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The map label for this gene is argG

Identifier: 78357574

GI number: 78357574

Start: 2550287

End: 2551489

Strand: Reverse

Name: argG

Synonym: Dde_2531

Alternate gene names: 78357574

Gene position: 2551489-2550287 (Counterclockwise)

Preceding gene: 78357575

Following gene: 78357573

Centisome position: 68.4

GC content: 57.44

Gene sequence:

>1203_bases
ATGGGTAAAGAAATCAAAAAGGTAGTGCTTGCCTATTCCGGCGGGCTGGATACGTCGGTCATCCTGAAGTGGATTGCCAA
GACATATGATTGCGAAGTGGTGACGCTGACTGCCGATCTGGGGCAGGAGGAAGATCTGGACGGCGTGGATGAAAAAGCGC
TGCGCACAGGGGCCACCAGAGCCTATGTGGAAGACCTGCGCGAAGAGTTCGCCCGCGATTTCATTTTTCCCATGATGCGT
GCCTGCGCCATTTACGAAGGCCGCTATCTGCTGGGCACTTCCATCGCCCGTCCGCTCATTACCCGCCGTCTGGTGGAAAT
AGCCCACGCGGAAGGAGCACAGGCAGTGGCCCACGGTGCTACCGGCAAAGGCAACGATCAGGTGCGGTTCGAGCTGGCTT
CCGCCGCACTTGACCCGTCGCTCAAGGTCATTGCTCCGTGGCGCGAATGGGATTTCCGCTCCCGTACCGACCTGCTCAAC
TTTGCTGCAGAAAATGATATTCCCGTTATTTCTGCCGGTAACCGCAAACTGTACAGTATGGACAGAAACATGCTGCACTG
CAGCTTTGAAGGCGGCGAACTGGAAGACCCGTGGAACGAGCCGGGACCGGGCAGTTATATCATGGCAGTACCGGTAGAGC
AGGCTCCTGACGAGCCGGAATACATCACCATCGATTTTGAAAAAGGCAACGCCGTGGCAATCAACGGTCAGGCCATGTCG
CCTGCCGCCATCATCAAAACGCTGAACACACTTGGCGGCAAGCACGGTGTAGGACGTCTGGACATGGTGGAAAACCGTTT
TGTGGGCATGAAGTCGCGCGGTGTGTATGAAACCCCCGGCGGCACCGTGCTGCATGCGGCACACCGCGACCTCGAAGGCA
TATGCCTTGACCGTGAAGCCCTGCATCTGCGCGACAGCCTGATACCCCGCTACGCCGCGGCCGTGTACAACGGTTTCTGG
TACTCGCCGGAGCGCGAAGCCCTGCAGGCTCTGGTAGACAAGACACAGGAAAACGTGACCGGAACAGTGCGCGTGAAGCT
GTATAAAGGCAATGTCGTGCCCGTGGGCCGCAAGTCGCCGTATTCACTGTACCGTATGGATCTTGCGACCTTTGAGGAAG
ATGAAGTTTACAATCAGGCAGACGCCGCCGGCTTTATCCGCCTGAACAGTCTGCGCATTCAGGGTTACGGCAGGAGAAGC
TGA

Upstream 100 bases:

>100_bases
GCGCAGATGACGGTTGTACCACCACGGGGCGCGGGGCGCCCCGTTTTCAGTAAGGGCGCTTCGCGCGTCCGGCGGGAAAT
AAAAGAGCTGAGGATATATC

Downstream 100 bases:

>100_bases
CATGACTGCGGGCAAGCTGTGGGGCGGGCGTTTTCGTGAGCGCACCGCCGGATTGGTGGAGGAATACACCGAGTCCGTTT
CGTACGACCGCGCGTTGTAC

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MGKEIKKVVLAYSGGLDTSVILKWIAKTYDCEVVTLTADLGQEEDLDGVDEKALRTGATRAYVEDLREEFARDFIFPMMR
ACAIYEGRYLLGTSIARPLITRRLVEIAHAEGAQAVAHGATGKGNDQVRFELASAALDPSLKVIAPWREWDFRSRTDLLN
FAAENDIPVISAGNRKLYSMDRNMLHCSFEGGELEDPWNEPGPGSYIMAVPVEQAPDEPEYITIDFEKGNAVAINGQAMS
PAAIIKTLNTLGGKHGVGRLDMVENRFVGMKSRGVYETPGGTVLHAAHRDLEGICLDREALHLRDSLIPRYAAAVYNGFW
YSPEREALQALVDKTQENVTGTVRVKLYKGNVVPVGRKSPYSLYRMDLATFEEDEVYNQADAAGFIRLNSLRIQGYGRRS

Sequences:

>Translated_400_residues
MGKEIKKVVLAYSGGLDTSVILKWIAKTYDCEVVTLTADLGQEEDLDGVDEKALRTGATRAYVEDLREEFARDFIFPMMR
ACAIYEGRYLLGTSIARPLITRRLVEIAHAEGAQAVAHGATGKGNDQVRFELASAALDPSLKVIAPWREWDFRSRTDLLN
FAAENDIPVISAGNRKLYSMDRNMLHCSFEGGELEDPWNEPGPGSYIMAVPVEQAPDEPEYITIDFEKGNAVAINGQAMS
PAAIIKTLNTLGGKHGVGRLDMVENRFVGMKSRGVYETPGGTVLHAAHRDLEGICLDREALHLRDSLIPRYAAAVYNGFW
YSPEREALQALVDKTQENVTGTVRVKLYKGNVVPVGRKSPYSLYRMDLATFEEDEVYNQADAAGFIRLNSLRIQGYGRRS
>Mature_399_residues
GKEIKKVVLAYSGGLDTSVILKWIAKTYDCEVVTLTADLGQEEDLDGVDEKALRTGATRAYVEDLREEFARDFIFPMMRA
CAIYEGRYLLGTSIARPLITRRLVEIAHAEGAQAVAHGATGKGNDQVRFELASAALDPSLKVIAPWREWDFRSRTDLLNF
AAENDIPVISAGNRKLYSMDRNMLHCSFEGGELEDPWNEPGPGSYIMAVPVEQAPDEPEYITIDFEKGNAVAINGQAMSP
AAIIKTLNTLGGKHGVGRLDMVENRFVGMKSRGVYETPGGTVLHAAHRDLEGICLDREALHLRDSLIPRYAAAVYNGFWY
SPEREALQALVDKTQENVTGTVRVKLYKGNVVPVGRKSPYSLYRMDLATFEEDEVYNQADAAGFIRLNSLRIQGYGRRS

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI53759107, Length=400, Percent_Identity=47, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI16950633, Length=400, Percent_Identity=47, Blast_Score=362, Evalue=1e-100,
Organism=Escherichia coli, GI1789563, Length=417, Percent_Identity=30.2158273381295, Blast_Score=142, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6324514, Length=406, Percent_Identity=44.3349753694581, Blast_Score=337, Evalue=1e-93,
Organism=Drosophila melanogaster, GI21358151, Length=405, Percent_Identity=45.679012345679, Blast_Score=337, Evalue=1e-92,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ASSY_DESDG (Q30YB8)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_389023.1
- HSSP:   Q9X2A1
- ProteinModelPortal:   Q30YB8
- SMR:   Q30YB8
- STRING:   Q30YB8
- PRIDE:   Q30YB8
- GeneID:   3757548
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2531
- NMPDR:   fig|207559.3.peg.3469
- eggNOG:   COG0137
- HOGENOM:   HBG335267
- OMA:   PLIAKRQ
- ProtClustDB:   PRK00509
- BioCyc:   DDES207559:DDE_2531-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00005
- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11587
- TIGRFAMs:   TIGR00032

Pfam domain/function: PF00764 Arginosuc_synth

EC number: =6.3.4.5

Molecular weight: Translated: 44359; Mature: 44228

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1; PS00565 ARGININOSUCCIN_SYN_2

Important sites: BINDING 38-38 BINDING 89-89 BINDING 94-94 BINDING 119-119 BINDING 121-121 BINDING 125-125 BINDING 125-125 BINDING 126-126 BINDING 129-129 BINDING 179-179 BINDING 188-188 BINDING 264-264 BINDING 276-276

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKEIKKVVLAYSGGLDTSVILKWIAKTYDCEVVTLTADLGQEEDLDGVDEKALRTGATR
CCHHHHEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHCCHH
AYVEDLREEFARDFIFPMMRACAIYEGRYLLGTSIARPLITRRLVEIAHAEGAQAVAHGA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
TGKGNDQVRFELASAALDPSLKVIAPWREWDFRSRTDLLNFAAENDIPVISAGNRKLYSM
CCCCCCEEEEEEEHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCEEECCCCEEEEC
DRNMLHCSFEGGELEDPWNEPGPGSYIMAVPVEQAPDEPEYITIDFEKGNAVAINGQAMS
CCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEECCCCCC
PAAIIKTLNTLGGKHGVGRLDMVENRFVGMKSRGVYETPGGTVLHAAHRDLEGICLDREA
HHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCEECCCCCEEEECCCCCCCEEECHHH
LHLRDSLIPRYAAAVYNGFWYSPEREALQALVDKTQENVTGTVRVKLYKGNVVPVGRKSP
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCEEECCCCCC
YSLYRMDLATFEEDEVYNQADAAGFIRLNSLRIQGYGRRS
CCEEEEHHHCCCHHHHHCCCCCCEEEEEEEEEEECCCCCC
>Mature Secondary Structure 
GKEIKKVVLAYSGGLDTSVILKWIAKTYDCEVVTLTADLGQEEDLDGVDEKALRTGATR
CHHHHEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHCCHH
AYVEDLREEFARDFIFPMMRACAIYEGRYLLGTSIARPLITRRLVEIAHAEGAQAVAHGA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
TGKGNDQVRFELASAALDPSLKVIAPWREWDFRSRTDLLNFAAENDIPVISAGNRKLYSM
CCCCCCEEEEEEEHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCEEECCCCEEEEC
DRNMLHCSFEGGELEDPWNEPGPGSYIMAVPVEQAPDEPEYITIDFEKGNAVAINGQAMS
CCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEECCCCCC
PAAIIKTLNTLGGKHGVGRLDMVENRFVGMKSRGVYETPGGTVLHAAHRDLEGICLDREA
HHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCEECCCCCEEEECCCCCCCEEECHHH
LHLRDSLIPRYAAAVYNGFWYSPEREALQALVDKTQENVTGTVRVKLYKGNVVPVGRKSP
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCEEECCCCCC
YSLYRMDLATFEEDEVYNQADAAGFIRLNSLRIQGYGRRS
CCEEEEHHHCCCHHHHHCCCCCCEEEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA