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The map label for this gene is hemF [H]

Identifier: 78484363

GI number: 78484363

Start: 20832

End: 21803

Strand: Reverse

Name: hemF [H]

Synonym: Tcr_0017

Alternate gene names: 78484363

Gene position: 21803-20832 (Counterclockwise)

Preceding gene: 78484365

Following gene: 78484362

Centisome position: 0.9

GC content: 46.6

Gene sequence:

>972_bases
ATGTTTGACCATACACAAGATGCCGTTAATGTTGAAAAAGTAAAAGAGTATTTACTCGGGTTGCAGGATGATATCTGTCA
GCAACTTGCCGAAGAAGATGGTTCAAATGACTTCATTGTTGATGCATGGGACAGAGAGCCGGATGAAGGGGTTATGGGAT
TGACGGGCGGAGGCCGAAGCCGAGTGCTTGAAGGCGGTGAGATCATTGAAAAAGGCGGGGTGAATTTTTCGCATGTCCGA
GGCAAGACCTTACCGGCTTCCGCGACGGCACACCGCCCTGAACTGGCGGGCCGCTCTTTTCAAGCACTGGGTGTTTCGTT
GGTGATTCACCCCCGTAATCCTTATGTACCGACGTCGCATGCTAATGTACGCTTGTTTATTGCCGAAAAAGAAGGTGAAG
CGCCCGTCTGGTGGTTTGGTGGCGGATTTGATTTAACGCCTTATTACCCTTTTGATCAGGATATTCTTCATTGGCATCTG
ACTTCAAAAGAAGCTTGCGATCCTTTTGGAACGGACGTGTATGCTAAATATAAAGAGTGGTGTGACGAGTATTTCTTTTT
GAAACACCGGAATGAAACCCGCGGTGTGGGCGGTTTATTTTACGATGATTTAAATGAAAGTACCTTTGGTTGGGATTTCG
ATAAGTGCTTTGCCTTTATGCAGTCGGTCGGCGACCATTTTATCAAAGCCTATCGTCCCATCGTTGCACGCCGTAAAAAT
ATGGATTATGGCGAACGCCAAAGAGATTTTCAGTTATATCGACGTGGGCGTTATGCGGAGTTTAATCTGGCTTTTGACCG
AGGCACGATATTTGGTCTGCAAACGGGTGGACGCACGGAATCGATTTTAATGTCGATGCCGCCTTTAGCAACCTGGAAAT
ACGATTACCATCCAGAGCCGGGTACAGAAGAAGCTAAAGTGTATGATTATCTTTCGCCTAGGGATTGGTTAGCTGACTTC
AACGATCGTTAA

Upstream 100 bases:

>100_bases
TTAAAGGACATGGCGTTTCTCTCAGATATGATCGGAATATTTTAAAGAAGTTATAAGGGTTTTTCTATAAAATACAAGCT
AAATAAACCAAGGAAATTCT

Downstream 100 bases:

>100_bases
ACAGGACAGATTGATGGATAGAGTCCGTATCGATAAATGGTTATGGGCCGCGCGATTTTTTAAAACCCGCGGTGTGGCAC
TGGATGCTGTGAAAGGTGGA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MFDHTQDAVNVEKVKEYLLGLQDDICQQLAEEDGSNDFIVDAWDREPDEGVMGLTGGGRSRVLEGGEIIEKGGVNFSHVR
GKTLPASATAHRPELAGRSFQALGVSLVIHPRNPYVPTSHANVRLFIAEKEGEAPVWWFGGGFDLTPYYPFDQDILHWHL
TSKEACDPFGTDVYAKYKEWCDEYFFLKHRNETRGVGGLFYDDLNESTFGWDFDKCFAFMQSVGDHFIKAYRPIVARRKN
MDYGERQRDFQLYRRGRYAEFNLAFDRGTIFGLQTGGRTESILMSMPPLATWKYDYHPEPGTEEAKVYDYLSPRDWLADF
NDR

Sequences:

>Translated_323_residues
MFDHTQDAVNVEKVKEYLLGLQDDICQQLAEEDGSNDFIVDAWDREPDEGVMGLTGGGRSRVLEGGEIIEKGGVNFSHVR
GKTLPASATAHRPELAGRSFQALGVSLVIHPRNPYVPTSHANVRLFIAEKEGEAPVWWFGGGFDLTPYYPFDQDILHWHL
TSKEACDPFGTDVYAKYKEWCDEYFFLKHRNETRGVGGLFYDDLNESTFGWDFDKCFAFMQSVGDHFIKAYRPIVARRKN
MDYGERQRDFQLYRRGRYAEFNLAFDRGTIFGLQTGGRTESILMSMPPLATWKYDYHPEPGTEEAKVYDYLSPRDWLADF
NDR
>Mature_323_residues
MFDHTQDAVNVEKVKEYLLGLQDDICQQLAEEDGSNDFIVDAWDREPDEGVMGLTGGGRSRVLEGGEIIEKGGVNFSHVR
GKTLPASATAHRPELAGRSFQALGVSLVIHPRNPYVPTSHANVRLFIAEKEGEAPVWWFGGGFDLTPYYPFDQDILHWHL
TSKEACDPFGTDVYAKYKEWCDEYFFLKHRNETRGVGGLFYDDLNESTFGWDFDKCFAFMQSVGDHFIKAYRPIVARRKN
MDYGERQRDFQLYRRGRYAEFNLAFDRGTIFGLQTGGRTESILMSMPPLATWKYDYHPEPGTEEAKVYDYLSPRDWLADF
NDR

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=314, Percent_Identity=43.312101910828, Blast_Score=250, Evalue=1e-66,
Organism=Escherichia coli, GI1788777, Length=308, Percent_Identity=65.5844155844156, Blast_Score=430, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6320249, Length=334, Percent_Identity=41.3173652694611, Blast_Score=244, Evalue=1e-65,
Organism=Drosophila melanogaster, GI17864388, Length=309, Percent_Identity=45.9546925566343, Blast_Score=260, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 37111; Mature: 37111

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDHTQDAVNVEKVKEYLLGLQDDICQQLAEEDGSNDFIVDAWDREPDEGVMGLTGGGRS
CCCCCCHHCCHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEECCCCHH
RVLEGGEIIEKGGVNFSHVRGKTLPASATAHRPELAGRSFQALGVSLVIHPRNPYVPTSH
HEECCCHHHHHCCCCEECCCCCCCCCCCCCCCCHHCCCCEEEEEEEEEEECCCCCCCCCC
ANVRLFIAEKEGEAPVWWFGGGFDLTPYYPFDQDILHWHLTSKEACDPFGTDVYAKYKEW
CCEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHH
CDEYFFLKHRNETRGVGGLFYDDLNESTFGWDFDKCFAFMQSVGDHFIKAYRPIVARRKN
HHHHEEEECCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MDYGERQRDFQLYRRGRYAEFNLAFDRGTIFGLQTGGRTESILMSMPPLATWKYDYHPEP
CCCCHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCCCCCEEEEECCCCEEEEECCCCCC
GTEEAKVYDYLSPRDWLADFNDR
CCCCCEEEECCCCHHHHCCCCCC
>Mature Secondary Structure
MFDHTQDAVNVEKVKEYLLGLQDDICQQLAEEDGSNDFIVDAWDREPDEGVMGLTGGGRS
CCCCCCHHCCHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEECCCCHH
RVLEGGEIIEKGGVNFSHVRGKTLPASATAHRPELAGRSFQALGVSLVIHPRNPYVPTSH
HEECCCHHHHHCCCCEECCCCCCCCCCCCCCCCHHCCCCEEEEEEEEEEECCCCCCCCCC
ANVRLFIAEKEGEAPVWWFGGGFDLTPYYPFDQDILHWHLTSKEACDPFGTDVYAKYKEW
CCEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHH
CDEYFFLKHRNETRGVGGLFYDDLNESTFGWDFDKCFAFMQSVGDHFIKAYRPIVARRKN
HHHHEEEECCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MDYGERQRDFQLYRRGRYAEFNLAFDRGTIFGLQTGGRTESILMSMPPLATWKYDYHPEP
CCCCHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCCCCCEEEEECCCCEEEEECCCCCC
GTEEAKVYDYLSPRDWLADFNDR
CCCCCEEEECCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA