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The map label for this gene is gmk

Identifier: 78357761

GI number: 78357761

Start: 2721190

End: 2721810

Strand: Reverse

Name: gmk

Synonym: Dde_2719

Alternate gene names: 78357761

Gene position: 2721810-2721190 (Counterclockwise)

Preceding gene: 78357762

Following gene: 78357760

Centisome position: 72.97

GC content: 61.35

Gene sequence:

>621_bases
ATGGTCCGTCCCCGTTCCGGCATAGTGCTGGTGCTCTGCGCACCCTCTGGCACAGGAAAAACCACGCTTACCCGCCGCCT
GCTGGAAGAATTCCCCCGGTTTGCCTTTTCTGTATCCTACACCACACGCCAGCCGCGTGCGGGCGAAGAGCACGGGCGCG
AATACAACTTTGTCGATGAAGAAACGTTCATCCGGCTGCGTGATGAAGGCTTTTTTGCCGAATGGGCCGAAGTGCACGGA
AATTTTTACGGAACCCCGCTGGAAGACACCCGCCAGCTGCTGGCCCGCGGGCGTGATGTGCTTTTTGACATCGATGTGCA
GGGCGCGGCGCAGCTGCGTGGTTCGCTTAAGCAGGGCTGCTATGTGTTTATTCTGCCGCCGTCCGGTGCCGAGCTTGAGC
GCCGGCTGCGTGCCAGAGGCACCGACCCCGAAGATACCATCCGCCGTCGTCTGGCCAACGCCCGCCGCGAACTGCAGCAG
GCCCACTGGTTCAACGCCTGGATAGTGAATGACAATCTGGAGCAGGCGTATGACGAGTTGCGTGCCGCGTATCTGGCTGC
CACCCTGTCGCCCACCTGCCGCCCGGAACTGGTGGACGAACTGCTGCAGGATTGGAGATGA

Upstream 100 bases:

>100_bases
AGACGCGGTCCATCATCGTCACCGATTCCAACCATGTCATACTGTCCGCCATTCAGGCGGAAACCATAGGACAACGTTTC
ATTCAGGAGGAAAACAGTTA

Downstream 100 bases:

>100_bases
TGATGCCGGAACTTGTGGTTGCTCTTGATTATCCTGAAAGCGAACAGGCTGTTGCCATGGCTGCACGGCTGCAAGGAAGC
TGCCCCTGGGTCAAGGTGGG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MVRPRSGIVLVLCAPSGTGKTTLTRRLLEEFPRFAFSVSYTTRQPRAGEEHGREYNFVDEETFIRLRDEGFFAEWAEVHG
NFYGTPLEDTRQLLARGRDVLFDIDVQGAAQLRGSLKQGCYVFILPPSGAELERRLRARGTDPEDTIRRRLANARRELQQ
AHWFNAWIVNDNLEQAYDELRAAYLAATLSPTCRPELVDELLQDWR

Sequences:

>Translated_206_residues
MVRPRSGIVLVLCAPSGTGKTTLTRRLLEEFPRFAFSVSYTTRQPRAGEEHGREYNFVDEETFIRLRDEGFFAEWAEVHG
NFYGTPLEDTRQLLARGRDVLFDIDVQGAAQLRGSLKQGCYVFILPPSGAELERRLRARGTDPEDTIRRRLANARRELQQ
AHWFNAWIVNDNLEQAYDELRAAYLAATLSPTCRPELVDELLQDWR
>Mature_206_residues
MVRPRSGIVLVLCAPSGTGKTTLTRRLLEEFPRFAFSVSYTTRQPRAGEEHGREYNFVDEETFIRLRDEGFFAEWAEVHG
NFYGTPLEDTRQLLARGRDVLFDIDVQGAAQLRGSLKQGCYVFILPPSGAELERRLRARGTDPEDTIRRRLANARRELQQ
AHWFNAWIVNDNLEQAYDELRAAYLAATLSPTCRPELVDELLQDWR

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=178, Percent_Identity=42.1348314606742, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI4504221, Length=178, Percent_Identity=42.1348314606742, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI226874831, Length=178, Percent_Identity=42.1348314606742, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI38570142, Length=174, Percent_Identity=35.0574712643678, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI4505237, Length=188, Percent_Identity=30.8510638297872, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI262118263, Length=187, Percent_Identity=31.0160427807487, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI262118259, Length=187, Percent_Identity=31.0160427807487, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI262118255, Length=188, Percent_Identity=30.8510638297872, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI21361598, Length=198, Percent_Identity=29.7979797979798, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI14780902, Length=200, Percent_Identity=31.5, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI52630447, Length=183, Percent_Identity=30.0546448087432, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI111154074, Length=176, Percent_Identity=29.5454545454545, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI186700629, Length=189, Percent_Identity=27.5132275132275, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI186700627, Length=189, Percent_Identity=27.5132275132275, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI186972120, Length=189, Percent_Identity=27.5132275132275, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI21536464, Length=190, Percent_Identity=26.8421052631579, Blast_Score=67, Evalue=8e-12,
Organism=Escherichia coli, GI1790080, Length=204, Percent_Identity=42.156862745098, Blast_Score=156, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI193203132, Length=176, Percent_Identity=42.0454545454545, Blast_Score=141, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17508835, Length=176, Percent_Identity=42.0454545454545, Blast_Score=140, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17557440, Length=190, Percent_Identity=29.4736842105263, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71988048, Length=174, Percent_Identity=28.1609195402299, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71988041, Length=174, Percent_Identity=28.1609195402299, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=185, Percent_Identity=41.6216216216216, Blast_Score=152, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21356141, Length=176, Percent_Identity=43.1818181818182, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI161077626, Length=189, Percent_Identity=30.6878306878307, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24640542, Length=176, Percent_Identity=31.8181818181818, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45554489, Length=176, Percent_Identity=31.8181818181818, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45554481, Length=176, Percent_Identity=31.8181818181818, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI116007136, Length=176, Percent_Identity=31.8181818181818, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI85724806, Length=176, Percent_Identity=31.8181818181818, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI221330162, Length=192, Percent_Identity=30.2083333333333, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI221330166, Length=192, Percent_Identity=30.2083333333333, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221330164, Length=192, Percent_Identity=30.2083333333333, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI161078487, Length=189, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24648808, Length=189, Percent_Identity=25.9259259259259, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161078485, Length=177, Percent_Identity=26.5536723163842, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24648810, Length=177, Percent_Identity=26.5536723163842, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281362230, Length=189, Percent_Identity=25.9259259259259, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281362232, Length=177, Percent_Identity=26.5536723163842, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_DESDG (Q30XT1)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_389210.1
- HSSP:   P60546
- ProteinModelPortal:   Q30XT1
- SMR:   Q30XT1
- STRING:   Q30XT1
- GeneID:   3757742
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2719
- NMPDR:   fig|207559.3.peg.3072
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   CLSK704923
- BioCyc:   DDES207559:DDE_2719-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23732; Mature: 23732

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRPRSGIVLVLCAPSGTGKTTLTRRLLEEFPRFAFSVSYTTRQPRAGEEHGREYNFVDE
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHEEEEEECCCCCCCCHHCCCCCCCCCH
ETFIRLRDEGFFAEWAEVHGNFYGTPLEDTRQLLARGRDVLFDIDVQGAAQLRGSLKQGC
HHEEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCC
YVFILPPSGAELERRLRARGTDPEDTIRRRLANARRELQQAHWFNAWIVNDNLEQAYDEL
EEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHH
RAAYLAATLSPTCRPELVDELLQDWR
HHHHHHHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MVRPRSGIVLVLCAPSGTGKTTLTRRLLEEFPRFAFSVSYTTRQPRAGEEHGREYNFVDE
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHEEEEEECCCCCCCCHHCCCCCCCCCH
ETFIRLRDEGFFAEWAEVHGNFYGTPLEDTRQLLARGRDVLFDIDVQGAAQLRGSLKQGC
HHEEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCC
YVFILPPSGAELERRLRARGTDPEDTIRRRLANARRELQQAHWFNAWIVNDNLEQAYDEL
EEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHH
RAAYLAATLSPTCRPELVDELLQDWR
HHHHHHHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA