRLHPTEVVEEFEKTILDELDMMREASNASQLRRNFEHSDLLYVPDIYWSHTN
DNVMTMERIYGIRISEIDKLKAANIDLTDLSAKGVTIFFTQVFKHNFFHADMHPGNIFVLPDGRYAAIDFGIMGTLNPED
QRYLAENFLAFFNRDYLRVSELHIESGWVPADTRVNELESAIRSVCEPIWDRPLKEISFGLFLMRLFQTARRFGMEVQPQ
LVLLQKTLLNIEGLGRQLDDELDLWDTAKPFLEDWMQERVGLKSLVKNTKANLPFWIEQAPSLPGLLHSSLQKLSHANFD
QQSEQIARLEQQLAKQQKADRNRAIAVLLFVVAAIPELTHVPYLMQQIWLQGLIALLGLYFLFKKP

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=231, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI41393593, Length=274, Percent_Identity=28.1021897810219, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI217035081, Length=186, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI32261307, Length=333, Percent_Identity=24.9249249249249, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI27363457, Length=279, Percent_Identity=25.4480286738351, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI217416386, Length=203, Percent_Identity=25.615763546798, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI2367309, Length=490, Percent_Identity=51.2244897959184, Blast_Score=486, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17559152, Length=283, Percent_Identity=28.2685512367491, Blast_Score=126, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6325148, Length=438, Percent_Identity=25.5707762557078, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6323282, Length=244, Percent_Identity=30.327868852459, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321319, Length=302, Percent_Identity=25.4966887417219, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24662575, Length=240, Percent_Identity=31.25, Blast_Score=135, Evalue=9e-32,
Organism=Drosophila melanogaster, GI22024280, Length=232, Percent_Identity=31.4655172413793, Blast_Score=122, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 62815; Mature: 62815

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIISKSFRQLTRIIKINRVLTHYQIDKLVLSDTKYAWLIVANLLLPWNWRFQSKGNRGE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCH
RIRLALEELGPIFIKLGQALSTRKDLLPEDISVELRKLQDDCPPFDEQHSISIIEKGLKR
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
PIEEAYASFDPTPMASASIAQVHAATLYDGSEVVVKVVRPDIKPVIEQDVSIMKSLAQLL
HHHHHHHCCCCCCCCCHHHHHHHHHHEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
EAAVKESKRLHPTEVVEEFEKTILDELDMMREASNASQLRRNFEHSDLLYVPDIYWSHTN
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEECCEEEECCC
DNVMTMERIYGIRISEIDKLKAANIDLTDLSAKGVTIFFTQVFKHNFFHADMHPGNIFVL
CCEEEHHHHHCCCHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHCCCEECCCCCCEEEEE
PDGRYAAIDFGIMGTLNPEDQRYLAENFLAFFNRDYLRVSELHIESGWVPADTRVNELES
ECCCEEEEEECEEECCCCHHHHHHHHHHHHHHCCCHHHHHHEEECCCCCCCCCHHHHHHH
AIRSVCEPIWDRPLKEISFGLFLMRLFQTARRFGMEVQPQLVLLQKTLLNIEGLGRQLDD
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCC
ELDLWDTAKPFLEDWMQERVGLKSLVKNTKANLPFWIEQAPSLPGLLHSSLQKLSHANFD
CCCCHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCCC
QQSEQIARLEQQLAKQQKADRNRAIAVLLFVVAAIPELTHVPYLMQQIWLQGLIALLGLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLFKKP
HHHCCC
>Mature Secondary Structure
MNIISKSFRQLTRIIKINRVLTHYQIDKLVLSDTKYAWLIVANLLLPWNWRFQSKGNRGE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCH
RIRLALEELGPIFIKLGQALSTRKDLLPEDISVELRKLQDDCPPFDEQHSISIIEKGLKR
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
PIEEAYASFDPTPMASASIAQVHAATLYDGSEVVVKVVRPDIKPVIEQDVSIMKSLAQLL
HHHHHHHCCCCCCCCCHHHHHHHHHHEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
EAAVKESKRLHPTEVVEEFEKTILDELDMMREASNASQLRRNFEHSDLLYVPDIYWSHTN
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEECCEEEECCC
DNVMTMERIYGIRISEIDKLKAANIDLTDLSAKGVTIFFTQVFKHNFFHADMHPGNIFVL
CCEEEHHHHHCCCHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHCCCEECCCCCCEEEEE
PDGRYAAIDFGIMGTLNPEDQRYLAENFLAFFNRDYLRVSELHIESGWVPADTRVNELES
ECCCEEEEEECEEECCCCHHHHHHHHHHHHHHCCCHHHHHHEEECCCCCCCCCHHHHHHH
AIRSVCEPIWDRPLKEISFGLFLMRLFQTARRFGMEVQPQLVLLQKTLLNIEGLGRQLDD
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCC
ELDLWDTAKPFLEDWMQERVGLKSLVKNTKANLPFWIEQAPSLPGLLHSSLQKLSHANFD
CCCCHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCCC
QQSEQIARLEQQLAKQQKADRNRAIAVLLFVVAAIPELTHVPYLMQQIWLQGLIALLGLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLFKKP
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA