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The map label for this gene is pgk

Identifier: 78357672

GI number: 78357672

Start: 2645441

End: 2646685

Strand: Reverse

Name: pgk

Synonym: Dde_2630

Alternate gene names: 78357672

Gene position: 2646685-2645441 (Counterclockwise)

Preceding gene: 78357673

Following gene: 78357667

Centisome position: 70.95

GC content: 60.96

Gene sequence:

>1245_bases
ATGCATGATCACATTCGCACCTTTTTTATGCTGTATCCTTCAGTCTTAGCCCGCAGGAGACTTCATATGAACGTACTGAA
AATGACTGATCTTGATCTGCGCGGAAAGCGTGTGCTTATCCGCGAGGACCTGAACGCTCCCATCAAGGACGGGGCGGTGG
CCAACGACAACAGGCTGCGCGCAGCCGCACCTACCATCCGCCTTGCCATGCAGGCAGGAGCACGGGTTATGGTGATGTCG
CATCTGGGCCGCCCGGCAGAAGGCGCGTTTGACGAATCGGCATCCATGGCACCTGTGGCGGCACGGCTGGCCGATATTCT
GGGCTGCCCCGTGCCGGTGGTGCGGGACTGGCTGGACGGGGTGGATGTGCCCGAAGGCGGCGTGGTGCTGACAGAGAATG
TACGCTTCAACAAGGGCGAAAAAAAGAACGACGAAGAGCTGGGCAGGCGCATGGCGGCCCTGTGCGATGTTTATGTGATG
GATGCTTTCGGCACGGCGCACCGTGCGCAGGCTTCCACCCATGCCGTTGCCGCATTTGCTCCCGTGGCCTGCGCGGGTCC
GCTGCTGGCGGCGGAGCTGGAAGCTCTGGGCAAGGCTCTTGGCGCCCCGCGCCACCCTGTGGTTGGCATCATCGGCGGTT
CCAAGGTCTCGACCAAGCTCACTCTGCTGGAAACGCTTTCCTCCAAGGTCGACAAGCTTATTGTGGGCGGGGGCATTGCC
AATACGTTTATCCGTGCCGCAGGTTTTGCCGTGGGCAAATCACTGTATGAAGAAGATCTGGTGGCCGAAGCCGCCCGCCT
GATGCAGGCCGCAGCCGCAGCCGGAGGAGAGATTCCCGTGCCTGTGGATGTGGTGGTGGCCACGGAGTTTGCCGAAACTG
CAACGCCTGTCTGCAAGCCGGTGGATCAGGTGGCCGATAATGAGATGATTATGGACATCGGGCCGCAAACCGCCGCCATG
TATGCAGAGGTGCTGCGCGGAGCAGGAACCATCGTGTGGAACGGACCTGTCGGGGTGTTCGAGTTTGATGCCTTCGGTGC
CGGTACAGAAGCGCTGTGCAGGGCTGTGGCGCAAAGCAGCGCCTTTTCCATCGCCGGCGGCGGTGACACTGTGGCCGCTG
TGGATAAATACGGCGTCCGTGACGGCGTATCCTATATATCCACGGGCGGAGGGGCTTTTCTGGAGTTTCTGGAAGGCAAG
GAGCTGCCGGCAGTGGCCATGCTGGAACAGCGCGCAAAAGCCTGA

Upstream 100 bases:

>100_bases
TACGGCAGACAATGTGGCTGCCGTGGCAAAAGAAGTGCTGTAGCGTTTTTCGGGGATGACCCCGGACGCTGTTCCATGTA
CAACAAAAGGTGCGGGTGTG

Downstream 100 bases:

>100_bases
GCACTGCGAGGGCGTAACTGCCGGTGAGCTTGTGCCGCCACCGGCTGCTGCCGCACCGGTTTTCCTTCGTTATATCTGAA
ACAGCAGTCCCCTGCCGGAC

Product: phosphoglycerate kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MHDHIRTFFMLYPSVLARRRLHMNVLKMTDLDLRGKRVLIREDLNAPIKDGAVANDNRLRAAAPTIRLAMQAGARVMVMS
HLGRPAEGAFDESASMAPVAARLADILGCPVPVVRDWLDGVDVPEGGVVLTENVRFNKGEKKNDEELGRRMAALCDVYVM
DAFGTAHRAQASTHAVAAFAPVACAGPLLAAELEALGKALGAPRHPVVGIIGGSKVSTKLTLLETLSSKVDKLIVGGGIA
NTFIRAAGFAVGKSLYEEDLVAEAARLMQAAAAAGGEIPVPVDVVVATEFAETATPVCKPVDQVADNEMIMDIGPQTAAM
YAEVLRGAGTIVWNGPVGVFEFDAFGAGTEALCRAVAQSSAFSIAGGGDTVAAVDKYGVRDGVSYISTGGGAFLEFLEGK
ELPAVAMLEQRAKA

Sequences:

>Translated_414_residues
MHDHIRTFFMLYPSVLARRRLHMNVLKMTDLDLRGKRVLIREDLNAPIKDGAVANDNRLRAAAPTIRLAMQAGARVMVMS
HLGRPAEGAFDESASMAPVAARLADILGCPVPVVRDWLDGVDVPEGGVVLTENVRFNKGEKKNDEELGRRMAALCDVYVM
DAFGTAHRAQASTHAVAAFAPVACAGPLLAAELEALGKALGAPRHPVVGIIGGSKVSTKLTLLETLSSKVDKLIVGGGIA
NTFIRAAGFAVGKSLYEEDLVAEAARLMQAAAAAGGEIPVPVDVVVATEFAETATPVCKPVDQVADNEMIMDIGPQTAAM
YAEVLRGAGTIVWNGPVGVFEFDAFGAGTEALCRAVAQSSAFSIAGGGDTVAAVDKYGVRDGVSYISTGGGAFLEFLEGK
ELPAVAMLEQRAKA
>Mature_414_residues
MHDHIRTFFMLYPSVLARRRLHMNVLKMTDLDLRGKRVLIREDLNAPIKDGAVANDNRLRAAAPTIRLAMQAGARVMVMS
HLGRPAEGAFDESASMAPVAARLADILGCPVPVVRDWLDGVDVPEGGVVLTENVRFNKGEKKNDEELGRRMAALCDVYVM
DAFGTAHRAQASTHAVAAFAPVACAGPLLAAELEALGKALGAPRHPVVGIIGGSKVSTKLTLLETLSSKVDKLIVGGGIA
NTFIRAAGFAVGKSLYEEDLVAEAARLMQAAAAAGGEIPVPVDVVVATEFAETATPVCKPVDQVADNEMIMDIGPQTAAM
YAEVLRGAGTIVWNGPVGVFEFDAFGAGTEALCRAVAQSSAFSIAGGGDTVAAVDKYGVRDGVSYISTGGGAFLEFLEGK
ELPAVAMLEQRAKA

Specific function: Second phase of glycolysis; second step. [C]

COG id: COG0126

COG function: function code G; 3-phosphoglycerate kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4505763, Length=415, Percent_Identity=39.0361445783133, Blast_Score=268, Evalue=5e-72,
Organism=Homo sapiens, GI31543397, Length=413, Percent_Identity=38.2566585956416, Blast_Score=261, Evalue=8e-70,
Organism=Escherichia coli, GI1789294, Length=391, Percent_Identity=65.2173913043478, Blast_Score=508, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17508823, Length=413, Percent_Identity=41.8886198547215, Blast_Score=290, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6319857, Length=421, Percent_Identity=40.3800475059382, Blast_Score=278, Evalue=1e-75,
Organism=Drosophila melanogaster, GI17136394, Length=415, Percent_Identity=40.2409638554217, Blast_Score=258, Evalue=6e-69,
Organism=Drosophila melanogaster, GI24581203, Length=411, Percent_Identity=37.4695863746959, Blast_Score=240, Evalue=1e-63,

Paralogues:

None

Copy number: 2990 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1460 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001576
- InterPro:   IPR015901
- InterPro:   IPR015911
- InterPro:   IPR015824 [H]

Pfam domain/function: PF00162 PGK [H]

EC number: =2.7.2.3 [H]

Molecular weight: Translated: 43395; Mature: 43395

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00111 PGLYCERATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDHIRTFFMLYPSVLARRRLHMNVLKMTDLDLRGKRVLIREDLNAPIKDGAVANDNRLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCC
AAAPTIRLAMQAGARVMVMSHLGRPAEGAFDESASMAPVAARLADILGCPVPVVRDWLDG
HHHHHHHHHHHCCCEEEEHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCC
VDVPEGGVVLTENVRFNKGEKKNDEELGRRMAALCDVYVMDAFGTAHRAQASTHAVAAFA
CCCCCCCEEEECCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
PVACAGPLLAAELEALGKALGAPRHPVVGIIGGSKVSTKLTLLETLSSKVDKLIVGGGIA
HHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHEEECCCHH
NTFIRAAGFAVGKSLYEEDLVAEAARLMQAAAAAGGEIPVPVDVVVATEFAETATPVCKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHCCHHHHH
VDQVADNEMIMDIGPQTAAMYAEVLRGAGTIVWNGPVGVFEFDAFGAGTEALCRAVAQSS
HHHHCCCCEEEECCCHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCHHHHHHHHHHCC
AFSIAGGGDTVAAVDKYGVRDGVSYISTGGGAFLEFLEGKELPAVAMLEQRAKA
CEEEECCCCCCHHHHHHCCHHCHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MHDHIRTFFMLYPSVLARRRLHMNVLKMTDLDLRGKRVLIREDLNAPIKDGAVANDNRLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCC
AAAPTIRLAMQAGARVMVMSHLGRPAEGAFDESASMAPVAARLADILGCPVPVVRDWLDG
HHHHHHHHHHHCCCEEEEHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCC
VDVPEGGVVLTENVRFNKGEKKNDEELGRRMAALCDVYVMDAFGTAHRAQASTHAVAAFA
CCCCCCCEEEECCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
PVACAGPLLAAELEALGKALGAPRHPVVGIIGGSKVSTKLTLLETLSSKVDKLIVGGGIA
HHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHEEECCCHH
NTFIRAAGFAVGKSLYEEDLVAEAARLMQAAAAAGGEIPVPVDVVVATEFAETATPVCKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHCCHHHHH
VDQVADNEMIMDIGPQTAAMYAEVLRGAGTIVWNGPVGVFEFDAFGAGTEALCRAVAQSS
HHHHCCCCEEEECCCHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCHHHHHHHHHHCC
AFSIAGGGDTVAAVDKYGVRDGVSYISTGGGAFLEFLEGKELPAVAMLEQRAKA
CEEEECCCCCCHHHHHHCCHHCHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA