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The map label for this gene is ribBA [H]

Identifier: 78357479

GI number: 78357479

Start: 2456901

End: 2458124

Strand: Direct

Name: ribBA [H]

Synonym: Dde_2436

Alternate gene names: 78357479

Gene position: 2456901-2458124 (Clockwise)

Preceding gene: 78357478

Following gene: 78357480

Centisome position: 65.86

GC content: 57.11

Gene sequence:

>1224_bases
ATGCCTATGTGCACGGCCGAAGAGGCCATTGAGGAAATCCGCAGCGGACGGATGCTCATTCTTGTAGACGACGAAGACCG
CGAAAATGAAGGCGACCTGACCATTGCAGCCGAGCATGTTACTCCGGAGATCATCAATTTCATGGCCATGCACGGCCGCG
GTCTCATATGCCTTGCCATGGCGCCCGAATGGGTGGACAAGCTGCAGCTGCCGCTGATGGCCCGCCGCAACGAATCCAAA
TTCGGCACCAACTTCACGGTATCCATCGAAGCCCGTCAGGGCGTCACCACCGGTATTTCCGCCAAAGACCGCGCAACGAC
CATTCTTACGGCAGTGAAAGACGACGTGAAGCCCGAAGACATAGTCACCCCCGGCCACATCTTTCCCCTGCGCGCCCAGA
AGGGCGGTGTCATGGTGCGTGCCGGACAGACCGAAGGCAGTGTGGATCTGGCCCGTCTTGCCGGTCTCAAGCCCGCCGCC
GTCATTTGCGAGATAATCCGCGACGACGGCGAAATGGCCCGCATGCCTGATCTTGTGGAATTTGCCGAAAAGCACGGCCT
GAAGATTGCCACCATACGCGATCTTATCAGGTACCGTATGCAGCCCGGACAACTTTCCGTACAGCGGGTGGCAGAAGCTA
AAATGCCTACCAAATACGGTGACTTCACTGTTATCGCCTACGAAAACGACCACGGTGACGAAACCCACCTTGCCATGGTC
AAAGGCGACATAAAAAATCAGGACGCCGTGCTTGTGCGCGTGCACTCCGAATGCCTCACCGGCGATGTGCTGGGATCGCT
GCGCTGCGACTGCGGCGATCAGCTGGCAGCCGCCATGTGCACCGTGGCAGCCGAAGGCGCAGGCGTTGTGCTGTATATGC
GTCAGGAAGGCCGCGGCATCGGACTGGCCAACAAGATCAAGGCTTATGCGCTGCAGGATCAGGGCTACGATACCGTGGAA
GCCAACCACAAGCTGGGTTTCAAGGCCGACCTGCGCGACTACGGCATCGGCGCACAGATTCTTGTGGATCTGGGCGTGCG
CAAAATGCGCATGATGACCAACAACCCGAAAAAAATCGTGGGCATAGAAGGCTACGGCATTCAGGTGGTCGAACGTGTTC
CCATCGAAATGCATGCCTGCGAATTTAACGAAAATTACCTGCGCACCAAAAAGGAAAAGATGGGGCATATGCTGCATCTT
TCCGACGAAGGGCAGGAACAGTAA

Upstream 100 bases:

>100_bases
GGACTTTCTGCGCGAACACGGCTTTTAACCGTAAAACGCCGCAAACCGCCGGCGGCACGACCGCCGGAGGATACCGCAAC
TTACCGAGAGGTTCCCAGAT

Downstream 100 bases:

>100_bases
CAGCCGGGGCGCCGGCCGCCCCCTCAATTTGTTGATGATGCGCACCCCGTGTTCCGGCACGGGGTGCGACCTGCATATTC
CACTTTGCCACGCGGCCCCC

Product: GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MPMCTAEEAIEEIRSGRMLILVDDEDRENEGDLTIAAEHVTPEIINFMAMHGRGLICLAMAPEWVDKLQLPLMARRNESK
FGTNFTVSIEARQGVTTGISAKDRATTILTAVKDDVKPEDIVTPGHIFPLRAQKGGVMVRAGQTEGSVDLARLAGLKPAA
VICEIIRDDGEMARMPDLVEFAEKHGLKIATIRDLIRYRMQPGQLSVQRVAEAKMPTKYGDFTVIAYENDHGDETHLAMV
KGDIKNQDAVLVRVHSECLTGDVLGSLRCDCGDQLAAAMCTVAAEGAGVVLYMRQEGRGIGLANKIKAYALQDQGYDTVE
ANHKLGFKADLRDYGIGAQILVDLGVRKMRMMTNNPKKIVGIEGYGIQVVERVPIEMHACEFNENYLRTKKEKMGHMLHL
SDEGQEQ

Sequences:

>Translated_407_residues
MPMCTAEEAIEEIRSGRMLILVDDEDRENEGDLTIAAEHVTPEIINFMAMHGRGLICLAMAPEWVDKLQLPLMARRNESK
FGTNFTVSIEARQGVTTGISAKDRATTILTAVKDDVKPEDIVTPGHIFPLRAQKGGVMVRAGQTEGSVDLARLAGLKPAA
VICEIIRDDGEMARMPDLVEFAEKHGLKIATIRDLIRYRMQPGQLSVQRVAEAKMPTKYGDFTVIAYENDHGDETHLAMV
KGDIKNQDAVLVRVHSECLTGDVLGSLRCDCGDQLAAAMCTVAAEGAGVVLYMRQEGRGIGLANKIKAYALQDQGYDTVE
ANHKLGFKADLRDYGIGAQILVDLGVRKMRMMTNNPKKIVGIEGYGIQVVERVPIEMHACEFNENYLRTKKEKMGHMLHL
SDEGQEQ
>Mature_406_residues
PMCTAEEAIEEIRSGRMLILVDDEDRENEGDLTIAAEHVTPEIINFMAMHGRGLICLAMAPEWVDKLQLPLMARRNESKF
GTNFTVSIEARQGVTTGISAKDRATTILTAVKDDVKPEDIVTPGHIFPLRAQKGGVMVRAGQTEGSVDLARLAGLKPAAV
ICEIIRDDGEMARMPDLVEFAEKHGLKIATIRDLIRYRMQPGQLSVQRVAEAKMPTKYGDFTVIAYENDHGDETHLAMVK
GDIKNQDAVLVRVHSECLTGDVLGSLRCDCGDQLAAAMCTVAAEGAGVVLYMRQEGRGIGLANKIKAYALQDQGYDTVEA
NHKLGFKADLRDYGIGAQILVDLGVRKMRMMTNNPKKIVGIEGYGIQVVERVPIEMHACEFNENYLRTKKEKMGHMLHLS
DEGQEQ

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=195, Percent_Identity=57.4358974358974, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1789420, Length=198, Percent_Identity=50.5050505050505, Blast_Score=218, Evalue=7e-58,
Organism=Saccharomyces cerevisiae, GI6320695, Length=200, Percent_Identity=41.5, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6319438, Length=170, Percent_Identity=45.8823529411765, Blast_Score=142, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44879; Mature: 44748

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMCTAEEAIEEIRSGRMLILVDDEDRENEGDLTIAAEHVTPEIINFMAMHGRGLICLAM
CCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCEEEEEE
APEWVDKLQLPLMARRNESKFGTNFTVSIEARQGVTTGISAKDRATTILTAVKDDVKPED
CHHHHHHHCCCHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHEEEHHHCCCCCCC
IVTPGHIFPLRAQKGGVMVRAGQTEGSVDLARLAGLKPAAVICEIIRDDGEMARMPDLVE
CCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHCCCCHHHHHHHHHHCCCCHHCCCHHHH
FAEKHGLKIATIRDLIRYRMQPGQLSVQRVAEAKMPTKYGDFTVIAYENDHGDETHLAMV
HHHHCCCEEEHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCCEEEEEE
KGDIKNQDAVLVRVHSECLTGDVLGSLRCDCGDQLAAAMCTVAAEGAGVVLYMRQEGRGI
ECCCCCCCEEEEEEECHHHCHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCC
GLANKIKAYALQDQGYDTVEANHKLGFKADLRDYGIGAQILVDLGVRKMRMMTNNPKKIV
CCHHHEEEEEECCCCCCEEECCCCCCCEECHHHCCCCHHHHHHHCHHHHHHHCCCCCEEE
GIEGYGIQVVERVPIEMHACEFNENYLRTKKEKMGHMLHLSDEGQEQ
EECCCCEEEEEECCEEEEEEECCCHHHHHHHHHCCCEEEECCCCCCC
>Mature Secondary Structure 
PMCTAEEAIEEIRSGRMLILVDDEDRENEGDLTIAAEHVTPEIINFMAMHGRGLICLAM
CCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCEEEEEE
APEWVDKLQLPLMARRNESKFGTNFTVSIEARQGVTTGISAKDRATTILTAVKDDVKPED
CHHHHHHHCCCHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHEEEHHHCCCCCCC
IVTPGHIFPLRAQKGGVMVRAGQTEGSVDLARLAGLKPAAVICEIIRDDGEMARMPDLVE
CCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHCCCCHHHHHHHHHHCCCCHHCCCHHHH
FAEKHGLKIATIRDLIRYRMQPGQLSVQRVAEAKMPTKYGDFTVIAYENDHGDETHLAMV
HHHHCCCEEEHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCCEEEEEE
KGDIKNQDAVLVRVHSECLTGDVLGSLRCDCGDQLAAAMCTVAAEGAGVVLYMRQEGRGI
ECCCCCCCEEEEEEECHHHCHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCC
GLANKIKAYALQDQGYDTVEANHKLGFKADLRDYGIGAQILVDLGVRKMRMMTNNPKKIV
CCHHHEEEEEECCCCCCEEECCCCCCCEECHHHCCCCHHHHHHHCHHHHHHHCCCCCEEE
GIEGYGIQVVERVPIEMHACEFNENYLRTKKEKMGHMLHLSDEGQEQ
EECCCCEEEEEECCEEEEEEECCCHHHHHHHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA