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The map label for this gene is hepT [H]

Identifier: 78358229

GI number: 78358229

Start: 3176692

End: 3177660

Strand: Direct

Name: hepT [H]

Synonym: Dde_3189

Alternate gene names: 78358229

Gene position: 3176692-3177660 (Clockwise)

Preceding gene: 78358228

Following gene: 78358230

Centisome position: 85.16

GC content: 59.34

Gene sequence:

>969_bases
ATGCAAGAACTTCTGGAATATCTGGGCGCCATCCAGCCCAAAGTGAATGAGACTCTGGCCGCGGAAACCGGCACTCTGAA
CACCATGGTGCAACCTGTGGCCACTCATGTGCTGAGCGCCGGCGGCAAACGCCTGCGGCCGCTGCTGGCCATACTTTTTG
CCCGTGCCCTGGGCCGCGGCGGCGACGATATATACCCGCTGGCCTGTTCCGTCGAGCTGCTGCACTCGGCCACACTGCTG
CACGACGACATCATAGACGACGCCGCGCTGCGCCGTGGTCTGCCCGCCGCGCACACACTTTTCGGCAGCACCAGAACCAT
CCTTGCAGGCGATGCGCTGCTGGCCCTCGCCAACCTCATTGTTTCGCGTTATGGTGATACGAGGCTTACCGAATGCATCG
CACGGGCCATCATTGAAACAGCCACCGGTGAAATTGCCGAAATCGAATACCTGCGCAGCACAGGCCACCCGCAGGAAACA
TATATAGAAATTATCAAAGGCAAAACCGCGTGGATGATTCAGGCTTCCTGTCAGCTGGGTGCCATTGCGGCCGGTGCCAC
GGCGCAGCAGGAGCAGGCAGCCTGCGACTTCGGCATGAATCTGGGCATAGCCTTCCAGATAGTGGATGATGCGCTGGACT
TTTCACCTTCTGCCGGAGAAACCGGCAAGCCGGTGGCCGGCGACCTGCGCGAAGGCAAGCTTACCCCGCCGCTGCACATG
TATCTGGAAAGGCTGGAAGGCGCCGACCGGCAGGAGTTTCTGCACAAATTCACCACCGGCACCTTTTCCGATGCCGATGT
GGACAACGTGGCAAGAGCGGTGCGCGGACAGGGGCTGGACAAAGCCACCAGAGACCTTGCCGACACCTATCTGAAAAAAG
CCGCAGACGCACTGCACATGCTGGACGAAAGCAGGGAAAAAACCGTGCTCAGGCAAACGGTGGATTATGTGAAAAACCGC
AGCAGGTAG

Upstream 100 bases:

>100_bases
TGGACGATGCATTCGCCTCGCTGGGGCAGGCCGCCCGCGCCCTGTTTGTCTGACAAAGATACACTTGCCTAGCGGCTTGA
AAAACGGAACAATACGGCTC

Downstream 100 bases:

>100_bases
GAAGGCCCATGACCACGCAAGAAGCAGCTGACCGCAGTAAGACCATGGAGTGGTACTCCGAGTGTCTTCAGCTCACGTTT
CCCCCTGTGATGGTCAAACT

Product: trans-hexaprenyltranstransferase

Products: NA

Alternate protein names: HEPPP synthase subunit 2; Spore germination protein C3 [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MQELLEYLGAIQPKVNETLAAETGTLNTMVQPVATHVLSAGGKRLRPLLAILFARALGRGGDDIYPLACSVELLHSATLL
HDDIIDDAALRRGLPAAHTLFGSTRTILAGDALLALANLIVSRYGDTRLTECIARAIIETATGEIAEIEYLRSTGHPQET
YIEIIKGKTAWMIQASCQLGAIAAGATAQQEQAACDFGMNLGIAFQIVDDALDFSPSAGETGKPVAGDLREGKLTPPLHM
YLERLEGADRQEFLHKFTTGTFSDADVDNVARAVRGQGLDKATRDLADTYLKKAADALHMLDESREKTVLRQTVDYVKNR
SR

Sequences:

>Translated_322_residues
MQELLEYLGAIQPKVNETLAAETGTLNTMVQPVATHVLSAGGKRLRPLLAILFARALGRGGDDIYPLACSVELLHSATLL
HDDIIDDAALRRGLPAAHTLFGSTRTILAGDALLALANLIVSRYGDTRLTECIARAIIETATGEIAEIEYLRSTGHPQET
YIEIIKGKTAWMIQASCQLGAIAAGATAQQEQAACDFGMNLGIAFQIVDDALDFSPSAGETGKPVAGDLREGKLTPPLHM
YLERLEGADRQEFLHKFTTGTFSDADVDNVARAVRGQGLDKATRDLADTYLKKAADALHMLDESREKTVLRQTVDYVKNR
SR
>Mature_322_residues
MQELLEYLGAIQPKVNETLAAETGTLNTMVQPVATHVLSAGGKRLRPLLAILFARALGRGGDDIYPLACSVELLHSATLL
HDDIIDDAALRRGLPAAHTLFGSTRTILAGDALLALANLIVSRYGDTRLTECIARAIIETATGEIAEIEYLRSTGHPQET
YIEIIKGKTAWMIQASCQLGAIAAGATAQQEQAACDFGMNLGIAFQIVDDALDFSPSAGETGKPVAGDLREGKLTPPLHM
YLERLEGADRQEFLHKFTTGTFSDADVDNVARAVRGQGLDKATRDLADTYLKKAADALHMLDESREKTVLRQTVDYVKNR
SR

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=315, Percent_Identity=27.3015873015873, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4758430, Length=240, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI83700220, Length=240, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1789578, Length=236, Percent_Identity=34.3220338983051, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI1786623, Length=216, Percent_Identity=32.8703703703704, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17505681, Length=304, Percent_Identity=30.9210526315789, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319475, Length=298, Percent_Identity=30.5369127516779, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6325188, Length=219, Percent_Identity=27.8538812785388, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24651612, Length=311, Percent_Identity=28.6173633440514, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI281365769, Length=224, Percent_Identity=29.4642857142857, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24660002, Length=224, Percent_Identity=29.4642857142857, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 34815; Mature: 34815

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQELLEYLGAIQPKVNETLAAETGTLNTMVQPVATHVLSAGGKRLRPLLAILFARALGRG
CHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
GDDIYPLACSVELLHSATLLHDDIIDDAALRRGLPAAHTLFGSTRTILAGDALLALANLI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHH
VSRYGDTRLTECIARAIIETATGEIAEIEYLRSTGHPQETYIEIIKGKTAWMIQASCQLG
HHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCC
AIAAGATAQQEQAACDFGMNLGIAFQIVDDALDFSPSAGETGKPVAGDLREGKLTPPLHM
HHCCCCCCHHHHHHHHCCCCCCCCEEEHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHH
YLERLEGADRQEFLHKFTTGTFSDADVDNVARAVRGQGLDKATRDLADTYLKKAADALHM
HHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LDESREKTVLRQTVDYVKNRSR
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQELLEYLGAIQPKVNETLAAETGTLNTMVQPVATHVLSAGGKRLRPLLAILFARALGRG
CHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
GDDIYPLACSVELLHSATLLHDDIIDDAALRRGLPAAHTLFGSTRTILAGDALLALANLI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHH
VSRYGDTRLTECIARAIIETATGEIAEIEYLRSTGHPQETYIEIIKGKTAWMIQASCQLG
HHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCC
AIAAGATAQQEQAACDFGMNLGIAFQIVDDALDFSPSAGETGKPVAGDLREGKLTPPLHM
HHCCCCCCHHHHHHHHCCCCCCCCEEEHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHH
YLERLEGADRQEFLHKFTTGTFSDADVDNVARAVRGQGLDKATRDLADTYLKKAADALHM
HHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LDESREKTVLRQTVDYVKNRSR
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 2121900; 9720033 [H]