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The map label for this gene is gmr [H]

Identifier: 78484542

GI number: 78484542

Start: 232720

End: 234243

Strand: Reverse

Name: gmr [H]

Synonym: Tcr_0197

Alternate gene names: 78484542

Gene position: 234243-232720 (Counterclockwise)

Preceding gene: 78484545

Following gene: 78484540

Centisome position: 9.65

GC content: 43.31

Gene sequence:

>1524_bases
ATGAAGACAGGTAATTCTTCTTCATTTCGCTACTTTTCTGCCTTTTTTCTGATCGTTTTTGGCTTTTTATTTATGGCCTC
TCAATACCCTATTGCCCCGATCACGGAAGTCGACATTAATTGGAATCTGTACTTTCAAATTGCCATTGCTCTGTTCTTTT
TATTCGCTTTTATCGGCTATAAACGATTCCAAAAACTGAACCAAGACACCCTAAGACAAGCGGAAGAAGCCAAACAAAAA
CTCCGTACTCTTAAGCGACAACATGAATTGGAAAAAAAACGGTTATCGTTTGTTTTAGACTGCGGTCGTCTGGCGTATTG
GGAATGGGATATCAAAAACAATCAAGCGTATTTTTCGAATTTATGGCAAGACATGATCGGCTTTACCGAGCATGACTTTC
CGCAAGACTTGCATGCCTGGCAAGCTCGTATCCACCCACTGGATCAAGAGCAGGTTCAAAAAAAGCTCCTTAAACTTCTG
AGCCACCAAATAACCGACTATGAAGACACCCACCGCGTCATGGACGTCAACGGAGATTACATTTGGGTGTATGACCGCGG
ACAAACCGTCACCAATGAGCTGGGCAATGTTGAAAAATTAAGCTGTGTCCGCTTAAACATCACTCAACAAAAACAATTGG
AAGAAGAGCTGACTTTAGACAAAATCTTACTTGAGAACACTCAGGAAGCGATTGCGATTACCAATGAAAACTTATCGTTC
ATTCGTACCAACCCGGCTTTCCACGATGCGTTTGGCTTAACGCAGTCCGATTTGGCTAAAATGACGCTCAAAGATCTATT
GGATAATTTACAGGACGAACCACCACAAGATATTTTAAGCCAAGTGGACAAAGACCTGGCTTGGCGCGGTGAACTGACGT
TGCACCACACCAACGGGGAGCTGGCGCGATCCAGTTTAGTGGATTGCCAAAAAGTCATCCACCAAACCACTCAGACAACG
CACTATGCCTTGGTGTACACCGACATTACCGAATTGAAACAAACCCAGCAAGAATTGAGTTTTTTAGCGAATACAGACAT
TGTTACCGGCTTACCGAATCGAAATTACTTTTACCAAGCATTAGAAGAATGGCTGGAAGCCTTTAAGGATTCTGGCAACA
AGTTTACTTTGATGTTTTTAGACTTGGATAACTTCAAAACCGTCAATGACACTCTGGGGCATGATACGGGTGATCATTTG
CTTAAATCAGTGAGTGAACTCATCGCGGAGCATATTGCGGAAGACACTTTATTTGCCCGCGTAGGAGGGGATGAATTTGT
GATTTTGTGTCGCGCCTACACCACACCTGAACAACTTAATGAAATTGGTCAAAACCTTAATCAACTTCTCAGTCAACCAT
TCAACATCGGTGACCATGAAATTAAAATTGGTTCCAGTATTGGGATCGCGCTCTTCCCCGACCATGGTTCAGACAAAGAA
ACCTTGCTTAAGCACGCCGATCAGGCGATGTATCAAGCGAAAAATGCCGGAAAAGGCCGTTATAGAATCTACCAGGCCTG
GTAG

Upstream 100 bases:

>100_bases
TCTTTACATGGGCCGTTTTTTTTTCAATAATCTCATTTACTTACAAAAAAATACTTATCAATGGTGATATGCTTTTATCA
ATTTGCCAGGTTTGGAAGAT

Downstream 100 bases:

>100_bases
ATTTTAACCTTTTGTCGGCAGCTTTAATGAAACACTTTACGACTTGTCAGATGTCTTTTTAGCCGGCGTTTTACGTGTTG
TTTTTTTAGCTGGCGCTTTC

Product: diguanylate cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MKTGNSSSFRYFSAFFLIVFGFLFMASQYPIAPITEVDINWNLYFQIAIALFFLFAFIGYKRFQKLNQDTLRQAEEAKQK
LRTLKRQHELEKKRLSFVLDCGRLAYWEWDIKNNQAYFSNLWQDMIGFTEHDFPQDLHAWQARIHPLDQEQVQKKLLKLL
SHQITDYEDTHRVMDVNGDYIWVYDRGQTVTNELGNVEKLSCVRLNITQQKQLEEELTLDKILLENTQEAIAITNENLSF
IRTNPAFHDAFGLTQSDLAKMTLKDLLDNLQDEPPQDILSQVDKDLAWRGELTLHHTNGELARSSLVDCQKVIHQTTQTT
HYALVYTDITELKQTQQELSFLANTDIVTGLPNRNYFYQALEEWLEAFKDSGNKFTLMFLDLDNFKTVNDTLGHDTGDHL
LKSVSELIAEHIAEDTLFARVGGDEFVILCRAYTTPEQLNEIGQNLNQLLSQPFNIGDHEIKIGSSIGIALFPDHGSDKE
TLLKHADQAMYQAKNAGKGRYRIYQAW

Sequences:

>Translated_507_residues
MKTGNSSSFRYFSAFFLIVFGFLFMASQYPIAPITEVDINWNLYFQIAIALFFLFAFIGYKRFQKLNQDTLRQAEEAKQK
LRTLKRQHELEKKRLSFVLDCGRLAYWEWDIKNNQAYFSNLWQDMIGFTEHDFPQDLHAWQARIHPLDQEQVQKKLLKLL
SHQITDYEDTHRVMDVNGDYIWVYDRGQTVTNELGNVEKLSCVRLNITQQKQLEEELTLDKILLENTQEAIAITNENLSF
IRTNPAFHDAFGLTQSDLAKMTLKDLLDNLQDEPPQDILSQVDKDLAWRGELTLHHTNGELARSSLVDCQKVIHQTTQTT
HYALVYTDITELKQTQQELSFLANTDIVTGLPNRNYFYQALEEWLEAFKDSGNKFTLMFLDLDNFKTVNDTLGHDTGDHL
LKSVSELIAEHIAEDTLFARVGGDEFVILCRAYTTPEQLNEIGQNLNQLLSQPFNIGDHEIKIGSSIGIALFPDHGSDKE
TLLKHADQAMYQAKNAGKGRYRIYQAW
>Mature_507_residues
MKTGNSSSFRYFSAFFLIVFGFLFMASQYPIAPITEVDINWNLYFQIAIALFFLFAFIGYKRFQKLNQDTLRQAEEAKQK
LRTLKRQHELEKKRLSFVLDCGRLAYWEWDIKNNQAYFSNLWQDMIGFTEHDFPQDLHAWQARIHPLDQEQVQKKLLKLL
SHQITDYEDTHRVMDVNGDYIWVYDRGQTVTNELGNVEKLSCVRLNITQQKQLEEELTLDKILLENTQEAIAITNENLSF
IRTNPAFHDAFGLTQSDLAKMTLKDLLDNLQDEPPQDILSQVDKDLAWRGELTLHHTNGELARSSLVDCQKVIHQTTQTT
HYALVYTDITELKQTQQELSFLANTDIVTGLPNRNYFYQALEEWLEAFKDSGNKFTLMFLDLDNFKTVNDTLGHDTGDHL
LKSVSELIAEHIAEDTLFARVGGDEFVILCRAYTTPEQLNEIGQNLNQLLSQPFNIGDHEIKIGSSIGIALFPDHGSDKE
TLLKHADQAMYQAKNAGKGRYRIYQAW

Specific function: Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG, csgBAC/ymaD and adrA (yaic). Activity of this protein is antag

COG id: COG2199

COG function: function code T; FOG: GGDEF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=196, Percent_Identity=40.8163265306122, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1788381, Length=440, Percent_Identity=25.6818181818182, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI145693134, Length=180, Percent_Identity=30.5555555555556, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1787262, Length=170, Percent_Identity=31.7647058823529, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788956, Length=151, Percent_Identity=35.7615894039735, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081977, Length=167, Percent_Identity=29.940119760479, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786584, Length=183, Percent_Identity=26.775956284153, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787816, Length=164, Percent_Identity=31.0975609756098, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87081881, Length=182, Percent_Identity=30.2197802197802, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI87082007, Length=175, Percent_Identity=27.4285714285714, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787802, Length=181, Percent_Identity=25.9668508287293, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87081921, Length=170, Percent_Identity=28.8235294117647, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788085, Length=185, Percent_Identity=27.027027027027, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081974, Length=156, Percent_Identity=28.8461538461538, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR000014
- InterPro:   IPR013767 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF00989 PAS [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 58685; Mature: 58685

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50113 PAC ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTGNSSSFRYFSAFFLIVFGFLFMASQYPIAPITEVDINWNLYFQIAIALFFLFAFIGY
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
KRFQKLNQDTLRQAEEAKQKLRTLKRQHELEKKRLSFVLDCGRLAYWEWDIKNNQAYFSN
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHH
LWQDMIGFTEHDFPQDLHAWQARIHPLDQEQVQKKLLKLLSHQITDYEDTHRVMDVNGDY
HHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCE
IWVYDRGQTVTNELGNVEKLSCVRLNITQQKQLEEELTLDKILLENTQEAIAITNENLSF
EEEEECCCHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEE
IRTNPAFHDAFGLTQSDLAKMTLKDLLDNLQDEPPQDILSQVDKDLAWRGELTLHHTNGE
EECCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCEEEEECCCH
LARSSLVDCQKVIHQTTQTTHYALVYTDITELKQTQQELSFLANTDIVTGLPNRNYFYQA
HHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHH
LEEWLEAFKDSGNKFTLMFLDLDNFKTVNDTLGHDTGDHLLKSVSELIAEHIAEDTLFAR
HHHHHHHHHCCCCEEEEEEEECCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEE
VGGDEFVILCRAYTTPEQLNEIGQNLNQLLSQPFNIGDHEIKIGSSIGIALFPDHGSDKE
ECCCEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCCCHH
TLLKHADQAMYQAKNAGKGRYRIYQAW
HHHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure
MKTGNSSSFRYFSAFFLIVFGFLFMASQYPIAPITEVDINWNLYFQIAIALFFLFAFIGY
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
KRFQKLNQDTLRQAEEAKQKLRTLKRQHELEKKRLSFVLDCGRLAYWEWDIKNNQAYFSN
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHH
LWQDMIGFTEHDFPQDLHAWQARIHPLDQEQVQKKLLKLLSHQITDYEDTHRVMDVNGDY
HHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCE
IWVYDRGQTVTNELGNVEKLSCVRLNITQQKQLEEELTLDKILLENTQEAIAITNENLSF
EEEEECCCHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEE
IRTNPAFHDAFGLTQSDLAKMTLKDLLDNLQDEPPQDILSQVDKDLAWRGELTLHHTNGE
EECCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCEEEEECCCH
LARSSLVDCQKVIHQTTQTTHYALVYTDITELKQTQQELSFLANTDIVTGLPNRNYFYQA
HHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHH
LEEWLEAFKDSGNKFTLMFLDLDNFKTVNDTLGHDTGDHLLKSVSELIAEHIAEDTLFAR
HHHHHHHHHCCCCEEEEEEEECCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEE
VGGDEFVILCRAYTTPEQLNEIGQNLNQLLSQPFNIGDHEIKIGSSIGIALFPDHGSDKE
ECCCEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCCCHH
TLLKHADQAMYQAKNAGKGRYRIYQAW
HHHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]