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The map label for this gene is gmd [H]

Identifier: 78357942

GI number: 78357942

Start: 2888968

End: 2890053

Strand: Reverse

Name: gmd [H]

Synonym: Dde_2901

Alternate gene names: 78357942

Gene position: 2890053-2888968 (Counterclockwise)

Preceding gene: 78357943

Following gene: 304570592

Centisome position: 77.48

GC content: 47.24

Gene sequence:

>1086_bases
ATGAAAAAAGCGTTGATTAGCGGGATTACCGGGCAGGATGGAGCCTATCTGGCAGAATTTTTACTGCAAAAAGGCTACGA
AGTGCATGGTATCAAGCGCCGTGCGTCTTTGTTTAATACAGACCGTATTGATCATTTATACGAAGACCCACATGCAGAGA
ACCGTAAATTTATTTTGCATTATGGCGACCTGAGTGATTCGACAAATCTCATCAGAATTATTCAGGAAGTGCAGCCTGAC
GAAATTTATAATCTTGCTGCACAAAGCCATGTACAGGTTTCCTTTGATTCGCCGGAGTACACCGCTAACGTAGATGCTTT
GGGCACGCTTCGCATTCTGGAAGCTATCCGTATTCTGGGTTTAGAAAAGAAAACTCGCTTTTATCAGGCGTCAACTTCGG
AGCTGTTCGGTCAGGTGCAGGAAATTCCGCAGACCGAAAAAACTCCGTTCTATCCGCGTTCCCCTTATGCCTGTGCAAAA
TTGTATGCGTATTGGATTTGCGTAAACTATCGTGAAGCCTACGGCATGTATGCCTGCAATGGGATTTTGTTTAACCATGA
GTCTCCCATTCGTGGCGAAACTTTTGTGACGCGTAAAATTACCAGAGCACTGGCGCGCATCAAGCTCGGCCTGCAAGATA
GGCTTTATCTTGGGAATATGAATGCATTACGCGACTGGGGCCACGCAAAAGACTATGTTGAGATGCAGTGGTTGATGCTC
CAACAGGATGCACCGCAAGATTTTGTTATTGCAACTGGTGAACAGCATTCAGTACGTGAATTTGTTGAGCTGGCAGCTAC
AGAACTGGGCATTTCCATTGAATGGCGTGGCTACGGCGAAGAAGAAAAAGGCTACGATACGGCGACAGGCAAGTGTATCG
TTGCGGTGGATAAAAAATACTATCGTCCCACAGAAGTGGAAACGTTGCTCGGTGATCCTGCCAAGGCCAAAAAAGAACTT
GGGTGGGTGCCGCGCACCACTTTTACCGAATTGGTTAAAGAAATGGTGCAGACGGACTTCCGAGAAGCAGAGCGAGAAAT
CTTGTGTACCGAGCACGGGTTCCCGGTCTGCCAGCCGCAGGAGTAA

Upstream 100 bases:

>100_bases
CTTCTTGCTTTTGCGTCTGGGGCAGGATACGTAAATCCGTTAATTTTATATTACCTCAGCTCGCGGCCGGCGTGCTGTGT
TTTTTGTTGTGAGAAGCATT

Downstream 100 bases:

>100_bases
GTATGACGCTGTCACCAGAAAGCTTGATTTATGTCGCAGGACATGGCGGTCTTGTGGGGGCTGCTATAGTCAGGCGACTA
CAGGCAGAAGGTTGCCAGAA

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MKKALISGITGQDGAYLAEFLLQKGYEVHGIKRRASLFNTDRIDHLYEDPHAENRKFILHYGDLSDSTNLIRIIQEVQPD
EIYNLAAQSHVQVSFDSPEYTANVDALGTLRILEAIRILGLEKKTRFYQASTSELFGQVQEIPQTEKTPFYPRSPYACAK
LYAYWICVNYREAYGMYACNGILFNHESPIRGETFVTRKITRALARIKLGLQDRLYLGNMNALRDWGHAKDYVEMQWLML
QQDAPQDFVIATGEQHSVREFVELAATELGISIEWRGYGEEEKGYDTATGKCIVAVDKKYYRPTEVETLLGDPAKAKKEL
GWVPRTTFTELVKEMVQTDFREAEREILCTEHGFPVCQPQE

Sequences:

>Translated_361_residues
MKKALISGITGQDGAYLAEFLLQKGYEVHGIKRRASLFNTDRIDHLYEDPHAENRKFILHYGDLSDSTNLIRIIQEVQPD
EIYNLAAQSHVQVSFDSPEYTANVDALGTLRILEAIRILGLEKKTRFYQASTSELFGQVQEIPQTEKTPFYPRSPYACAK
LYAYWICVNYREAYGMYACNGILFNHESPIRGETFVTRKITRALARIKLGLQDRLYLGNMNALRDWGHAKDYVEMQWLML
QQDAPQDFVIATGEQHSVREFVELAATELGISIEWRGYGEEEKGYDTATGKCIVAVDKKYYRPTEVETLLGDPAKAKKEL
GWVPRTTFTELVKEMVQTDFREAEREILCTEHGFPVCQPQE
>Mature_361_residues
MKKALISGITGQDGAYLAEFLLQKGYEVHGIKRRASLFNTDRIDHLYEDPHAENRKFILHYGDLSDSTNLIRIIQEVQPD
EIYNLAAQSHVQVSFDSPEYTANVDALGTLRILEAIRILGLEKKTRFYQASTSELFGQVQEIPQTEKTPFYPRSPYACAK
LYAYWICVNYREAYGMYACNGILFNHESPIRGETFVTRKITRALARIKLGLQDRLYLGNMNALRDWGHAKDYVEMQWLML
QQDAPQDFVIATGEQHSVREFVELAATELGISIEWRGYGEEEKGYDTATGKCIVAVDKKYYRPTEVETLLGDPAKAKKEL
GWVPRTTFTELVKEMVQTDFREAEREILCTEHGFPVCQPQE

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=337, Percent_Identity=65.5786350148368, Blast_Score=459, Evalue=1e-129,
Organism=Escherichia coli, GI1788366, Length=366, Percent_Identity=69.672131147541, Blast_Score=542, Evalue=1e-155,
Organism=Escherichia coli, GI48994969, Length=350, Percent_Identity=25.4285714285714, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788353, Length=316, Percent_Identity=24.0506329113924, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17539424, Length=341, Percent_Identity=65.6891495601173, Blast_Score=469, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17507723, Length=341, Percent_Identity=66.5689149560117, Blast_Score=469, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17539422, Length=341, Percent_Identity=65.6891495601173, Blast_Score=468, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI133901786, Length=341, Percent_Identity=65.6891495601173, Blast_Score=468, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI133901788, Length=341, Percent_Identity=65.6891495601173, Blast_Score=468, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI133901790, Length=341, Percent_Identity=65.6891495601173, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24158427, Length=340, Percent_Identity=63.8235294117647, Blast_Score=466, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 41418; Mature: 41418

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKALISGITGQDGAYLAEFLLQKGYEVHGIKRRASLFNTDRIDHLYEDPHAENRKFILH
CCCCHHCCCCCCCHHHHHHHHHHCCCCEECHHHHHHHHCCHHHHHHHCCCCCCCCEEEEE
YGDLSDSTNLIRIIQEVQPDEIYNLAAQSHVQVSFDSPEYTANVDALGTLRILEAIRILG
ECCCCCCHHHHHHHHHCCHHHHHHHHHCCEEEEEECCCCCEECCCHHHHHHHHHHHHHHC
LEKKTRFYQASTSELFGQVQEIPQTEKTPFYPRSPYACAKLYAYWICVNYREAYGMYACN
CCHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHEEEHHHHCCEEEEC
GILFNHESPIRGETFVTRKITRALARIKLGLQDRLYLGNMNALRDWGHAKDYVEMQWLML
EEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCCCCHHHHHHHHEE
QQDAPQDFVIATGEQHSVREFVELAATELGISIEWRGYGEEEKGYDTATGKCIVAVDKKY
CCCCCCCEEEECCCCHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCEEEEECCCC
YRPTEVETLLGDPAKAKKELGWVPRTTFTELVKEMVQTDFREAEREILCTEHGFPVCQPQ
CCCCHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC
E
C
>Mature Secondary Structure
MKKALISGITGQDGAYLAEFLLQKGYEVHGIKRRASLFNTDRIDHLYEDPHAENRKFILH
CCCCHHCCCCCCCHHHHHHHHHHCCCCEECHHHHHHHHCCHHHHHHHCCCCCCCCEEEEE
YGDLSDSTNLIRIIQEVQPDEIYNLAAQSHVQVSFDSPEYTANVDALGTLRILEAIRILG
ECCCCCCHHHHHHHHHCCHHHHHHHHHCCEEEEEECCCCCEECCCHHHHHHHHHHHHHHC
LEKKTRFYQASTSELFGQVQEIPQTEKTPFYPRSPYACAKLYAYWICVNYREAYGMYACN
CCHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHEEEHHHHCCEEEEC
GILFNHESPIRGETFVTRKITRALARIKLGLQDRLYLGNMNALRDWGHAKDYVEMQWLML
EEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCCCCHHHHHHHHEE
QQDAPQDFVIATGEQHSVREFVELAATELGISIEWRGYGEEEKGYDTATGKCIVAVDKKY
CCCCCCCEEEECCCCHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCEEEEECCCC
YRPTEVETLLGDPAKAKKELGWVPRTTFTELVKEMVQTDFREAEREILCTEHGFPVCQPQ
CCCCHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]