Click here to switch to the map view.

The map label for this gene is bioD [H]

Identifier: 78484606

GI number: 78484606

Start: 310257

End: 310916

Strand: Reverse

Name: bioD [H]

Synonym: Tcr_0261

Alternate gene names: 78484606

Gene position: 310916-310257 (Counterclockwise)

Preceding gene: 78484607

Following gene: 78484583

Centisome position: 12.81

GC content: 46.06

Gene sequence:

>660_bases
ATGCCTTTCGAAGGTCTTCTTAACTATCTCAAAACCACCCAGCCCGGTGGTTTTTTTATAACCGGGACAGATACGGACAT
TGGTAAAACATTTGTCAGCTGTACAGTTGCACAGTATCTGTTGGAAAAACAGCCAGGCCTGGCCATTTCTCCACGCAAGC
CCATTGCATCAGGTGCATTAAGAGACCACAACGGAGAACTGTATTCTGAAGACGCTGTCCAGCTCCACCAAGCGTGTAAA
AGTCAGGAACCTCTTAACACAGTGTGTCCCTATCTGCTTGAGCCAGCCATTTCACCTGCCAGAGCGATTCAGCAAGCCAA
ACAAACCATCACCATTCATGACCTCGTCTTAGCATGCAAGGTACCTCAACAAACAGTAGCATTTGTTGAAGGCGCGGGAG
GAATTTACTCTCCACTGGCATCAGATGGCCTTAATATTGATCTTGCAAAACAGCTTGGTTATCCGGTTATTCTAGTCGTT
GGCAACAGATTAGGGTGTTTAAACCACGCCTTACTCAGCATTGCTGCTATTGAAAATGCCGGGTTAGAAATTGCTCACAT
TTTTGTGAATAATTTATCCGACCAAGCCGACCCTGAGAACATCACGGACTTGCAATCCCTCACCACGCATCCTGTTAGTT
TGGTTCCGTATCAAGCTTAA

Upstream 100 bases:

>100_bases
GGGACAAAACCGCTCCCGGCCCGGAATTACCGGAAGAAGTCGTTGATATGACTTTCCAGAAGTATCAGGAAGCGCAAGCG
CGCTTAATGGAAAACCCATA

Downstream 100 bases:

>100_bases
CTCAGCTAACAAGCGCTTACCAACGACCCGTGTTTTTTAAGACCGCTTTATTAGGAGCGGTTTTTTGCATCATCATGCCT
CCCCAGCTGGGAAAGCTTTG

Product: dethiobiotin synthase

Products: NA

Alternate protein names: DTB synthetase; DTBS; Dethiobiotin synthase [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MPFEGLLNYLKTTQPGGFFITGTDTDIGKTFVSCTVAQYLLEKQPGLAISPRKPIASGALRDHNGELYSEDAVQLHQACK
SQEPLNTVCPYLLEPAISPARAIQQAKQTITIHDLVLACKVPQQTVAFVEGAGGIYSPLASDGLNIDLAKQLGYPVILVV
GNRLGCLNHALLSIAAIENAGLEIAHIFVNNLSDQADPENITDLQSLTTHPVSLVPYQA

Sequences:

>Translated_219_residues
MPFEGLLNYLKTTQPGGFFITGTDTDIGKTFVSCTVAQYLLEKQPGLAISPRKPIASGALRDHNGELYSEDAVQLHQACK
SQEPLNTVCPYLLEPAISPARAIQQAKQTITIHDLVLACKVPQQTVAFVEGAGGIYSPLASDGLNIDLAKQLGYPVILVV
GNRLGCLNHALLSIAAIENAGLEIAHIFVNNLSDQADPENITDLQSLTTHPVSLVPYQA
>Mature_218_residues
PFEGLLNYLKTTQPGGFFITGTDTDIGKTFVSCTVAQYLLEKQPGLAISPRKPIASGALRDHNGELYSEDAVQLHQACKS
QEPLNTVCPYLLEPAISPARAIQQAKQTITIHDLVLACKVPQQTVAFVEGAGGIYSPLASDGLNIDLAKQLGYPVILVVG
NRLGCLNHALLSIAAIENAGLEIAHIFVNNLSDQADPENITDLQSLTTHPVSLVPYQA

Specific function: Bioconversion of pimelate into dethiobiotin. [C]

COG id: COG0132

COG function: function code H; Dethiobiotin synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dethiobiotin synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1786995, Length=201, Percent_Identity=35.3233830845771, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI87081944, Length=177, Percent_Identity=33.8983050847458, Blast_Score=70, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324385, Length=197, Percent_Identity=31.4720812182741, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004472
- InterPro:   IPR002586 [H]

Pfam domain/function: PF01656 CbiA [H]

EC number: =6.3.3.3 [H]

Molecular weight: Translated: 23429; Mature: 23298

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFEGLLNYLKTTQPGGFFITGTDTDIGKTFVSCTVAQYLLEKQPGLAISPRKPIASGAL
CCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCC
RDHNGELYSEDAVQLHQACKSQEPLNTVCPYLLEPAISPARAIQQAKQTITIHDLVLACK
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
VPQQTVAFVEGAGGIYSPLASDGLNIDLAKQLGYPVILVVGNRLGCLNHALLSIAAIENA
CCHHHHHHHHCCCCCCCHHHCCCCCEEEHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCC
GLEIAHIFVNNLSDQADPENITDLQSLTTHPVSLVPYQA
CCEEEEHHHHCCCCCCCCCCHHHHHHHHCCCCEECCCCC
>Mature Secondary Structure 
PFEGLLNYLKTTQPGGFFITGTDTDIGKTFVSCTVAQYLLEKQPGLAISPRKPIASGAL
CHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCC
RDHNGELYSEDAVQLHQACKSQEPLNTVCPYLLEPAISPARAIQQAKQTITIHDLVLACK
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
VPQQTVAFVEGAGGIYSPLASDGLNIDLAKQLGYPVILVVGNRLGCLNHALLSIAAIENA
CCHHHHHHHHCCCCCCCHHHCCCCCEEEHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCC
GLEIAHIFVNNLSDQADPENITDLQSLTTHPVSLVPYQA
CCEEEEHHHHCCCCCCCCCCHHHHHHHHCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA