Click here to switch to the map view.

The map label for this gene is yqeC [H]

Identifier: 78358509

GI number: 78358509

Start: 3431290

End: 3432207

Strand: Direct

Name: yqeC [H]

Synonym: Dde_3470

Alternate gene names: 78358509

Gene position: 3431290-3432207 (Clockwise)

Preceding gene: 78358504

Following gene: 78358510

Centisome position: 91.99

GC content: 62.75

Gene sequence:

>918_bases
ATGCAGATAGCCATCATAGGACTGGGCAGAATGGGCATGAACATGGCCCGGCGCCTGCTGCGCGGAGGACACGAGGTTGC
CGTATGGAACCGCAGCCCTGCCAAAACACAGGTAATGGAGGCCGAAGGTGCCGCCGGATTCACCAGCCTGCAGGCACTGG
CCGCCAGTCTTGCCCCGCCGCGTACGCTGTGGTTCATGCTGCCCGCCGGAGAGGCCACGCAACAGCGCATGGACGAAGTA
CTGCCGTTTCTGCAGCCCGGCGATGTGGTAGTGGACGGTGCCAATGCCTACTGGAAGGACGACCGGCCCCGTGCCGACAG
GCTGGCCGCACACGGCATACGGTATGTGGACGCAGGAGTTTCCGGCGGCATATGGGGACTGGAAAACGGATACTGCACCA
TGCTGGGGGGTGAAGCGGCTGATATCCGGCATCTGGCGCCGGTACTGGATACGCTGGCCCCGCCGCAGGGCTGGATGCAT
TGCGGCCCGGCCGGAGCCGGACACTTTGTCAAAATGGTCCATAACGGCATTGAATACGCCATGATGGAGTCATACGGCGA
AGGGTTTGACCTGCTGCGCAACGGCCCGTTCAGCGGGCTGGACCTGCAGGGTATCGCCGCCCTGTGGAACAGGGGCAGCG
TGGTACGCTCGTGGCTGCTGGAACTGCTGGATGCGGCGCTGAAAAAAGACCCCGGCCTTGCATCGCTGAAAGGATATGTG
GACGATTCCGGCGAGGGACGCTGGACAGTAACCGATGCCGTGGACCATGCGGTGCCGGTGCCGGTACTGGCACAGGCGCT
GTTCCGGCGGTTCGAATCACGGCAGGACGATCTGTTTTCCAACAAGGTGCTGGCCGCCCTGCGCAACGAATTCGGCGGGC
ATGCGGTAAAAAACACTGACGAAGGGGATGCCTCATGA

Upstream 100 bases:

>100_bases
CCGCGGCCGCGCCGATACGCTATGCTGGGGGCAAACCGCACCCGTGCGGCCCCGCGGCGGCAGCAATACGCCGCGGGTAC
AACACCAACGGAGCATACAC

Downstream 100 bases:

>100_bases
GTCCCGCAGACACCCGCGTGACCATAGGCAGAGCCATGTGCGAGGAAACACCGCCGGAACCGTGCGGTATGGTCATATTC
GGCGCATCCGGCGATCTGGT

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MQIAIIGLGRMGMNMARRLLRGGHEVAVWNRSPAKTQVMEAEGAAGFTSLQALAASLAPPRTLWFMLPAGEATQQRMDEV
LPFLQPGDVVVDGANAYWKDDRPRADRLAAHGIRYVDAGVSGGIWGLENGYCTMLGGEAADIRHLAPVLDTLAPPQGWMH
CGPAGAGHFVKMVHNGIEYAMMESYGEGFDLLRNGPFSGLDLQGIAALWNRGSVVRSWLLELLDAALKKDPGLASLKGYV
DDSGEGRWTVTDAVDHAVPVPVLAQALFRRFESRQDDLFSNKVLAALRNEFGGHAVKNTDEGDAS

Sequences:

>Translated_305_residues
MQIAIIGLGRMGMNMARRLLRGGHEVAVWNRSPAKTQVMEAEGAAGFTSLQALAASLAPPRTLWFMLPAGEATQQRMDEV
LPFLQPGDVVVDGANAYWKDDRPRADRLAAHGIRYVDAGVSGGIWGLENGYCTMLGGEAADIRHLAPVLDTLAPPQGWMH
CGPAGAGHFVKMVHNGIEYAMMESYGEGFDLLRNGPFSGLDLQGIAALWNRGSVVRSWLLELLDAALKKDPGLASLKGYV
DDSGEGRWTVTDAVDHAVPVPVLAQALFRRFESRQDDLFSNKVLAALRNEFGGHAVKNTDEGDAS
>Mature_305_residues
MQIAIIGLGRMGMNMARRLLRGGHEVAVWNRSPAKTQVMEAEGAAGFTSLQALAASLAPPRTLWFMLPAGEATQQRMDEV
LPFLQPGDVVVDGANAYWKDDRPRADRLAAHGIRYVDAGVSGGIWGLENGYCTMLGGEAADIRHLAPVLDTLAPPQGWMH
CGPAGAGHFVKMVHNGIEYAMMESYGEGFDLLRNGPFSGLDLQGIAALWNRGSVVRSWLLELLDAALKKDPGLASLKGYV
DDSGEGRWTVTDAVDHAVPVPVLAQALFRRFESRQDDLFSNKVLAALRNEFGGHAVKNTDEGDAS

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=293, Percent_Identity=33.4470989761092, Blast_Score=125, Evalue=4e-29,
Organism=Escherichia coli, GI1788341, Length=301, Percent_Identity=32.2259136212625, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI145693186, Length=195, Percent_Identity=26.1538461538462, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17542558, Length=290, Percent_Identity=32.4137931034483, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6321695, Length=290, Percent_Identity=33.448275862069, Blast_Score=156, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6321977, Length=301, Percent_Identity=32.5581395348837, Blast_Score=141, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24639279, Length=290, Percent_Identity=33.1034482758621, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24655230, Length=280, Percent_Identity=25, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19922568, Length=280, Percent_Identity=25, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 32907; Mature: 32907

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIAIIGLGRMGMNMARRLLRGGHEVAVWNRSPAKTQVMEAEGAAGFTSLQALAASLAPP
CEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCCHHHHHHHHHHCCCC
RTLWFMLPAGEATQQRMDEVLPFLQPGDVVVDGANAYWKDDRPRADRLAAHGIRYVDAGV
CEEEEEECCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHCCCEEEECCC
SGGIWGLENGYCTMLGGEAADIRHLAPVLDTLAPPQGWMHCGPAGAGHFVKMVHNGIEYA
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MMESYGEGFDLLRNGPFSGLDLQGIAALWNRGSVVRSWLLELLDAALKKDPGLASLKGYV
HHHHCCCCHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCC
DDSGEGRWTVTDAVDHAVPVPVLAQALFRRFESRQDDLFSNKVLAALRNEFGGHAVKNTD
CCCCCCCEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EGDAS
CCCCC
>Mature Secondary Structure
MQIAIIGLGRMGMNMARRLLRGGHEVAVWNRSPAKTQVMEAEGAAGFTSLQALAASLAPP
CEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCCHHHHHHHHHHCCCC
RTLWFMLPAGEATQQRMDEVLPFLQPGDVVVDGANAYWKDDRPRADRLAAHGIRYVDAGV
CEEEEEECCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHCCCEEEECCC
SGGIWGLENGYCTMLGGEAADIRHLAPVLDTLAPPQGWMHCGPAGAGHFVKMVHNGIEYA
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MMESYGEGFDLLRNGPFSGLDLQGIAALWNRGSVVRSWLLELLDAALKKDPGLASLKGYV
HHHHCCCCHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCC
DDSGEGRWTVTDAVDHAVPVPVLAQALFRRFESRQDDLFSNKVLAALRNEFGGHAVKNTD
CCCCCCCEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EGDAS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]