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The map label for this gene is fcl [C]

Identifier: 304570592

GI number: 304570592

Start: 2888030

End: 2889010

Strand: Reverse

Name: fcl [C]

Synonym: NA

Alternate gene names: 304570592

Gene position: 2889010-2888030 (Counterclockwise)

Preceding gene: 78357942

Following gene: 78357940

Centisome position: 77.45

GC content: 50.36

Gene sequence:

>981_bases
GTGTACCGAGCACGGGTTCCCGGTCTGCCAGCCGCAGGAGTAAGTATGACGCTGTCACCAGAAAGCTTGATTTATGTCGC
AGGACATGGCGGTCTTGTGGGGGCTGCTATAGTCAGGCGACTACAGGCAGAAGGTTGCCAGAATCTTCTGCTGCGCCGAA
GCCGCGAATTGGATTTGCGCAATCAGCAAGCTGTGGACGACTTTTTTGCGACGTATCGTCCTGAATATGTGTTTCTTGCA
GCCGCAAAAGTGGGCGGGATTCATGCAAATAGCACGTATCCTGCTGACTTCATTCGCGATAACTTGCAAATCCAGACCAA
TGTCATTGATGCAGCATACCGCAATGGTACCCAGAAGCTACTCTTTTTGGGGTCATCATGCATTTATCCAAAGTTTGCAC
CGCAGCCCATGCCCGAGGATTGCCTGCTCACCAGTGCATTGGAGCCGACTAATGAGTGCTACGCTCTTGCAAAAATAGCA
GGCATCAAAATGTGCCAAGCCTATCGGAAGCAGTATGGCTTTGATGCGATTAGCGCAATGCCCACAAACTTGTATGGACC
GGGTGACAATTACCACCCTGAAAACAGCCACGTCATTCCTGCCCTGATCCGACGGTTTCATGAAGCAAAGGTGCAAGGGC
TTCCCCAAGTGACCATATGGGGAACAGGCGCGCCACGGCGGGAGTTTCTCTATTCCGACGATCTCGGAGACGCGCTGGTC
TTTCTTATGAAAAATTATTCGGACATAGAGCATGTGAACGTGGGGTACGGTGAAGACGTTACAATTAAAGAGTTAGCAGG
GCTTGTAGCAAAGGTTGTGGGATATGCTGGTGAAATTTTGACTGATCCCTCAATGCCTGATGGAACACCTCGGAAACTTC
TGGATTGTACGAAGCTATTCTCTATGGGGTGGCGCCCTCATGTGCAGCTTGCAGAAGGATTAGACTTTGCTTATCGCGAT
TTTACGGCAGTTCTGCCATAA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: GDP-fucose synthetase NAD dependent epimerase/dehydratase

Products: GDP-4-dehydro-6-deoxy-D-mannose; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:
NA

Sequences:

>Translated_326_residues
MYRARVPGLPAAGVSMTLSPESLIYVAGHGGLVGAAIVRRLQAEGCQNLLLRRSRELDLRNQQAVDDFFATYRPEYVFLA
AAKVGGIHANSTYPADFIRDNLQIQTNVIDAAYRNGTQKLLFLGSSCIYPKFAPQPMPEDCLLTSALEPTNECYALAKIA
GIKMCQAYRKQYGFDAISAMPTNLYGPGDNYHPENSHVIPALIRRFHEAKVQGLPQVTIWGTGAPRREFLYSDDLGDALV
FLMKNYSDIEHVNVGYGEDVTIKELAGLVAKVVGYAGEILTDPSMPDGTPRKLLDCTKLFSMGWRPHVQLAEGLDFAYRD
FTAVLP
>Mature_326_residues
MYRARVPGLPAAGVSMTLSPESLIYVAGHGGLVGAAIVRRLQAEGCQNLLLRRSRELDLRNQQAVDDFFATYRPEYVFLA
AAKVGGIHANSTYPADFIRDNLQIQTNVIDAAYRNGTQKLLFLGSSCIYPKFAPQPMPEDCLLTSALEPTNECYALAKIA
GIKMCQAYRKQYGFDAISAMPTNLYGPGDNYHPENSHVIPALIRRFHEAKVQGLPQVTIWGTGAPRREFLYSDDLGDALV
FLMKNYSDIEHVNVGYGEDVTIKELAGLVAKVVGYAGEILTDPSMPDGTPRKLLDCTKLFSMGWRPHVQLAEGLDFAYRD
FTAVLP

Specific function: Putative nucleotide sugar epimerase/dehydrogenase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fucose synthase family [H]

Homologues:

Organism=Homo sapiens, GI4507709, Length=282, Percent_Identity=34.0425531914894, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI42516563, Length=317, Percent_Identity=28.0757097791798, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI7657641, Length=269, Percent_Identity=24.5353159851301, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1788365, Length=307, Percent_Identity=56.0260586319218, Blast_Score=357, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17554428, Length=284, Percent_Identity=29.5774647887324, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI19922778, Length=289, Percent_Identity=34.6020761245675, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21356223, Length=310, Percent_Identity=26.7741935483871, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 1.1.1.271

Molecular weight: Translated: 35956; Mature: 35956

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRARVPGLPAAGVSMTLSPESLIYVAGHGGLVGAAIVRRLQAEGCQNLLLRRSRELDLR
CCCCCCCCCCCCCCEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NQQAVDDFFATYRPEYVFLAAAKVGGIHANSTYPADFIRDNLQIQTNVIDAAYRNGTQKL
HHHHHHHHHHHCCCCEEEEEEEECCCEECCCCCCHHHHHCCCEEEEHHHHHHHHCCCEEE
LFLGSSCIYPKFAPQPMPEDCLLTSALEPTNECYALAKIAGIKMCQAYRKQYGFDAISAM
EEECCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHC
PTNLYGPGDNYHPENSHVIPALIRRFHEAKVQGLPQVTIWGTGAPRREFLYSDDLGDALV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHCEECCCHHHHHH
FLMKNYSDIEHVNVGYGEDVTIKELAGLVAKVVGYAGEILTDPSMPDGTPRKLLDCTKLF
HHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
SMGWRPHVQLAEGLDFAYRDFTAVLP
HCCCCCCHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure
MYRARVPGLPAAGVSMTLSPESLIYVAGHGGLVGAAIVRRLQAEGCQNLLLRRSRELDLR
CCCCCCCCCCCCCCEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NQQAVDDFFATYRPEYVFLAAAKVGGIHANSTYPADFIRDNLQIQTNVIDAAYRNGTQKL
HHHHHHHHHHHCCCCEEEEEEEECCCEECCCCCCHHHHHCCCEEEEHHHHHHHHCCCEEE
LFLGSSCIYPKFAPQPMPEDCLLTSALEPTNECYALAKIAGIKMCQAYRKQYGFDAISAM
EEECCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHC
PTNLYGPGDNYHPENSHVIPALIRRFHEAKVQGLPQVTIWGTGAPRREFLYSDDLGDALV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHCEECCCHHHHHH
FLMKNYSDIEHVNVGYGEDVTIKELAGLVAKVVGYAGEILTDPSMPDGTPRKLLDCTKLF
HHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
SMGWRPHVQLAEGLDFAYRDFTAVLP
HCCCCCCHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDP-L-fucose; NADP+

Specific reaction: GDP-L-fucose + NADP+ = GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]