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The map label for this gene is ribH

Identifier: 78357480

GI number: 78357480

Start: 2458251

End: 2458721

Strand: Direct

Name: ribH

Synonym: Dde_2437

Alternate gene names: 78357480

Gene position: 2458251-2458721 (Clockwise)

Preceding gene: 78357479

Following gene: 78357481

Centisome position: 65.9

GC content: 61.57

Gene sequence:

>471_bases
ATGATGCACCTGAAAACCATCGAAGGCCAGTTCGACGCCAAGGGGCTGAAGTTCGCCATCATCGCCACCCGCTTCAATGA
CTTTGTCGTTGACCGTCTGGTTGGCGGCGCCGTCGACTACCTGACCCGCTGCGGCGGCAGCCGCGAAGACATGACCCTCA
TCCGTCTGCCCGGCGCATTCGAAATGCCCGTGGCCGCCAAAAAGCTGGCCGCCTCCGGCAAATACGACGGCGTGATCGCT
CTGGGTGCCGTCATCCGCGGTGCCACTCCGCACTTTGATTTTGTGGCCAACGAAGCCACCAAAGGCCTTGCACAGGTTGC
GCTGGAATCCGGCGTACCCGTGGGATTCGGCCTGCTGACCACCGACACGCTGGAACAGGCCATCGAGCGCGCCGGTTCCA
AGGGCGGAAACAAAGGCGTGGAAGCTGCTTCCGCCGTTCTTGAAACGATCCGAGTACTGGAGCAGCTGTAA

Upstream 100 bases:

>100_bases
ATTTGTTGATGATGCGCACCCCGTGTTCCGGCACGGGGTGCGACCTGCATATTCCACTTTGCCACGCGGCCCCCGCGCCG
CCATCAGGAGACTTTTTACC

Downstream 100 bases:

>100_bases
CACATGGCCGCAAAAGGTAACAATTCATCGCGGCGCTCTTCGCGGGCGCTTGCTTTTCAGGTTCTTTACGGGCTTAACTT
TTCGCCCGCCAAGGATCTGG

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MMHLKTIEGQFDAKGLKFAIIATRFNDFVVDRLVGGAVDYLTRCGGSREDMTLIRLPGAFEMPVAAKKLAASGKYDGVIA
LGAVIRGATPHFDFVANEATKGLAQVALESGVPVGFGLLTTDTLEQAIERAGSKGGNKGVEAASAVLETIRVLEQL

Sequences:

>Translated_156_residues
MMHLKTIEGQFDAKGLKFAIIATRFNDFVVDRLVGGAVDYLTRCGGSREDMTLIRLPGAFEMPVAAKKLAASGKYDGVIA
LGAVIRGATPHFDFVANEATKGLAQVALESGVPVGFGLLTTDTLEQAIERAGSKGGNKGVEAASAVLETIRVLEQL
>Mature_156_residues
MMHLKTIEGQFDAKGLKFAIIATRFNDFVVDRLVGGAVDYLTRCGGSREDMTLIRLPGAFEMPVAAKKLAASGKYDGVIA
LGAVIRGATPHFDFVANEATKGLAQVALESGVPVGFGLLTTDTLEQAIERAGSKGGNKGVEAASAVLETIRVLEQL

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=154, Percent_Identity=51.9480519480519, Blast_Score=159, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6324429, Length=127, Percent_Identity=34.6456692913386, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_DESDG (Q30YL2)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388929.1
- ProteinModelPortal:   Q30YL2
- SMR:   Q30YL2
- STRING:   Q30YL2
- GeneID:   3757453
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2437
- NMPDR:   fig|207559.3.peg.2795
- eggNOG:   COG0054
- HOGENOM:   HBG311126
- OMA:   KAGNKGW
- ProtClustDB:   PRK00061
- BioCyc:   DDES207559:DDE_2437-MONOMER
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 16409; Mature: 16409

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMHLKTIEGQFDAKGLKFAIIATRFNDFVVDRLVGGAVDYLTRCGGSREDMTLIRLPGAF
CCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
EMPVAAKKLAASGKYDGVIALGAVIRGATPHFDFVANEATKGLAQVALESGVPVGFGLLT
CCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
TDTLEQAIERAGSKGGNKGVEAASAVLETIRVLEQL
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMHLKTIEGQFDAKGLKFAIIATRFNDFVVDRLVGGAVDYLTRCGGSREDMTLIRLPGAF
CCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
EMPVAAKKLAASGKYDGVIALGAVIRGATPHFDFVANEATKGLAQVALESGVPVGFGLLT
CCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
TDTLEQAIERAGSKGGNKGVEAASAVLETIRVLEQL
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA