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The map label for this gene is tktA [H]

Identifier: 78357673

GI number: 78357673

Start: 2646743

End: 2648737

Strand: Reverse

Name: tktA [H]

Synonym: Dde_2631

Alternate gene names: 78357673

Gene position: 2648737-2646743 (Counterclockwise)

Preceding gene: 78357674

Following gene: 78357672

Centisome position: 71.01

GC content: 61.25

Gene sequence:

>1995_bases
ATGGCTTCCCGCAAGGATCTTGCCAACGCTATCCGCGCACTCAGCATGGACGCCGTGGAAAAGGCCAAATCAGGCCACCC
CGGTGCGCCCATGGGTATGGCCGACATGGCCGAAGTTCTGTGGAACGATTTCATGAAGCATAACCCCGCCAACCCCGGCT
GGGCAGACCGCGACCGCTTCGTGCTTTCCAACGGACACGGTTCCATGCTTATTTATTCGCTGCTGCACCTTTCCGGCTAC
GATCTCAGCATCGACGACATCAGAAATTTCCGGCAGCTGCATTCCAAAACTCCGGGCCACCCCGAATACGGCGTGACCCC
CGGCGTGGAAACCACCACCGGCCCGCTGGGGCAGGGCATCGCCACGGCCGTGGGCATGGCCATGGCAGAACGCATGCTGG
CCGAAGCCTTCAACCGCGACGGATTCACCGTTGTCGATCACCACACCTATGTGTTTCTGGGTGACGGCTGCATGATGGAA
GGTCTGTCGCATGAAGCCTGCTCTCTGGCCGGTACGCTGGGCCTGGGCAAGCTTGTGGCGCTGTACGATGATAACGGCAT
TTCCATTGACGGTCGTATCGACAGCTGGTTCGGCGATGATACCCCCGCCCGTTTCCGTGCCTACGGCTGGCATGTGGTGG
CCGGTGTGGACGGACACGATGCCGAAGCCGTGCGCAAAGCCATTGAAGAAGCCAGAGCAGAAACAGGACGTCCCAGCCTG
ATCTGCTGCAAGACCAAGATAGGCATGGGCGCCCCCAATATGGCTGATTCCAGCAAAGTGCACGGTGCGCCGCTGGGTGC
GGATGAAATAGCCGCCACCCGCGCCAACATAGGTTGGAATCATCCTCCGTTCGAGATTCCGGCCGATGTGTATGCAGGTT
GGGACGCACGGCCCAGAGGCGCTGCCGCCCAGCAGGTATGGGATGACATGTTTGCTGCTTATGCCGCAGCACACCCTGCG
CTTGCCGCGGAATTCACCCGCCGCATGGCAGGCGATCTGCCCGAAGGCTGGAAGGAGCTTTGCGAAAAAGCACTGGCGCA
GATTGTGGCCGCTGCCGAAAACCTTGCCACCCGCAAGGCCTGCAACAAATCGCTTGAAGCCATCGGCCCTGCGCTGCCCG
AAATGGTGGGCGGTTCCGCCGACCTTACCGGCTCCGTAGGTACCAAATGGAGTGGCAGCAGGCTGCTGGACAGCGCCAAC
TGGGGCGGCAACTATATTTCCTATGGTGTGCGTGAGTTCGCCATGGGTGCCATCATGAACGGCCTGACCCTGCATGGCGG
CTTCCTGCCTTACGCCGGTACGTTCCTCATTTTCTCCGATTACGCCAAAAATGCGTTCCGTCTTTCCGCGCTGATGGGCA
TCCGCACCGTCTGGGTGCTGACGCACGACTCCATCGGTGTGGGCGAAGACGGCCCCACGCACCAGCCGGTGGAACAGCTG
GCCGGTCTGCGTCTTATTCCCGGGGCTCATGTGTGGCGCCCCTGCGATACCGTGGAAACTCAGGTTGCCTGGCAGAGTGC
CGTTGAATACAAAAACGGCCCCACAGCGCTGTCGTTTACGCGGCAGGGTGTGCCTTTCATGCAGCGTGATGATGCCGCAG
TGCGGAACATCGCCCGCGGCGGTTATGTGCTGCGTGACTGCGAGGGTACCCCGGAAGTCATCCTTATCGCCACCGGTTCG
GAAGTGGGCGTGGCCGCCGGAGCCTGCGACAGGCTGACAGCCGAAGGCCGCAGGGTACGGCTTGTTTCCATGCCGTGCAG
CAATATCTTCGACCGGCAGGACGCCGCCTACCGTGAATCGGTACTGCCCGCAGCTGTTGAGGCCCGTGTGGCCGTTGAAG
CCGCCGCTTCTGACTTCTGGTGGAAATACGTGGGGCTGAAAGGCCGCGTGGTGGGTATGACCACCTTTGGCGAATCCGCC
CCCGGCAAGGTGCTGTTCGAACACTTCGGCTTTACGGCAGACAATGTGGCTGCCGTGGCAAAAGAAGTGCTGTAG

Upstream 100 bases:

>100_bases
AATGATTTCAGTGGTTGTCTTCCCCGCTTCAAGCGACTAGGGATGCACCAGCCGGCGCGGGTTTACGCACCGGCAATCAG
TCACTCTTCAGGAGGATCAG

Downstream 100 bases:

>100_bases
CGTTTTTCGGGGATGACCCCGGACGCTGTTCCATGTACAACAAAAGGTGCGGGTGTGATGCATGATCACATTCGCACCTT
TTTTATGCTGTATCCTTCAG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MASRKDLANAIRALSMDAVEKAKSGHPGAPMGMADMAEVLWNDFMKHNPANPGWADRDRFVLSNGHGSMLIYSLLHLSGY
DLSIDDIRNFRQLHSKTPGHPEYGVTPGVETTTGPLGQGIATAVGMAMAERMLAEAFNRDGFTVVDHHTYVFLGDGCMME
GLSHEACSLAGTLGLGKLVALYDDNGISIDGRIDSWFGDDTPARFRAYGWHVVAGVDGHDAEAVRKAIEEARAETGRPSL
ICCKTKIGMGAPNMADSSKVHGAPLGADEIAATRANIGWNHPPFEIPADVYAGWDARPRGAAAQQVWDDMFAAYAAAHPA
LAAEFTRRMAGDLPEGWKELCEKALAQIVAAAENLATRKACNKSLEAIGPALPEMVGGSADLTGSVGTKWSGSRLLDSAN
WGGNYISYGVREFAMGAIMNGLTLHGGFLPYAGTFLIFSDYAKNAFRLSALMGIRTVWVLTHDSIGVGEDGPTHQPVEQL
AGLRLIPGAHVWRPCDTVETQVAWQSAVEYKNGPTALSFTRQGVPFMQRDDAAVRNIARGGYVLRDCEGTPEVILIATGS
EVGVAAGACDRLTAEGRRVRLVSMPCSNIFDRQDAAYRESVLPAAVEARVAVEAAASDFWWKYVGLKGRVVGMTTFGESA
PGKVLFEHFGFTADNVAAVAKEVL

Sequences:

>Translated_664_residues
MASRKDLANAIRALSMDAVEKAKSGHPGAPMGMADMAEVLWNDFMKHNPANPGWADRDRFVLSNGHGSMLIYSLLHLSGY
DLSIDDIRNFRQLHSKTPGHPEYGVTPGVETTTGPLGQGIATAVGMAMAERMLAEAFNRDGFTVVDHHTYVFLGDGCMME
GLSHEACSLAGTLGLGKLVALYDDNGISIDGRIDSWFGDDTPARFRAYGWHVVAGVDGHDAEAVRKAIEEARAETGRPSL
ICCKTKIGMGAPNMADSSKVHGAPLGADEIAATRANIGWNHPPFEIPADVYAGWDARPRGAAAQQVWDDMFAAYAAAHPA
LAAEFTRRMAGDLPEGWKELCEKALAQIVAAAENLATRKACNKSLEAIGPALPEMVGGSADLTGSVGTKWSGSRLLDSAN
WGGNYISYGVREFAMGAIMNGLTLHGGFLPYAGTFLIFSDYAKNAFRLSALMGIRTVWVLTHDSIGVGEDGPTHQPVEQL
AGLRLIPGAHVWRPCDTVETQVAWQSAVEYKNGPTALSFTRQGVPFMQRDDAAVRNIARGGYVLRDCEGTPEVILIATGS
EVGVAAGACDRLTAEGRRVRLVSMPCSNIFDRQDAAYRESVLPAAVEARVAVEAAASDFWWKYVGLKGRVVGMTTFGESA
PGKVLFEHFGFTADNVAAVAKEVL
>Mature_663_residues
ASRKDLANAIRALSMDAVEKAKSGHPGAPMGMADMAEVLWNDFMKHNPANPGWADRDRFVLSNGHGSMLIYSLLHLSGYD
LSIDDIRNFRQLHSKTPGHPEYGVTPGVETTTGPLGQGIATAVGMAMAERMLAEAFNRDGFTVVDHHTYVFLGDGCMMEG
LSHEACSLAGTLGLGKLVALYDDNGISIDGRIDSWFGDDTPARFRAYGWHVVAGVDGHDAEAVRKAIEEARAETGRPSLI
CCKTKIGMGAPNMADSSKVHGAPLGADEIAATRANIGWNHPPFEIPADVYAGWDARPRGAAAQQVWDDMFAAYAAAHPAL
AAEFTRRMAGDLPEGWKELCEKALAQIVAAAENLATRKACNKSLEAIGPALPEMVGGSADLTGSVGTKWSGSRLLDSANW
GGNYISYGVREFAMGAIMNGLTLHGGFLPYAGTFLIFSDYAKNAFRLSALMGIRTVWVLTHDSIGVGEDGPTHQPVEQLA
GLRLIPGAHVWRPCDTVETQVAWQSAVEYKNGPTALSFTRQGVPFMQRDDAAVRNIARGGYVLRDCEGTPEVILIATGSE
VGVAAGACDRLTAEGRRVRLVSMPCSNIFDRQDAAYRESVLPAAVEARVAVEAAASDFWWKYVGLKGRVVGMTTFGESAP
GKVLFEHFGFTADNVAAVAKEVL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=603, Percent_Identity=25.7048092868988, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI4507521, Length=603, Percent_Identity=25.7048092868988, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI133778974, Length=579, Percent_Identity=26.0794473229706, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI225637459, Length=582, Percent_Identity=23.3676975945017, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI225637463, Length=503, Percent_Identity=23.2604373757455, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI225637461, Length=552, Percent_Identity=23.0072463768116, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI48994911, Length=664, Percent_Identity=64.7590361445783, Blast_Score=921, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=662, Percent_Identity=62.3867069486405, Blast_Score=882, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=684, Percent_Identity=26.0233918128655, Blast_Score=168, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6325331, Length=669, Percent_Identity=47.3841554559043, Blast_Score=592, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6319593, Length=667, Percent_Identity=44.0779610194903, Blast_Score=553, Evalue=1e-158,
Organism=Drosophila melanogaster, GI45551847, Length=689, Percent_Identity=26.7053701015965, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI45550715, Length=689, Percent_Identity=26.7053701015965, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24645119, Length=655, Percent_Identity=26.1068702290076, Blast_Score=149, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24666278, Length=265, Percent_Identity=30.9433962264151, Blast_Score=122, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 71047; Mature: 70916

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASRKDLANAIRALSMDAVEKAKSGHPGAPMGMADMAEVLWNDFMKHNPANPGWADRDRF
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLSGYDLSIDDIRNFRQLHSKTPGHPEYGVTPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHH
ATAVGMAMAERMLAEAFNRDGFTVVDHHTYVFLGDGCMMEGLSHEACSLAGTLGLGKLVA
HHHHHHHHHHHHHHHHHCCCCCEEEECCEEEEECCCHHHCCCCHHHHHHHHHCCCCEEEE
LYDDNGISIDGRIDSWFGDDTPARFRAYGWHVVAGVDGHDAEAVRKAIEEARAETGRPSL
EECCCCEEECCCCCCCCCCCCCHHHEEECEEEEECCCCCCHHHHHHHHHHHHHHCCCCCE
ICCKTKIGMGAPNMADSSKVHGAPLGADEIAATRANIGWNHPPFEIPADVYAGWDARPRG
EEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCC
AAAQQVWDDMFAAYAAAHPALAAEFTRRMAGDLPEGWKELCEKALAQIVAAAENLATRKA
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
CNKSLEAIGPALPEMVGGSADLTGSVGTKWSGSRLLDSANWGGNYISYGVREFAMGAIMN
HHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHC
GLTLHGGFLPYAGTFLIFSDYAKNAFRLSALMGIRTVWVLTHDSIGVGEDGPTHQPVEQL
CCEECCCCHHHHCCEEEEEHHHCHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCHHHHH
AGLRLIPGAHVWRPCDTVETQVAWQSAVEYKNGPTALSFTRQGVPFMQRDDAAVRNIARG
CCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHC
GYVLRDCEGTPEVILIATGSEVGVAAGACDRLTAEGRRVRLVSMPCSNIFDRQDAAYRES
CCEEEECCCCCCEEEEECCCCCCCCCCCHHHHCCCCCEEEEEECCHHHHHCCCHHHHHHH
VLPAAVEARVAVEAAASDFWWKYVGLKGRVVGMTTFGESAPGKVLFEHFGFTADNVAAVA
HCHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEEECCCCCCCHHHHHHCCCCHHHHHHHH
KEVL
HHCC
>Mature Secondary Structure 
ASRKDLANAIRALSMDAVEKAKSGHPGAPMGMADMAEVLWNDFMKHNPANPGWADRDRF
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLSGYDLSIDDIRNFRQLHSKTPGHPEYGVTPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHH
ATAVGMAMAERMLAEAFNRDGFTVVDHHTYVFLGDGCMMEGLSHEACSLAGTLGLGKLVA
HHHHHHHHHHHHHHHHHCCCCCEEEECCEEEEECCCHHHCCCCHHHHHHHHHCCCCEEEE
LYDDNGISIDGRIDSWFGDDTPARFRAYGWHVVAGVDGHDAEAVRKAIEEARAETGRPSL
EECCCCEEECCCCCCCCCCCCCHHHEEECEEEEECCCCCCHHHHHHHHHHHHHHCCCCCE
ICCKTKIGMGAPNMADSSKVHGAPLGADEIAATRANIGWNHPPFEIPADVYAGWDARPRG
EEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCC
AAAQQVWDDMFAAYAAAHPALAAEFTRRMAGDLPEGWKELCEKALAQIVAAAENLATRKA
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
CNKSLEAIGPALPEMVGGSADLTGSVGTKWSGSRLLDSANWGGNYISYGVREFAMGAIMN
HHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHC
GLTLHGGFLPYAGTFLIFSDYAKNAFRLSALMGIRTVWVLTHDSIGVGEDGPTHQPVEQL
CCEECCCCHHHHCCEEEEEHHHCHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCHHHHH
AGLRLIPGAHVWRPCDTVETQVAWQSAVEYKNGPTALSFTRQGVPFMQRDDAAVRNIARG
CCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHC
GYVLRDCEGTPEVILIATGSEVGVAAGACDRLTAEGRRVRLVSMPCSNIFDRQDAAYRES
CCEEEECCCCCCEEEEECCCCCCCCCCCHHHHCCCCCEEEEEECCHHHHHCCCHHHHHHH
VLPAAVEARVAVEAAASDFWWKYVGLKGRVVGMTTFGESAPGKVLFEHFGFTADNVAAVA
HCHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEEECCCCCCCHHHHHHCCCCHHHHHHHH
KEVL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]