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The map label for this gene is lpxC

Identifier: 78358026

GI number: 78358026

Start: 2966706

End: 2967623

Strand: Direct

Name: lpxC

Synonym: Dde_2986

Alternate gene names: 78358026

Gene position: 2966706-2967623 (Clockwise)

Preceding gene: 78358025

Following gene: 78358027

Centisome position: 79.53

GC content: 57.3

Gene sequence:

>918_bases
ATGAACCAGACCACCATCAAAAAAACCATCGGATGCTCGGGCATCGGACTGCACAGCGGCAAAGTGGTCAGACTGACACT
GCGCCCCGCCCCCGAAGACACCGGCATCGTATTTCATATCCGCACAGAAGACGGCGTACACCGCCTTACCCCCAGACCTG
ACGATGTCATCGCCACCGGTCTTGCCACCACACTGGGCCTCAACGGCTCGTCCGTAGCCACGGTGGAACATCTGCTGGCC
GCCATACGCGGCATGCAGATTGACAACATCCAGATAGACATCGAAGGCAACGAAATCCCCATCATGGACGGCAGCGCCGC
ATCTTTCGTTTTTCTGCTGAAGGATGCAGGCATCGCGCGGCAGAACAAGCCGCGACAGGTCTACCGCATCAAAAAGCCGG
TGACCTACGAACGTGACGGCAAGTGGATAAAAGCCGCACCGCATGACGGACTGCGCATCGAATACACCATAGAATTCGAC
CACCCGGCCATCGGCAGACAGTCCATGGACATCGAAGTCACCCCCGAAGCATTCGCGGGCATCATCGCCAAAGCACGCAC
ATTCGGCTTTCTGCGCGAAGTGGAGTACCTGCACAGCAACGGTCTGGCGCTGGGCGGCTCTCTGGACAACGCCATAGTTC
TGGATGAATACAATGTGCTCAACGAAGACGGCCTCCGGTTCGATGACGAGTTCGTGCGCCATAAAATTCTCGACTTCATC
GGAGACATGGCACTGCTGGGCGCCCCGCTGCAGGGGCATTTTCAGGTTCATTGCTCCGGCCATGCCCTTAATAACGGCTT
TTTGCGCACCATAAGCGAGCACGAAGAACTCTACTTGAAAAGAGTGGAGCTCTCGGAAACGGCACAGCGCGAGCACGCCG
TTGAAGCAGCACCAGCAGGAACGCCTGTAGCTGCTTAG

Upstream 100 bases:

>100_bases
GCGGCACAGCCTGCCTGAAAAAACATCTCATAAAATCAGCGGACTACAACCAATACCGCAACGGCACGATTATTGCTTTA
TCGATGGCACCGGAGGGTTT

Downstream 100 bases:

>100_bases
CCGTACTCCGGTACAATGCACAGAAAAAAGCCGTCCGTCGCCGGACGGCTTTTTCAATATCCGTGTCCCGTCCTGAAATA
GGTTGACAAGTAAGGAGCCT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MNQTTIKKTIGCSGIGLHSGKVVRLTLRPAPEDTGIVFHIRTEDGVHRLTPRPDDVIATGLATTLGLNGSSVATVEHLLA
AIRGMQIDNIQIDIEGNEIPIMDGSAASFVFLLKDAGIARQNKPRQVYRIKKPVTYERDGKWIKAAPHDGLRIEYTIEFD
HPAIGRQSMDIEVTPEAFAGIIAKARTFGFLREVEYLHSNGLALGGSLDNAIVLDEYNVLNEDGLRFDDEFVRHKILDFI
GDMALLGAPLQGHFQVHCSGHALNNGFLRTISEHEELYLKRVELSETAQREHAVEAAPAGTPVAA

Sequences:

>Translated_305_residues
MNQTTIKKTIGCSGIGLHSGKVVRLTLRPAPEDTGIVFHIRTEDGVHRLTPRPDDVIATGLATTLGLNGSSVATVEHLLA
AIRGMQIDNIQIDIEGNEIPIMDGSAASFVFLLKDAGIARQNKPRQVYRIKKPVTYERDGKWIKAAPHDGLRIEYTIEFD
HPAIGRQSMDIEVTPEAFAGIIAKARTFGFLREVEYLHSNGLALGGSLDNAIVLDEYNVLNEDGLRFDDEFVRHKILDFI
GDMALLGAPLQGHFQVHCSGHALNNGFLRTISEHEELYLKRVELSETAQREHAVEAAPAGTPVAA
>Mature_305_residues
MNQTTIKKTIGCSGIGLHSGKVVRLTLRPAPEDTGIVFHIRTEDGVHRLTPRPDDVIATGLATTLGLNGSSVATVEHLLA
AIRGMQIDNIQIDIEGNEIPIMDGSAASFVFLLKDAGIARQNKPRQVYRIKKPVTYERDGKWIKAAPHDGLRIEYTIEFD
HPAIGRQSMDIEVTPEAFAGIIAKARTFGFLREVEYLHSNGLALGGSLDNAIVLDEYNVLNEDGLRFDDEFVRHKILDFI
GDMALLGAPLQGHFQVHCSGHALNNGFLRTISEHEELYLKRVELSETAQREHAVEAAPAGTPVAA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=308, Percent_Identity=46.1038961038961, Blast_Score=257, Evalue=5e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_DESDG (Q30X16)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_389475.1
- ProteinModelPortal:   Q30X16
- SMR:   Q30X16
- STRING:   Q30X16
- GeneID:   3757991
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2986
- NMPDR:   fig|207559.3.peg.3041
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- ProtClustDB:   PRK13186
- BioCyc:   DDES207559:DDE_2986-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 33430; Mature: 33430

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQTTIKKTIGCSGIGLHSGKVVRLTLRPAPEDTGIVFHIRTEDGVHRLTPRPDDVIATG
CCCCCCHHHCCCCCEEECCCCEEEEEEECCCCCCCEEEEEECCCCCEECCCCCHHHHHHH
LATTLGLNGSSVATVEHLLAAIRGMQIDNIQIDIEGNEIPIMDGSAASFVFLLKDAGIAR
HHHHCCCCCCCHHHHHHHHHHHHCCEECCEEEEEECCEEEEECCCCCEEEEEEECCCCCC
QNKPRQVYRIKKPVTYERDGKWIKAAPHDGLRIEYTIEFDHPAIGRQSMDIEVTPEAFAG
CCCCCEEEEECCCCEECCCCCEEEECCCCCEEEEEEEEECCCCCCCCCCEEEECHHHHHH
IIAKARTFGFLREVEYLHSNGLALGGSLDNAIVLDEYNVLNEDGLRFDDEFVRHKILDFI
HHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
GDMALLGAPLQGHFQVHCSGHALNNGFLRTISEHEELYLKRVELSETAQREHAVEAAPAG
HHHHHHCCCCCCEEEEEEECEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TPVAA
CCCCC
>Mature Secondary Structure
MNQTTIKKTIGCSGIGLHSGKVVRLTLRPAPEDTGIVFHIRTEDGVHRLTPRPDDVIATG
CCCCCCHHHCCCCCEEECCCCEEEEEEECCCCCCCEEEEEECCCCCEECCCCCHHHHHHH
LATTLGLNGSSVATVEHLLAAIRGMQIDNIQIDIEGNEIPIMDGSAASFVFLLKDAGIAR
HHHHCCCCCCCHHHHHHHHHHHHCCEECCEEEEEECCEEEEECCCCCEEEEEEECCCCCC
QNKPRQVYRIKKPVTYERDGKWIKAAPHDGLRIEYTIEFDHPAIGRQSMDIEVTPEAFAG
CCCCCEEEEECCCCEECCCCCEEEECCCCCEEEEEEEEECCCCCCCCCCEEEECHHHHHH
IIAKARTFGFLREVEYLHSNGLALGGSLDNAIVLDEYNVLNEDGLRFDDEFVRHKILDFI
HHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
GDMALLGAPLQGHFQVHCSGHALNNGFLRTISEHEELYLKRVELSETAQREHAVEAAPAG
HHHHHHCCCCCCEEEEEEECEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TPVAA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA