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The map label for this gene is moeA [C]

Identifier: 78358268

GI number: 78358268

Start: 3216964

End: 3218964

Strand: Direct

Name: moeA [C]

Synonym: Dde_3228

Alternate gene names: 78358268

Gene position: 3216964-3218964 (Clockwise)

Preceding gene: 78358267

Following gene: 78358269

Centisome position: 86.24

GC content: 63.02

Gene sequence:

>2001_bases
ATGTCTTCCTTCAAGCGCAATGTCTACCTGAAGACAGTTCCCATACCGCAGGCTGTGGAAACCGTACGCGGGGCGCTCGA
CCGCGAATCGCTCGTACGCACACAGCGCGTCGCCTCGCACGAGGCCGCGGGCAGGGTGACTGCCGAAGCCGTGTACGCCC
GTTTTTCCTCCCCCACATTTCACAGCGCAGCCATGGACGGTTTTGCCGTGCGCGCCGACGACACCTTTGCCGCGCGCGAA
GATGCGGCGGTGACGCTGCAGGTGCAGACCGCCCGGACCGGCGGGCCGCTGCAGGCCGGACACGCCGTGGCGGTCAACAC
GGGACACCCGCTGCCCGAAGGTGCCGATGCCGTTATCATGATTGAAAATGTGGTTGCCGCCCTGCCCGACAGCACCGCCC
CGCAAAGCATCTCCATAGAAGCACCCGCCTTTCCGTGGCAGCATGTACGCCGCATCGGTGAAGACATCGTGGCGACGGAA
CTGCTTTTTCCGCAGGGGCACACCCTGACCGCATACGACGTGGGCACGCTGCTTTCCGGCGGCATATGGGAAGTACGGGT
GTATGAACGCATCAGAGTCCGCATTATCCCCACCGGAGACGAAGTGCTGGACTTCACGGCACGTCCGGAACCCGGTCCCG
GGCAGGTCATTGAAAGCAATTCACAGGTGCTGGCCACTCTGGCGCGCGGCCTGGGCTGCGAAGTGGAAAGGGTGGCTCCG
GTGCCCGACGTTCCCGAAGTCATCCGGCAGGCGGTTACCGCTTCGCTGGACGACAACGTGCACCTGACGGTCATCTGTGC
CGGTTCGTCGGCAGGCAGCAAGGATTACACACGCGCCACCATTGCGGCACTGGGTGAAGTGCTGGTGCACGGCATAGCAG
CCATGCCCGGCAAACCTTCACTGCTGGGGCTGTGCAAGGGACGGCTGGTGGCAGGTGCACCGGGCTATCCTGTAAGCTCG
GTCATCTGTTTTGAAGAACTGCTCGCCCCGCTCATAGCCTGGCTGGGACGCGGCGAGGCACCCCGCCGCGAAAGCGTCAC
CGTGGAAATGACGCGCAAAGTCCCCTCCAAGCTGGGAGTGGAAGAATTTCTGCGCCTTTCCGTGGGACGCGTAGGATACA
AATACATGGCCACTCCGCTGGGACGCGGGGCAGGCTGCATCACCACGCTGTCGCGGGCACAGGCCGTCACACGCATACCC
GCCAACGCCGAAGGTCTCGAACAGGGGCAGTCCGTACCTGCCGAGCTTATGGTATCGCGCACGGCGCTGGAACGTACTCT
GGTATGTGTGGGCAGCCACGACAACACACTGGACGCGCTGGCCGATGAACTGATGGGACTGGACACCCCCTGCCGTCTCG
CCTCCAGCCATGTGGGCAGCATGGGCGGCATCATGGCGGTCAAAAACGGCTCGTGCCACATGGCCGGAGTGCATCTGTTC
GACCCCGATTCGGGCGACTACAATATGCCGTTCATTCGCAAATACCTGCCGGAAACACCCGCCGTACTGATCAATCTTGC
CATACGGCATCAGGGTTTCATCGTACCGGCGGGCAACCCCCACAACATCCGCGGCATAGAAGACGTGGCCCGGCAAGGGC
TGCGCTTCATCAACAGACAGCGCGGCGCAGGTACCCGCATACTTTTTGACTGGCACCTGAAGCAATGCGGGCTGCAGTCC
GATGCAATCCGCGGCTACGGCAAGGAAGAATACACCCACATGGCCGTGGCAGCCAATGTGCTGACCGGCAGTGCCGACTG
CGGGCTGGGCATACGGGCCGCCGCCAAAGCGCTGGGGCTGGATTTTGTTCCGCTGGCGCGCGAACGCTACGACCTGCTTA
TCCCCGAACAGTTCATGGAAGACCCGCGCGTCATGGCCGTCATGCAGCTGCTGGGCTCGCCCGCTTTTCTGGCACGCATA
GAAGCGCTGGGCGGATACGAGACAACACTCACCGGACAGGTCATGCAGGCCGGTACCGCACTGGGAGAACACGGCAGATG
A

Upstream 100 bases:

>100_bases
CCACCAGTTTCGCGGGTTGTTCCGCAAACATAAACAGGATATTGTCGCTGACCCGTAAGGATGTAAACACGCACACAACA
GCACACAAGCGAGTAATGCC

Downstream 100 bases:

>100_bases
AACTGAAAAGTCCCATATTCGAACAAGGTGAACTGCTGCCCGCGGCCAACCCGCAACACGGCGGAGAATCACCGCCTCTT
GCGTGGGAAGATGTGCCGGA

Product: putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MSSFKRNVYLKTVPIPQAVETVRGALDRESLVRTQRVASHEAAGRVTAEAVYARFSSPTFHSAAMDGFAVRADDTFAARE
DAAVTLQVQTARTGGPLQAGHAVAVNTGHPLPEGADAVIMIENVVAALPDSTAPQSISIEAPAFPWQHVRRIGEDIVATE
LLFPQGHTLTAYDVGTLLSGGIWEVRVYERIRVRIIPTGDEVLDFTARPEPGPGQVIESNSQVLATLARGLGCEVERVAP
VPDVPEVIRQAVTASLDDNVHLTVICAGSSAGSKDYTRATIAALGEVLVHGIAAMPGKPSLLGLCKGRLVAGAPGYPVSS
VICFEELLAPLIAWLGRGEAPRRESVTVEMTRKVPSKLGVEEFLRLSVGRVGYKYMATPLGRGAGCITTLSRAQAVTRIP
ANAEGLEQGQSVPAELMVSRTALERTLVCVGSHDNTLDALADELMGLDTPCRLASSHVGSMGGIMAVKNGSCHMAGVHLF
DPDSGDYNMPFIRKYLPETPAVLINLAIRHQGFIVPAGNPHNIRGIEDVARQGLRFINRQRGAGTRILFDWHLKQCGLQS
DAIRGYGKEEYTHMAVAANVLTGSADCGLGIRAAAKALGLDFVPLARERYDLLIPEQFMEDPRVMAVMQLLGSPAFLARI
EALGGYETTLTGQVMQAGTALGEHGR

Sequences:

>Translated_666_residues
MSSFKRNVYLKTVPIPQAVETVRGALDRESLVRTQRVASHEAAGRVTAEAVYARFSSPTFHSAAMDGFAVRADDTFAARE
DAAVTLQVQTARTGGPLQAGHAVAVNTGHPLPEGADAVIMIENVVAALPDSTAPQSISIEAPAFPWQHVRRIGEDIVATE
LLFPQGHTLTAYDVGTLLSGGIWEVRVYERIRVRIIPTGDEVLDFTARPEPGPGQVIESNSQVLATLARGLGCEVERVAP
VPDVPEVIRQAVTASLDDNVHLTVICAGSSAGSKDYTRATIAALGEVLVHGIAAMPGKPSLLGLCKGRLVAGAPGYPVSS
VICFEELLAPLIAWLGRGEAPRRESVTVEMTRKVPSKLGVEEFLRLSVGRVGYKYMATPLGRGAGCITTLSRAQAVTRIP
ANAEGLEQGQSVPAELMVSRTALERTLVCVGSHDNTLDALADELMGLDTPCRLASSHVGSMGGIMAVKNGSCHMAGVHLF
DPDSGDYNMPFIRKYLPETPAVLINLAIRHQGFIVPAGNPHNIRGIEDVARQGLRFINRQRGAGTRILFDWHLKQCGLQS
DAIRGYGKEEYTHMAVAANVLTGSADCGLGIRAAAKALGLDFVPLARERYDLLIPEQFMEDPRVMAVMQLLGSPAFLARI
EALGGYETTLTGQVMQAGTALGEHGR
>Mature_665_residues
SSFKRNVYLKTVPIPQAVETVRGALDRESLVRTQRVASHEAAGRVTAEAVYARFSSPTFHSAAMDGFAVRADDTFAARED
AAVTLQVQTARTGGPLQAGHAVAVNTGHPLPEGADAVIMIENVVAALPDSTAPQSISIEAPAFPWQHVRRIGEDIVATEL
LFPQGHTLTAYDVGTLLSGGIWEVRVYERIRVRIIPTGDEVLDFTARPEPGPGQVIESNSQVLATLARGLGCEVERVAPV
PDVPEVIRQAVTASLDDNVHLTVICAGSSAGSKDYTRATIAALGEVLVHGIAAMPGKPSLLGLCKGRLVAGAPGYPVSSV
ICFEELLAPLIAWLGRGEAPRRESVTVEMTRKVPSKLGVEEFLRLSVGRVGYKYMATPLGRGAGCITTLSRAQAVTRIPA
NAEGLEQGQSVPAELMVSRTALERTLVCVGSHDNTLDALADELMGLDTPCRLASSHVGSMGGIMAVKNGSCHMAGVHLFD
PDSGDYNMPFIRKYLPETPAVLINLAIRHQGFIVPAGNPHNIRGIEDVARQGLRFINRQRGAGTRILFDWHLKQCGLQSD
AIRGYGKEEYTHMAVAANVLTGSADCGLGIRAAAKALGLDFVPLARERYDLLIPEQFMEDPRVMAVMQLLGSPAFLARIE
ALGGYETTLTGQVMQAGTALGEHGR

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=319, Percent_Identity=27.5862068965517, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI66932975, Length=319, Percent_Identity=27.5862068965517, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1787049, Length=325, Percent_Identity=32, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25147659, Length=348, Percent_Identity=27.5862068965517, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17136978, Length=280, Percent_Identity=23.9285714285714, Blast_Score=77, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24638841, Length=280, Percent_Identity=23.9285714285714, Blast_Score=77, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 71041; Mature: 70910

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFKRNVYLKTVPIPQAVETVRGALDRESLVRTQRVASHEAAGRVTAEAVYARFSSPTF
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCH
HSAAMDGFAVRADDTFAAREDAAVTLQVQTARTGGPLQAGHAVAVNTGHPLPEGADAVIM
HHHHCCCEEEECCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEE
IENVVAALPDSTAPQSISIEAPAFPWQHVRRIGEDIVATELLFPQGHTLTAYDVGTLLSG
HHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHCC
GIWEVRVYERIRVRIIPTGDEVLDFTARPEPGPGQVIESNSQVLATLARGLGCEVERVAP
CEEEEEEEEEEEEEEEECCCHHEEECCCCCCCCCCEECCCHHHHHHHHHHCCCCCCCCCC
VPDVPEVIRQAVTASLDDNVHLTVICAGSSAGSKDYTRATIAALGEVLVHGIAAMPGKPS
CCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
LLGLCKGRLVAGAPGYPVSSVICFEELLAPLIAWLGRGEAPRRESVTVEMTRKVPSKLGV
HHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHCHHHCCH
EEFLRLSVGRVGYKYMATPLGRGAGCITTLSRAQAVTRIPANAEGLEQGQSVPAELMVSR
HHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHH
TALERTLVCVGSHDNTLDALADELMGLDTPCRLASSHVGSMGGIMAVKNGSCHMAGVHLF
HHHHEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEECCCEEEEEEEEE
DPDSGDYNMPFIRKYLPETPAVLINLAIRHQGFIVPAGNPHNIRGIEDVARQGLRFINRQ
CCCCCCCCCCHHHHHCCCCCCEEEEEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHHC
RGAGTRILFDWHLKQCGLQSDAIRGYGKEEYTHMAVAANVLTGSADCGLGIRAAAKALGL
CCCCCEEEEEECHHHCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCC
DFVPLARERYDLLIPEQFMEDPRVMAVMQLLGSPAFLARIEALGGYETTLTGQVMQAGTA
CCCHHHHHHHCEECCHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
LGEHGR
HCCCCC
>Mature Secondary Structure 
SSFKRNVYLKTVPIPQAVETVRGALDRESLVRTQRVASHEAAGRVTAEAVYARFSSPTF
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCH
HSAAMDGFAVRADDTFAAREDAAVTLQVQTARTGGPLQAGHAVAVNTGHPLPEGADAVIM
HHHHCCCEEEECCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEE
IENVVAALPDSTAPQSISIEAPAFPWQHVRRIGEDIVATELLFPQGHTLTAYDVGTLLSG
HHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHCC
GIWEVRVYERIRVRIIPTGDEVLDFTARPEPGPGQVIESNSQVLATLARGLGCEVERVAP
CEEEEEEEEEEEEEEEECCCHHEEECCCCCCCCCCEECCCHHHHHHHHHHCCCCCCCCCC
VPDVPEVIRQAVTASLDDNVHLTVICAGSSAGSKDYTRATIAALGEVLVHGIAAMPGKPS
CCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
LLGLCKGRLVAGAPGYPVSSVICFEELLAPLIAWLGRGEAPRRESVTVEMTRKVPSKLGV
HHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHCHHHCCH
EEFLRLSVGRVGYKYMATPLGRGAGCITTLSRAQAVTRIPANAEGLEQGQSVPAELMVSR
HHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHH
TALERTLVCVGSHDNTLDALADELMGLDTPCRLASSHVGSMGGIMAVKNGSCHMAGVHLF
HHHHEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEECCCEEEEEEEEE
DPDSGDYNMPFIRKYLPETPAVLINLAIRHQGFIVPAGNPHNIRGIEDVARQGLRFINRQ
CCCCCCCCCCHHHHHCCCCCCEEEEEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHHC
RGAGTRILFDWHLKQCGLQSDAIRGYGKEEYTHMAVAANVLTGSADCGLGIRAAAKALGL
CCCCCEEEEEECHHHCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCC
DFVPLARERYDLLIPEQFMEDPRVMAVMQLLGSPAFLARIEALGGYETTLTGQVMQAGTA
CCCHHHHHHHCEECCHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
LGEHGR
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]