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The map label for this gene is cysK [H]

Identifier: 78358120

GI number: 78358120

Start: 3070183

End: 3071112

Strand: Direct

Name: cysK [H]

Synonym: Dde_3080

Alternate gene names: 78358120

Gene position: 3070183-3071112 (Clockwise)

Preceding gene: 78358119

Following gene: 78358121

Centisome position: 82.31

GC content: 61.08

Gene sequence:

>930_bases
GTGAACATCGCAGAAAACATGGCCGCTCTGGTCGGAAACACCCCGCTGGTACGCCTGAACAGGCTGGCACGGGGTTGTCA
CGCCGAAGTTGTCGCCAAACTGGAATTTTACAACCCCTGCGCCTCGGTAAAAGACAGAATCGCCCGCAGCATGATCGAAT
CGGCACTGGAGTCGGGAGAAATCAACGCCGATTCGCTGCTGGTGGAACCCACCAGCGGCAATACCGGTGTGGGGCTGGCG
TTCATCTGCGCGGTTCACGGGCTGCGGCTGACCCTGACCATGCCGGAATCCATGAGCGACGAACGTAAAAAACTGCTGCG
CAGTTTCGGCACCACGCTGGTGCTCACCCCCGCGGCACAGGGTATGCGCGGCGCCATTGCAGAAGCCGAGCGCATCGTGC
GTGAAACCCCGGGAGCCGTCATGCTGCAGCAGTTTGCCAATCCCGCCAACCCCGCGGCACATTACGCCACAACGGCTGAA
GAAATATGGCGCGACACAGACGGCAGGGTGGATGCGTTTGTGGCCGGTGTAGGCACCGGCGGCACCATCACCGGTACCGG
CAGACGCCTGCGCGAGCTTAATGCGGGGGTGCGCATCATCGCCGTGGAACCTGAAGCATCCCCCGTGCTTTCGGGCGGTG
CTCCCGCACCCCACCCCATTCAGGGCATAGGCGCAGGCTTTGTCCCTGAAGTGCTGGATACCGGAATCTACGACGAAGTA
TTCAAGGTTTCCGGTGACGACGCCATGAACACCGCACGCGACCTGCTGCGTCAGGAAGGTATTCTGTGCGGCATTTCCTC
GGGGGCAAATGCATTTGCCGCACTGGAAGCGGCCAGACGGCCCGAAATGAAAGGCAAGCGCATCGTATTCATTGTCTGCG
ACACCGGCGAACGCTACCTGAGCACACCGCTTTTTTCCGGCCAGAGCTAG

Upstream 100 bases:

>100_bases
TGCTGAAACGGCCCGGGCATACATGCATCCGAGGGGCCGGAAACGGACGCACTGCGCGTCCGGTTCCGGCCTTTTTTTTA
CAGCAAATGGAGGAAACACC

Downstream 100 bases:

>100_bases
CACGCTTTTTTGCCAACCCTCCAGCAGAGCAACGGAACACATATGAGGAACTGCAGTAAAGAACCGGACAACATATGCGC
AGACGGCATGGACTGGCTTG

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MNIAENMAALVGNTPLVRLNRLARGCHAEVVAKLEFYNPCASVKDRIARSMIESALESGEINADSLLVEPTSGNTGVGLA
FICAVHGLRLTLTMPESMSDERKKLLRSFGTTLVLTPAAQGMRGAIAEAERIVRETPGAVMLQQFANPANPAAHYATTAE
EIWRDTDGRVDAFVAGVGTGGTITGTGRRLRELNAGVRIIAVEPEASPVLSGGAPAPHPIQGIGAGFVPEVLDTGIYDEV
FKVSGDDAMNTARDLLRQEGILCGISSGANAFAALEAARRPEMKGKRIVFIVCDTGERYLSTPLFSGQS

Sequences:

>Translated_309_residues
MNIAENMAALVGNTPLVRLNRLARGCHAEVVAKLEFYNPCASVKDRIARSMIESALESGEINADSLLVEPTSGNTGVGLA
FICAVHGLRLTLTMPESMSDERKKLLRSFGTTLVLTPAAQGMRGAIAEAERIVRETPGAVMLQQFANPANPAAHYATTAE
EIWRDTDGRVDAFVAGVGTGGTITGTGRRLRELNAGVRIIAVEPEASPVLSGGAPAPHPIQGIGAGFVPEVLDTGIYDEV
FKVSGDDAMNTARDLLRQEGILCGISSGANAFAALEAARRPEMKGKRIVFIVCDTGERYLSTPLFSGQS
>Mature_309_residues
MNIAENMAALVGNTPLVRLNRLARGCHAEVVAKLEFYNPCASVKDRIARSMIESALESGEINADSLLVEPTSGNTGVGLA
FICAVHGLRLTLTMPESMSDERKKLLRSFGTTLVLTPAAQGMRGAIAEAERIVRETPGAVMLQQFANPANPAAHYATTAE
EIWRDTDGRVDAFVAGVGTGGTITGTGRRLRELNAGVRIIAVEPEASPVLSGGAPAPHPIQGIGAGFVPEVLDTGIYDEV
FKVSGDDAMNTARDLLRQEGILCGISSGANAFAALEAARRPEMKGKRIVFIVCDTGERYLSTPLFSGQS

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=310, Percent_Identity=40.9677419354839, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI295821200, Length=310, Percent_Identity=40.9677419354839, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI4557415, Length=310, Percent_Identity=40.9677419354839, Blast_Score=233, Evalue=1e-61,
Organism=Escherichia coli, GI1788754, Length=314, Percent_Identity=50.3184713375796, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI2367138, Length=296, Percent_Identity=43.5810810810811, Blast_Score=231, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=53.921568627451, Blast_Score=304, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=47.8688524590164, Blast_Score=294, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI17562970, Length=297, Percent_Identity=50.1683501683502, Blast_Score=292, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI32566674, Length=291, Percent_Identity=50.5154639175258, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17561720, Length=297, Percent_Identity=48.4848484848485, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=52.112676056338, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17534315, Length=306, Percent_Identity=40.8496732026144, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25147552, Length=308, Percent_Identity=37.987012987013, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17561716, Length=119, Percent_Identity=48.7394957983193, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71996324, Length=310, Percent_Identity=25.4838709677419, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=316, Percent_Identity=40.8227848101266, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6321449, Length=335, Percent_Identity=34.3283582089552, Blast_Score=139, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24643623, Length=310, Percent_Identity=40, Blast_Score=200, Evalue=8e-52,
Organism=Drosophila melanogaster, GI20129101, Length=310, Percent_Identity=40, Blast_Score=200, Evalue=8e-52,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32650; Mature: 32650

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00901 CYS_SYNTHASE ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIAENMAALVGNTPLVRLNRLARGCHAEVVAKLEFYNPCASVKDRIARSMIESALESGE
CCHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
INADSLLVEPTSGNTGVGLAFICAVHGLRLTLTMPESMSDERKKLLRSFGTTLVLTPAAQ
CCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCEEEEECCCC
GMRGAIAEAERIVRETPGAVMLQQFANPANPAAHYATTAEEIWRDTDGRVDAFVAGVGTG
CHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCC
GTITGTGRRLRELNAGVRIIAVEPEASPVLSGGAPAPHPIQGIGAGFVPEVLDTGIYDEV
CEEECCHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHH
FKVSGDDAMNTARDLLRQEGILCGISSGANAFAALEAARRPEMKGKRIVFIVCDTGERYL
HHCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCHHH
STPLFSGQS
CCCCCCCCC
>Mature Secondary Structure
MNIAENMAALVGNTPLVRLNRLARGCHAEVVAKLEFYNPCASVKDRIARSMIESALESGE
CCHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
INADSLLVEPTSGNTGVGLAFICAVHGLRLTLTMPESMSDERKKLLRSFGTTLVLTPAAQ
CCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCEEEEECCCC
GMRGAIAEAERIVRETPGAVMLQQFANPANPAAHYATTAEEIWRDTDGRVDAFVAGVGTG
CHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCC
GTITGTGRRLRELNAGVRIIAVEPEASPVLSGGAPAPHPIQGIGAGFVPEVLDTGIYDEV
CEEECCHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHH
FKVSGDDAMNTARDLLRQEGILCGISSGANAFAALEAARRPEMKGKRIVFIVCDTGERYL
HHCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCHHH
STPLFSGQS
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]