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The map label for this gene is atoC [H]

Identifier: 78358137

GI number: 78358137

Start: 3086421

End: 3088028

Strand: Direct

Name: atoC [H]

Synonym: Dde_3097

Alternate gene names: 78358137

Gene position: 3086421-3088028 (Clockwise)

Preceding gene: 78358136

Following gene: 78358139

Centisome position: 82.74

GC content: 62.44

Gene sequence:

>1608_bases
ATGGCCCAGATTCTCCTCGTAGACGCAGACTCAGGTTTTGCCCACATGCTGGGTGCCATCATAGAGGGACTGGGGCACAG
GGTACACCACGCCGCATCGCTCAGGGAGGGACGAGCCCTTGCCGCTGCGGCCGAAACCGATGTGGTGTATCTGCATGTTC
AACTGCCCGACGGCAGCGGTACAACCGCGGTGGAATCGTTCCGGTCGGCCCCCGGCCGTCCGGAGGTGGTGCTGCTGACA
GACCACGGCGACCCCGACACCGCGGAAGAAGCAATCCGCATGGGAGTCTGGGAATATGTGGAAAAAAGCAGTCCGGCTGA
CAGGATAATTCTGCCTCTGCTGCGTGCGCTTGACTACAGGGGCAGACGGCCTTCGCGACGCAGTACGGCCAGCCTCAAGC
GCGATGACATCATCGGCAGCAGCCGTGCCCTGCAAAAATGCCTTGATACCGTCTCGGAAGCTGCCTTCAGCGATGCATCA
GTGTTGCTTTTCGGCGAAACGGGCGCAGGCAAGGAAGTATTTGCACGCGCCATTCACGACAACAGCCACCGTGCCGGCGG
TCCCTTTGTGGCCGTGGACTGCGCATCGCTCACCCGTACGCTGGCGGGCAGCATACTCTTCGGCCACCGCAAAGGCGCCT
TTACCGGTGCGGAACAAAACAAGGACGGTCTGGTGCTGCAGGCGCACCGGGGCACACTCTTTCTGGATGAGGTGGGCGAA
CTGCCTCTTTCCATGCAGAAGCTCTTTCTGCGGGTGCTTCAGGAACACCGCTTCCGGCCGGTAGGCGGCAGAAACGAGGT
GACCAGCGATTTCCGTCTTATCGCCGCAACCAACCGGGACCTTGAAAAAATGGTGTCGCAGGGCACATTCCGTTCCGACC
TTTTGTACCGCATGCGCACCATTGTCATGCATCTGCCGCCTCTGCGCAGCCGCACCGAAGACATTACCGAACTTGCCGAC
CACTACCTGCAACGCATGTGCGGCAAATACGGCGTTCCGCACAAAAGCATGGCCCCCGACCTGCAGGAAACGCTGCGCGC
CTATGCCTGGCCGGGCAACGTCCGGGAGCTTATCCACACGCTGGAACGTGCCGTACTTGCCGCACAGGATGAACCACGGC
TCTTTGCCCGCCACCTGCCTGACCATGTGCGCATAAGCACCGCGCGGGCGGCTTTGCAGCAACGCAGAACAGACAGCACC
GCCGCTGCGCAGCCGTCCCGTGACGAAGACACCGCATCCGGTGCACCCGAAAGCCGCCCGCAGGCACCGCGGCCGTGTCA
TACCTGCGGCACCCTGCCGGAATCTTACGGCACGCCCGCCGTACAACCTGAGTCCACAGGCCAAGGCCTGCCGCACCTGC
ACGACACTGCCGGACACAATGCCGCCGTCCCACAGGAAAAACACCCTCTTTCTCCGGACCACAGCCCCCTGCCGCCGTTT
TTCACCTTCCGCGACAACATGTTCCGCGACTACCTGCGCGAACTGCTGCGCCGTACAGACAACGACATCGCCGCGGCATG
CGCCATGTCGGGACTTTCCCGTTCTTACCTGTATGACCTGCTGCGGCGCCACGGCCTGCGCAACGGCGGTACAACATCCG
GCAGCTAG

Upstream 100 bases:

>100_bases
CGTGCAGACTGGCGCGCAAACCGCTGGACGGAGCCGCCCGCACACGCCTCGTCGAGCTTATGCTCTCCCGCAACACCGAC
AAGACGGCAGGACAACGCTC

Downstream 100 bases:

>100_bases
CGAAGCATACCGTGCAATACCGCCCGCAGGCGCCCACGGTAGGGGCATGTATCTGCGTGCTTCACAAATGGAATCGCCGC
ATAGCGCCACCATATGCCGG

Product: two component Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MAQILLVDADSGFAHMLGAIIEGLGHRVHHAASLREGRALAAAAETDVVYLHVQLPDGSGTTAVESFRSAPGRPEVVLLT
DHGDPDTAEEAIRMGVWEYVEKSSPADRIILPLLRALDYRGRRPSRRSTASLKRDDIIGSSRALQKCLDTVSEAAFSDAS
VLLFGETGAGKEVFARAIHDNSHRAGGPFVAVDCASLTRTLAGSILFGHRKGAFTGAEQNKDGLVLQAHRGTLFLDEVGE
LPLSMQKLFLRVLQEHRFRPVGGRNEVTSDFRLIAATNRDLEKMVSQGTFRSDLLYRMRTIVMHLPPLRSRTEDITELAD
HYLQRMCGKYGVPHKSMAPDLQETLRAYAWPGNVRELIHTLERAVLAAQDEPRLFARHLPDHVRISTARAALQQRRTDST
AAAQPSRDEDTASGAPESRPQAPRPCHTCGTLPESYGTPAVQPESTGQGLPHLHDTAGHNAAVPQEKHPLSPDHSPLPPF
FTFRDNMFRDYLRELLRRTDNDIAAACAMSGLSRSYLYDLLRRHGLRNGGTTSGS

Sequences:

>Translated_535_residues
MAQILLVDADSGFAHMLGAIIEGLGHRVHHAASLREGRALAAAAETDVVYLHVQLPDGSGTTAVESFRSAPGRPEVVLLT
DHGDPDTAEEAIRMGVWEYVEKSSPADRIILPLLRALDYRGRRPSRRSTASLKRDDIIGSSRALQKCLDTVSEAAFSDAS
VLLFGETGAGKEVFARAIHDNSHRAGGPFVAVDCASLTRTLAGSILFGHRKGAFTGAEQNKDGLVLQAHRGTLFLDEVGE
LPLSMQKLFLRVLQEHRFRPVGGRNEVTSDFRLIAATNRDLEKMVSQGTFRSDLLYRMRTIVMHLPPLRSRTEDITELAD
HYLQRMCGKYGVPHKSMAPDLQETLRAYAWPGNVRELIHTLERAVLAAQDEPRLFARHLPDHVRISTARAALQQRRTDST
AAAQPSRDEDTASGAPESRPQAPRPCHTCGTLPESYGTPAVQPESTGQGLPHLHDTAGHNAAVPQEKHPLSPDHSPLPPF
FTFRDNMFRDYLRELLRRTDNDIAAACAMSGLSRSYLYDLLRRHGLRNGGTTSGS
>Mature_534_residues
AQILLVDADSGFAHMLGAIIEGLGHRVHHAASLREGRALAAAAETDVVYLHVQLPDGSGTTAVESFRSAPGRPEVVLLTD
HGDPDTAEEAIRMGVWEYVEKSSPADRIILPLLRALDYRGRRPSRRSTASLKRDDIIGSSRALQKCLDTVSEAAFSDASV
LLFGETGAGKEVFARAIHDNSHRAGGPFVAVDCASLTRTLAGSILFGHRKGAFTGAEQNKDGLVLQAHRGTLFLDEVGEL
PLSMQKLFLRVLQEHRFRPVGGRNEVTSDFRLIAATNRDLEKMVSQGTFRSDLLYRMRTIVMHLPPLRSRTEDITELADH
YLQRMCGKYGVPHKSMAPDLQETLRAYAWPGNVRELIHTLERAVLAAQDEPRLFARHLPDHVRISTARAALQQRRTDSTA
AAQPSRDEDTASGAPESRPQAPRPCHTCGTLPESYGTPAVQPESTGQGLPHLHDTAGHNAAVPQEKHPLSPDHSPLPPFF
TFRDNMFRDYLRELLRRTDNDIAAACAMSGLSRSYLYDLLRRHGLRNGGTTSGS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=389, Percent_Identity=41.1311053984576, Blast_Score=292, Evalue=4e-80,
Organism=Escherichia coli, GI1790437, Length=377, Percent_Identity=36.604774535809, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1790299, Length=400, Percent_Identity=36.75, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1788905, Length=365, Percent_Identity=36.986301369863, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI87082117, Length=264, Percent_Identity=44.6969696969697, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1789087, Length=248, Percent_Identity=46.3709677419355, Blast_Score=209, Evalue=5e-55,
Organism=Escherichia coli, GI1789233, Length=232, Percent_Identity=43.1034482758621, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI87082152, Length=254, Percent_Identity=42.1259842519685, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI87081872, Length=233, Percent_Identity=42.0600858369099, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI1786524, Length=297, Percent_Identity=38.7205387205387, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1787583, Length=229, Percent_Identity=39.7379912663755, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1789828, Length=255, Percent_Identity=38.0392156862745, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI87081858, Length=232, Percent_Identity=32.7586206896552, Blast_Score=114, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 58773; Mature: 58642

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQILLVDADSGFAHMLGAIIEGLGHRVHHAASLREGRALAAAAETDVVYLHVQLPDGSG
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCEEEEEEEECCCCC
TTAVESFRSAPGRPEVVLLTDHGDPDTAEEAIRMGVWEYVEKSSPADRIILPLLRALDYR
HHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
GRRPSRRSTASLKRDDIIGSSRALQKCLDTVSEAAFSDASVLLFGETGAGKEVFARAIHD
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHC
NSHRAGGPFVAVDCASLTRTLAGSILFGHRKGAFTGAEQNKDGLVLQAHRGTLFLDEVGE
CCCCCCCCEEEEEHHHHHHHHHHHHHEECCCCCCCCCCCCCCCEEEEECCCEEEHHHHCC
LPLSMQKLFLRVLQEHRFRPVGGRNEVTSDFRLIAATNRDLEKMVSQGTFRSDLLYRMRT
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCHHHHHHHHHHH
IVMHLPPLRSRTEDITELADHYLQRMCGKYGVPHKSMAPDLQETLRAYAWPGNVRELIHT
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHH
LERAVLAAQDEPRLFARHLPDHVRISTARAALQQRRTDSTAAAQPSRDEDTASGAPESRP
HHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCC
QAPRPCHTCGTLPESYGTPAVQPESTGQGLPHLHDTAGHNAAVPQEKHPLSPDHSPLPPF
CCCCCCHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
FTFRDNMFRDYLRELLRRTDNDIAAACAMSGLSRSYLYDLLRRHGLRNGGTTSGS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AQILLVDADSGFAHMLGAIIEGLGHRVHHAASLREGRALAAAAETDVVYLHVQLPDGSG
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCEEEEEEEECCCCC
TTAVESFRSAPGRPEVVLLTDHGDPDTAEEAIRMGVWEYVEKSSPADRIILPLLRALDYR
HHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
GRRPSRRSTASLKRDDIIGSSRALQKCLDTVSEAAFSDASVLLFGETGAGKEVFARAIHD
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHC
NSHRAGGPFVAVDCASLTRTLAGSILFGHRKGAFTGAEQNKDGLVLQAHRGTLFLDEVGE
CCCCCCCCEEEEEHHHHHHHHHHHHHEECCCCCCCCCCCCCCCEEEEECCCEEEHHHHCC
LPLSMQKLFLRVLQEHRFRPVGGRNEVTSDFRLIAATNRDLEKMVSQGTFRSDLLYRMRT
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCHHHHHHHHHHH
IVMHLPPLRSRTEDITELADHYLQRMCGKYGVPHKSMAPDLQETLRAYAWPGNVRELIHT
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHH
LERAVLAAQDEPRLFARHLPDHVRISTARAALQQRRTDSTAAAQPSRDEDTASGAPESRP
HHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCC
QAPRPCHTCGTLPESYGTPAVQPESTGQGLPHLHDTAGHNAAVPQEKHPLSPDHSPLPPF
CCCCCCHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
FTFRDNMFRDYLRELLRRTDNDIAAACAMSGLSRSYLYDLLRRHGLRNGGTTSGS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]