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The map label for this gene is pyrC [H]

Identifier: 78358005

GI number: 78358005

Start: 2948110

End: 2949390

Strand: Direct

Name: pyrC [H]

Synonym: Dde_2965

Alternate gene names: 78358005

Gene position: 2948110-2949390 (Clockwise)

Preceding gene: 78358004

Following gene: 78358006

Centisome position: 79.03

GC content: 62.22

Gene sequence:

>1281_bases
ATGTCTGATCATATTTCCGGCACACTGTTTGTTTCGGGCGCGCTTCTTTCCGGGCGCACGGTTGATGTCACCGTATCGGG
CGGACGCATTGCCGCCGTCAGCGAACACGGGGCGGCCCCCGCGCCGCAGCACGCCGAAACTGTGGAAGCCGCGGGCAAGA
TACTGTTTCCCAGTTTTATTGACTGCCACGTGCACCTGCGCGAACCCGGTTTTGAGTACAAGGAAGACATTGCCTCCGGA
CTCGCAGCCGCTGCGCACGGCGGATTCGGGGCGGTACTGCCCATGGCCAATACCAGTCCCGTCAACGATCAGGGCAGTGT
GACCGAGCTGATGCTGGAACGCGCCCGCAAGGCATGGCCCCACGGCCCGCGCGTGCATCCTGTGGGTGCCGCCACCAAAG
GACTGAAAGGCGAAGAACTGGCCCCCATGGGCGAACTGGCCGCCGCGGGCTGCGTCGCCTTTTCCAACGACGGACTGCCG
GTGGGCGGTGCCGAAATGTTCCGCCGCTGCATGGAATACGCCGCAGACTTCGGTAAAATAGTCATCGATCACTGCGAAGA
TCCTTCACTGGCGCGCGGCACACACATGAACGAAGGGGTGACCAGCGGACGCCTGGGAGTCAAAGGACAGTCGGTGGTGG
CCGAATCGGTACAGGTGGCCCGCGACATTCTGCTGGCCGAATATCTGGGCATTCCGGTCCATCTGGCACATATCAGCTGC
CGTCAGTCCGTGGAGCTTATCGCGTGGGCCAAGCAGCGCGGCGTAAGAGTAACGGCCGAAACCTGCCCGCACTATCTGCT
GCTGGACGATCTGGCACTGGAACAGTACTCCACAGCAGCCAAGGTCAACCCGCCGCTGCGCACCCCCGACGACGTGGCGG
CCATGCGCCGTGCCGTGGCTGACGGCACCATAGACATACTGGTGACAGACCACGCCCCGCATGCCGCGCACGAAAAGGAT
ACCCCGCTGGATGAAGCGCCCAACGGCATTTCCGGTCTGGATACGGCGGTGGCTCTGACATGGCGTCTGGTGCAGGAAGG
CCTGCTGACCGAAGCCGACATGGTGCGCCTGTGGTGCCATGCTCCGGGCAGCCTGTTCCGTCTGCCGGTAAACCGCTTCA
CGGCGGGCGACCCTGCAGATTTTTTCCTGTTCGACCCTGCGCATGAATGGACTGTGACCCCTGAGGCGATGCATTCAAAA
GGCAAAAACACGCCCTTTACCGGGTGGAAGCTTACCGGTAAGGTGACATCCCACTGGATGGGCGGTCACAGAATAGCATG
A

Upstream 100 bases:

>100_bases
CCGGCCAGAGTCTGGTGCTTGACCAGGTGGCTTCCGGCGTGGCCACACGCATGGCCATTCTGTTTCTTCATGCAACCCGC
AAAGACACGGGAGACCGCTG

Downstream 100 bases:

>100_bases
CCGCAATAATGCCTTTCGGGCGGTTCCGGCTTGACAACGCACGGTTAGCTTGAAATGCATTGGCTGAACGAACAGCTTTT
CCGCCGAAAGCCGGCGTATG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSDHISGTLFVSGALLSGRTVDVTVSGGRIAAVSEHGAAPAPQHAETVEAAGKILFPSFIDCHVHLREPGFEYKEDIASG
LAAAAHGGFGAVLPMANTSPVNDQGSVTELMLERARKAWPHGPRVHPVGAATKGLKGEELAPMGELAAAGCVAFSNDGLP
VGGAEMFRRCMEYAADFGKIVIDHCEDPSLARGTHMNEGVTSGRLGVKGQSVVAESVQVARDILLAEYLGIPVHLAHISC
RQSVELIAWAKQRGVRVTAETCPHYLLLDDLALEQYSTAAKVNPPLRTPDDVAAMRRAVADGTIDILVTDHAPHAAHEKD
TPLDEAPNGISGLDTAVALTWRLVQEGLLTEADMVRLWCHAPGSLFRLPVNRFTAGDPADFFLFDPAHEWTVTPEAMHSK
GKNTPFTGWKLTGKVTSHWMGGHRIA

Sequences:

>Translated_426_residues
MSDHISGTLFVSGALLSGRTVDVTVSGGRIAAVSEHGAAPAPQHAETVEAAGKILFPSFIDCHVHLREPGFEYKEDIASG
LAAAAHGGFGAVLPMANTSPVNDQGSVTELMLERARKAWPHGPRVHPVGAATKGLKGEELAPMGELAAAGCVAFSNDGLP
VGGAEMFRRCMEYAADFGKIVIDHCEDPSLARGTHMNEGVTSGRLGVKGQSVVAESVQVARDILLAEYLGIPVHLAHISC
RQSVELIAWAKQRGVRVTAETCPHYLLLDDLALEQYSTAAKVNPPLRTPDDVAAMRRAVADGTIDILVTDHAPHAAHEKD
TPLDEAPNGISGLDTAVALTWRLVQEGLLTEADMVRLWCHAPGSLFRLPVNRFTAGDPADFFLFDPAHEWTVTPEAMHSK
GKNTPFTGWKLTGKVTSHWMGGHRIA
>Mature_425_residues
SDHISGTLFVSGALLSGRTVDVTVSGGRIAAVSEHGAAPAPQHAETVEAAGKILFPSFIDCHVHLREPGFEYKEDIASGL
AAAAHGGFGAVLPMANTSPVNDQGSVTELMLERARKAWPHGPRVHPVGAATKGLKGEELAPMGELAAAGCVAFSNDGLPV
GGAEMFRRCMEYAADFGKIVIDHCEDPSLARGTHMNEGVTSGRLGVKGQSVVAESVQVARDILLAEYLGIPVHLAHISCR
QSVELIAWAKQRGVRVTAETCPHYLLLDDLALEQYSTAAKVNPPLRTPDDVAAMRRAVADGTIDILVTDHAPHAAHEKDT
PLDEAPNGISGLDTAVALTWRLVQEGLLTEADMVRLWCHAPGSLFRLPVNRFTAGDPADFFLFDPAHEWTVTPEAMHSKG
KNTPFTGWKLTGKVTSHWMGGHRIA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=399, Percent_Identity=30.3258145363409, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1786722, Length=426, Percent_Identity=27.4647887323944, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI87082175, Length=412, Percent_Identity=23.7864077669903, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193204318, Length=413, Percent_Identity=27.6029055690073, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6322218, Length=391, Percent_Identity=25.3196930946292, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24642586, Length=387, Percent_Identity=32.0413436692506, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI18859883, Length=198, Percent_Identity=29.7979797979798, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45387; Mature: 45256

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDHISGTLFVSGALLSGRTVDVTVSGGRIAAVSEHGAAPAPQHAETVEAAGKILFPSFI
CCCCCCEEEEEEEEEECCCEEEEEECCCEEEEEECCCCCCCCCHHHHHHHCCCEECCCEE
DCHVHLREPGFEYKEDIASGLAAAAHGGFGAVLPMANTSPVNDQGSVTELMLERARKAWP
EEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCC
HGPRVHPVGAATKGLKGEELAPMGELAAAGCVAFSNDGLPVGGAEMFRRCMEYAADFGKI
CCCCCCCCCCHHCCCCCCCCCCHHHHHHHCEEEECCCCCCCCHHHHHHHHHHHHHHHCCE
VIDHCEDPSLARGTHMNEGVTSGRLGVKGQSVVAESVQVARDILLAEYLGIPVHLAHISC
EEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHH
RQSVELIAWAKQRGVRVTAETCPHYLLLDDLALEQYSTAAKVNPPLRTPDDVAAMRRAVA
HHHHHHHHHHHHCCCEEEHHHCCCEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
DGTIDILVTDHAPHAAHEKDTPLDEAPNGISGLDTAVALTWRLVQEGLLTEADMVRLWCH
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHEEEEC
APGSLFRLPVNRFTAGDPADFFLFDPAHEWTVTPEAMHSKGKNTPFTGWKLTGKVTSHWM
CCCCEEECCHHHCCCCCCCCEEEECCCCCCEECHHHHHCCCCCCCCCCEEEECCHHHHCC
GGHRIA
CCCCCC
>Mature Secondary Structure 
SDHISGTLFVSGALLSGRTVDVTVSGGRIAAVSEHGAAPAPQHAETVEAAGKILFPSFI
CCCCCEEEEEEEEEECCCEEEEEECCCEEEEEECCCCCCCCCHHHHHHHCCCEECCCEE
DCHVHLREPGFEYKEDIASGLAAAAHGGFGAVLPMANTSPVNDQGSVTELMLERARKAWP
EEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCC
HGPRVHPVGAATKGLKGEELAPMGELAAAGCVAFSNDGLPVGGAEMFRRCMEYAADFGKI
CCCCCCCCCCHHCCCCCCCCCCHHHHHHHCEEEECCCCCCCCHHHHHHHHHHHHHHHCCE
VIDHCEDPSLARGTHMNEGVTSGRLGVKGQSVVAESVQVARDILLAEYLGIPVHLAHISC
EEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHH
RQSVELIAWAKQRGVRVTAETCPHYLLLDDLALEQYSTAAKVNPPLRTPDDVAAMRRAVA
HHHHHHHHHHHHCCCEEEHHHCCCEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
DGTIDILVTDHAPHAAHEKDTPLDEAPNGISGLDTAVALTWRLVQEGLLTEADMVRLWCH
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHEEEEC
APGSLFRLPVNRFTAGDPADFFLFDPAHEWTVTPEAMHSKGKNTPFTGWKLTGKVTSHWM
CCCCEEECCHHHCCCCCCCCEEEECCCCCCEECHHHHHCCCCCCCCCCEEEECCHHHHCC
GGHRIA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA