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The map label for this gene is lpxK

Identifier: 78357642

GI number: 78357642

Start: 2619102

End: 2620172

Strand: Reverse

Name: lpxK

Synonym: Dde_2600

Alternate gene names: 78357642

Gene position: 2620172-2619102 (Counterclockwise)

Preceding gene: 78357643

Following gene: 78357641

Centisome position: 70.24

GC content: 62.65

Gene sequence:

>1071_bases
ATGTCTTCTCTGCCGTTGCAGAAATCTCTTTACCCCCTGCTGCGTCCGCTGGGCGCGGCATATCGTGTATTGATGCGGGC
GCGCAGACGCCGGTACGAAAACGGCGCCGCCTGCGGCACTGATGTTCCGTGTGTTTCCGTGGGCAACATCGGCTGGGGCG
GCAGCGGCAAGACGCCGGTGGTGCAGTGGTTGCTGCAGTGGGCTGCCGTACACGGCCTGCACGCCGTGGTGCTGACGCGC
GGTTACAAGGCTTCGCCGCCCGGACTGCCTTATGTGGTGACGCCGCAAAGCTCTGCGGCACATGCGGGGGACGAACCGCT
GATGCTGGCGCGCAGCTGTCCGCAGGCCACTGTGGTAGTGGACCCTGTGCGCAGCCGGTCCGCCCGTTGGGCGCAGGAGC
GGCTGGCTCCCGATTTTTTTGTGCTGGATGACGGATTCCAGCATGTGCAGGTAGCCCGCGATACTGATCTGGTTCTGCTG
AAAAAAGATGATCTGCACGCGGAATGGGGGCGTGTATTGCCTGCCGGTTCATGGCGCGAAGGGCCGGAAGCCCTCTCACG
CGCAGCGGCGTTCTGCATAAAGTGCGGCAGCGGTGAATTTTCCGGCCTTGTTCCGGATTTTGAGAACCGGCTGGGCAGCT
TCGGAGTGCCGGTGTTCGGTTTTTCACTGCGGCCCGGCGCCCTGATACCTGTCTGCGGTGCGCATGAAGGTGCGCAGCTG
CCTGCGGGGGCGCCGTATGTGCTTTTCAGCGGTGTGGGCGACCCTGCTCAGGTTGCAGTTACCGTCAGCAGTTTTTTAGG
GTATGATCCCGTCAGGCATCATGTGTTTGCCGACCATCACGGGTATACACAGGCGGACATGGACCGCATGGCCGGTTACG
GGCTGCCGCTGGTGTGTACTCCCAAAGATGCGGTAAAACTGACGGCACCGTGCGGGGTTCCGGTGTGGACCCTGTCGCTG
GAGACAAATTTTCATTCCGTATGGAACGCGCAACCTCCGGCAGGGCAGGCCGGTGAAGGTTTTGCGCAATGGTGGCAGTG
CCGCTGGCAACGGCTGGCAGGCCTGCGCTGA

Upstream 100 bases:

>100_bases
CTGTTCCTGATGCTTCTCAGGCTCTTCGGCGGAGCACGGGATTAACCGTCAAATGAGTACACGAAGGGAGCCGTGAGGCT
CCCTTTTTTGTGGTGGCTGC

Downstream 100 bases:

>100_bases
AGGTGCGGCATGCCGGATATACGGTGGCGTATGTCCGCATGTTGCCGGATGACGGCAGCATGACAGCTGCCGGTTTTTCA
AAGGTTCTTTCGGGGCCGGT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSSLPLQKSLYPLLRPLGAAYRVLMRARRRRYENGAACGTDVPCVSVGNIGWGGSGKTPVVQWLLQWAAVHGLHAVVLTR
GYKASPPGLPYVVTPQSSAAHAGDEPLMLARSCPQATVVVDPVRSRSARWAQERLAPDFFVLDDGFQHVQVARDTDLVLL
KKDDLHAEWGRVLPAGSWREGPEALSRAAAFCIKCGSGEFSGLVPDFENRLGSFGVPVFGFSLRPGALIPVCGAHEGAQL
PAGAPYVLFSGVGDPAQVAVTVSSFLGYDPVRHHVFADHHGYTQADMDRMAGYGLPLVCTPKDAVKLTAPCGVPVWTLSL
ETNFHSVWNAQPPAGQAGEGFAQWWQCRWQRLAGLR

Sequences:

>Translated_356_residues
MSSLPLQKSLYPLLRPLGAAYRVLMRARRRRYENGAACGTDVPCVSVGNIGWGGSGKTPVVQWLLQWAAVHGLHAVVLTR
GYKASPPGLPYVVTPQSSAAHAGDEPLMLARSCPQATVVVDPVRSRSARWAQERLAPDFFVLDDGFQHVQVARDTDLVLL
KKDDLHAEWGRVLPAGSWREGPEALSRAAAFCIKCGSGEFSGLVPDFENRLGSFGVPVFGFSLRPGALIPVCGAHEGAQL
PAGAPYVLFSGVGDPAQVAVTVSSFLGYDPVRHHVFADHHGYTQADMDRMAGYGLPLVCTPKDAVKLTAPCGVPVWTLSL
ETNFHSVWNAQPPAGQAGEGFAQWWQCRWQRLAGLR
>Mature_355_residues
SSLPLQKSLYPLLRPLGAAYRVLMRARRRRYENGAACGTDVPCVSVGNIGWGGSGKTPVVQWLLQWAAVHGLHAVVLTRG
YKASPPGLPYVVTPQSSAAHAGDEPLMLARSCPQATVVVDPVRSRSARWAQERLAPDFFVLDDGFQHVQVARDTDLVLLK
KDDLHAEWGRVLPAGSWREGPEALSRAAAFCIKCGSGEFSGLVPDFENRLGSFGVPVFGFSLRPGALIPVCGAHEGAQLP
AGAPYVLFSGVGDPAQVAVTVSSFLGYDPVRHHVFADHHGYTQADMDRMAGYGLPLVCTPKDAVKLTAPCGVPVWTLSLE
TNFHSVWNAQPPAGQAGEGFAQWWQCRWQRLAGLR

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=322, Percent_Identity=31.9875776397516, Blast_Score=109, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_DESDG (Q30Y50)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_389091.1
- STRING:   Q30Y50
- GeneID:   3757622
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2600
- NMPDR:   fig|207559.3.peg.2625
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   IPAGSWR
- ProtClustDB:   CLSK705802
- BioCyc:   DDES207559:DDE_2600-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 38412; Mature: 38281

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLPLQKSLYPLLRPLGAAYRVLMRARRRRYENGAACGTDVPCVSVGNIGWGGSGKTPV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCHH
VQWLLQWAAVHGLHAVVLTRGYKASPPGLPYVVTPQSSAAHAGDEPLMLARSCPQATVVV
HHHHHHHHHHHHHHEEEEECCCCCCCCCCCEEECCCCCCCCCCCCCEEEECCCCCCEEEE
DPVRSRSARWAQERLAPDFFVLDDGFQHVQVARDTDLVLLKKDDLHAEWGRVLPAGSWRE
CCHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCEEEEECCCCCHHHCCCCCCCCCCC
GPEALSRAAAFCIKCGSGEFSGLVPDFENRLGSFGVPVFGFSLRPGALIPVCGAHEGAQL
CHHHHHHHHHHEEECCCCCCCCCCCCHHHHHCCCCCCEEEEECCCCCEEEECCCCCCCCC
PAGAPYVLFSGVGDPAQVAVTVSSFLGYDPVRHHVFADHHGYTQADMDRMAGYGLPLVCT
CCCCCEEEEECCCCHHHHEEEHHHHHCCCHHHHHEEECCCCCCHHHHHHHHCCCCCEEEC
PKDAVKLTAPCGVPVWTLSLETNFHSVWNAQPPAGQAGEGFAQWWQCRWQRLAGLR
CCCCEEEECCCCCEEEEEEEECCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SSLPLQKSLYPLLRPLGAAYRVLMRARRRRYENGAACGTDVPCVSVGNIGWGGSGKTPV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCHH
VQWLLQWAAVHGLHAVVLTRGYKASPPGLPYVVTPQSSAAHAGDEPLMLARSCPQATVVV
HHHHHHHHHHHHHHEEEEECCCCCCCCCCCEEECCCCCCCCCCCCCEEEECCCCCCEEEE
DPVRSRSARWAQERLAPDFFVLDDGFQHVQVARDTDLVLLKKDDLHAEWGRVLPAGSWRE
CCHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCEEEEECCCCCHHHCCCCCCCCCCC
GPEALSRAAAFCIKCGSGEFSGLVPDFENRLGSFGVPVFGFSLRPGALIPVCGAHEGAQL
CHHHHHHHHHHEEECCCCCCCCCCCCHHHHHCCCCCCEEEEECCCCCEEEECCCCCCCCC
PAGAPYVLFSGVGDPAQVAVTVSSFLGYDPVRHHVFADHHGYTQADMDRMAGYGLPLVCT
CCCCCEEEEECCCCHHHHEEEHHHHHCCCHHHHHEEECCCCCCHHHHHHHHCCCCCEEEC
PKDAVKLTAPCGVPVWTLSLETNFHSVWNAQPPAGQAGEGFAQWWQCRWQRLAGLR
CCCCEEEECCCCCEEEEEEEECCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA