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The map label for this gene is mltA [H]

Identifier: 78357775

GI number: 78357775

Start: 2736241

End: 2737479

Strand: Reverse

Name: mltA [H]

Synonym: Dde_2733

Alternate gene names: 78357775

Gene position: 2737479-2736241 (Counterclockwise)

Preceding gene: 78357779

Following gene: 78357770

Centisome position: 73.39

GC content: 61.5

Gene sequence:

>1239_bases
ATGCGTGTTGGGCGGCCCATGGCGCCGCGGCTGCGGCTGCTGTTGCTGGCTGCTTGCTGTACTGTGTTGCTGGCGGCCGG
CGGGTGTGCCGTAACTACGGAACAGGCACCCGTGTTCCGCGAGGTTCCGCAGGACGAGGCGCGCGATCTGACCCGCAGTC
TGGACCCGCGGCGGCAGGGACTTGATTCGTGGCTGGCGCTGCGGCCTGCGCTGGAAAGAAGTCTGGAATATGTGCGCCGT
CGTCCTGCACAGGATGCGGCGCTGGATAAATACGGACGCAGAGTCACATGGGATCAGCTGCGTTCGTCGCTGGAACTTTT
TGTCAGCCTGCTGCCGCAGCTCGACAGCCGTCCGGAACTGCTGGCGCGGCATTTCACTTTTCTGCGGCTGGAACCGGGCC
CGCTGTTTACCGGTTATTACGAGCCCTATATTCATGCTTCGCCCGTGCGCAGTGCGGCGTACCCTTTTCCGCTGTACGGC
AAGCCGCAGGATCTGAAAACCGTGCGGCTGGAAGCGTTTCACCCGCGGTGGAAAGGGCAGGTGCTGACATACAGGGTGGA
AAACGGCGAAGTGGTGCCCTACCATGACCGCGAAACCATAGACAGCGGCGGGGCGTTGGAAGGCAAGGGGCTGGAGATAG
CATGGGTGCAGGATCCTGCGGATATATTCTTTCTGCAGGTGCAGGGTTCCGGCAGGCTGATAATGCCCGACGGCACGGAA
AAGCATGTGCTGTACGCCGGTAAAAACGGCAGGGAATATGTATCGCTGGGCAGAGTGATGAAAGAGCGCGGTCTGTTGCC
TGCGGACGGTATTTCCATGCAGTCCATCAGGGCGTATCTGGCTGCGCATCCCGAAAAAGAGCGCGAACTGTTGAATACCA
ATCCGAGCTATGTGTTCTTCCGGCTTTCCGATGACGGGCCTTACGGCAGCATCAATCAGGTGCTTACGCCGTGGGTCAGT
CTGGCCACCGACCGTGCGACTCTGCCGCTGGGCAGCGCCATGCTGTTTTCAGTACCCAGACCGCTGCCCGCCACGGTGCA
GCAGCACGGAACAGATGGCAGGGCATATGCGGAGCAGCCGTTTACGGGCATAGGTCTGGCTCAGGATACCGGCGGCGCCA
TCAAGGAGCACCGGATAGACCTGTTCAGCGGCAGCGGTGAACTGGCGGAATTTGTGGCCGGGCATCTGGCGGCGCGGGGC
AGTGTATATCTGCTGCTGCCGCGGCAGACAGCGCCTTAG

Upstream 100 bases:

>100_bases
CCGCGGACGGGTGCCGTGTGTTGCCGTGTGCGGCAGCGGCTGTGCAGGCCCGTGCGGGACAAGGTCAGGATGGCATAACG
TGAAAGGTATGTTTGTTGAA

Downstream 100 bases:

>100_bases
CATGTGCTGAAAGCGACCTGAGGCGCCCGTGTACCCGACGGGCGCTTTTTTTTGCCCTCGTGCATAAAAAGATGAGTCAG
ACAGAAGGGCTGCAGGCATG

Product: transglycosylase

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MRVGRPMAPRLRLLLLAACCTVLLAAGGCAVTTEQAPVFREVPQDEARDLTRSLDPRRQGLDSWLALRPALERSLEYVRR
RPAQDAALDKYGRRVTWDQLRSSLELFVSLLPQLDSRPELLARHFTFLRLEPGPLFTGYYEPYIHASPVRSAAYPFPLYG
KPQDLKTVRLEAFHPRWKGQVLTYRVENGEVVPYHDRETIDSGGALEGKGLEIAWVQDPADIFFLQVQGSGRLIMPDGTE
KHVLYAGKNGREYVSLGRVMKERGLLPADGISMQSIRAYLAAHPEKERELLNTNPSYVFFRLSDDGPYGSINQVLTPWVS
LATDRATLPLGSAMLFSVPRPLPATVQQHGTDGRAYAEQPFTGIGLAQDTGGAIKEHRIDLFSGSGELAEFVAGHLAARG
SVYLLLPRQTAP

Sequences:

>Translated_412_residues
MRVGRPMAPRLRLLLLAACCTVLLAAGGCAVTTEQAPVFREVPQDEARDLTRSLDPRRQGLDSWLALRPALERSLEYVRR
RPAQDAALDKYGRRVTWDQLRSSLELFVSLLPQLDSRPELLARHFTFLRLEPGPLFTGYYEPYIHASPVRSAAYPFPLYG
KPQDLKTVRLEAFHPRWKGQVLTYRVENGEVVPYHDRETIDSGGALEGKGLEIAWVQDPADIFFLQVQGSGRLIMPDGTE
KHVLYAGKNGREYVSLGRVMKERGLLPADGISMQSIRAYLAAHPEKERELLNTNPSYVFFRLSDDGPYGSINQVLTPWVS
LATDRATLPLGSAMLFSVPRPLPATVQQHGTDGRAYAEQPFTGIGLAQDTGGAIKEHRIDLFSGSGELAEFVAGHLAARG
SVYLLLPRQTAP
>Mature_412_residues
MRVGRPMAPRLRLLLLAACCTVLLAAGGCAVTTEQAPVFREVPQDEARDLTRSLDPRRQGLDSWLALRPALERSLEYVRR
RPAQDAALDKYGRRVTWDQLRSSLELFVSLLPQLDSRPELLARHFTFLRLEPGPLFTGYYEPYIHASPVRSAAYPFPLYG
KPQDLKTVRLEAFHPRWKGQVLTYRVENGEVVPYHDRETIDSGGALEGKGLEIAWVQDPADIFFLQVQGSGRLIMPDGTE
KHVLYAGKNGREYVSLGRVMKERGLLPADGISMQSIRAYLAAHPEKERELLNTNPSYVFFRLSDDGPYGSINQVLTPWVS
LATDRATLPLGSAMLFSVPRPLPATVQQHGTDGRAYAEQPFTGIGLAQDTGGAIKEHRIDLFSGSGELAEFVAGHLAARG
SVYLLLPRQTAP

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=280, Percent_Identity=33.5714285714286, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 45785; Mature: 45785

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGRPMAPRLRLLLLAACCTVLLAAGGCAVTTEQAPVFREVPQDEARDLTRSLDPRRQG
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHCCCHHHHHHHHHCCHHHHH
LDSWLALRPALERSLEYVRRRPAQDAALDKYGRRVTWDQLRSSLELFVSLLPQLDSRPEL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHH
LARHFTFLRLEPGPLFTGYYEPYIHASPVRSAAYPFPLYGKPQDLKTVRLEAFHPRWKGQ
HHHHEEEEEECCCCEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCC
VLTYRVENGEVVPYHDRETIDSGGALEGKGLEIAWVQDPADIFFLQVQGSGRLIMPDGTE
EEEEEECCCCEECCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCCEEECCCCCC
KHVLYAGKNGREYVSLGRVMKERGLLPADGISMQSIRAYLAAHPEKERELLNTNPSYVFF
CEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCEEEE
RLSDDGPYGSINQVLTPWVSLATDRATLPLGSAMLFSVPRPLPATVQQHGTDGRAYAEQP
EECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHEECCCCCCHHHHHCCCCCCEECCCC
FTGIGLAQDTGGAIKEHRIDLFSGSGELAEFVAGHLAARGSVYLLLPRQTAP
CCCCCCCCCCCCCHHHHEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCC
>Mature Secondary Structure
MRVGRPMAPRLRLLLLAACCTVLLAAGGCAVTTEQAPVFREVPQDEARDLTRSLDPRRQG
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHCCCHHHHHHHHHCCHHHHH
LDSWLALRPALERSLEYVRRRPAQDAALDKYGRRVTWDQLRSSLELFVSLLPQLDSRPEL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHH
LARHFTFLRLEPGPLFTGYYEPYIHASPVRSAAYPFPLYGKPQDLKTVRLEAFHPRWKGQ
HHHHEEEEEECCCCEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCC
VLTYRVENGEVVPYHDRETIDSGGALEGKGLEIAWVQDPADIFFLQVQGSGRLIMPDGTE
EEEEEECCCCEECCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCCEEECCCCCC
KHVLYAGKNGREYVSLGRVMKERGLLPADGISMQSIRAYLAAHPEKERELLNTNPSYVFF
CEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCEEEE
RLSDDGPYGSINQVLTPWVSLATDRATLPLGSAMLFSVPRPLPATVQQHGTDGRAYAEQP
EECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHEECCCCCCHHHHHCCCCCCEECCCC
FTGIGLAQDTGGAIKEHRIDLFSGSGELAEFVAGHLAARGSVYLLLPRQTAP
CCCCCCCCCCCCCHHHHEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]