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The map label for this gene is zwf [H]

Identifier: 78358510

GI number: 78358510

Start: 3432204

End: 3433745

Strand: Direct

Name: zwf [H]

Synonym: Dde_3471

Alternate gene names: 78358510

Gene position: 3432204-3433745 (Clockwise)

Preceding gene: 78358509

Following gene: 78358512

Centisome position: 92.01

GC content: 60.89

Gene sequence:

>1542_bases
ATGAGTCCCGCAGACACCCGCGTGACCATAGGCAGAGCCATGTGCGAGGAAACACCGCCGGAACCGTGCGGTATGGTCAT
ATTCGGCGCATCCGGCGATCTGGTGGCGCGCAAACTGCTGCCGGCGCTGTTCGGGCTGTTCCGCCGCGGGCTGCTGCCCG
AACGCTTTTTCATGCTGGGTTTTGCCCGCACCCCCATGACGGATGACGACTTCCGCGGCAGAGTAAGCGAATCCATCCTT
GCCGCGCACCCGCAGGGCGCCGGCCAGCTGGACGATTTTCTGGCGCTGTGCCGTTACACCTACGGCGACTACGACGACCC
CGCGGCCTATACCAACCTTGCGCTGTGTTCTTCGGAATGCGTCATGGACTACCACGCCGCGGAAAACCTGCTGTTTTATC
TGGCTCTGCCGCCGCACCTGCACGCCGGAGTGGTGCGTCATCTGCACGGCGCCGGTCTTACGGCGGAAGGTGAAAACGGC
AGCCCGTGGCGCAGAGTTGTTTTTGAAAAACCCTTCGGTCACGATCTTGCCTCGGCGCTGGAACTTGACAGCAGGCTGTG
CTCCGTGCTGCGGCAGGAACAGATTTTCCGCATGGACCACTATCTGGGCAAGGAAACAGTGCAGTCCATACTGATGTTCC
GCTTTGCCAATGCCATTTTCGAACCGCTGTGGAACAGGGGCTATGTGGACCATGTACAGATAACCGTGGCCGAATCGCTG
GGCATAGAACACAGGGGGGCATACTACGACAGTGCCGGCTGTCTGCGTGACATGTTCCAGAACCATATGATGCAGATGCT
GGCGCTGGTGGCCATGGAACCGCCCACAAGTTTCGACCCGGAACGGGTACGCGACGAGCGGGTCAAACTGCTGCACTCCA
TCCGGCCGTGGACAGCGGACGACATGCGCCACTGGGTCGTGCGCGGCCAGTATACACAGGGAGTTACCGCCGAAGGCGCA
TCGCTGGCAGGTTACCGCCACGAACCCCGTGTGGCCGAAGGCAGCACCACGGAAACCTATGTGGCAGCGCGGCTTTTCAT
CGACAACTGGCGCTGGCAGGGCGTTCCTTTTTTTCTGCGCAGCGGCAAACGCATGCCCCGCAAGGTCAGCGAAATTGCCG
TCACCTTCCGGCGGGTGCCCCACTCCATGTTCGGCATGCACTCAAAATCCGAAATGCCGGCCAATGTACTGGTACTCAAA
ATCCAGCCGGAAGAAGGCATCGACCTGCATATTCAGGCCAAGCAGCCCGGCCCGAAATCATGCATGGCAACCATGGCTCT
GGCATTCAAGTACAGAGAAATTTTCGGCATCAACCCTCCGGACGCCTACGAGCGGCTTTTGCTGGACTGCATGCTGGGCG
ACAGGACCCTGTTCTGGAGCCGCGAAGGTGTGGAAGCTTCGTGGCGGCTGATAACCCCGGTGCTGGATACATGGTGCGAC
AACCCGCAGACTTCGCCGCTGCATCAGTACACAGCCGGCACATGGGGGCCGGAAGCCGCGCAGCGGATGATCAGTGCCGC
AGGGCGTCAGTGGCGGCGCTGA

Upstream 100 bases:

>100_bases
AATCACGGCAGGACGATCTGTTTTCCAACAAGGTGCTGGCCGCCCTGCGCAACGAATTCGGCGGGCATGCGGTAAAAAAC
ACTGACGAAGGGGATGCCTC

Downstream 100 bases:

>100_bases
AAAAATGACAAAAACCGCCCGCGCATCATGCGCGGGCGGCCGGAATTCATCCGTATACGCGGCTACTCAGGCGCCGCAGC
CGCAGCAGGGCTGCGGGGGG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MSPADTRVTIGRAMCEETPPEPCGMVIFGASGDLVARKLLPALFGLFRRGLLPERFFMLGFARTPMTDDDFRGRVSESIL
AAHPQGAGQLDDFLALCRYTYGDYDDPAAYTNLALCSSECVMDYHAAENLLFYLALPPHLHAGVVRHLHGAGLTAEGENG
SPWRRVVFEKPFGHDLASALELDSRLCSVLRQEQIFRMDHYLGKETVQSILMFRFANAIFEPLWNRGYVDHVQITVAESL
GIEHRGAYYDSAGCLRDMFQNHMMQMLALVAMEPPTSFDPERVRDERVKLLHSIRPWTADDMRHWVVRGQYTQGVTAEGA
SLAGYRHEPRVAEGSTTETYVAARLFIDNWRWQGVPFFLRSGKRMPRKVSEIAVTFRRVPHSMFGMHSKSEMPANVLVLK
IQPEEGIDLHIQAKQPGPKSCMATMALAFKYREIFGINPPDAYERLLLDCMLGDRTLFWSREGVEASWRLITPVLDTWCD
NPQTSPLHQYTAGTWGPEAAQRMISAAGRQWRR

Sequences:

>Translated_513_residues
MSPADTRVTIGRAMCEETPPEPCGMVIFGASGDLVARKLLPALFGLFRRGLLPERFFMLGFARTPMTDDDFRGRVSESIL
AAHPQGAGQLDDFLALCRYTYGDYDDPAAYTNLALCSSECVMDYHAAENLLFYLALPPHLHAGVVRHLHGAGLTAEGENG
SPWRRVVFEKPFGHDLASALELDSRLCSVLRQEQIFRMDHYLGKETVQSILMFRFANAIFEPLWNRGYVDHVQITVAESL
GIEHRGAYYDSAGCLRDMFQNHMMQMLALVAMEPPTSFDPERVRDERVKLLHSIRPWTADDMRHWVVRGQYTQGVTAEGA
SLAGYRHEPRVAEGSTTETYVAARLFIDNWRWQGVPFFLRSGKRMPRKVSEIAVTFRRVPHSMFGMHSKSEMPANVLVLK
IQPEEGIDLHIQAKQPGPKSCMATMALAFKYREIFGINPPDAYERLLLDCMLGDRTLFWSREGVEASWRLITPVLDTWCD
NPQTSPLHQYTAGTWGPEAAQRMISAAGRQWRR
>Mature_512_residues
SPADTRVTIGRAMCEETPPEPCGMVIFGASGDLVARKLLPALFGLFRRGLLPERFFMLGFARTPMTDDDFRGRVSESILA
AHPQGAGQLDDFLALCRYTYGDYDDPAAYTNLALCSSECVMDYHAAENLLFYLALPPHLHAGVVRHLHGAGLTAEGENGS
PWRRVVFEKPFGHDLASALELDSRLCSVLRQEQIFRMDHYLGKETVQSILMFRFANAIFEPLWNRGYVDHVQITVAESLG
IEHRGAYYDSAGCLRDMFQNHMMQMLALVAMEPPTSFDPERVRDERVKLLHSIRPWTADDMRHWVVRGQYTQGVTAEGAS
LAGYRHEPRVAEGSTTETYVAARLFIDNWRWQGVPFFLRSGKRMPRKVSEIAVTFRRVPHSMFGMHSKSEMPANVLVLKI
QPEEGIDLHIQAKQPGPKSCMATMALAFKYREIFGINPPDAYERLLLDCMLGDRTLFWSREGVEASWRLITPVLDTWCDN
PQTSPLHQYTAGTWGPEAAQRMISAAGRQWRR

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=492, Percent_Identity=39.0243902439024, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI109389365, Length=492, Percent_Identity=39.0243902439024, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI52145310, Length=493, Percent_Identity=29.0060851926978, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1788158, Length=504, Percent_Identity=39.0873015873016, Blast_Score=354, Evalue=9e-99,
Organism=Caenorhabditis elegans, GI17538218, Length=505, Percent_Identity=36.2376237623762, Blast_Score=327, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6324088, Length=490, Percent_Identity=35.3061224489796, Blast_Score=305, Evalue=9e-84,
Organism=Drosophila melanogaster, GI24643350, Length=486, Percent_Identity=36.8312757201646, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24643352, Length=486, Percent_Identity=36.8312757201646, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI221513548, Length=493, Percent_Identity=31.0344827586207, Blast_Score=229, Evalue=4e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 58062; Mature: 57931

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPADTRVTIGRAMCEETPPEPCGMVIFGASGDLVARKLLPALFGLFRRGLLPERFFMLG
CCCCCCEEHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
FARTPMTDDDFRGRVSESILAAHPQGAGQLDDFLALCRYTYGDYDDPAAYTNLALCSSEC
HCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VMDYHAAENLLFYLALPPHLHAGVVRHLHGAGLTAEGENGSPWRRVVFEKPFGHDLASAL
HHHHHHHCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHEEECCCCCHHHHHHH
ELDSRLCSVLRQEQIFRMDHYLGKETVQSILMFRFANAIFEPLWNRGYVDHVQITVAESL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHC
GIEHRGAYYDSAGCLRDMFQNHMMQMLALVAMEPPTSFDPERVRDERVKLLHSIRPWTAD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHH
DMRHWVVRGQYTQGVTAEGASLAGYRHEPRVAEGSTTETYVAARLFIDNWRWQGVPFFLR
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHH
SGKRMPRKVSEIAVTFRRVPHSMFGMHSKSEMPANVLVLKIQPEEGIDLHIQAKQPGPKS
CCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCHHH
CMATMALAFKYREIFGINPPDAYERLLLDCMLGDRTLFWSREGVEASWRLITPVLDTWCD
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCC
NPQTSPLHQYTAGTWGPEAAQRMISAAGRQWRR
CCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SPADTRVTIGRAMCEETPPEPCGMVIFGASGDLVARKLLPALFGLFRRGLLPERFFMLG
CCCCCEEHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
FARTPMTDDDFRGRVSESILAAHPQGAGQLDDFLALCRYTYGDYDDPAAYTNLALCSSEC
HCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VMDYHAAENLLFYLALPPHLHAGVVRHLHGAGLTAEGENGSPWRRVVFEKPFGHDLASAL
HHHHHHHCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHEEECCCCCHHHHHHH
ELDSRLCSVLRQEQIFRMDHYLGKETVQSILMFRFANAIFEPLWNRGYVDHVQITVAESL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHC
GIEHRGAYYDSAGCLRDMFQNHMMQMLALVAMEPPTSFDPERVRDERVKLLHSIRPWTAD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHH
DMRHWVVRGQYTQGVTAEGASLAGYRHEPRVAEGSTTETYVAARLFIDNWRWQGVPFFLR
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHH
SGKRMPRKVSEIAVTFRRVPHSMFGMHSKSEMPANVLVLKIQPEEGIDLHIQAKQPGPKS
CCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCHHH
CMATMALAFKYREIFGINPPDAYERLLLDCMLGDRTLFWSREGVEASWRLITPVLDTWCD
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCC
NPQTSPLHQYTAGTWGPEAAQRMISAAGRQWRR
CCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]