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The map label for this gene is flp [H]

Identifier: 78357686

GI number: 78357686

Start: 2660844

End: 2661590

Strand: Reverse

Name: flp [H]

Synonym: Dde_2644

Alternate gene names: 78357686

Gene position: 2661590-2660844 (Counterclockwise)

Preceding gene: 78357690

Following gene: 78357682

Centisome position: 71.35

GC content: 57.16

Gene sequence:

>747_bases
ATGAACCATGGTGTAATCATTGTCGGCTTTGTGGGCAAGGTGCCGCACGGAGCGGAGAACAGAATGGAAAACAGTCTTTT
TCTGGGGCGTATTCCCCTTTTCAGCGGGTTGTCGGCTCAGCAGCTGGAATCCATGGCATCCATAGCCGTGGACAGGCCGG
TGGACAAGGGGCAGATTATTTTTGTCGAAGGAACGCGTGCAGAAGGCCTGTACATAGTGCTGGATGGCCGTGTCAAAATA
TTCAAGACGGCTCCGGACGGACGCGAGGCGGTGATGCATGTGTTCGGCGCGGGAGAGCCTTTCGGCGAGGTGGCTGTGTT
TCAGAACGATGTCTTTCCGGCCAATGCCATGGCGGTGGAACAGAGCCGCGTTCTTTTTTTGCCGCGCAGGGGCATTGTGG
ACCGCATTGCCCAAGACCCGTCACTGGCAATGAACATGCTGGCTGCCCTTTCGCGCAAGCTGCGCATGTTCACCCGGCAG
GTGGAGGCGCTGACCCTCAAGGAGATTCCCCAGCGTCTGGCGGCGTATCTGCTGCATCTCAGTGTGAAAAAAGGGCACAA
GGACGTTATCAGGCTGGATGTTTCGAAAAGTCTGCTGGCGGGTGTGCTGGGCACTGCGCGTGAAACTCTTTCGCGGGCAC
TGGCAAAACTGGTGGAAACAGGGGCCATAACCATGGAAGGCCGCACCATCACCATTACAGACCGTGAATACCTGACCGCA
CTGGCCGAAGGGCATGAGTCGCTGTAG

Upstream 100 bases:

>100_bases
TTCCGGCGATGTTCCGCGGGGTGCTTGCCATGCTGTGTAATCCTCCGTAAGTATGTGACTATGAAATCACCGCGCCGTGG
TGTCGCGGTGCTGTCTGCGT

Downstream 100 bases:

>100_bases
CGCGTAGCGGGGCCGCTGTGTATGTGCTGCCGGTCTGTCAGACCTTGTGATCAGCTTCCGGCAGGCGGACCACCAGAACA
GGCACCGGGCAGCGCGAAAC

Product: Crp/FNR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MNHGVIIVGFVGKVPHGAENRMENSLFLGRIPLFSGLSAQQLESMASIAVDRPVDKGQIIFVEGTRAEGLYIVLDGRVKI
FKTAPDGREAVMHVFGAGEPFGEVAVFQNDVFPANAMAVEQSRVLFLPRRGIVDRIAQDPSLAMNMLAALSRKLRMFTRQ
VEALTLKEIPQRLAAYLLHLSVKKGHKDVIRLDVSKSLLAGVLGTARETLSRALAKLVETGAITMEGRTITITDREYLTA
LAEGHESL

Sequences:

>Translated_248_residues
MNHGVIIVGFVGKVPHGAENRMENSLFLGRIPLFSGLSAQQLESMASIAVDRPVDKGQIIFVEGTRAEGLYIVLDGRVKI
FKTAPDGREAVMHVFGAGEPFGEVAVFQNDVFPANAMAVEQSRVLFLPRRGIVDRIAQDPSLAMNMLAALSRKLRMFTRQ
VEALTLKEIPQRLAAYLLHLSVKKGHKDVIRLDVSKSLLAGVLGTARETLSRALAKLVETGAITMEGRTITITDREYLTA
LAEGHESL
>Mature_248_residues
MNHGVIIVGFVGKVPHGAENRMENSLFLGRIPLFSGLSAQQLESMASIAVDRPVDKGQIIFVEGTRAEGLYIVLDGRVKI
FKTAPDGREAVMHVFGAGEPFGEVAVFQNDVFPANAMAVEQSRVLFLPRRGIVDRIAQDPSLAMNMLAALSRKLRMFTRQ
VEALTLKEIPQRLAAYLLHLSVKKGHKDVIRLDVSKSLLAGVLGTARETLSRALAKLVETGAITMEGRTITITDREYLTA
LAEGHESL

Specific function: Global Transcription Factor That Controls The Expression Of Over 100 Target Genes In Response To Anoxia. It Facilitates The Adaptation To Anaerobic Growth Conditions By Regulating The Expression Of Gene Products That Are Involved In Anaerobic Energy Metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=214, Percent_Identity=27.1028037383178, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1789756, Length=177, Percent_Identity=23.728813559322, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 27088; Mature: 27088

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHGVIIVGFVGKVPHGAENRMENSLFLGRIPLFSGLSAQQLESMASIAVDRPVDKGQII
CCCCEEEEEECCCCCCCHHHHHHCCEEEECCCHHCCCCHHHHHHHHHHHHCCCCCCCEEE
FVEGTRAEGLYIVLDGRVKIFKTAPDGREAVMHVFGAGEPFGEVAVFQNDVFPANAMAVE
EEECCCCCCEEEEEECCEEEEEECCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEC
QSRVLFLPRRGIVDRIAQDPSLAMNMLAALSRKLRMFTRQVEALTLKEIPQRLAAYLLHL
CCCEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVKKGHKDVIRLDVSKSLLAGVLGTARETLSRALAKLVETGAITMEGRTITITDREYLTA
HHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEEECHHHHHH
LAEGHESL
HHHCCCCC
>Mature Secondary Structure
MNHGVIIVGFVGKVPHGAENRMENSLFLGRIPLFSGLSAQQLESMASIAVDRPVDKGQII
CCCCEEEEEECCCCCCCHHHHHHCCEEEECCCHHCCCCHHHHHHHHHHHHCCCCCCCEEE
FVEGTRAEGLYIVLDGRVKIFKTAPDGREAVMHVFGAGEPFGEVAVFQNDVFPANAMAVE
EEECCCCCCEEEEEECCEEEEEECCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEC
QSRVLFLPRRGIVDRIAQDPSLAMNMLAALSRKLRMFTRQVEALTLKEIPQRLAAYLLHL
CCCEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVKKGHKDVIRLDVSKSLLAGVLGTARETLSRALAKLVETGAITMEGRTITITDREYLTA
HHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEEECHHHHHH
LAEGHESL
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2113923; 8441692 [H]