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The map label for this gene is 78358720

Identifier: 78358720

GI number: 78358720

Start: 3642341

End: 3643375

Strand: Reverse

Name: 78358720

Synonym: Dde_3681

Alternate gene names: NA

Gene position: 3643375-3642341 (Counterclockwise)

Preceding gene: 78358721

Following gene: 78358719

Centisome position: 97.67

GC content: 60.77

Gene sequence:

>1035_bases
GTGAGTTATTTCATATCTGATAAAAACCCCGTGTTTGTGATAGCCGAAATCGGCGGCAACCACGAAGGCGATTTCGCCTA
CGCCAGAAAGCTTGTCTCGCTGGCCATTGAATCCGGCGCTGATGCCGTGAAGCTGCAGGTGTACGCCGGTGATGCTCTGG
TCAGCCGCGTTGAAAGTCCTGACCGCAACCGGCATTTTAAAAAATTTGAATTGAGCCGCGGGCAGTACGAGGCGCTTATC
GACATGTGCCGCCATGCGGGGGTGCAGTTCATGGCCTCGGCATGGGACAGGGAACGGCTGGGCTGGATAGAACCGCATGT
GCGTATTCACAAGGCTGGTTCCGGCGACCTCACCGCCTACCCCATGCTGCGGGCACTGGTGTCCACGGGTAAGCCGCTGG
TTCTGTCCACGGGGCTGTCCACCATGCCGGAAGTGGAAGCCGCGGTGCGGTATATCGGCAGTCTGGATTCCTCCTATATC
ACGCAGGGCAAACTGGCGTTGCTGCAGTGTTCCTCGGCATACCCCTGTCCGGACGGCGACGCCAACCTGAATGTCATGCA
TTCGCTGCGTCAGGCATTCGGCCTGCCGGTGGGCTATTCCGACCACACCACGGACAGCGAGGCGGCCTATGCCGCTGCCG
TCATGGGTGCGCAGATACTCGAGCTGCATTTTACGGATACGCGGGAAGGAAAAAGTTTCCGCGACCATCTTGTTTCAATC
ACGCGGGACGAACTGCGCGACCTGCTGAAACGCATCCGCAGGGCGCGCACGCTGCAGGGCAGCTGGGTCAAGCAGCCCAC
GGACACAGAAAAGGCGCAGGGACATGTGACATCGTTCCGGCGTTCCGTGTACGCGGCGCAGGATATAGCCGCCGGACAGC
TGTTTACTGAAGACAACCTGACAGTGCTGCGGCCCGCGCACGGCGTGTGCGCCACCCGCTACGAGGATTTTCTGGGGCGC
AGGGCGCCGCGCAGCATGGGAGCGCACGAGGTGCTTACGGCTGCCGATCTGCAGGCCGTGCTGGAACAGGAGTGA

Upstream 100 bases:

>100_bases
ACCACGGCCGGTGTCCGCAACCGCGGCAGGGCGTCAGATGCGGGCTGCCGCGAGATGACGGTTTTGAACAGCAAAATTGA
ACGCACATGGTGAAAAAGCT

Downstream 100 bases:

>100_bases
TCATGATGTCTTCAGAGATGCAGCCCCCGCAGCACGGCCCGGATGAAAGACGTTTTCAGAGCCGCGTGCGCACGGCGGCG
TCCGGCGGGCTGTGGCACGA

Product: N-acetylneuraminate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MSYFISDKNPVFVIAEIGGNHEGDFAYARKLVSLAIESGADAVKLQVYAGDALVSRVESPDRNRHFKKFELSRGQYEALI
DMCRHAGVQFMASAWDRERLGWIEPHVRIHKAGSGDLTAYPMLRALVSTGKPLVLSTGLSTMPEVEAAVRYIGSLDSSYI
TQGKLALLQCSSAYPCPDGDANLNVMHSLRQAFGLPVGYSDHTTDSEAAYAAAVMGAQILELHFTDTREGKSFRDHLVSI
TRDELRDLLKRIRRARTLQGSWVKQPTDTEKAQGHVTSFRRSVYAAQDIAAGQLFTEDNLTVLRPAHGVCATRYEDFLGR
RAPRSMGAHEVLTAADLQAVLEQE

Sequences:

>Translated_344_residues
MSYFISDKNPVFVIAEIGGNHEGDFAYARKLVSLAIESGADAVKLQVYAGDALVSRVESPDRNRHFKKFELSRGQYEALI
DMCRHAGVQFMASAWDRERLGWIEPHVRIHKAGSGDLTAYPMLRALVSTGKPLVLSTGLSTMPEVEAAVRYIGSLDSSYI
TQGKLALLQCSSAYPCPDGDANLNVMHSLRQAFGLPVGYSDHTTDSEAAYAAAVMGAQILELHFTDTREGKSFRDHLVSI
TRDELRDLLKRIRRARTLQGSWVKQPTDTEKAQGHVTSFRRSVYAAQDIAAGQLFTEDNLTVLRPAHGVCATRYEDFLGR
RAPRSMGAHEVLTAADLQAVLEQE
>Mature_343_residues
SYFISDKNPVFVIAEIGGNHEGDFAYARKLVSLAIESGADAVKLQVYAGDALVSRVESPDRNRHFKKFELSRGQYEALID
MCRHAGVQFMASAWDRERLGWIEPHVRIHKAGSGDLTAYPMLRALVSTGKPLVLSTGLSTMPEVEAAVRYIGSLDSSYIT
QGKLALLQCSSAYPCPDGDANLNVMHSLRQAFGLPVGYSDHTTDSEAAYAAAVMGAQILELHFTDTREGKSFRDHLVSIT
RDELRDLLKRIRRARTLQGSWVKQPTDTEKAQGHVTSFRRSVYAAQDIAAGQLFTEDNLTVLRPAHGVCATRYEDFLGRR
APRSMGAHEVLTAADLQAVLEQE

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=312, Percent_Identity=31.7307692307692, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI21357081, Length=359, Percent_Identity=29.5264623955432, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 37973; Mature: 37842

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50844 AFP_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYFISDKNPVFVIAEIGGNHEGDFAYARKLVSLAIESGADAVKLQVYAGDALVSRVESP
CCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECHHHHHHHCCC
DRNRHFKKFELSRGQYEALIDMCRHAGVQFMASAWDRERLGWIEPHVRIHKAGSGDLTAY
CCCCCCHHHHCCCCHHHHHHHHHHHCCHHHHHHHHCHHHCCCCCCCEEEEECCCCCCHHH
PMLRALVSTGKPLVLSTGLSTMPEVEAAVRYIGSLDSSYITQGKLALLQCSSAYPCPDGD
HHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCHHHHCCCCEEEEEECCCCCCCCCC
ANLNVMHSLRQAFGLPVGYSDHTTDSEAAYAAAVMGAQILELHFTDTREGKSFRDHLVSI
CCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHH
TRDELRDLLKRIRRARTLQGSWVKQPTDTEKAQGHVTSFRRSVYAAQDIAAGQLFTEDNL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCE
TVLRPAHGVCATRYEDFLGRRAPRSMGAHEVLTAADLQAVLEQE
EEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYFISDKNPVFVIAEIGGNHEGDFAYARKLVSLAIESGADAVKLQVYAGDALVSRVESP
CEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECHHHHHHHCCC
DRNRHFKKFELSRGQYEALIDMCRHAGVQFMASAWDRERLGWIEPHVRIHKAGSGDLTAY
CCCCCCHHHHCCCCHHHHHHHHHHHCCHHHHHHHHCHHHCCCCCCCEEEEECCCCCCHHH
PMLRALVSTGKPLVLSTGLSTMPEVEAAVRYIGSLDSSYITQGKLALLQCSSAYPCPDGD
HHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCHHHHCCCCEEEEEECCCCCCCCCC
ANLNVMHSLRQAFGLPVGYSDHTTDSEAAYAAAVMGAQILELHFTDTREGKSFRDHLVSI
CCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHH
TRDELRDLLKRIRRARTLQGSWVKQPTDTEKAQGHVTSFRRSVYAAQDIAAGQLFTEDNL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCE
TVLRPAHGVCATRYEDFLGRRAPRSMGAHEVLTAADLQAVLEQE
EEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]