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The map label for this gene is purC [H]

Identifier: 78484607

GI number: 78484607

Start: 310916

End: 311803

Strand: Reverse

Name: purC [H]

Synonym: Tcr_0262

Alternate gene names: 78484607

Gene position: 311803-310916 (Counterclockwise)

Preceding gene: 78484608

Following gene: 78484606

Centisome position: 12.84

GC content: 45.83

Gene sequence:

>888_bases
ATGCAACCACTTTTCGAATCAAATTTAACCAGCTTGCCTTTGATTAACAAAGGGAAAGTACGCGACTTGTATGACATTGA
TGAAAACCACTTGCTCATTGTCACCACAGATCGAATTTCCGCATTTGATGTGGTGCTGCCAACGCCTATTCCAGGAAAAG
GGCGTATTCTGACTGAAACCGCACAGTTCTGGATGAAGAAAGCCAGTCACATCCTGCCGAATCAACTAGCGGATGATATG
CAACTGTCTGATGTACTGACGCCAGATGAACTTCTTCAACTGGATGGTCGAGGCATGATTGTACGCAAACTGACGCCTCT
GCCAGTCGAGGCCATTGTGCGCGGCTACCTAGTAGGCTCGGGTTGGAAAGAATACAAAAAAACACAAACGGTCTGTGGCA
TTGAACTGCCTAAAGGACTCAAGAAAGCACAACAATTACCTGAACCCCTTTTTACACCATCAACGAAAGCCGAGATAGGA
GATCATGATGAAAACATCTCTTTTGAAGAAGTGGTTAAGTTAATTGGTGAAAAGAAAGCACAAAAGGTTAAAGAATACAG
CTTGGCGCTCTACAAAATGGCCGCTGAGTTTGCGGCTGAACGCGGCATTATTATCGCGGATACCAAGTTTGAATTCGGCG
AGGATGAACACGGTGTCATCCACTTAATCGATGAAGCCCTGACACCAGACAGCTCTCGCTTCTGGCCGGCAAAAACCTAC
CAAGTCGGTAAAAACCCAGACAGTTTCGACAAACAATACATTCGTGATTATTTAGAATCGCTGGACTGGGACAAAACCGC
TCCCGGCCCGGAATTACCGGAAGAAGTCGTTGATATGACTTTCCAGAAGTATCAGGAAGCGCAAGCGCGCTTAATGGAAA
ACCCATAA

Upstream 100 bases:

>100_bases
CCGCAGCGGTCATTATTTTACGATATGGGCATTTGAAACTGCCCTACTCTGACCGAAAGCAGCTTGAAGACAACTTAAAG
AAATAACTGGAAGAGATTGT

Downstream 100 bases:

>100_bases
TGCCTTTCGAAGGTCTTCTTAACTATCTCAAAACCACCCAGCCCGGTGGTTTTTTTATAACCGGGACAGATACGGACATT
GGTAAAACATTTGTCAGCTG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MQPLFESNLTSLPLINKGKVRDLYDIDENHLLIVTTDRISAFDVVLPTPIPGKGRILTETAQFWMKKASHILPNQLADDM
QLSDVLTPDELLQLDGRGMIVRKLTPLPVEAIVRGYLVGSGWKEYKKTQTVCGIELPKGLKKAQQLPEPLFTPSTKAEIG
DHDENISFEEVVKLIGEKKAQKVKEYSLALYKMAAEFAAERGIIIADTKFEFGEDEHGVIHLIDEALTPDSSRFWPAKTY
QVGKNPDSFDKQYIRDYLESLDWDKTAPGPELPEEVVDMTFQKYQEAQARLMENP

Sequences:

>Translated_295_residues
MQPLFESNLTSLPLINKGKVRDLYDIDENHLLIVTTDRISAFDVVLPTPIPGKGRILTETAQFWMKKASHILPNQLADDM
QLSDVLTPDELLQLDGRGMIVRKLTPLPVEAIVRGYLVGSGWKEYKKTQTVCGIELPKGLKKAQQLPEPLFTPSTKAEIG
DHDENISFEEVVKLIGEKKAQKVKEYSLALYKMAAEFAAERGIIIADTKFEFGEDEHGVIHLIDEALTPDSSRFWPAKTY
QVGKNPDSFDKQYIRDYLESLDWDKTAPGPELPEEVVDMTFQKYQEAQARLMENP
>Mature_295_residues
MQPLFESNLTSLPLINKGKVRDLYDIDENHLLIVTTDRISAFDVVLPTPIPGKGRILTETAQFWMKKASHILPNQLADDM
QLSDVLTPDELLQLDGRGMIVRKLTPLPVEAIVRGYLVGSGWKEYKKTQTVCGIELPKGLKKAQQLPEPLFTPSTKAEIG
DHDENISFEEVVKLIGEKKAQKVKEYSLALYKMAAEFAAERGIIIADTKFEFGEDEHGVIHLIDEALTPDSSRFWPAKTY
QVGKNPDSFDKQYIRDYLESLDWDKTAPGPELPEEVVDMTFQKYQEAQARLMENP

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=289, Percent_Identity=48.0968858131488, Blast_Score=270, Evalue=2e-73,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 33376; Mature: 33376

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPLFESNLTSLPLINKGKVRDLYDIDENHLLIVTTDRISAFDVVLPTPIPGKGRILTET
CCCCHHCCCCCCCCCCCCCCCHHEECCCCCEEEEEECCCCEEEEEECCCCCCCCCEEHHH
AQFWMKKASHILPNQLADDMQLSDVLTPDELLQLDGRGMIVRKLTPLPVEAIVRGYLVGS
HHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCC
GWKEYKKTQTVCGIELPKGLKKAQQLPEPLFTPSTKAEIGDHDENISFEEVVKLIGEKKA
CHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QKVKEYSLALYKMAAEFAAERGIIIADTKFEFGEDEHGVIHLIDEALTPDSSRFWPAKTY
HHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEHHHCCCCCCCCCCCCCE
QVGKNPDSFDKQYIRDYLESLDWDKTAPGPELPEEVVDMTFQKYQEAQARLMENP
ECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQPLFESNLTSLPLINKGKVRDLYDIDENHLLIVTTDRISAFDVVLPTPIPGKGRILTET
CCCCHHCCCCCCCCCCCCCCCHHEECCCCCEEEEEECCCCEEEEEECCCCCCCCCEEHHH
AQFWMKKASHILPNQLADDMQLSDVLTPDELLQLDGRGMIVRKLTPLPVEAIVRGYLVGS
HHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCC
GWKEYKKTQTVCGIELPKGLKKAQQLPEPLFTPSTKAEIGDHDENISFEEVVKLIGEKKA
CHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QKVKEYSLALYKMAAEFAAERGIIIADTKFEFGEDEHGVIHLIDEALTPDSSRFWPAKTY
HHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEHHHCCCCCCCCCCCCCE
QVGKNPDSFDKQYIRDYLESLDWDKTAPGPELPEEVVDMTFQKYQEAQARLMENP
ECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA