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The map label for this gene is acrR [H]

Identifier: 78357580

GI number: 78357580

Start: 2556751

End: 2557014

Strand: Direct

Name: acrR [H]

Synonym: Dde_2537

Alternate gene names: 78357580

Gene position: 2556751-2557014 (Clockwise)

Preceding gene: 78357578

Following gene: 78357581

Centisome position: 68.54

GC content: 49.62

Gene sequence:

>264_bases
ATGGCTCGAAAAACCAAAGAAGAAGCTGAAAAAACCCGTCAGCTTCTGCTGGATTGCGCACTGACGGTATTCCTGCGCAA
AGGTTACTCCGCAACTACTCTGAACGACATTGCAGAAGAAGCAAACCTGACAAGGGGCGCTGTCTACTGGCATTTTAAAA
ATAAAGTAGACGTTTTTTCCGCCGTCATGGACAAAGCGTTCGACCCCATTCAAGGCTGGTCCGCCATATTCTTGAGCGGG
GCGGAGACCCCATGTTTGTGCTGA

Upstream 100 bases:

>100_bases
AACTAACATTACGGCTGTCATCCGCGGGGTCTGCCGACCACTGGAAAGTCATAGCAATTCCTGATAAAATATATTCACCG
ACACTAACAAAGGGATGTAC

Downstream 100 bases:

>100_bases
CAGAAGTGCTGCAGCACTGGATGCTTAAGCTGGCAGTGGACGACACCATGCAGAAGGCGCTGGAGCTGGTGATGACCAAA
ACCGAGCACAGCGAAGAACT

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Potential acrAB operon repressor [H]

Number of amino acids: Translated: 87; Mature: 86

Protein sequence:

>87_residues
MARKTKEEAEKTRQLLLDCALTVFLRKGYSATTLNDIAEEANLTRGAVYWHFKNKVDVFSAVMDKAFDPIQGWSAIFLSG
AETPCLC

Sequences:

>Translated_87_residues
MARKTKEEAEKTRQLLLDCALTVFLRKGYSATTLNDIAEEANLTRGAVYWHFKNKVDVFSAVMDKAFDPIQGWSAIFLSG
AETPCLC
>Mature_86_residues
ARKTKEEAEKTRQLLLDCALTVFLRKGYSATTLNDIAEEANLTRGAVYWHFKNKVDVFSAVMDKAFDPIQGWSAIFLSGA
ETPCLC

Specific function: Potential regulator protein for the acrAB genes [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=62, Percent_Identity=58.0645161290323, Blast_Score=83, Evalue=4e-18,
Organism=Escherichia coli, GI1789664, Length=60, Percent_Identity=58.3333333333333, Blast_Score=78, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 9746; Mature: 9615

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKTKEEAEKTRQLLLDCALTVFLRKGYSATTLNDIAEEANLTRGAVYWHFKNKVDVFS
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEECCHHHHHH
AVMDKAFDPIQGWSAIFLSGAETPCLC
HHHHHCCCCCCCCHHEEECCCCCCCCC
>Mature Secondary Structure 
ARKTKEEAEKTRQLLLDCALTVFLRKGYSATTLNDIAEEANLTRGAVYWHFKNKVDVFS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEECCHHHHHH
AVMDKAFDPIQGWSAIFLSGAETPCLC
HHHHHCCCCCCCCHHEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]